RU2237065C2 - Иммуногенная библиотека химерных пептидов, мимикрирующая генетическое многообразие гипервариабельного района v3 белка оболочки gp120 вируса иммунодефицита человека - Google Patents

Иммуногенная библиотека химерных пептидов, мимикрирующая генетическое многообразие гипервариабельного района v3 белка оболочки gp120 вируса иммунодефицита человека Download PDF

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Publication number
RU2237065C2
RU2237065C2 RU2002126396/13A RU2002126396A RU2237065C2 RU 2237065 C2 RU2237065 C2 RU 2237065C2 RU 2002126396/13 A RU2002126396/13 A RU 2002126396/13A RU 2002126396 A RU2002126396 A RU 2002126396A RU 2237065 C2 RU2237065 C2 RU 2237065C2
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RU
Russia
Prior art keywords
hiv
library
chimeric peptides
antibodies
protein
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RU2002126396/13A
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English (en)
Russian (ru)
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RU2002126396A (ru
Inventor
А.З. Максютов (RU)
А.З. Максютов
А.А. Колобов (RU)
А.А. Колобов
А.Б. Рыжиков (RU)
А.Б. Рыжиков
А.Н. Канев (RU)
А.Н. Канев
З.А. Максютов (RU)
З.А. Максютов
Original Assignee
Государственный научный центр вирусологии и биотехнологии "Вектор"
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Priority to RU2002126396/13A priority Critical patent/RU2237065C2/ru
Priority to US10/529,885 priority patent/US20060153865A1/en
Priority to NZ539606A priority patent/NZ539606A/en
Priority to RU2005108567/04A priority patent/RU2312941C2/ru
Priority to AU2003269748A priority patent/AU2003269748A1/en
Priority to CA002500401A priority patent/CA2500401A1/en
Priority to PCT/RU2003/000421 priority patent/WO2004031212A1/en
Priority to JP2004541361A priority patent/JP2006519160A/ja
Priority to CNA038255375A priority patent/CN1714100A/zh
Priority to EP03751670A priority patent/EP1558628A4/en
Priority to KR1020057005874A priority patent/KR20050067411A/ko
Priority to PCT/RU2003/000423 priority patent/WO2004031226A1/ru
Publication of RU2002126396A publication Critical patent/RU2002126396A/ru
Application granted granted Critical
Publication of RU2237065C2 publication Critical patent/RU2237065C2/ru

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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/21Retroviridae, e.g. equine infectious anemia virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047Simultaneous synthesis of different peptide species; Peptide libraries
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08RNA viruses
    • C07K14/15Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus human T-cell leukaemia-lymphoma virus
    • C07K14/155Lentiviridae, e.g. human immunodeficiency virus [HIV], visna-maedi virus or equine infectious anaemia virus
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    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/44Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
    • C07K14/445Plasmodium
    • AHUMAN NECESSITIES
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    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55566Emulsions, e.g. Freund's adjuvant, MF59
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
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    • C12N2730/00011Details
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    • C12N2740/10011Retroviridae
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    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/16011Human Immunodeficiency Virus, HIV
    • C12N2740/16111Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2740/10011Retroviridae
    • C12N2740/16011Human Immunodeficiency Virus, HIV
    • C12N2740/16111Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2770/24211Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
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    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2002126396/13A 2002-10-03 2002-10-03 Иммуногенная библиотека химерных пептидов, мимикрирующая генетическое многообразие гипервариабельного района v3 белка оболочки gp120 вируса иммунодефицита человека RU2237065C2 (ru)

Priority Applications (12)

Application Number Priority Date Filing Date Title
RU2002126396/13A RU2237065C2 (ru) 2002-10-03 2002-10-03 Иммуногенная библиотека химерных пептидов, мимикрирующая генетическое многообразие гипервариабельного района v3 белка оболочки gp120 вируса иммунодефицита человека
US10/529,885 US20060153865A1 (en) 2002-10-03 2003-08-19 Antigenic peptides
RU2005108567/04A RU2312941C2 (ru) 2002-10-03 2003-09-25 Антигенные пептиды
AU2003269748A AU2003269748A1 (en) 2002-10-03 2003-09-25 Antigenic peptides
CA002500401A CA2500401A1 (en) 2002-10-03 2003-09-25 Antigenic peptides
PCT/RU2003/000421 WO2004031212A1 (en) 2002-10-03 2003-09-25 Antigenic peptides
NZ539606A NZ539606A (en) 2002-10-03 2003-09-25 Antigenic peptides
JP2004541361A JP2006519160A (ja) 2002-10-03 2003-09-25 抗原性ペプチド
CNA038255375A CN1714100A (zh) 2002-10-03 2003-09-25 抗原肽
EP03751670A EP1558628A4 (en) 2002-10-03 2003-09-25 ANTIGENIC PEPTIDES
KR1020057005874A KR20050067411A (ko) 2002-10-03 2003-09-25 항원성 펩티드
PCT/RU2003/000423 WO2004031226A1 (fr) 2002-10-03 2003-09-29 Bibliotheque immunogene de peptides chimeriques imitant la diversite genetique de la region hypervariable v3 de la proteine d'enveloppe gp120 du virus de l'immunodeficience humaine

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Application Number Priority Date Filing Date Title
RU2002126396/13A RU2237065C2 (ru) 2002-10-03 2002-10-03 Иммуногенная библиотека химерных пептидов, мимикрирующая генетическое многообразие гипервариабельного района v3 белка оболочки gp120 вируса иммунодефицита человека

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RU2002126396A RU2002126396A (ru) 2004-07-20
RU2237065C2 true RU2237065C2 (ru) 2004-09-27

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RU2002126396/13A RU2237065C2 (ru) 2002-10-03 2002-10-03 Иммуногенная библиотека химерных пептидов, мимикрирующая генетическое многообразие гипервариабельного района v3 белка оболочки gp120 вируса иммунодефицита человека

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Country Link
US (1) US20060153865A1 (https=)
EP (1) EP1558628A4 (https=)
JP (1) JP2006519160A (https=)
KR (1) KR20050067411A (https=)
CN (1) CN1714100A (https=)
AU (1) AU2003269748A1 (https=)
CA (1) CA2500401A1 (https=)
NZ (1) NZ539606A (https=)
RU (1) RU2237065C2 (https=)
WO (2) WO2004031212A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013040040A1 (en) * 2011-09-12 2013-03-21 New York University School Of Medicine Peptides mimicking hiv-1 viral epitopes in the v2 loop for the gp120 surface envelope glycoprotein
RU2505604C2 (ru) * 2007-10-09 2014-01-27 Текнолоджи Интеграл Лтд. Профилактическая вакцина против вич, основанная на вич-специфических антителах
RU2603732C2 (ru) * 2011-02-25 2016-11-27 Лабораторьос Дель Др. Эстеве, С.А. Способ быстрого отбора вариантов gp-120 вич

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2601394A1 (en) * 2005-03-17 2006-09-28 Primex Clinical Laboratories, Inc. Immunogens for vaccines against antigenically variable pathogens and diseases
WO2007079755A1 (en) * 2006-01-12 2007-07-19 Janus Beierholm Holding Aps Reimmunization and antibody design
EP2027158B1 (en) 2006-05-02 2012-09-19 Carviar ApS Method for immunizing an avian species
JP2010530356A (ja) * 2007-03-27 2010-09-09 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 急性伝染hivエンベロープ・サイン
KR20100028031A (ko) * 2007-06-06 2010-03-11 다니스코 유에스 인크. 단백질 특성의 개선 방법
SG10202007719TA (en) 2008-12-05 2020-09-29 Takeda Vaccines Inc Compositions, methods and uses for inducing viral growth
WO2011138032A2 (en) * 2010-05-05 2011-11-10 Artemev, Timur Universal influenza vaccines and methods for their generation
EP2422618A1 (en) * 2010-08-27 2012-02-29 Technologie Integrale Ltd. Animal model for the evaluation of the efficacy of an HIV vaccine
US10383927B2 (en) 2015-01-09 2019-08-20 Primex Clinical Laboratories, Inc. Variable epitope library compositions and methods of therapeutic and prophylactic use
WO2020264441A1 (en) * 2019-06-27 2020-12-30 Roche Sequencing Solutions, Inc. Peptide libraries having enhanced subsequence diversity and methods for use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6042836A (en) * 1993-06-07 2000-03-28 Genentech, Inc. HIV envelope polypeptides

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2260754T3 (es) * 1992-06-18 2006-11-01 Creagen, Inc. Metodo para producir un conjunto de antigenos polipeptidicos combinatorios.
GB2282378A (en) * 1993-09-30 1995-04-05 Merck & Co Inc Conjugates of epitopes of HIV with a protein complex from Neisseria
WO1995011998A1 (en) * 1993-10-26 1995-05-04 United Biomedical, Inc. Structured synthetic antigen libraries as diagnostics, vaccines and therapeutics
IT1277057B1 (it) * 1995-12-11 1997-11-04 Tecnogen Scpa Peptidi antigenici migliorati
ATE533113T1 (de) * 2002-02-08 2011-11-15 Variation Biotechnologies Inc Verfahren zur herstellung von immunogenen zusammensetzungen aus variablen peptidepitopen

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6042836A (en) * 1993-06-07 2000-03-28 Genentech, Inc. HIV envelope polypeptides

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ESTAQUIER J. et al. The mixotope: a combinatorial library as a T cell and B cell immunogen. Eur. J. Immunol, 1994 Nov.; 24(11):2789-95. CARLOS M.P. et al. Immunogenicity of a vaccine preparation representing the variable regions of the HIV type 1 envelope glycoprotein. AIDS Res. Hum. Retroviruses, 2000 Jan. 20; 16(2):153-61. *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2505604C2 (ru) * 2007-10-09 2014-01-27 Текнолоджи Интеграл Лтд. Профилактическая вакцина против вич, основанная на вич-специфических антителах
RU2603732C2 (ru) * 2011-02-25 2016-11-27 Лабораторьос Дель Др. Эстеве, С.А. Способ быстрого отбора вариантов gp-120 вич
WO2013040040A1 (en) * 2011-09-12 2013-03-21 New York University School Of Medicine Peptides mimicking hiv-1 viral epitopes in the v2 loop for the gp120 surface envelope glycoprotein
US9611294B2 (en) 2011-09-12 2017-04-04 New York University Peptides mimicking HIV-1 viral epitopes in the V2 loop for the GP120 surface envelope glycoprotein

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CN1714100A (zh) 2005-12-28
AU2003269748A1 (en) 2004-04-23
US20060153865A1 (en) 2006-07-13
NZ539606A (en) 2008-08-29
EP1558628A1 (en) 2005-08-03
WO2004031226A1 (fr) 2004-04-15
WO2004031212A1 (en) 2004-04-15
EP1558628A4 (en) 2006-05-31
JP2006519160A (ja) 2006-08-24
KR20050067411A (ko) 2005-07-01
CA2500401A1 (en) 2004-04-15

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