DE60204125D1 - Verfahren zur herstellung von metoprolol enthaltenden mikropartikeln - Google Patents

Verfahren zur herstellung von metoprolol enthaltenden mikropartikeln

Info

Publication number
DE60204125D1
DE60204125D1 DE60204125T DE60204125T DE60204125D1 DE 60204125 D1 DE60204125 D1 DE 60204125D1 DE 60204125 T DE60204125 T DE 60204125T DE 60204125 T DE60204125 T DE 60204125T DE 60204125 D1 DE60204125 D1 DE 60204125D1
Authority
DE
Germany
Prior art keywords
metoprolol
containing microparticles
producing
microparticles
producing metoprolol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60204125T
Other languages
English (en)
Other versions
DE60204125T2 (de
Inventor
Alf Djurle
Mikael Hansson
Malin Soederbom
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of DE60204125D1 publication Critical patent/DE60204125D1/de
Application granted granted Critical
Publication of DE60204125T2 publication Critical patent/DE60204125T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
DE60204125T 2001-03-09 2002-03-06 Verfahren zur herstellung von metoprolol enthaltenden mikropartikeln Expired - Fee Related DE60204125T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0100824 2001-03-09
SE0100824A SE0100824D0 (sv) 2001-03-09 2001-03-09 Method III to obtain microparticles
PCT/SE2002/000401 WO2002072074A1 (en) 2001-03-09 2002-03-06 Method to prepare microparticles metoprolol that contain

Publications (2)

Publication Number Publication Date
DE60204125D1 true DE60204125D1 (de) 2005-06-16
DE60204125T2 DE60204125T2 (de) 2006-01-19

Family

ID=20283295

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60204125T Expired - Fee Related DE60204125T2 (de) 2001-03-09 2002-03-06 Verfahren zur herstellung von metoprolol enthaltenden mikropartikeln

Country Status (25)

Country Link
US (1) US20040116392A1 (de)
EP (1) EP1370245B1 (de)
JP (1) JP2004522798A (de)
KR (1) KR20030081507A (de)
CN (1) CN1236761C (de)
AT (1) ATE295153T1 (de)
AU (1) AU2002235102B2 (de)
BR (1) BR0207919A (de)
CA (1) CA2440167A1 (de)
DE (1) DE60204125T2 (de)
ES (1) ES2240691T3 (de)
HK (1) HK1059737A1 (de)
HU (1) HUP0303450A2 (de)
IL (1) IL157777A0 (de)
IS (1) IS6937A (de)
MX (1) MXPA03008088A (de)
NO (1) NO20033967L (de)
NZ (1) NZ528168A (de)
PL (1) PL363972A1 (de)
PT (1) PT1370245E (de)
RU (1) RU2292878C2 (de)
SE (1) SE0100824D0 (de)
UA (1) UA75909C2 (de)
WO (1) WO2002072074A1 (de)
ZA (1) ZA200306880B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060159756A1 (en) * 1999-09-10 2006-07-20 Brita Sjoblom Method to obtain microparticles containing an H+,K+-ATP-ASE inhibitor
SE0100823D0 (sv) * 2001-03-09 2001-03-09 Astrazeneca Ab Method I to obtain microparticles
SE0100822D0 (sv) * 2001-03-09 2001-03-09 Astrazeneca Ab Method II to obtain microparticles
US8006685B2 (en) * 2002-07-05 2011-08-30 Turbochef Technologies, Inc. Re-circulating oven with gas clean-up
PL1915137T3 (pl) 2005-08-10 2014-03-31 Add Advanced Drug Delivery Tech Ltd Preparat doustny o kontrolowanym uwalnianiu
US20070053983A1 (en) * 2005-09-06 2007-03-08 Girish Jain Extended release compositions of metoprolol succinate
US20090324717A1 (en) * 2006-07-28 2009-12-31 Farmaprojects, S. A. Extended release pharmaceutical formulation of metoprolol and process for its preparation
CA2678956C (en) * 2007-02-23 2013-11-19 Glatt Air Techniques, Inc. Method of determining the weight of the coating to be applied to form a controlled release dosage form
CN101269056B (zh) * 2007-03-19 2010-05-19 天津药物研究院 一种美托洛尔盐类口服脉冲微丸制剂
MX339320B (es) * 2007-10-10 2016-05-20 Avantor Performance Mat Inc Excipiente basado en celulosa microcristalina granular con alta funcionalidad y directamente comprimible, procedimiento de elaboracion y uso del mismo.
US20100055180A1 (en) * 2007-10-10 2010-03-04 Mallinckrodt Baker, Inc. Directly Compressible Granular Microcrystalline Cellulose Based Excipient, Manufacturing Process and Use Thereof
CN102641257A (zh) * 2012-03-31 2012-08-22 内蒙古医学院 阿替洛尔缓释微囊及其制备方法
RU2585023C1 (ru) * 2014-12-18 2016-05-27 Общество с ограниченной ответственностью "Нанолек" Способ гранулирования
CN104739805B (zh) * 2015-04-09 2017-12-19 邸蓉 制备琥珀酸美托洛尔缓释微丸的复相乳液法
WO2019183470A2 (en) 2018-03-22 2019-09-26 Incarda Therapeutics, Inc. A novel method to slow ventricular rate
CN115252913A (zh) * 2022-08-02 2022-11-01 赛诺神畅医疗科技有限公司 一种血管给药涂层及其制备方法和应用

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US653014A (en) * 1899-10-06 1900-07-03 Ashley & Bailey Company Process of silkifying cotton.
SE354851B (de) * 1970-02-18 1973-03-26 Haessle Ab
EP0163836B1 (de) * 1984-04-07 1988-10-12 Bayer Ag Verfahren und Vorrichtung zur Herstellung von Granulaten
IE58110B1 (en) * 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
SE455836B (sv) * 1985-10-11 1988-08-15 Haessle Ab Beredning med kontrollerad frisettning innehallande ett salt av metoprolol samt metod for framstellning av denna beredning
SE450087B (sv) * 1985-10-11 1987-06-09 Haessle Ab Korn med kontrollerad frisettning av farmaceutiskt aktiva emnen som anbringats teckande pa ett kompakt olosligt kernmaterial
DE3909455A1 (de) * 1989-03-22 1990-09-27 Hoechst Ag Verfahren zur herstellung von wasserdispergierbaren granulaten
FR2725623A1 (fr) * 1994-10-18 1996-04-19 Flamel Tech Sa Microcapsules medicamenteuses et/ou nutritionnelles pour administration per os
DE69617245T2 (de) * 1995-08-17 2002-07-25 Csir Pretoria Produkte mit gesteuerter freisetzung
DE19613395A1 (de) * 1996-04-03 1997-10-09 Basf Ag Granulate hygroskopischer, wasserlöslicher Produkte
US6096339A (en) * 1997-04-04 2000-08-01 Alza Corporation Dosage form, process of making and using same
US5891474A (en) * 1997-01-29 1999-04-06 Poli Industria Chimica, S.P.A. Time-specific controlled release dosage formulations and method of preparing same
DE19733094A1 (de) * 1997-07-31 1999-02-04 Merck Patent Gmbh Formulierung auf der Basis von Ascorbinsäure mit verbesserter Farbstabilität
CN1154510C (zh) * 1997-10-15 2004-06-23 默克专利股份有限公司 直压制片助剂的生产方法
EP0987020A1 (de) * 1998-09-04 2000-03-22 Pharma Pass LLC Zusammensetzung enthaltend Metoprolol und Verfahren zur Herstellung
US6395300B1 (en) * 1999-05-27 2002-05-28 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
SE0100823D0 (sv) * 2001-03-09 2001-03-09 Astrazeneca Ab Method I to obtain microparticles
US20060159756A1 (en) * 1999-09-10 2006-07-20 Brita Sjoblom Method to obtain microparticles containing an H+,K+-ATP-ASE inhibitor
EP1320362B1 (de) * 2000-09-20 2011-08-31 Jagotec AG Stabilisierte fibrat-mikropartikel
SE0100822D0 (sv) * 2001-03-09 2001-03-09 Astrazeneca Ab Method II to obtain microparticles

Also Published As

Publication number Publication date
NO20033967L (no) 2003-10-28
ATE295153T1 (de) 2005-05-15
AU2002235102B2 (en) 2006-08-31
US20040116392A1 (en) 2004-06-17
ZA200306880B (en) 2004-12-03
EP1370245A1 (de) 2003-12-17
UA75909C2 (en) 2006-06-15
EP1370245B1 (de) 2005-05-11
JP2004522798A (ja) 2004-07-29
HK1059737A1 (en) 2004-07-16
RU2292878C2 (ru) 2007-02-10
CN1507345A (zh) 2004-06-23
NO20033967D0 (no) 2003-09-08
HUP0303450A2 (hu) 2004-01-28
RU2003127739A (ru) 2005-03-10
ES2240691T3 (es) 2005-10-16
BR0207919A (pt) 2004-04-27
PL363972A1 (en) 2004-11-29
IL157777A0 (en) 2004-03-28
PT1370245E (pt) 2005-08-31
WO2002072074A1 (en) 2002-09-19
CN1236761C (zh) 2006-01-18
SE0100824D0 (sv) 2001-03-09
CA2440167A1 (en) 2002-09-19
KR20030081507A (ko) 2003-10-17
NZ528168A (en) 2005-01-28
IS6937A (is) 2003-09-03
MXPA03008088A (es) 2003-12-12
DE60204125T2 (de) 2006-01-19

Similar Documents

Publication Publication Date Title
DE60204125D1 (de) Verfahren zur herstellung von metoprolol enthaltenden mikropartikeln
ATA152591A (de) Verfahren zur herstellung von zusammensetzungen, die stoffe anhaltend abgeben und so erhaltene zusammensetzungen
DE69226495T2 (de) Verfahren zur herstellung überzogener mikrobieller pestizide und so hergestellte pestizide
ATE267657T1 (de) Verfahren zur herstellung von freiform-produkten
DE60030883D1 (de) Verfahren zur herstellung von alfentanil, sufentanil und remifentanil
ATE306252T1 (de) Verfahren zur herstellung kristalliner partikel zur inhalation
DE69302907T2 (de) Verfahren zur herstellung von feuchtigkeitsbeständigem aluminiumnitridpulver und dadurch hergestelltes pulver
ATE388135T1 (de) Verfahren zur herstellung von 1,3-substituierte indene und aryl-annellierte azapolycyclische verbindungen
DE69920676D1 (de) Verfahren zur Herstellung von Amin-Umsetzungsprodukt-Teilchen
ATE116541T1 (de) Verfahren zur herstellung mikronisierter bioabbaubarer partikel.
ATE290003T1 (de) Verfahren zur herstellung von pyrazolo-(4,3- d)pyrimidin-7-ones und zwischenprodukte davon
DE69517191T2 (de) Wasserlösliche derivate epipodophyllotoxine, verfahren zu ihrer herstellung, ihre verwendung als medikament und ihre verwendung zur herstellung eines antikrebsmittels
DE60040125D1 (de) Verfahren zur Transformierung von Pflanzen, transformierte Pflanzen und Verfahren zur Herstellung von Polyestern
DE59102357D1 (de) Verfahren zur Herstellung von Diphenylaminen.
ATE446963T1 (de) Verfahren zur herstellung von isocyanatoorganosilanen
ATE325794T1 (de) Verfahren zur herstellung und zwischenprodukte von pyridin-2-yl-amin
DE69205601D1 (de) Verfahren zur Herstellung von 3-Cyano-3,5,5-trimethylcyclohexanon.
ATE286899T1 (de) Verfahren zur herstellung von 3- pyridylsulphonylpyrazolo(4,3-d)pyrimidin-7-one und zwischenprodukte
DE60231018D1 (de) Verfahren zur Herstellung von wärmehärtenden Zusammensetzungen und Zähigkeitsregulatoren
ATE208368T1 (de) Verfahren zur herstellung von 3,4 disubstituirten dinitroanilinen
ATE374229T1 (de) Granulatförmige organosilan-präparation, verfahren zu ihrer herstellung und ihrer verwendung
DE60005183D1 (de) Polymerisierbare sauere verbindungen und verfahren zur herstellung
DE69213268D1 (de) Verfahren zur Herstellung eines feinen dendritischen Pulvers und nach diesem Verfahren erzeugtes Pulver
DE69111082D1 (de) Verfahren zur Herstellung von festen Betainen.
DE60332384D1 (de) Verfahren zur herstellung von 1,5-diaminonaphthalin

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee