CN1318074C - Medicine for treating child spasm syndrome and its preparation method - Google Patents
Medicine for treating child spasm syndrome and its preparation method Download PDFInfo
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Abstract
The present invention relates to a medicine for treating childhood spasm syndrome and a preparation method thereof. The medicine for treating childhood spasm syndrome is characterized in that the medicine is prepared from monarch medicines of prepared rehmannia root and tall gastrodis tuber, minister medicines of gentian root, carapax testudinis, uncaria and crude dragon bone and adjuvant medicines of stiff silkorm, lapis chloriti and processed pinellia tuber; all the medicines are mixed, and granular medicines are prepared from the mixed medicines by procedures of decoction, concentration, granulation, etc. The medicine for treating childhood spasm syndrome of the present invention has the efficiency of nourishing yin, supplementing the kidney, calming the liver, extinguishing wind, resolving phlegm and calming mind, and has a conspicuous therapeutic effect on the treatment of childhood spasm syndrome and coprolalia syndrome. Proved by the statistical data of clinical application, the medicine for treating childhood spasm syndrome has an effective rate of 92% and a cure rate of 73%.
Description
Technical field
The present invention is the medicine that is used for the treatment of child's twitch-tourette syndrome.
Background technology
Gilles de la Tourette syndrome is a kind of children's's neuropsychiatric disease that increases gradually in recent years, most of onsets are in 2-15 between year, mainly show as a certain position muscle (as face, head and neck, extremity or trunk etc.) involuntary twitch of infant health clinically or be a kind of syndrome of feature with the heterophonia of throat, its symptom repeatedly, as involuntary nictation, frown, alarm nose, open one's mouth, yaw, turn round neck, movingly take on, swing one's arm, endure the sound etc. that abdomen or throat send " uttering a sound or a word ".Patient clinically belongs to damage of kidney-YIN, liver-wind stirring up internally type for seeing more more, and performances absent minded and that little trick is many are arranged.Charles Robert Richet George Gilles de la Tourette reported 9 routine cases in 1885, and had made detailed description.Over more than 100 year, its cause of disease is not bright all the time.Recent research shows that also the generation of child tic disorder and immunologic function disorder also have certain relation.At present, this kind disease Drug therapy commonly used have that Western medicine haloperidol, croak fan are clear, Tai Bili etc.But they still do not reach the promising result of expection to the part patient, and some patient Ze Yin is difficult to tolerate side effects of pharmaceutical drugs and influences therapeutic effect.Chinese medicine also has some reports at present, is 01104315.6 patent as the patent No., though can treat child spasm syndrome, contain Rhizoma Pinelliae and Zaocys Chinese medicine in its prescription, and Rhizoma Pinelliae is toxic, and Zaocys is a state guarantee class animal.
Summary of the invention
The objective of the invention is to overcome the shortcoming of prior art, the medicine that provide a kind of and be convenient to take, safety, side effect is used for the treatment of child's twitch-tourette syndrome for a short time.
Realize the main technical schemes of the object of the invention: adopting Radix Rehmanniae Preparata, Rhizoma Gastrodiae is " monarch " medicine, Radix Gentianae, Carapax et Plastrum Testudinis, Ramulus Uncariae Cum Uncis, Os Draconis are " minister " medicine, Bombyx Batryticatus, Lapis Chloriti, Rhizoma Pinelliae Preparatum are " assistant " medicine, and all medicines cooperates, by decoct, concentrate, step such as pelletize makes.
Medicine of the present invention is made (in parts by weight) by following component:
Rhizoma Gastrodiae 2-6 part, Radix Rehmanniae Preparata 3-9 part, Radix Gentianae 2-5 part, Carapax et Plastrum Testudinis 2-5 part, Ramulus Uncariae Cum Uncis 2-5 part, Os Draconis 8-13 part, Bombyx Batryticatus 2-5 part, Lapis Chloriti 5-9 part, Rhizoma Pinelliae Preparatum 2-6 part.
The preparation method of medicine of the present invention comprises the steps:
(1). get Rhizoma Gastrodiae and add 75% alcohol reflux three times, each 1 hour, each amount of alcohol added was 6 times of Rhizoma Gastrodiae amount, and three times extracting solution merges after filtering, and reclaiming ethanol then and being concentrated into 50 ℃ of relative densities is 1.20, obtains extractum A;
(2). hook taking rattan, Bombyx Batryticatus add 60% alcohol reflux three times, each 1.5 hours, each amount of alcohol added was Ramulus Uncariae Cum Uncis and Bombyx Batryticatus amount 8 times, and three extracting solution are merged after filtering, reclaiming ethanol then and being concentrated into 50 ℃ of relative densities is 1.20, obtains extractum B;
(3). after earlier Carapax et Plastrum Testudinis, Os Draconis, Lapis Chloriti being decocted with water 1 hour, add the water yield and be higher than powder 3-5cm, add Radix Rehmanniae Preparata, Radix Gentianae, Rhizoma Pinelliae Preparatum three flavor Chinese medicines then, decoct three times, each 1 hour, it was 1.05 that three filtrate merging are concentrated into 50 ℃ of relative densities, filter adds ethanol in night to be made and contains the alcohol amount and reach 60%, cold preservation 24 hours, reclaiming ethanol then and being concentrated into 50 ℃ of relative densities is 1.20, obtains extractum C;
(4). extractum A, B, C are mixed, add steviosin and dextrin then, mixing promptly obtains granular medicament through mist projection granulating, and last packing gets final product.
Advantage of the present invention:
To child " twitch-tourette syndrome ", motherland's medical science is thought: children's is the body of the young sun of young the moon, the dirty weakness of bowing, and QI and blood is not filled, essence in kidney is not vigorous as yet-and " the kidney being always deficient ", blastoprolepsis, taste burden adult is attached most importance to relatively, and the breast food is not known from joint in addition, select food and do not distinguish good and bad, easily cause spleen injury, expectorant is given birth in removing dampness, causes deficiency of kidney yin, liver-wind stirring up internally, the wind-phlegm resistance is closed, and holds together the random mind, so the mind laxes, absent minded etc., therefore the present invention adopts Chinese medicine " monarch; minister; assistant; make " principle, from its therapeutic effect and untoward reaction aspect such as less, shows many advantages, it has remedied the deficiency on the modern western medical treatment greatly, further enriched our medical circle treatment content, improved curative effect, and prior art (patent No. is 01104315.6) is improved primary disease.The prescription that the present invention uses enriching yin and nourishing kidney, suppressing the hyperactive liver to relieve the wind syndrome, the treatment rule of allaying excitement of reducing phlegm cooperates, monarch drug: Rhizoma Gastrodiae has effects such as calmness, convulsion, analgesia, Radix Rehmanniae Preparata have enrich blood, effect such as slow down aging, the central nervous system is also had significantly sedation; Ministerial drug: except Radix Gentianae, Carapax et Plastrum Testudinis, Os Draconis; also has Ramulus Uncariae Cum Uncis; Radix Gentianae has sedation; Carapax et Plastrum Testudinis has the effect of nourishing YIN for suppressing the hyperactive YANG, kidney tonifying bone strengthening, replenishing blood for nourishing heart; Ramulus Uncariae Cum Uncis has the effect of heat clearing away suppressing the hyperactive liver, dispelling wind and relieving convulsion, wherein is subjected to the Zaocys of national animal protection in the alternative prior art of Ramulus Uncariae Cum Uncis.Os Draconis have calm the nerves, astringent or styptic treatment for spontaneous sweating effect, belong to settling tranquilizer; Adjuvant drug: Bombyx Batryticatus has the effect of expelling wind for relieving convulsion, dissipating phlegm and resolving masses, and Lapis Chloriti has the expectorant of the bob therapeutic method to keep the adverse QI flowing downwards, the effect of checking hyperfunction of the liver for relieving convulsion, and Rhizoma Pinelliae Preparatum has the effect of drying dampness to eliminate phlegm, and avirulence, and wherein Rhizoma Pinelliae Preparatum substitutes virose Rhizoma Pinelliae in the prior art.All medicines cooperate, and cure mainly damage of kidney-YIN, liver-wind stirring up internally type child-tourette syndrome.Through the more than ten years clinical statistics, medicine effective percentage of the present invention reaches 92%, cure rate 73%, and safety non-toxic.Drug administration method of the present invention: every day 2 times, each 1-2 bag (every bag of 6g) according to the degree of being in a bad way, can be taken 1-4 the course of treatment, 30 days each courses of treatment.
In addition, existing technology is carried according to having only twice back of Herba indigoferae Pseudotinctoriae alcohol extraction to merge water with remaining nine flavor medicine in the prescription ten flavor medicines, concentrates and granulates, every bag of specification 8g, a lot of medical material paste-forming rates in the former prescription are higher, and this technology is more coarse, impurity is more, has day big problem of taking dose; Technology of the present invention is according to three flavor medicine alcohol extractions three times are arranged in prescription nine flavors, remaining Six-element liquid medicine is carried precipitate with ethanol, and impurity has been removed in more extraction active ingredients, existing technology preparation, every bag of specification 6g according to the quality investigation good stability, absorbs fast, be convenient to store, oral consumption reduces, and mouthfeel is better, is more suitable for children taking.
The present invention is through pharmacological toxicology research, and research process is as follows:
One, the main pharmacodynamics of medicine of the present invention research
(1), medicine of the present invention is a kind of nervus centralis toxin with multiple effect with iminobis-propanenitrile (IDPN), just be applied to neuro pathology's research after the fifties, it can cause brain stem and midbrain place nuclear group " change of aixs cylinder balloon sample ", thereby can also damage the generation that vestibule snail cell causes the animal anomaly circling behavior.Nineteen eighty-two, Bruce I Diamond has founded the animal model of plan Gilles de la Tourette's syndrome (TS) at first in the world: rat model can produce head, cervical region independently do not wave, behavioristics's performance of nictation, unconscious dehisce behavior and the unusual rotation of body, and is approximate with clinical patient TS.
Originally grind and give male SD rat IDPN150mg/kg/ day continuous lumbar injection after 7 days, as seen automatisms such as significantly blinking, dehisce appears in the model group rat, head is to swinging back, vacillating now to the left, now to the right, lurch, health falls to an inclination, with significantly independently not placing behavior, approximate with clinical patient TS.Net measuring animal coordination exercise ability is climbed in application.The normal matched group of model group rat harmony obviously reduces, and shows as and grabs the bar shakiness, moves comparatively rigidly, is easy to fall.But the content of dopamine (DA) is compared no significant difference with matched group in the model group rat striatum.The normal matched group of model group rat T lymphocyte subsets CD8 ratio raises to some extent.
Medicine medication group of the present invention was from modeling same day, little, in, heavy dose of group gives medicine 4.5g/kg of the present invention, 9g/kg, 18g/kg, 3 weeks of continuous irrigation stomach respectively.The gait of the medication group rat of medicine of the present invention is obviously improved than rat model, and its not autonomous rotating cycle reduces than rat model; Sports coordination increases, and climbing the net time significantly increases than model group; The content of intrastriatal DA significantly reduces than model group; The ratio of CD8 significantly reduces than model group in the T lymphocyte subsets.
(2) medicine of the present invention is to the pharmacological action of phenylpropyl alcohol model mice
Amfetamine is a kind of short dopamine releasing agent, can cause that DOPAMINE CONTENT IN RABBIT raises in the animal pattern striatum, thereby causes independent activity of animals to strengthen, and this is consistent with the performance that clinical patient moves more.
In this research, give male mice in kunming lumbar injection amfetamine 5mg/kg, model mice occurs that autonomic activities increases, bellicose, irritability; Dopamine (DA) content obviously raises than matched group in the striatum, and the content of its metabolite-DOPAC and HVA all obviously reduces.
Medicine medication group of the present invention gives medicine 5g/kg of the present invention, 15g/kg, 45g/kg respectively, irritates stomach 3 all pneumoretroperitoneum benzene injection propylamine 5mg/kg.Medicine medication group mice of the present invention is than the model group peace and quiet, and movable number reduces, and irritability is lower; The content of DA also significantly reduces than model group in the striatum.
(3), medicine of the present invention is to the pharmacological action of apomorphine type mice
Apomorphine is a dopamine-receptor stimulant, and more heavy dose of application can cause the increase of animal pattern autonomic activities and influence the animal limbic system, makes it special climbing behavior occur.
This research gives male mice in kunming cervical region subcutaneous injection Piao morphine 1mg/kg, and special climbing behavior appears in the model group mice: extremity are all sought connections with on vertical iron wire cylinder mould railing, seldom get back at the bottom of the cage sustainable 60 minutes of this kind behavior.
Medicine medication group mice of the present invention gives medicine 7.5g/kg of the present invention, 15g/kg, 30g/kg respectively, irritate 3 week of stomach back cervical region subcutaneous injection apomorphine 1mg/kg, after measuring 20 minutes, medicine medication group mice of the present invention is up and down in measuring cage, and the behavior convergence is normal.
Two, medicine acute toxicity testing of the present invention
20 of ICR mices, male and female half and half, body weight 18 ± 2g.Mice fasting 16 hours is by 443.2g crude drug/kg gastric infusion (being equivalent to 295.47 times of clinical application amounts) at twice.Through 7 days continuous observation, situations such as the autonomic activities of animal, the mental status, breathing, diet and drainage were all normal, and none example is dead.Conclusion: the maximum tolerated dose of medicine of the present invention is 295.47 times of clinical consumption.
Three, medicine long term toxicity test of the present invention
100 of VAF level Wistar rats, body weight 80-100g is divided into 4 groups with rat at random by body weight, be the normal control group, heavy dose of group 75g crude drug/kg, middle dosage group 37.5g crude drug/kg, small dose group 18.75g crude drug/kg is equivalent to 50 times of clinical application amount respectively, 25 times and 12.5 times.Every group 24, male and female half and half, every day, gastric infusion was 2 times, each 15ml/kg, continuous 3 months.
The result:
General situation: after large, medium and small three the dosage groups of medicine of the present invention administration 3 months and convalescent period, the mental status of each family animal, autonomic activities, body development, body weight gain and feed situation are normal substantially.
Clotting time and hematology: after 3 months, the rat clotting time is not seen obvious influence to each treated animal at successive administration.The hematology shows, heavy dose is organized female rats erythrocyte (RBC), blood cell specific volume (HCT), hemoglobin (HGB) is on the low side than the blank group, (WBC) is higher for leukocyte, in dosage group female rats erythrocyte (RBC), blood cell specific volume (HCT), hemoglobin (HGB) is on the low side than the blank group, (MCH) is higher for mean corpuscular hemoglobin, small dose group female rats erythrocyte (RBC), blood cell specific volume (HCT) is on the low side than the blank group, and (MCH) is higher for mean corpuscular hemoglobin.After convalescent period, only the leukocyte (WBC) of middle dosage group female rats is on the low side than blank, and all hematological indices of other each dosage groups there is no obvious change.More than change the fluctuation that all belongs in the range of normal value, do not have closely related property with drug toxicity.
Blood biochemical is learned: at successive administration after 3 months, heavy dose is organized male rat glutamic oxaloacetic transaminase, GOT (AST), blood urea nitrogen (BUN), flesh liver (Cr) is on the low side than the blank group, triglyceride (TG) is on the low side than the blank group, albumin (ALB) is higher than the blank group, and middle dosage group female rats flesh liver (Cr), total bilirubin (TBIL) are higher than the blank group; Small dose group female rats triglyceride (TG) is on the low side than the blank group, and low dose of male rat glutamic oxaloacetic transaminase, GOT (AST) is on the low side than the blank group, and (ALB) is higher for albumin; After convalescent period, heavy dose of group male rat triglyceride (TG) is higher than the blank group, and middle dosage group male rat glutamic oxaloacetic transaminase, GOT (AST) is on the low side than the blank group, and T-CHOL (CHO), triglyceride (TG) are higher than the blank group.More than change the fluctuation that all belongs in the range of normal value, do not have closely related property with drug toxicity.
Internal organs are dissected: all internal organs colors of large, medium and small three the dosage treated animals of medicine of the present invention are ruddy, form is normal, and numerical value such as organ weights and organ index are all in normal range.
Histopathology: gross anatomy and histopathology check finding, each experimental group there is no obvious toxic pathology and changes, and is close with matched group.
Conclusion:
Rat is irritated stomach after 3 months through the medicine of treatment Gilles de la Tourette's syndrome of the present invention, learns and histopathologic examination by hematology, blood biochemical, does not find because of the long-term caused drug accumulation toxic reaction of this medicine of large dose oral administration; By 2 convalescent periods in week observations, do not find the toxic reaction that any delay occurs.
Conclusion:
The medicine of treatment Gilles de la Tourette's syndrome of the present invention causes for IDPN and intends TS rat model, amfetamine model and apomorphine and cause and twitch mouse model and all have good improvement effect at aspects such as behavioristics, neural biochemical changes, short-term heavy dose (being equivalent to 295.47 times of clinical application amounts) is used and is not seen toxic reaction, and prolonged application is free of toxic effects also.The medicine that this shows treatment Gilles de la Tourette's syndrome of the present invention is a comparatively safe medicine.
The specific embodiment
Further specify characteristics of the present invention with example below:
Example 1-3
The prescription of example 1-3 sees attached list 1.
Concrete preparation process: Rhizoma Gastrodiae is added 75% alcohol reflux three times, obtain extractum A behind the recovery ethanol; Ramulus Uncariae Cum Uncis, Bombyx Batryticatus add 60% alcohol reflux three times, obtain extractum B behind the recovery ethanol; Carapax et Plastrum Testudinis, Os Draconis, Lapis Chloriti decocted 1 hour earlier, and three flavors such as adding Radix Rehmanniae Preparata are fried in shallow oil three times, and three decoction liquor are filtered, mixed, and add ethanol, obtain extractum C behind the recovery ethanol; Extractum A, B, C are mixed the back add steviosin, dextrin, mixing again through the sponging granulator pelletize, is made 1000g altogether, and packing (every bag of 6g) promptly obtains required product.
Example 4
This example is 15 cases treatment situations taking passages from clinical for over ten years.
(1) blue XX, man, 9 years old, the prescription on individual diagnosis on the 20th of nineteen ninety JIUYUE.In the time of 5 years old, inarticulateness during once because of back of the body Tang poetry is snapped head off by father's anger, and a palm is beaten on the face, and from then on Xiao Lan has fallen the defect of liking nictation, once nervous ceaselessly nictation.Past several years, the defect of Xiao Lan constantly increases the weight of, sometimes make eyes the cough of shrugging sometimes, even also cough and send some strange sound on the classroom with losing control of, the dreaminess of sleeping less, body of the tongue is normal, white and thin fur, deficient and stringy pulse, the coprolalia syndrome that belongs to the being terrified suddenly type is taken the medicine that the present invention treats Gilles de la Tourette's syndrome and is fully recovered after 5 months.Follow up a case by regular visits to and do not see recurrence in 3 years.
(2) journey XX, the man, 7 years old, went to a doctor October 26 nineteen ninety.Infant is not independently opened one's mouth, and shakes the head, and abdominal muscles is twitched, sounding is nearly 2 years in the larynx, once examines in local hospital to be coprolalia syndrome, and it is not controlled to give the western medicine state of an illness such as Tai Bili, and occurring that health is got fat and side effect such as drowsiness, the infant happiness is carnivorous, and is restless and sleepless, irritated thirsty, red tongue, thick and greasy fur, stringy and rolling pulse, belong to phlegm-fire Phlegm-Heat Internal confusion Type Gilles de la Tourette's syndrome after diagnosing, take the medicine that the present invention treats Gilles de la Tourette's syndrome and fully recover after 4 months.Following up a case by regular visits to 3 years, all are normal.
(3) Liu XX, the man, 8 years old, on May 25th, 1992 went to a doctor.Occur nictation in the time of 6 years old, cervical region is twitched, and it is normal to look into electroencephalogram in local hospital, examines to be Gilles de la Tourette's syndrome, and taking western medicine has alleviation, but repeatability is strong.Infant is to shake the head during prescription on individual diagnosis, and it is main shrugging, and twitches frequently effectively, shout frequently, and being irritable and irascible, headache, flushing conjunctival congestion, big dry stool, yellow urine, red tongue, yellow and thin fur, wiry and frequent pulse is loud strong, belongs to liver-wind stirring up internally type coprolalia syndrome after diagnosing.Take medicine that the present invention treats Gilles de la Tourette's syndrome after 3 months the state of an illness be clearly better, twitch frequency and alleviate, temper is improved, and consolidates the back in 2 months continue clothes and fully recovers.Follow up a case by regular visits to and do not rebound in 2 years.
(4) Zhu XX, the man, 10 years old, JIUYUE was gone to a doctor on the 8th in 1993.Occurred slight winking, pout one's lips before 4 years, do not cause that the head of a family notes, then comparatively frequent afterwards, neck occurs turning round, talk Billingsgate, increase the weight of when excited or nervous.The infant body is wan and sallow during prescription on individual diagnosis, and is tired out, feverish sensation in the palms and soles, dizzy thirsty, constipation, red tongue with lack of fluid, tongue is few, and thready and rapid pulse belongs to the liver-kidney yin deficiency coprolalia syndrome after diagnosing, take medicine that the present invention treats Gilles de la Tourette's syndrome after 3 months, the December further consultation, symptom is obviously alleviated, and does not see the untoward reaction of taking medicine, after continuing to treat for 1 course of treatment, symptom disappears substantially.Follow up a case by regular visits to and do not see recurrence in 3 years.
(5) strongly fragrant XX, the woman, 9 years old, on June 22nd, 1994 went to a doctor.Occur to twitch symptom half a year, irregularly hands is trembled in outbreak repeatedly, kicking has expectorant in the larynx, make a sound constantly and send the sound of shouting strangely, once used treatment by Chinese herbs, sx but have repeatedly, the infant yellowish complexion is tired out, inappetence, thready and stringy pulse is unable, belongs to the coprolalia syndrome of insufficiency of the spleen liver-fire type after diagnosing, takes medicine further consultation after 4 months that the present invention treats Gilles de la Tourette's syndrome, symptom is obviously alleviated, and consolidates recovery from illness after 2 months.Follow up a case by regular visits to and do not occur repeatedly in 2 years.
(6) open XX, the man, 7 years old, went to a doctor May 15 nineteen ninety-five.Occur to twitch in the kindergarten top class in a kindergarten, take Tai Bili after symptom disappear substantially frequently occur repeatedly again owing to see TV, with nictation, it is main grinning during prescription on individual diagnosis, wilfulness, irritability is examined and is seen thin white fur of tongue, rolling pulse is examined and is multiple pumping symptoms.Take medicine that the present invention treats Gilles de la Tourette's syndrome after 3 months, twitch frequency and reduce, wilfulness also takes a turn for the better to some extent, continue clothes after 2 months shape disappear.Follow up a case by regular visits to and do not find repeatedly in 2 years.
(7) Hao XX, the woman, 10 years old, on April 15th, 1996 went to a doctor.The facial muscle that occurs the year before winking is twitched, and invalid through ophthalmic procedures, it is effective to take Chinese medicine in the locality, but recurrence again " is uttered a sound or a word " sometimes after the flu, frequent micturition (more obvious before sleeping), timid, red tongue, tongue is few, thready pulse, be diagnosed as Gilles de la Tourette's syndrome, sb.'s illness took a favorable turn in 2 months to take the medicine that the present invention treats Gilles de la Tourette's syndrome, and the frequent micturition phenomenon disappears, and consolidates transference cure after 3 months again.Follow up a case by regular visits to not have repeatedly in 2 years and occur.
(8) field XX, the man, 12 years old, on June 11st, 1997 went to a doctor.Occurred pouting one's lips as a signal before 2 years, nod, clear one's throat, shout laugh, irritated irritability, absent minded, once took the treatment of haloperidol and trihexyphenidyl and take a turn for the better to some extent, but recurrence again after the drug withdrawal is examined and seen dry mouth with bitter taste, the tinnitus dreaminess, red tongue margin, yellow and greasy fur, slippery and rapid pulse, be diagnosed as coprolalia syndrome, take medicine symptom improvement after 3 months that the present invention treats Gilles de la Tourette's syndrome, continue after treatment drug withdrawal after 3 months again.Follow up a case by regular visits to not recurrence in 3 years.
(9) woods XX, the woman, 11 years old, on August 20th, 1998 went to a doctor.Arranged before 3 years nictation, shake the head, occur kicking then again,, occur repeatedly with the sound that hawks, can't automatic control, once each ground warp repeatedly integrative therapy all take a turn for the better the thin irritability of infant body, the diet inequality, the xerostomia halitosis, how moving forgetful, red tongue margin, yellow and greasy fur, rolling pulse, belong to excessive rising of liver-YANG, disturb on the phlegm-fire, be diagnosed as coprolalia syndrome, take the medicine symptom improvement in 3 months that the present invention treats Gilles de la Tourette's syndrome, most of symptom of twitching disappears, continue clothes drug withdrawal observation after 3 months.Follow up a case by regular visits to and do not occur recurrence in 3 years.
(10) Hu XX, the man, 13 years old, JIUYUE was gone to a doctor on the 7th in 1998.Absent minded from the discovery of last class hour, and increase the weight of gradually, amiable, active thing is lost control of.Found in nearest 1 year to nod, squeeze eyebrow, turn round neck, shrugging occurs repeatedly, can't automatic control.The stubborn irritability of infant, the xerostomia halitosis, the red tongue margin rolling pulse, yellowish fur, yellowish urine, diet is irregular, is diagnosed as multiple pumping symptoms.Take the medicine treatment in 3 months that the present invention treats Gilles de la Tourette's syndrome, twitch transference cure, also can keep one's mind on studying, achievement rises gradually, drug withdrawal after consolidating 3 months again.Follow up a case by regular visits to not recurrence in 3 years.
(11) king XX, the man, 10 years old, on April 12nd, 1999 went to a doctor.Occurred shaking the head before 3 years, limbs twistings, companion's yaup can't automatic control, alternately occurs, repeatedly outbreak.And the obstacle of being in a bad mood, conduct disorder, learning difficulty, multi-treatment is invalid, and the twitch frequency is more during prescription on individual diagnosis, and day outbreak 30-40 time is examined and is seen the irritability stubbornness, and dysphoria with feverish sensation in the chest palms and soles is forgetful, red tongue, rapid pulse is diagnosed as coprolalia syndrome.Take medicine that the present invention treats Gilles de la Tourette's syndrome after 3 months symptom be clearly better, emotion makes moderate progress, and obeys drug withdrawal after 3 months again.Follow up a case by regular visits to and do not have recurrence in 3 years.
(12) old XX, the woman 9 years old, came first visit on May 24th, 1999.Before the patient 4 months, facial muscle occur and twitch red tongue margin, stringy and tense pulse, examine and be multiple pumping symptoms, take the medicine 2 months that the present invention treats Gilles de la Tourette's syndrome, symptom disappears substantially, drug withdrawal after obeying 1 month because flu slightly recurs, was taken drug withdrawal observation after 2 months again after 5 months.Follow up a case by regular visits in 3 years and do not occur repeatedly.
(13) fourth XX, man, 11 years old, first visit on June 30 in 2000.Occur to twitch symptom before 1 year, when alleviating to some extent after Chinese traditional treatment, cardinal symptom is the drum cheek, shoulder, cervical region twitch when examining, red tongue, and red lip, tongue is few, and a little prickle is arranged, and crackle is arranged, and rapid pulse is examined and is multiple pumping symptoms.Take medicine that the present invention treats Gilles de la Tourette's syndrome after 3 months, twitch symptom and be clearly better, symptom all disappears after consolidating 2 months again.Follow up a case by regular visits to not recurrence in 2 years.
(14) poplar XX, man, 10 years old, JIUYUE in 2000 first visit on the 12nd.2-3 occurred trunk in the past and twitched, and gave the treatment of clothes haloperidol and trihexyphenidyl, transference cure after month and drug withdrawal, but recurrence again soon, dry cough occurs, alarm nose, open one's mouth, short-tempered, bold, learn fair, thready and stringy pulse, thick fur is white, examines to be coprolalia syndrome.Take the medicine that the present invention treats Gilles de la Tourette's syndrome and examined check afterwards in 3 months, symptom turns for the better by and large, continue clothes after 3 months drug withdrawal observe.Follow up a case by regular visits in 3 years and do not occur repeatedly.
(15) Lee XX, man, 9 years old, first visit on October 8 in 2000.Find that Gilles de la Tourette's syndrome 3 years is surplus, during prescription on individual diagnosis mainly based on nictation, exert nose, nod, throat's sounding, the time heavy when light, the enuresis sometimes, thin white fur of tongue, rolling pulse is examined and is coprolalia syndrome.Take medicine that the present invention treats Gilles de la Tourette's syndrome after 2 months, twitch symptom and be clearly better, enuresis phenomenon disappears, drug withdrawal after obeying 3 months again.Follow up a case by regular visits in 2 years and do not occur repeatedly.
Table 1 unit: gram
| The medicine name | Example 1 | Implement 2 | Implement 3 |
| The blue or green chlorite schist rhizoma pinellinae praeparata of the stiff silkworm of prepared rhizome of rehmannia rhizoma Gastrodiae felwort tortoiseshell yncaria stem with hooks Os Draconis | 840 504 420 420 420 1260 420 840 504 | 750 404 375 375 375 1100 375 750 404 | 340 304 220 220 220 800 220 640 304 |
Claims (2)
1, a kind of medicine for the treatment of Gilles de la Tourette's syndrome is characterized in that described medicine is to be made by the raw material of following parts by weight: Radix Rehmanniae Preparata 3-9 part, Rhizoma Gastrodiae 2-6 part, Radix Gentianae 2-5, Carapax et Plastrum Testudinis 2-5 part, Ramulus Uncariae Cum Uncis 2-5 part, Os Draconis 8-13 part, Bombyx Batryticatus 2-5 part, Lapis Chloriti 5-9 part, Rhizoma Pinelliae Preparatum 2-6 part.
2, the described process for preparing medicine of claim 1 is characterized in that preparation process may further comprise the steps:
(1) get Rhizoma Gastrodiae and add 75% alcohol reflux three times, each 1 hour, each amount of alcohol added was 6 times of Rhizoma Gastrodiae amount, and three times extracting solution merges after filtering, and reclaiming ethanol then and being concentrated into 50 ℃ of relative densities is 1.20, obtains extractum A;
(2) hook taking rattan, Bombyx Batryticatus add 60% alcohol reflux three times, and each 1.5 hours, each amount of alcohol added was Ramulus Uncariae Cum Uncis and Bombyx Batryticatus amount 8 times, and three extracting solution are merged after filtering, and reclaiming ethanol then and being concentrated into 50 ℃ of relative densities is 1.20, obtains extractum B;
(3) after elder generation decocts with water 1 hour with Carapax et Plastrum Testudinis, Os Draconis, Lapis Chloriti, the water yield is higher than powder 3-5cm, add Radix Rehmanniae Preparata, Radix Gentianae, Rhizoma Pinelliae Preparatum three flavor Chinese medicines then, decoct three times, each 1 hour, it was 1.05 that three filtrate merging are concentrated into 50 ℃ of relative densities, adding ethanol in the filtrate makes and contains alcohol amount and reach 60%, cold preservation 24 hours, reclaiming ethanol then and being concentrated into 50 ℃ of relative densities is 1.20, obtains extractum C;
(4) extractum A, B, C are mixed, add steviosin and dextrin then, mixing promptly obtains granular medicament through mist projection granulating, and last packing gets final product.
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