RU2152221C1 - Agent with hepatoprotective, cholesterol and glucose content regulating effect - Google Patents

Abstract

FIELD: medicine, chemical-pharmaceutical industry. SUBSTANCE: invention proposes the complex of saltwort (Salsola) herb dried extract and different filling agents taken at the different ratios. Proposed agent decreases the level of total cholesterol due to effect on content of low density lipoproteins as display of antistress effect, normalizes glucose level as result of insulin-like effect of saltwort, shows tendency to decrease bilirubinemia as result of hepatotrophic effect of food addition and so on. Individual intolerance to plant preparations is noticed. EFFECT: enhanced curative effect of agent, absence of contraindications and withdrawal syndrome. 10 cl

Description

 The invention relates to medicine, namely to the development of domestic herbal pharmaceuticals for detoxification and treatment of the body.

 Environmental pollution, excessive consumption of synthetic drugs, food additives and preservatives that humans are not evolutionarily adapted to, as well as a lack of plant components containing natural antioxidants, antiallergens, antimutagens, anticarcinogens, contribute to the growth of allergic, oncological and, in particular, diseases liver and gastrointestinal tract. These circumstances also serve as a reason for increased interest in the search for preventive and therapeutic agents of natural origin.

 According to modern concepts, herbal medicine is a whole, bioenergetically developed complex that includes active substances and secondary metabolites, proteins, essential oils, chlorophyll, inorganic salts, vitamins, etc. (M.L. Grinevich, 1990).

 The main advantages of herbal preparations should be called the versatility and gentleness of the effect on the body, the absence or insignificant side effect, and, as a rule, good tolerance to patients.

 Herbal preparations account for approximately 30% of the total number used in practical medicine.

 All the above properties of herbal preparations make them indispensable in medical practice, and with a rational combination with synthetic agents, therapeutic possibilities are significantly expanded.

 The nomenclature of drugs of hepatoprotective action is very extensive; Essential, Lipotabil, Silibinin, LIV-52, Flaming, Silibor, etc.

 Despite the success of chemistry, which gave medicine a lot of effective medicines, the use of medicinal plants is becoming increasingly widespread.

 The increasing attention to medicinal plants is facilitated by a large number of cases of intolerance to a number of synthetic drugs, side effects during their use and, sometimes, the occurrence of the so-called "drug disease". Interest in herbal remedies is also associated with a change in the age structure of the population: there are more elderly and senile people who are characterized by chronic diseases. They require long-term use of drugs and in the case of the use of synthetic products that are foreign to the human body, there is a great danger of side effects. Herbal preparations are closer to human nature, they are better tolerated and can be used for a long time.

 An object of the present invention is to provide an agent with a broad pharmacological action based on a plant component.

 This problem is solved by using a dry extract of grass hodgepodge hill obtained by treating the grass with ethanol or water, followed by its concentration, and a physiologically acceptable filler, in the following ratio of components, wt.%: Dry extract of grass hodgepodge 0.25 - 99.9 and filler - the rest. The proposed tool can be made in the form of a liquid extract, tablets, capsules of syrup, granules and can be intended for the treatment of various forms of hepatitis, coronary heart disease, to normalize cholesterol levels and for diet therapy.

 Moth solyanka (Salsola collina) - a plant of the Marevaya family (Chenopodiaceae) - is an annual semi-shrubby short and stiff-haired plant up to 40 cm tall, with a branched stem, alternating, threadlike, spiny leaves and small flowers.

 The healing properties of a plant are determined by the content of substances in it, which are capable of exerting a definite effect both on the organism as a whole and on its organs and systems.

As the studies showed, the biologically active complex obtained from the aerial part of the hillwort contains the following classes of compounds:
- flavonoids (tricin, isoramnetin, quercetin, rutin)
- polysaccharides
- carotenoids
- sterols characteristic only for this type of plant
- saponins
- lipids
- amino acids
- trace elements.

 Flavonoid-containing hepatoprotectors are quite widely studied and known.

 Of particular interest is the unique and wide range of amino acids, both interchangeable and essential (indispensable). According to our own data (AAA amino acid analyzer) and data of the Vitebsk State Medical University, free and in the composition of proteins in the grass of the hodgepodge hill contains interchangeable and irreplaceable amino acids.

 The presence of such a microelement as silicon (a skeleton-forming element that is washed out during the course of a person’s life, which is one of the causes of “decrepitation” of the body) is very important. It practically does not recover, since there are few natural sources of silicon, assimilated by the body from a biopharmaceutical point of view: there are few sources of silicon: nettle, yarrow, horsetail, larch, mountaineer, bamboo and some other plants. The silicon content in the grass of hodgepodge - 50 mg / l (more than in nettle).

 Of particular note is the presence of copper in the grass, the lack of which leads to anemia, since the absorption of iron and red blood cells is inhibited.

 The dry extract of the herb Solyanka hill can be obtained either by extraction with ethanol or water. The extraction with water takes place in the usual way established in the pharmacy, the extraction with ethanol is carried out according to the technology of obtaining according to the patent of Russia N 2118167 (1998).

Extraction is carried out at a temperature of 35 - 50 ^o C by maceration with pulsating mixing of a mixture of raw materials and 20-40% ethanol. Extraction is carried out in an extractor filter equipped with pneumopulsators for intensive mixing of raw materials and ethanol. The extract obtained is purified by separation from fine impurities and filtered through a filter at a pressure of 0.3-0.5 atm.

 The preparation of the extract of solyanka mollusk does not have toxicity in experiments when the doses of the drug exceed the recommended for humans per 1 kg of mass when administered to rats 140-490 times, and when administered to dogs by 9.3 times.

 According to the invention, the proposed dry extract of grass of Solyuba hillica can be made in various dosage forms and, depending on this form, contain different physiological acceptable excipients. The concentration of the active substance, namely the extract of the herb Solyanka hill may be in the range of 0.25 - 99.9.

 Dry extract of Solyanka hill grass is a dry lyophilized powder, soluble in water and aqueous-alcoholic liquids. It can be used in food, pharmaceutical, cosmetic and confectionery products.

 The extract of grass of Solyanka hillock is stored in 100 ml vials with mandatory opening control. Contains 3 ± 0.1% of dry herb extract in 10% ethanol. Alcoprotector. Quickly relieves withdrawal symptoms, reduces craving for alcohol, subjectively and objectively improves the patient's condition. The course of application, depending on the severity of alcohol intoxication, is from several hours to several days according to the scheme. A homeopathic dose of ethanol - less than 2 ml per dose, does not cause a hangover, but it contributes to the targeted delivery of biologically active substances to the liver and heart muscle. Perhaps brain activity is improving.

 For preventive purposes, to protect the liver, it is enough to apply a liquid extract of 1 teaspoon per day for 3 weeks, repeating the course 4 times a year (seasonally).

 The tablet preparation based on the extract of solyanka hilly - "lohein" is intended for the treatment of coronary heart disease. The tool has a positive effect on the effectiveness of treatment of patients, while normalizing the performance of patients with lipid and mineral metabolism.

 A dry granular drink called Extracol (20 sachets of 2.0 g each) contains at least 50 mg dry extract of hill hodgepodge grass in each sachet. Especially effective for relieving liver intoxication. It is used as an additional tool in the diet therapy of diabetes. Normalizes blood sugar. Actively involved in the stabilization of the hepatobiliary system, normalizing cholesterol and lipoproteins of various densities. The course of use is from 2 to 6 weeks, 2 to 6 sachets per day with water, tea, coffee.

 The biological effect of preparations of hodgepodge, their biostimulating effects are determined by the insulin-like and antioxidant effects, as well as the amino acid composition (amino acids necessary for biosynthesis of urea in the liver, and amino acids with branched radicals necessary for the manifestation of insulin-like and neurotropic effects). This allows us to consider the possibility of using the extract of hodgepodge and "Askohol" as an effective component of rehabilitation of people in a sanatorium and dispensary (relatively short periods of use). For this, special forms of nutritional supplements have been developed in the form of a 3% syrup and Askohol (adding a water-soluble antioxidant vitamin C). The aim of the work was to study the effect of syrup of hodgepodge and Ascohol on biochemical blood parameters and the general condition of patients in an industrial sanatorium - a dispensary.

We can consider it appropriate to introduce syrup of hodgepodge in the complex of rehabilitation measures in the conditions of an industrial sanatorium in the following positions:
the absence of negative subjectively and objectively recorded effects from taking a dietary supplement;
a decrease in total cholesterol due to LDL cholesterol as a manifestation of an antistress effect;
normalization of glucose levels as a result of the appearance of the insulin-like effect of hodgepodge;
a tendency to a decrease in bilirubinemia as a result of the hepatotropic effect of the food supplement.

 The study of the medicinal properties of preparations of hodgepodge was conducted in various clinics in Moscow.

 None of the preparations based on moth solyanka is addictive. There is no withdrawal syndrome.

 No contraindications have been identified. There is an individual intolerance to herbal preparations.

Claims (9)

1. A tool with hepatoprotective, cholesterol and sugar regulating action, containing as an active component dry extract of grass of hodgepodge, obtained by treating the herb with ethanol or water, followed by its concentration, and a physiologically acceptable excipient in the following ratio, wt.%:
Dry extract of herb Solyanka hill - 0.25 - 99.9
Filler - Else
2. The tool according to claim 1, characterized in that it is a liquid extract.  3. The tool according to claim 1, characterized in that it is a tablet form.  4. The tool according to claim 1, characterized in that it is a granule.  5. The tool according to claim 1, characterized in that it is a capsule.  6. The tool according to claim 1, characterized in that it is a syrup.  7. The tool according to claim 1, characterized in that it is intended for the treatment of various forms of hepatitis.  8. The tool according to claim 1, characterized in that it is intended for the treatment of coronary heart disease.  9. The tool according to claim 1, characterized in that it is intended to normalize cholesterol.  10. The tool according to claim 1, characterized in that it is intended for diet therapy.