RU2172634C2 - Bronchial asthma treatment method - Google Patents

Abstract

FIELD: clinical phytotherapy. SUBSTANCE: water-soluble forms of chitosan with antiasthmatic vegetable materials taken in certain proportions in a variety of medicinal forms (ointments, tinctures, extracts, those combined with powdered water-soluble chitosan form, tablets, and in pure state) are proposed to treat bronchial asthma. EFFECT: accelerated arrest of shortness of breath, cough, asphyxia attacks, intoxication, and prevented complications. 4 cl, 2 tbl, 9 ex

Description

 The invention relates to medicine, namely to clinical phytology and herbal medicine, and for the use along with herbal medicine of water-soluble forms of chitosan for the treatment of respiratory diseases.

 Known collection for the treatment of bronchitis [1] and a method for the treatment of cancer [2], which consists in using, along with conventional chitosan in the form of a salt form with L-glutamic acid in combination with special herbal remedies used strictly in accordance with the prognosis of cancer.

 The data [1] show the need for a comprehensive effect on the body during the symptomatic and pathogenetic treatment of bronchial asthma complicated by bronchitis and pneumonia, by increasing the body's reactivity, anti-inflammatory, anti-allergic, absorbable, detoxifying, bronchodilator, antimicrobial effects.

 The aim of the invention is to enhance anti-allergic, antimicrobial and detoxification effects, accelerate the removal of painful symptoms, increase the effectiveness of treatment of bronchial asthma and its accompanying respiratory diseases and prevent side undesirable complications (ulcerative stomatitis, intoxication, decreased immunity, blood pressure and others).

 This goal is achieved by using water-soluble forms of chitosan in conjunction with herbal medicine, the priority of which is determined by the type of respiratory disease.

 The validity of the use of food chitosan in the form of its water-soluble forms in combination with herbal medicine was shown by us earlier [2]. We note the main features of this application.

 The unique tendency of chitosan to complexation and chelating due to the high concentration of electrophilic and nucleophilic centers among water-soluble synthetic and natural polymers in the repeating unit determines the prolonged, detoxification, anti-inflammatory and anti-allergic properties of drugs based on it.

 The inhibitory effect of chitin, chitosan oligomers and their derivatives on phytopathogenic bacteria [3] and streptococcus mutans adsorbed on hydroxyapatite [4], as well as the sensitivity of hemolytic and non-hemolytic (white) streptococci, golden, epidermal and saprophyte established in the LHC of the NSC RAS polyclinic staphylococci can expand the complex effect on the body in the treatment of respiratory diseases complicated by infections.

 Decreased blood cholesterol levels under the action of chitosan [5], the wound healing property of freshly formed coatings and films based on it [6, 7], the calming effect on the central nervous system and the immunostimulating effect similar to β-1,3-glucan [8] also contribute to strengthening therapeutic effect.

 It is known that the adaptogenic, tonic, immunostimulating effect of drugs is associated with their antioxidant activity and it is proposed to introduce this indicator into the regulatory documentation for preparations from plant and animal raw materials [9]. A reduction in the intensity of oxidative processes is necessary in the presence of inflammation at any stage, in the treatment and prevention of atherosclerosis [10], when correction of lipid metabolism and lipid peroxidation processes is required, as well as in the treatment of gerontological patients with bronchial asthma [11] and cancer patients [12] ], when it is necessary to simultaneously carry out correction of the patient’s immune system.

 Note that trials of chitosan with free radical damage to biological objects [13] confirmed its action as an antioxidant that traps reactive oxygen species. The presence of an amino group in the coordination sphere of the metal, as in chelates based on chitosan [14, 15, 16], activates it in the destruction of hydroperoxides without the formation of radicals, which essentially enhances the antioxidant effect [17]. Therefore, the combination of chitosan-based preparations with a dry extract of phyto-collections, in which there is a significant amount of metals with a transition valency (iron, copper, manganese, etc.) similar to phenolic preparations of plant origin [12] will lead to increased inhibition of free radical reactions. Considering the immunostimulating effect of chitosan [7, 8] and its antioxidant properties [13], as well as the high clinical efficacy of the antiallergic and bronchodilator effects of phyto harvests [1], proven in clinical practice, the proposed method may have an enhanced therapeutic effect and will be suitable both for prevention and for the treatment of patients with bronchial asthma and related respiratory diseases.

 Of the allergic diseases, the most common is allergic rhinitis (hay runny nose, polynosis), the typical symptoms of which are runny nose and nasal secretions when irritated by an allergen, sometimes lacrimation, redness of the eyes and conjunctivitis. For the treatment of hay rhinitis, it is recommended to use several drugs that combine the effect on local symptoms with a cleansing detoxification effect on the whole body [18]. Tests have shown that complex preparations based on dry extracts of phyto-harvests and water-soluble forms of food chitosan possess such qualities.

 Experimentally on volunteers since 1992 it was found that the proposed method for the treatment of respiratory diseases has a synergistic therapeutic effect (tables 1 and 2). The disappearance of symptoms is achieved in a shorter time. The total number of symptoms that disappear as a result of treatment by the proposed method is increased by 25% compared with the treatment of such diseases only by herbal medicine [19, p. 19] (table 1). The number of convalescents during treatment by the proposed method (table 2) is increased by 10% compared with herbal medicine [19, p. 31]. Analysis of the therapeutic effect by age and gender (table 2) shows a particularly high result in the treatment of patients with an age of ≅ 14 years, when an unfavorable outcome of treatment is completely absent.

 Freshly prepared infusions were used for the treatment: one tablespoon of the collection (the compositions are given below) or 5-6 g in the form of a powder, tea or tablet, brew 1/2 liter of boiling water. Insist for 1 h, strain, drink 1/4 cup (50 ml) at a time 8 times a day for 2 to 3 days. Then 1/2 cup (100 ml) 4 times a day 15 minutes before meals and at bedtime. If it is difficult to take by mouth, you can enter in the form of suppositories 2 g of collection 3 times a day into the rectum. The internal intake should be combined with local application in the form of lotions, poultices, microclysters (50 ml) from the second fraction (re-welding of thick grass with one glass of boiling water, strain after exposure for one hour).

 Phyto-ointments are prepared on the basis of pork interior fat according to the technology described in the book [20, p. 134] and patent [21], contain an extract of phyto-collection and low molecular weight chitosan or its soluble salt form.

 Chitodez is a complex of chitosan with L-glutamic acid, obtained at an equifunctional ratio.

 Phytochitodesis - a mixture of chitodez powders and a dry extract of phyto-collections is obtained in a single technological cycle with the final stage of lyophilization under mild conditions. The numbering of phytochitodes corresponds to the numbering of phyto harvests.

 Chitodez take 0.025 g under the tongue 30 minutes after eating, rinse your mouth and swallow after 1 hour. Reception of tablets on the basis of phytochitodes is similar. A dose of 0.025 g is taken 3-4 times a day, and if suffocation, cough, pain and other painful symptoms occur, an additional unlimited number of times. Phytomus with chitosan is applied to the skin of the neck, chest, as well as per rectum and to the nose.

 The following are the compositions of phyto-collections used in the treatment of bronchial asthma (the numbering of phyto-collections is identical [2]).

 Collection No. 3 - the main anti-allergic and bronchodilator collection (an improved version of the collection [1]): grass of oak birch, common saplings, a series of three-parted, coltsfoot 9 parts by weight each; buds of common pine, herb of Veronica officinalis, ivy buds, color, leaves and branches of common lilac, scepter mullein in 7 parts by weight; the color of chamomile officinalis, grass of melilotus officinalis, capitals of thyme, creeping thyme, color, leaf and branches of small-leaved linden, black elderberry, white cinnamon, horsetail, tricolor and field violets, marsh purum, creeping wheatgrass root, 5 weight parts; large celandine grass, marsh cinquefoil, the color of tansy ordinary in 3 parts by weight; grass of ordinary yarrow, Hypericum perforatum, silver cinquefoil, goose cinquefoil, common oregano, meadow geranium, common fennel, urban gravilate, common cuff, plantain leaf large, color of calendula officinalis, elecampane root, 2 parts by weight; peppermint leaf, white birch, narrow-leaved fireweed, big burdock grass, bird highlander grass, dioica nettle, marsh dried cinnamon, prickly salmon, marsh rosemary, tarragon (tarragon), medicinal smoky, narrow-leaved fireweed, meadow clover, meadow clover, dandelion officinalis, burdock, angelica officinalis, 1 part by weight.

 Collection N 8 - antifungal action (option [22]) in parts by weight: yarrow grass - 9, white birch leaf - 7, common wormwood grass (Chernobyl) - 5, Veronica officinalis - 4, three-colored violets - 4, chamomile - 2, oregano - 2, marshmallows - 2, the color of calendula officinalis - 2, the color of tansy ordinary - 1, the color of clover meadow -1.

 Collection No. 9 - antistaphylococcal (option [23]) in parts by weight: ordinary yarrow grass - 6, burdock leaf - 5, St. John's wort perforated, medicinal sweet clover, oregano, dioecious nettle leaf, large plantain, 3 parts by weight; grass of coltsfoot, mountaineer, bird rosehips of cinnamon, roots of cinquefoil erect, dandelion officinalis, the color of calendula officinalis, tansy ordinary in 2 parts by weight; the color of chamomile officinalis, field horsetail grass in 1 part by weight.

 The proposed method is confirmed by examples from 124 cases of treatment (table 2).

 Example 1. Patient K., 9 years old. The diagnosis is bronchial asthma of physical stress with frequent attacks, vasomotor rhinitis. From the age of three, frequent attacks of suffocation and coughing, asthopen and other drugs were used to relieve the attack, was repeatedly treated in children's clinics, and there was no improvement. After a 10-day course of herbal medicine: collection of N 3 with the simultaneous administration of chitodez of 0.012 g under the tongue three times a day half an hour after a meal, a significant improvement was observed. Already the first night passed without an attack and in the following days no attacks occurred, breathing through the nose was restored. When viewed after 15 days - almost healthy.

 Example 2. Patient S., 38 years old. The diagnosis is bronchial asthma, chronic tonsillitis, chronic bronchitis, chronic renitis. In childhood, a nasal polyp was removed, a constant painful dry cough disturbs, a runny nose, tonsils are enlarged, loose, occasionally large attacks of suffocation, difficulty in nasal breathing. Appointed: herbal medicine - collection of N 3 and chitodez at 0.025 g under the tongue. After 15 days - there is no cough, no runny nose, free breathing, tonsils are not enlarged, no complaints.

 Example 3. Patient S., 42 years old. The diagnosis is bronchial asthma of physical stress, immunodeficiency, the study found a lack of interferon. Frequent acute respiratory viral infections, acute respiratory infections, sore throat, pharyngitis, sinusitis, bronchitis, pneumonia, bronchospasm, difficulty breathing, shortness of breath during physical exertion, dysbiosis (little E. coli), herpetic infection, she had tuberculous mesodenitis at the age of 10. Appointed: herbal medicine - collection of N 3 inside, from the second fraction of the infusion of microclysters, ointment based on collection of N 3 with chitosan in the nose, rectum and vagina, phytochitodes-3 under the tongue 3 times a day after meals after 30 minutes. Improvement came after 5 days, after 15 days no complaints. In the morning, mucous sputum leaves, menstruation, which has not been there for six months, has resumed, it has not proceeded abundantly for 5 days. ARVI once proceeded easily, without complications.

 Example 4. Patient A., 72 years old. From the age of 70 he suffers from bronchial asthma with frequent attacks (up to 10 times a day) of suffocation and cough, inhalation with a barotek up to 10 times a day. Constantly 2–3 times a day, took one and a half tablets of teofedrine, but suffocation and cough were relieved for a short time, disturbed by strong excitement, weakness, palpitations - 120 beats / min. During the illness, she lost 28 kg (from 70 to 42 kg). She was treated for asthma in a hospital, and often called an ambulance. Turned at the time of asthma and coughing attacks, could not move, pulse 120 beats / min, in the lungs an abundant amount of wheezing dry rales, boxy shade of percussion sound, breathing weakened, exhalation was difficult. After taking a dose of 0.025 chitodez under the tongue, a sharp improvement occurred in 2 minutes, suffocation disappeared, coughing, the pulse decreased to 100 beats / min, wheezing was not audible in the lungs, the general condition improved, it moves freely. Appointed: herbal medicine - collection N 3 and an ointment based on this collection in the nose and lubricate the chest, microclysters with the second fraction, dose-controlled chitosis 30 minutes after eating three times a day and during the attack. After 5 days of treatment, a sharp improvement, asthma attacks did not occur during the day, barotek only once at night and a half-tablet of teofedrine at night. When viewed after a month, the condition is good, no complaints, pulse 80 beats / min, vesicular breathing in the lungs, wheezing is not audible, there were no more attacks of suffocation, the barotek did not accept. The course of treatment is extended to three months.

 Example 5. Patient B., 50 years old. She addressed about bronchial asthma, nodular re-arteritis, bronchitis. Since childhood, frequent attacks of suffocation and cough, hypochromic anemia (hemoglobin 80 - 90 g / l). In addition, systemic vasculitis, polymyositis, widespread endometriosis, myosthenic syndrome, secondary immunodeficiency - three years take prednisolone 50 mg every other day. Mycoses periodically occur in the mouth, ears, intestines, gynecological organs, and hypertension for more than 20 years (from 190/120 to 200/130). Appointed: herbal medicine - alternate collection of N 3 and 8, ointment based on the collection of N 3 with chitosan to lubricate the nose and skin of the neck, chest and limbs. When re-examined after three months, a significant improvement in general condition was noted, asthma attacks disappeared, coughing rarely, muscle atrophy did not progress, mycoses did not occur, pressure decreased to 140/90. The continuation of herbal medicine is prescribed.

 Example 6. Patient D., 73 years old. At 59 years old she got bronchial asthma, frequent attacks of suffocation and cough. At 69, she suffered a myocardial infarction, after which she lost weight dramatically, increased irritability, mental depression, chronic gastritis, duodenitis, chronic colitis, and blood pressure 220/130. From 67 years old she was treated by various plants at her discretion, but the seizures did not disappear, sometimes there were several seizures, with ARVI cough with sputum, shortness of breath almost constantly, rapid breathing, pulse 90 - 100 beats / min, severe weakness, fatigue. In 73 years, a 10-day course of chitodesis treatment was prescribed, already the first chitodesis treatment made breathing easier, relieved an asthmatic attack after 7 minutes, after this course her condition improved, herbal therapy was prescribed by collection N 3. There were no bronchial asthma attacks for three months. A / D 140/80.

 Example 7. Patient A., 62 years old. 5 - 7 years ago, bronchial asthma was diagnosed, bronchitis, which gradually turned into a chronic form. Attacks of suffocation, coughing were repeated several times a day. Often got into the intensive care unit with asthmatic status. He used inhalers several times a day and night, took prednisone and other hormonal drugs, but there was no cure. There were attacks of suffocation and coughing, dry wheezing was heard, often exacerbation of the disease. Reception of chitodesis and phytochitodes-3 for ≅ 10 minutes removed attacks of suffocation, coughing, wheezing disappeared. Within a month, she continues to take phytochitodes-3. Attacks of suffocation and coughing were no longer observed, gradually reducing the dose, stopped taking prednisolone.

 Example 8. Patient D., 5 years. In January 1998, after the flu for acute bronchitis, a broad-spectrum antibiotic course was given - attacks of suffocation and coughing appeared. The attacks were long and severe. After examinations, the diagnosis was established: bronchial asthma with frequent attacks, bronchitis, pharyngitis, otitis media, sinusitis and candidomycosis. Treatment with antiallergic, bronchodilator, antifungal chemotherapy failed. In May 1998, herbal medicine was prescribed: alternately collecting N 3 and 8 for one dessert spoon, brew a glass of boiling water, insist for 1 h, drink 50 ml 4 times a day, the second fraction of the microclyster infusion of 30 ml, lotions on the chest, wiping skin. Phytomaz-3 and 8 with chitosan 2 times a day in the nose and rectum. At the same time, phytochitodes-3 and 8 were prescribed under the tongue. 10 minutes after the first administration of tablets under the tongue during an asthma attack, the latter underwent a reverse development. Choking and dry wheezing disappeared and no longer arose. In the next 14 days, cough and sputum discharge intensified without an attack of suffocation, then the cough disappeared and no longer arose. Herbal medicine, the intake of phytochitodes, phytomaz with chitosan lasted three months. The disease no longer manifested. Simultaneously with bronchial asthma, the phenomena of bronchitis, pharyngitis, otitis media, sinusitis disappeared.

Example 9. Patient L., 10 years old. From the age of 8, frequent acute respiratory viral infections and acute respiratory infections, diagnosed with staphylococcal bronchitis, bronchial asthma with frequent attacks of suffocation and cough, severe pharyngitis, tracheitis and dysbiosis. Frequent bouts of coughing and expiratory dyspnea, in the evenings a temperature of 37.5 ^o C, swelling of the pharynx, loose stools twice a day. Phytotherapy was prescribed: collection of N 3 and 9 alternately for 7 days for three months. At the same time, phytochitodes-3 at 0.025 g under the tongue 30 minutes after eating three times a day, phyto-ointment-3 with chitosan in the nose, rectum, microclysters from the second fraction on the neck and chest. All symptoms disappeared after 7 days. Subsequently, during acute respiratory viral infections for 14 to 30 days, the disease did not recur. The course of treatment is three months.

 The combination of infusions of medicinal plants with a powdery water-soluble form of chitosan (chitodez), the use of ointments based on medicinal plant materials with the addition of low molecular weight food chitosan and phytochitodes based on a mixture of powders of dry extracts of various phyto-collections and chitodez increases the effectiveness of the treatment of bronchial asthma by prolonging and accelerating the action of medicinal phyto-medications , strengthening antioxidant, detoxification and immunostimulating effects.

Sources of information
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Claims (4)

1. A method of treating bronchial asthma, including herbal medicine, characterized in that the patient is injected with water-soluble forms of food chitosan and phytobox, which is a mixture in a weight ratio of components:
Oak browning grass - 9
Common Dreams Grass - 9
Grass of a series of three-parted - 9
Coltsfoot Grass - 9
Kidney pine ordinary - 7
Veronica officinalis herb - 7
Ivy-shaped Budra Grass - 7
Common lilac (color, leaves and branches) - 7
Scepter Mullein - 7
Chamomile officinalis color - 5
Melilotus officinalis herb - 5
Herb initial letters - 5
Creeping Thyme Grass - 5
Color, leaf and branches of small-leaved linden - 5
Color, leaf and branches of elderberry black - 5
Color, leaf and twigs of the white crypt - 5
Color, leaf and branches of horsetail - 5
Color, leaf and twigs of violet tricolor and field - 5
The color, leaf and branches of the purpid marsh - 5
Creeping Wheatgrass Root - 5
Large celandine grass - 3
Marsh Cinquefoil Grass - 3
Tansy flowers - 3
Yarrow herb - 2
Hypericum perforatum herb - 2
Silver Potentilla Grass - 2
Goose cinquefoil grass - 2
Origanum ordinary grass - 2
Meadow Geranium Grass - 2
Common Fennel Grass - 2
City Gravilata - 2
Common cuff grass - 2
Leaf of a large plantain - 2
Calendula officinalis color - 2
Elecampane root - 2
Peppermint leaf - 1
White Birch Leaf - 1
Narrow leaf fireweed leaf - 1
Greater Burdock Leaf - 1
Angelica officinalis leaf - 1
moreover, the collection is introduced in the form of infusion, and the repeated fraction of the infusion is introduced in the form of microclysters of 50 ml, lotions are applied and rubbed on her neck and chest, and phyto-ointment prepared on the basis of pig interior fat and said phyto-collection is applied to the nose, rectum, on the skin of the neck and chest. 2. The method according to claim 1, characterized in that with the fungal etiology of bronchial asthma, a collection is additionally introduced, which is a mixture in a weight ratio of components:
Yarrow herb - 9
White Birch Leaf - 7
Common wormwood grass (Chernobyl) - 5
Veronica officinalis herb - 4
Tricolor violet grass - 4
Chamomile officinalis herb - 2
Origanum ordinary grass - 2
Mushroom sushnitsa grass - 2
Calendula officinalis color - 2
The color of tansy ordinary - 1
Meadow clover color - 1
moreover, the fees are applied alternately. 3. The method according to claim 1, characterized in that with staphylococcal etiology of bronchial asthma, an additional collection is introduced, which is a mixture in a weight ratio of components:
Yarrow herb - 6
Burdock leaf - 5
Hypericum perforatum grass - 3
Melilotus officinalis herb - 3
Large Plantain Grass - 3
Coltsfoot Grass - 2
Highlander's Grass - 2
Cinnamon rose hips - 2
Root cinquefoil roots - 2
The roots of dandelion officinalis - 2
Calendula officinalis color - 2
The color of tansy ordinary - 2
Chamomile officinalis color - 2
Field Horsetail Grass - 2
moreover, the fees are applied alternately.  4. The method according to claim 1, characterized in that the patient takes a mixture of powders of chitosan with L-glutamic acid and a dry extract of phyto-collection (phytochitodes).

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