RU2273476C2 - Каннабиноидные лекарственные средства - Google Patents
Каннабиноидные лекарственные средства Download PDFInfo
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- RU2273476C2 RU2273476C2 RU2002133868/15A RU2002133868A RU2273476C2 RU 2273476 C2 RU2273476 C2 RU 2273476C2 RU 2002133868/15 A RU2002133868/15 A RU 2002133868/15A RU 2002133868 A RU2002133868 A RU 2002133868A RU 2273476 C2 RU2273476 C2 RU 2273476C2
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- Prior art keywords
- cells
- compound
- thc
- cell proliferation
- alkyl
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A—HUMAN NECESSITIES
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
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- A—HUMAN NECESSITIES
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11285131B2 (en) | 2017-08-04 | 2022-03-29 | Merck Sharp & Dohme Corp. | Benzo[b]thiophene STING agonists for cancer treatment |
| US11312772B2 (en) | 2017-08-04 | 2022-04-26 | Merck Sharp & Dohme Corp. | Combinations of PD-1 antagonists and benzo [b] thiophene STING agonists for cancer treatment |
| RU2771811C2 (ru) * | 2017-08-04 | 2022-05-12 | Мерк Шарп И Доум Корп. | БЕНЗО[b]ТИОФЕНОВЫЕ АГОНИСТЫ STING ДЛЯ ЛЕЧЕНИЯ РАКА |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1487436A4 (en) | 2002-03-08 | 2009-06-03 | Signal Pharm Inc | POLYTHERAPY FOR TREATING, PREVENTING OR MANAGING PROLIFERATIVE DISORDERS AND CANCERS |
| DE60320784D1 (de) * | 2002-06-06 | 2008-06-19 | Yissum Res Dev Co | Stände zur modulierung des knochenwachstums |
| US20040186166A1 (en) * | 2002-12-19 | 2004-09-23 | Burstein Sumner H. | Cannabinoid analogs as peroxisome proliferator activated nuclear receptor gamma activators |
| EP1633733B1 (en) * | 2003-05-20 | 2011-01-26 | The University of Tennessee Research Foundation | Cannabinoid derivatives, methods of making, and use thereof |
| US8580842B2 (en) | 2003-09-30 | 2013-11-12 | Abbott Gmbh & Co. Kg | Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them |
| US20050070718A1 (en) | 2003-09-30 | 2005-03-31 | Abbott Gmbh & Co. Kg | Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them |
| GB2418612A (en) * | 2004-10-01 | 2006-04-05 | Gw Pharma Ltd | Inhibition of tumour cell migration with cannabinoids |
| US20060128738A1 (en) * | 2004-12-13 | 2006-06-15 | Indevus Pharmaceuticals, Inc. | Treatment of interstitial cystitis using cannabinoid analogs |
| WO2006065793A2 (en) * | 2004-12-13 | 2006-06-22 | Indevus Pharmaceuticals, Inc. | TREATMENT OF INTERSTITIAL CYSTITIS USING (6aR,10aR)-Δ8-TETRAHYDROCANNABINOL-11-OIC ACIDS |
| US20070037873A1 (en) * | 2005-08-08 | 2007-02-15 | Zurier Robert B | Airway remodeling treatments |
| US7597910B2 (en) * | 2005-08-20 | 2009-10-06 | Slgm Medical Research Institute | Compositions and methods for treating prostate disorders |
| AU2006297300B2 (en) * | 2005-09-29 | 2012-05-10 | Albany Molecular Research, Inc. | Process for production of delta-9-tetrahydrocannabinol |
| US20070093519A1 (en) * | 2005-10-20 | 2007-04-26 | Indevus Pharmaceuticals, Inc. | Anti-emetic uses of cannabinoid analogs |
| WO2007055806A1 (en) * | 2005-10-31 | 2007-05-18 | Indevus Pharmaceuticals, Inc. | Anti-emetic uses of (3r,4r)-δ8-tetrahydrocannabinol-11-oic acids |
| US20080167286A1 (en) | 2006-12-12 | 2008-07-10 | Abbott Laboratories | Pharmaceutical compositions and their methods of use |
| US8486979B2 (en) | 2006-12-12 | 2013-07-16 | Abbvie Inc. | 1,2,4 oxadiazole compounds and methods of use thereof |
| UY30846A1 (es) | 2006-12-30 | 2008-07-31 | Abbott Gmbh & Amp | Derivados de oxindol sustituidos, medicamentos que los comprenden y uso de los mismos |
| US7781650B2 (en) * | 2007-04-30 | 2010-08-24 | Monsanto Technology Llc | Plants and seeds of corn variety CV202909 |
| US9084771B2 (en) | 2007-05-17 | 2015-07-21 | Sutter West Bay Hospitals | Methods and compositions for treating cancer |
| WO2009071687A1 (de) | 2007-12-07 | 2009-06-11 | Abbott Gmbh & Co. Kg | Amidomethyl-substituierte oxindol-derivate und ihre verwendung zur behandlung von vasopressin-abhängigen erkrankungen |
| US8546401B2 (en) | 2007-12-07 | 2013-10-01 | AbbVie Deutschland GmbH & Co. KG | 5,6-disubstituted oxindole-derivatives and use thereof for treating vasopressin-dependent diseases |
| WO2010009775A1 (de) | 2007-12-07 | 2010-01-28 | Abbott Gmbh & Co. Kg | Carbamat-substituierte oxindol-derivate und ihre verwendung zur behandlung von vasopressin-abhängigen erkrankungen |
| BRPI0820668A2 (pt) | 2007-12-07 | 2017-08-22 | Abbott Gmbh & Co Kg | Derivados de oxindol substituídos por 5-halogênio e seu uso para tratar doenças dependentes de vasopressina |
| GB2471987B (en) | 2008-06-04 | 2012-02-22 | Gw Pharma Ltd | Anti-tumoural effects of cannabinoid combinations |
| EP2435080A2 (en) | 2009-05-29 | 2012-04-04 | Abbott Laboratories | Pharmaceutical compositions for the treatment of pain |
| GB2478595B (en) | 2010-03-12 | 2018-04-04 | Gw Pharma Ltd | Phytocannabinoids in the treatment of glioma |
| GB2487712B (en) | 2011-01-04 | 2015-10-28 | Otsuka Pharma Co Ltd | Use of the phytocannabinoid cannabidiol (CBD) in combination with a standard anti-epileptic drug (SAED) in the treatment of epilepsy |
| GB2514054A (en) | 2011-09-29 | 2014-11-12 | Gw Pharma Ltd | A pharmaceutical composition comprising the phytocannabinoids cannabidivarin (CBDV) and cannabidiol (CBD) |
| GB2516814B (en) | 2013-06-19 | 2016-08-31 | Otsuka Pharma Co Ltd | Use of phytocannabinoids for increasing radiosensitivity in the treatment of cancer |
| CN111233814A (zh) * | 2020-03-02 | 2020-06-05 | 福建省中科生物股份有限公司 | 一种萜酚类化合物zkyy-057及其制备方法和应用 |
| US12029718B2 (en) | 2021-11-09 | 2024-07-09 | Cct Sciences, Llc | Process for production of essentially pure delta-9-tetrahydrocannabinol |
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| US5340565A (en) * | 1987-08-25 | 1994-08-23 | Oxi-Gene, Inc. | Tumor or cancer cell killing therapy and agents useful therefor |
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| US5A (en) * | 1836-08-10 | Thomas Blanchard | Machine for mortising solid wooden shells of ships' tackle-blocks | |
| US4327028A (en) * | 1978-08-17 | 1982-04-27 | Calcol, Inc. | Composition of matter |
| US4973603A (en) * | 1988-06-16 | 1990-11-27 | Sumner Burstein | Platelet activating factor antagonist and methods of use therefor |
| US4880030A (en) * | 1988-07-25 | 1989-11-14 | Terry Paul E | Safety flow control fluid shutoff device |
| US5635530A (en) * | 1991-09-12 | 1997-06-03 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | (3S,4S)-delta-6-tetrahydrocannabinol-7-oic acids and derivatives thereof, processors for their preparation and pharmaceutical compositions containing them |
| US5538993A (en) * | 1991-09-12 | 1996-07-23 | Yissum Research Development Company | Certain tetrahydrocannabinol-7-oic acid derivatives |
| US6162829A (en) * | 1997-10-17 | 2000-12-19 | Atlantic Pharmaceuticals, Inc. | (3R,4R)-Δ8 -tetrahydrocannabinol-11-oic acids useful as antiinflammatory agents and analgesics |
| ES1045342Y (es) * | 2000-02-11 | 2001-02-16 | Alvarez Manuel Couto | Expositor giratorio para postales, fotos y similares. |
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2001
- 2001-05-08 US US09/851,122 patent/US6448288B1/en not_active Expired - Lifetime
- 2001-05-17 CN CNB018130100A patent/CN1273123C/zh not_active Expired - Fee Related
- 2001-05-17 AU AU6169501A patent/AU6169501A/xx active Pending
- 2001-05-17 AT AT01939128T patent/ATE406156T1/de not_active IP Right Cessation
- 2001-05-17 AU AU2001263217A patent/AU2001263217A1/en not_active Abandoned
- 2001-05-17 CA CA002409005A patent/CA2409005A1/en not_active Abandoned
- 2001-05-17 HU HU0700039A patent/HUP0700039A2/hu unknown
- 2001-05-17 US US10/276,819 patent/US6914072B2/en not_active Expired - Fee Related
- 2001-05-17 DE DE60135557T patent/DE60135557D1/de not_active Expired - Fee Related
- 2001-05-17 CN CNB018129161A patent/CN1227007C/zh not_active Expired - Fee Related
- 2001-05-17 RU RU2002133869/14A patent/RU2272620C2/ru not_active IP Right Cessation
- 2001-05-17 IL IL15289201A patent/IL152892A0/xx unknown
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- 2001-05-17 WO PCT/US2001/015916 patent/WO2001087295A1/en not_active Ceased
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- 2001-05-17 RU RU2002133868/15A patent/RU2273476C2/ru not_active IP Right Cessation
- 2001-05-17 EP EP01939128A patent/EP1307188B1/en not_active Expired - Lifetime
- 2001-05-17 CA CA002408961A patent/CA2408961A1/en not_active Abandoned
- 2001-05-17 IL IL15289101A patent/IL152891A0/xx unknown
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- 2001-05-17 AU AU6468001A patent/AU6468001A/xx active Pending
- 2001-05-17 NZ NZ523028A patent/NZ523028A/en unknown
- 2001-05-17 JP JP2001583765A patent/JP2003533479A/ja active Pending
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| US5340565A (en) * | 1987-08-25 | 1994-08-23 | Oxi-Gene, Inc. | Tumor or cancer cell killing therapy and agents useful therefor |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11285131B2 (en) | 2017-08-04 | 2022-03-29 | Merck Sharp & Dohme Corp. | Benzo[b]thiophene STING agonists for cancer treatment |
| US11312772B2 (en) | 2017-08-04 | 2022-04-26 | Merck Sharp & Dohme Corp. | Combinations of PD-1 antagonists and benzo [b] thiophene STING agonists for cancer treatment |
| RU2771811C2 (ru) * | 2017-08-04 | 2022-05-12 | Мерк Шарп И Доум Корп. | БЕНЗО[b]ТИОФЕНОВЫЕ АГОНИСТЫ STING ДЛЯ ЛЕЧЕНИЯ РАКА |
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