RU2197257C2 - Medicinal agent "fitobalzam fabatseron" with sedative effect for immunocorrection - Google Patents

Abstract

FIELD: medicine, immunology, pharmacy. SUBSTANCE: invention relates to pharmacological agents used in immunodeficient states. The proposed agent is 40^° spirituous tincture prepared of 10 medicinal plants of leguminous family with addition of sweet clover honey. Agent does not exhibit adverse effect but elicits expressed immunocorrecting effect with mild sedative manifestation. EFFECT: enhanced effectiveness and valuable medicinal properties of agent. 1 ex

Description

 The invention relates to medicine, namely to the pharmacology of immunodeficiency states.

 Currently, in connection with the widespread spread of immunodeficiencies, the search for new means of immunocorrection is the most important task of medicine.

 The most effective plant immunostimulants known as adaptogens are rhodiola rosea, prickly eleutherococcus, safflower levzea, real ginseng [1].

 Treatment with the above adaptogens may be accompanied by a noticeable tonic effect on the central nervous system, they are contraindicated in case of increased excitability, insomnia, epilepsy, diseases of the nervous system [1].

 In situations where acquired immunodeficiency (HIV infection or AIDS) in itself is a severe nervous shock for the patient, treatment with herbal psychostimulants can provoke a neuropsychic breakdown.

 Therefore, the creation of herbal immunocorrective drugs with a sedative effect can be considered a promising direction in the pharmacology of immunodeficiencies.

 Known methods of treatment with drugs from the legume family, which have immunostimulating and sedative properties. For example, medicinal sweet clover [2], meadow clover [3], yellow alfalfa [4], Siberian penny [4].

 Licorice root is a part of children's soothing tea [2]. China meadow is used for insomnia [3].

 The disadvantage is that medicinal plants from the legume family, which have an immunomodelling effect, were practically not used together. Meanwhile, it is the plant family of legumes that is one of the most promising in terms of use for immunocorrection.

 The closest technical solution, selected as a prototype, is a commercial phytopreparation "Alfalfa" - USA, made on the basis of a plant of the legume alfalfa family. In addition to increasing general immunity, alfalfa replenishes the deficiency of vitamins, proteins, minerals, increases hemoglobin, purifies the blood, relieves pain, normalizes water-electrolyte metabolism, and removes uric acid salts. The drug is taken by adults 2-3 capsules 3 times a day with meals.

 The disadvantages of this tool are: the inability to accurately dose this drug to children of different ages; alfalfa-based drug - Alfalfa is imported to Russia from abroad and is quite expensive; the main purpose of this drug is blood purification, and the immunomodulating effect only accompanies the main action, therefore, in order to achieve a more powerful immunomodulating effect, alfalfa should be used in combination with other plant components.

 The objective of the invention is the manufacture of immunocorrective agents with sedative effect based on a group of medicinal plants from the legume family.

This task is achieved in that the immunocorrection drug with sedative effect contains a half-alcohol extract of 10 medicinal plants of the legume family with the addition of melilot honey and alcohol 40 ^o , in the following ratio, wt.%:
Alfalfa yellow, grass - 3.0-3.5
Melilotus officinalis, grass - 1.0-1.5
Meadow clover, flowers - 3.0-3.5
Astragalus webbed, grass and root - 2.0-3.0
Rising astragalus, grass - 2.0-3.0
Danish astragalus, grass - 0.5-1.0
Ural licorice, root - 1.0-1.5
Siberian penny, grass - 3.0-3.5
Sainfoin sand, grass - 0.5-1.0
China meadow, grass - 0.5-1.0
Melilot honey - 8.0-10.0
Alcohol 40 ^o - Else
The drug is prepared as follows. All plant components must be in a dried state. It is important that plants are used in the first year from the moment of collecting the raw materials. Plants are taken in a certain proportion and are crushed using a 100 W chopper. The finished crushed mixture is poured into a dark glass container. Then, clover honey diluted with 40 ^o alcohol is added to it. Melilot honey should be mature, not young. The resulting mixture is poured with 40 ^o alcohol and infused in a dark place at room temperature and daily mixing of the precipitate and supernatant for at least 20 days. With the help of filtration, a herbal preparation is ready for use, which should have the smell and taste of melilot. Adult patients take the drug 15 drops 3 times a day before meals with water or tea. The course of treatment is 1 month.

 Example for clinical use.

Patient Alexey R. - 30 years old. Turned on 02/18/2000. Diagnosis: HIV infection. Immune deficiency Chronic prostatitis. Intestinal dysbiosis. Biliary dyskinesia. Hypochromic anemia. Hypopolivitaminosis. Neurosis. Complaints about weakened immunity, increased irritability, periodically cramping pains in the abdomen. Used for treatment all known domestic and foreign antibiotics. Laboratory examination: 02.15.2000. Immunogram - reduced the number of T-suppressors. The immunoregulatory index is 11.25. The phagocytic activity of the blood is reduced. There is an increased content in the blood serum of immunoglobulins A and M. The content of zero lymphocytes is reduced. Blood test for vitamins and minerals: the content of vitamins B ₂ , B ₆ , E is reduced; the content of iodine, potassium, magnesium is reduced. 02/18/2000 an. blood: red blood cells 3.0 • 10 ¹² ; HB 90 g / l; white blood cells 3.1 • 10 ⁹ ; eosinophils 4; sticks 3; lymphocytes 18; segments 70; monocytes 5.

 Considering the clinical and laboratory data, the patient was prescribed a phabobalam "Faberon" for 1 month 15 drops 3 times a day 30 minutes before meals in 100 ml of water or tea. 03/17/2000, a second laboratory examination was carried out. Repeated immunogram - increased phagocytic activity of blood to 1 thousand. Phagocytic index of 7.0.

Repeated blood test for vitamins and minerals: vitamin B ₂ and potassium levels have risen to normal. Repeated blood test: red blood cells 3.2 • 10 ¹² ; HB 110 g / l; white blood cells 4.3 • 10 ⁹ ; eosinophils 2; sticks 3; lymphocytes 21; segments 66; monocytes 8.

During treatment, the patient improved erythro- and leukopoiesis. Positive dynamics in the immune status indicates that the manufactured drug enhances the phagocytic activity of blood cells. During treatment, the patient has increased levels of vitamin B ₂ and potassium in the blood serum; the patient has become less irritable and excitable; sleep improved.

 In the future, the patient was recommended to continue treatment with herbal immunostimulants, the Fabaceron phytobalm was not prescribed again.

 Indications for the use of the drug are: immunodeficiencies as a result of treatment with antibiotics, hormones; immunodeficiency due to allergic diseases, kidney diseases, as well as HIV infection at the stage of carriage of the immunodeficiency virus.

 In general, the Fabazeron phytobalm was prescribed to 12 patients. 11 patients had secondary immunodeficiency due to chemotherapy, diseases of the respiratory tract, urinary system (chronic pyelonephritis); 1 patient is HIV infected. In 100% of cases, patients 3-4 weeks after treatment showed an increase in the number of leukocytes in the general blood test; mild sedative effect on the function of the central nervous system, improvement in night sleep was noted. As an accompanying positive property of phytobalm, a pronounced gastro-projective effect can be noted. Within 15-20 minutes after taking the drug, abdominal pain and heartburn disappear.

 Thus, the proposed drug due to the biologically active substances of the alfalfa yellow plant, as well as a large group of plants from the legume family, has both immunomodulating and mild sedative effects, which fully meets the objective of the invention.

Sources of information
1. Mikhailov I., Schröter A. Modern drugs from medicinal plants. M., 1999, p. 36-45.

 2. Zavrazhanov I.I. Medicinal plants, therapeutic and prophylactic use. Voronezh, 1994, p.207, 272.

 3. Minaev V.G. Medicinal plants of Siberia. Novosibirsk, 1991, p. 268, 269.

 4. Telyatiev VV Useful plants of central Siberia. Irkutsk, 1987, p. 160, 168.

Claims (1)

A medicinal product for immunocorrection with a sedative effect, including yellow alfalfa grass, characterized in that it contains melilot honey, alcohol 40 ^o and a group of medicinal plants from the legume family: medicinal melilot (grass), meadow clover (grass), astragalus membranous (grass, root), rising astragalus (grass), Danish astragalus (grass), Ural licorice (root), Siberian penny (grass), sainfoin (grass), meadow ritual (grass) in the following ratio of components, wt. %:
Alfalfa yellow, grass - 3.0-3.5
Melilotus officinalis, grass - 1.0-1.5
Meadow clover, flowers - 3.0-3.5
Astragalus webbed, grass and root - 2.0-3.0
Rising astragalus, grass - 2.0-3.0
Danish astragalus, grass - 0.5-1.0
Ural licorice, root - 1.0-1.5
Siberian penny, grass - 3.0-3.5
Sainfoin sand, grass - 0.5-1.0
China meadow, grass - 0.5-1.0
Melilot honey - 8.0-10.0
Alcohol 40 ^o - Else