RU2174401C1 - Method of preparing antiparasitic tincture - Google Patents

Abstract

FIELD: medicine, parasitology, pharmaceutical technology. SUBSTANCE: method involves infusion of biologically matured walnut pericarps in ethyl alcohol aqueous solution up to the moment of kernels falling out from pericarps taken in the following ratio of components, wt.%: pericarps, 4-6; ethyl alcohol aqueous solution, 94-96. Ethyl alcohol content in an aqueous solution is 30% vol, not less. Infusion is carried out for 35 days, not less. EFFECT: decreased course of antiparasitic treatment, retained effectiveness, decreased total alcohol amount used in tincture intake. 2 cl

Description

 The invention relates to medicine and can be used in the manufacture of a medicinal product and the dosage of its use to get rid of various parasites, in particular from various types of helminths.

State of the art
It is known that to get rid of helminths, in particular, in the treatment of ascariasis, anthelmintics of the synthetic series are used: piperazine, naphthamone, decaris, etc. (Mashkovsky M.D. Medicines, M., Medicine, 1986, part II, p. 372 ) These drugs have negative side effects in the form of nausea, abdominal pain, headaches. In case of an overdose, for example, piperazine, muscle weakness, tremor are possible. Contraindications to the use of these drugs are organic diseases of the central nervous system and impaired liver function. Most synthetic drugs are taken from 2 to 5 days.

 A known method of obtaining funds for deworming, in particular cucurbin, including direct extraction of crushed pumpkin seeds, double degreasing with petroleum ether in a ratio of 1: 1 after separation of the syrup and precipitation from ballast with methanol in a ratio of 1: 3 to 1: 4 in the cold (SU 1223912 , A 61 K 35/78, 04/15/86). This anthelmintic is not effective enough, and the use of toxic substances in its preparation does not exclude its toxic effects.

 There is also known a method for producing a drug having an antiascarid effect, including extraction of raw materials in the form of dairy ripe walnuts (RU 2136304, A 61 K 35/78, 09/10/99). As an extractant, purified kerosene is used with a ratio of raw materials and extractant from 1: 0.8 to 1: 1.5, after which sunflower oil is added to the total content of fatty oils in the final product at 11%. Animal experiments have shown that the effectiveness of this drug reaches 100% with a maximum non-lethal dose for mice of 19 g / kg. Nevertheless, the use of kerosene as an extractant is a significant obstacle to the widespread use of the drug for the treatment of people.

 The closest in technical essence and the achieved result to the described method for producing antiparasitic tincture is a method for producing antiparasitic tincture, including infusion of raw materials based on walnut in an aqueous solution of alcohol (RU 2135200, A 61 K 35/78, 08/27/99). The method involves the use of unripened black walnuts as a raw material. The increase in the concentration of drugs in an aqueous solution of alcohol is due to the fact that per 100 parts by weight of walnuts take from 100 wt. hours to 1000 parts by weight alcohol solution with an alcohol content in the solution of from 40 vol.% to 96%. Infusion is carried out within 3-21 days. The increased content of the drug in the solution, on the one hand, enhances the effectiveness of the effect, and on the other hand, limits the duration of use, since with a daily average intake of 50 drops, the duration of the course should not exceed 1.5 months. Otherwise, taking so many drops of a highly concentrated alcohol-containing solution daily may lead the patient to alcohol dependence.

SUMMARY OF THE INVENTION
The objective of the present invention is to provide a method for producing antiparasitic tinctures with improved quality characteristics.

 As a result of solving this problem, technical results can be obtained consisting in the fact that the duration of the course of antiparasitic exposure is reduced while maintaining efficiency, the total amount of alcohol consumed when taking tinctures is reduced, the body is encoded to recognize and destroy helminths.

These technical results are achieved by the fact that in the method for producing an antiparasitic tincture, including infusion of initial raw materials based on walnuts in an aqueous solution of alcohol, the pericarp of biologically mature walnut is used as the initial raw material until the fruit falls out of the pericarp at a ratio of components (wt.%) :
Mature Walnut Pericarp - 4-6
Aqueous solution of alcohol - 94-96
moreover, the alcohol content in an aqueous solution of alcohol is at least 30 vol.%, and infusion is carried out for at least 35 days.

A distinctive feature of the present invention is as follows. As a raw material, the pericarp of a biologically ripe walnut is used, i.e. open pericarp. Moreover, it was experimentally established that the effect will be achieved if the pericarp is ripped off before the fetus falls out. From the plucked pericarp, fruits are extracted, after which the pericarp is poured with an aqueous solution of alcohol in a ratio of components, wt.%:
Pericarp of ripe walnut - 4 - 6
Aqueous solution of alcohol - 94 - 96
The given ratio of components is selected on the basis that the entire mass of the feedstock will be guaranteed to be coated with a layer of an aqueous solution of alcohol. The alcohol content in an aqueous alcohol solution of at least 30 (vol.%) Is due to the fact that at a lower alcohol concentration, the concentration of drugs in the tincture sharply decreases. When the infusion time is less than 35 days, there is no way out into the infused solution of all medicinal substances that make up the basis of the tincture.

 It is advisable to insist the pericarp of a biologically ripe walnut in the amount of 4.76 wt.%.

Information confirming the possibility of carrying out the invention
Features of the present invention are illustrated by examples.

Example 1. Patient K., 43 years old. He was admitted with a severe blood disease - thrombocytopenia. He was treated according to standard schemes for five years in hematological departments. Therapy worsened the condition, the disease manifested itself brighter. Chronic hepatitis, pancreatitis, duodenal ulcer (8 years), thrombocytopenia, blood vessels burst (bruising under the skin), fatigue, depression, fears. In the diagnosis, 6 types of worms in the liver, trichomoniasis and symbiosis of other parasites were identified. For six days, he took antiparasitic tincture of the pericarp of a biologically ripe walnut until the fetus fell out of the pericarp in an aqueous solution of alcohol in the ratio of the components wt.%:
Mature Walnut Pericarp - 4
Aqueous solution of alcohol - 96
when the alcohol content in the aqueous solution is 60 vol.%. Infusion was carried out for 40 days. When the pericarp content is less than 4 wt.%, The concentration of drugs in the tincture is insufficient for effective exposure. During the first five days, he took on an empty stomach two drops of tincture diluted in 100 ml of water. From the sixth to the eighth day - two teaspoons diluted in 50 ml of water. After the course was examined in the clinic. The conclusion is almost healthy. Six months has been using prophylactic tincture. When checking always - infection with worms 0%. Is healthy. Works. The diseases mentioned above are gone.

Example 2. Patient G., 53 years old. Migraine, hypertension, overweight, cholecystitis, pancreatitis, pyelonephritis. She took systematically more than ten drugs; heart surgery (for tachycardia) was proposed. Treatment according to traditional schemes for ten years did not bring relief. During the initial diagnosis, helminths of four classes were found - tape, round, trematodes, and bacterioses. Toxoplasmosis and trichomoniasis, chlamydia attracted special attention. During the first five days, I took tincture, starting with one drop with a subsequent increase in one drop daily. The tincture was prepared by 45 daily infusion of pericarp of ripe walnut in an aqueous solution of alcohol with a ratio of components wt.%):
Mature Walnut Pericarp - 5
Aqueous solution of alcohol - 95
when the alcohol content in an aqueous solution of 30 vol.%.

 Tincture was diluted in 80 ml of water. On the sixth day, the intake was 1.5 teaspoons of tincture in 40 ml of water. After the course, the condition improved - headaches disappeared, blood pressure returned to normal, weight decreased by 15 kg. Patient G. praised the properties of tinctures, acting as a powerful deworming, creating immunity against worms.

Example 3. Patient S. (10 years old) - former champion in rhythmic gymnastics. During the year it became motionless, the joints did not function. The treatment with antibiotics, antihistamines. The condition worsened. It is proposed to fill out disability in childhood. The diagnosis is chlamydial oligoarthritis. In the initial diagnosis, worm infection of four classes was determined, including chlamydia and toxoplasmosis. During the 21st daily general health course, tincture was taken on an empty stomach (from the ninth day of the general course), 3 drops in 60 ml of water. The tincture was obtained by 35-day infusion of pericarp of a biologically ripe walnut in an aqueous solution of alcohol in the ratio of components wt.%:
Mature Walnut Pericarp - 6
Aqueous solution of alcohol - 94
when the alcohol content in the aqueous solution of 96 vol.%. If the amount of walnut pericarp is more than 6 wt.%, Then an aqueous solution of alcohol may not completely cover the mass of pericarp, which swells during infusion. Lack of alcohol leads to the possibility of oxidation of the mass of pericarp. To obtain high-quality tinctures, it is necessary that the raw material is completely coated with alcohol with the possibility of impregnation of the entire mass.

 The dose of tincture on the sixth day was 1.5 teaspoons in 120 ml of water. Additionally, for two more days, 2 teaspoons of tincture in 120 ml of water were taken. After completing a general wellness course, including the use of antiparasitic tinctures, the girl began to walk, write, and resumed school, physical education. The condition is satisfactory. Parents' opinion - tincture restored the girl’s health.

 Example 4. Patient Sh., (22 years old). I used tincture myself. Prior to the use of tincture, she was twice operated on in gynecology for ovarian cysts; roundworms, toxoplasmosis, trichomonads, mycoplasma fungi were found. In the first five days, the dose of tincture was - five drops in 120 ml of water, on the sixth day - 1.5 teaspoons in 40 ml of water. The preparation was obtained by infusing 1 part (4.76 wt.%) Of walnut pericarp in 20 parts (95.24 wt.%) Of an aqueous alcohol solution with an alcohol content of 40 vol.%. After taking the tincture, the newly formed cysts resolved. The need for surgery has disappeared. The patient’s opinion - tincture helped to get rid of the parasites that created the ovarian cyst, it destroys the worms of the brain - toxoplasmosis and round roundworms. Despite the specifics of the work (pig farm), after deworming, infection with worms and fungi is 0%.

Claims (2)

1. A method of obtaining an antiparasitic tincture, including infusion of raw materials based on walnuts in an aqueous solution of alcohol, characterized in that as the raw materials used are pericarp of biologically mature walnut until the fruit falls out of the pericarp in a ratio of components, wt.%:
Pericarp of ripe walnut - 4 - 6
Aqueous solution of alcohol - 94 - 96
moreover, the alcohol content in an aqueous solution of alcohol is at least 30 vol.%, and infusion is carried out for at least 35 days.  2. The method according to claim 1, characterized in that the raw material used is the pericarp of a biologically ripe walnut until the fruit falls out of the pericarp in an amount of 4.76 wt.%.