RU2257198C2 - Композиции микрочастиц и способы их получения - Google Patents

Композиции микрочастиц и способы их получения Download PDF

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Publication number
RU2257198C2
RU2257198C2 RU2003112239/15A RU2003112239A RU2257198C2 RU 2257198 C2 RU2257198 C2 RU 2257198C2 RU 2003112239/15 A RU2003112239/15 A RU 2003112239/15A RU 2003112239 A RU2003112239 A RU 2003112239A RU 2257198 C2 RU2257198 C2 RU 2257198C2
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RU
Russia
Prior art keywords
detergent
microparticles
polymer
poly
biologically active
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RU2003112239/15A
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English (en)
Russian (ru)
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RU2003112239A (ru
Inventor
Джиа-Хва ФАНГ (US)
Джиа-Хва ФАНГ
Манмохан СИНГХ (US)
Манмохан Сингх
Дерек О`ХЭЙГАН (US)
Дерек О`ХЭЙГАН
Маниндер ХОРА (US)
Маниндер ХОРА
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Чирон Корпорейшн
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Publication of RU2003112239A publication Critical patent/RU2003112239A/ru
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
RU2003112239/15A 2000-09-28 2001-09-28 Композиции микрочастиц и способы их получения RU2257198C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23607700P 2000-09-28 2000-09-28
US60/236,077 2000-09-28

Publications (2)

Publication Number Publication Date
RU2003112239A RU2003112239A (ru) 2004-08-27
RU2257198C2 true RU2257198C2 (ru) 2005-07-27

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Country Status (14)

Country Link
US (2) US6753015B2 (enExample)
EP (1) EP1322292B1 (enExample)
JP (2) JP2004509914A (enExample)
CN (2) CN101428006A (enExample)
AT (1) ATE350015T1 (enExample)
AU (2) AU9489801A (enExample)
BR (1) BR0114304A (enExample)
CA (1) CA2420621C (enExample)
DE (1) DE60125795T2 (enExample)
ES (1) ES2278786T3 (enExample)
MX (1) MXPA03002643A (enExample)
RU (1) RU2257198C2 (enExample)
WO (1) WO2002026212A2 (enExample)
ZA (1) ZA200301743B (enExample)

Cited By (6)

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RU2327170C2 (ru) * 2006-02-27 2008-06-20 Закрытое акционерное общество "ДиТест" Способ комплексной диагностики вирусного гепатита в, вирусного гепатита с, вич-инфекции и сифилиса
RU2326655C1 (ru) * 2006-11-09 2008-06-20 Федеральное государственное учреждение "48 Центральный научно-исследовательский институт Министерства обороны Российской Федерации" Способ инкапсулирования белоксодержащих веществ в микросферы из сополимера полилактид-полигликолид
RU2392668C1 (ru) * 2008-12-15 2010-06-20 Федеральное государственное учреждение "Ростовский научно-исследовательский онкологический институт Росмедтехнологий" Способ индукции антипролиферативного, цитотоксического эффекта в опухолевых клетках линейных и свежевыделенных культур
RU2413311C1 (ru) * 2009-07-29 2011-02-27 Федеральное государственное учреждение "Ростовский научно-исследовательский онкологический институт Росмедтехнологий" Способ индукции антипролиферативного действия в эксперименте
WO2014089160A1 (en) * 2012-12-04 2014-06-12 Phosphorex, Inc. Microparticles and nanoparticles having negative surface charges
RU2594249C2 (ru) * 2010-04-09 2016-08-10 Иммурон Лимитед Способы и композиции для предотвращения передачи вич-инфекции

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RU2327170C2 (ru) * 2006-02-27 2008-06-20 Закрытое акционерное общество "ДиТест" Способ комплексной диагностики вирусного гепатита в, вирусного гепатита с, вич-инфекции и сифилиса
RU2326655C1 (ru) * 2006-11-09 2008-06-20 Федеральное государственное учреждение "48 Центральный научно-исследовательский институт Министерства обороны Российской Федерации" Способ инкапсулирования белоксодержащих веществ в микросферы из сополимера полилактид-полигликолид
RU2392668C1 (ru) * 2008-12-15 2010-06-20 Федеральное государственное учреждение "Ростовский научно-исследовательский онкологический институт Росмедтехнологий" Способ индукции антипролиферативного, цитотоксического эффекта в опухолевых клетках линейных и свежевыделенных культур
RU2413311C1 (ru) * 2009-07-29 2011-02-27 Федеральное государственное учреждение "Ростовский научно-исследовательский онкологический институт Росмедтехнологий" Способ индукции антипролиферативного действия в эксперименте
RU2594249C2 (ru) * 2010-04-09 2016-08-10 Иммурон Лимитед Способы и композиции для предотвращения передачи вич-инфекции
WO2014089160A1 (en) * 2012-12-04 2014-06-12 Phosphorex, Inc. Microparticles and nanoparticles having negative surface charges
US10780053B2 (en) 2012-12-04 2020-09-22 Phosphorex, Inc. Microparticles and nanoparticles having negative surface charges
US11771654B2 (en) 2012-12-04 2023-10-03 Cytodigm, Inc. Microparticles and nanoparticles having negative surface charges
US12569441B2 (en) 2012-12-04 2026-03-10 Cytodigm, Inc. Microparticles and nanoparticles having negative surface charges

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EP1322292B1 (en) 2007-01-03
US20040156913A1 (en) 2004-08-12
CN101428006A (zh) 2009-05-13
BR0114304A (pt) 2003-07-29
ES2278786T3 (es) 2007-08-16
US20020136776A1 (en) 2002-09-26
US6753015B2 (en) 2004-06-22
ATE350015T1 (de) 2007-01-15
WO2002026212A2 (en) 2002-04-04
AU2001294898B2 (en) 2006-02-02
AU9489801A (en) 2002-04-08
DE60125795D1 (de) 2007-02-15
CN1535140A (zh) 2004-10-06
DE60125795T2 (de) 2007-10-18
WO2002026212A3 (en) 2003-03-27
US7846479B2 (en) 2010-12-07
JP2004509914A (ja) 2004-04-02
ZA200301743B (en) 2004-10-04
JP2013147514A (ja) 2013-08-01
CA2420621A1 (en) 2002-04-04
CA2420621C (en) 2011-05-24
EP1322292A2 (en) 2003-07-02
MXPA03002643A (es) 2003-06-19

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