CN111228455A - A Chinese medicinal preparation for treating cough and asthma - Google Patents
A Chinese medicinal preparation for treating cough and asthma Download PDFInfo
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- CN111228455A CN111228455A CN202010296818.8A CN202010296818A CN111228455A CN 111228455 A CN111228455 A CN 111228455A CN 202010296818 A CN202010296818 A CN 202010296818A CN 111228455 A CN111228455 A CN 111228455A
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/758—Zanthoxylum, e.g. pricklyash
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8884—Arisaema, e.g. Jack in the pulpit
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/88—Liliopsida (monocotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
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Abstract
The invention provides a traditional Chinese medicine preparation for treating cough and asthma, which is prepared from pummelo peel, alum, pinellia ternate, pericarpium zanthoxyli, meadowrue root and rhizome, arisaema tuber, myrobalan, white arbor, poria cocos blocks and dried ginger in certain parts by weight. Clinical tests prove that the traditional Chinese medicine composition has obvious curative effects of treating both principal and secondary aspects of diseases on various coughs, acute and chronic bronchitis, bronchial asthma and emphysema, and can be used for coughing viscous sputum accumulated in the deep lung for a long time.
Description
Technical Field
The invention belongs to the field of traditional Chinese medicines, and relates to a traditional Chinese medicine preparation for treating cough and asthma.
Background
According to incomplete statistics, the number of patients suffering from various coughs in human beings is about 30% of the population, and the number of patients suffering from coughs after colds is even more countless. Over 80% of asthma patients suffer from lung capacity reduction caused by allergic spasm of the bronchial region of the larynx, severe hypoxia of the whole body due to blood hypoxia, blue and purple lips of the patients, phlegm whine accumulation in the larynx and the like. Because of the lack of oxygen in the body, the transportation and transformation of the zang-fu organs are abnormal, so that excessive water cannot be discharged in time and accumulated into phlegm, and the excessive phlegm is difficult to expectorate. At present, a plurality of medicines for treating cough and asthma exist, but the effect is not ideal. Because asthma has recurrent attacks, chemical drugs such as glucocorticoid and theophylline have more adverse reactions in the treatment process, and the choice of preventive drugs is small, and traditional Chinese medicines have better curative effects on asthma, particularly chronic asthma and preventive drugs in the remission stage, so that people increasingly pay attention to the traditional Chinese medicines.
Disclosure of Invention
The invention aims to provide a Chinese medicinal compound preparation for safely and effectively treating cough and asthma.
The compound preparation comprises the following raw materials in parts by weight:
1-9 parts of pummelo peel, 1-9 parts of alum, 0.1-1 part of pinellia ternate, 0.2-1.5 parts of pericarpium zanthoxyli, 1-7 parts of meadow clover, 0.5-4 parts of rhizoma arisaematis, 0.5-2 parts of myrobalan, 0.4-2 parts of white arbor, 1-9 parts of poria cocos blocks and 1-9 parts of dried ginger.
The preferable mixture ratio is as follows: 3-7 parts of pummelo peel, 3-7 parts of alum, 0.3-0.5 part of pinellia ternate, 0.5-0.8 part of pericarpium zanthoxyli, 2-4 parts of meadow clover, 1-2 parts of rhizoma arisaematis, 0.7-1.5 parts of myrobalan, 0.6-1.5 parts of white arbor fruit, 3-5 parts of poria cocos blocks and 3-7 parts of dried ginger.
The optimal proportion is as follows: 5 parts of pummelo peel, 5 parts of alum, 0.45 part of pinellia ternate, 0.7 part of pericarpium zanthoxyli, 3.5 parts of meadow rue, 1.5 parts of rhizoma arisaematis, 1 part of myrobalan, 0.8 part of white arbor, 4 parts of poria cocos blocks and 5 parts of dried ginger.
The Chinese medicinal compound preparation can be prepared into various oral preparations, such as granules, capsules, pills and the like, according to the conventional process and auxiliary materials of pharmacy.
The medicine is a traditional Chinese medicine preparation, wherein the pummelo peel, the alum, the pinellia ternate, the pericarpium zanthoxyli, the meadowrue, the rhizoma arisaematis, the myrobalan, the white arbor, the poria cocos blocks and the dried ginger have the effects of clearing away the lung-heat, reducing phlegm, relieving cough and asthma, promoting blood circulation to remove blood stasis, dredging channels and collaterals, diminishing inflammation, expelling toxin, moistening the lung and clearing blood; has good therapeutic effect on cough due to bronchial asthma, pulmonary heart disease, lung cancer, pulmonary tuberculosis, common cold, excessive phlegm, and no phlegm.
The efficacy and side effects of the pharmaceutical composition of the present invention in treating various coughs are demonstrated by animal acute toxicity tests and clinical trials.
Acute toxicity test of animals
1. The purpose of the test is as follows: the drug of the present invention was observed in the acute toxicity and death after a single administration to mice.
2. Test animals: the hybrid mice, 30, half male and half female, weigh 18.2-20.1 g. Feeding granulated feed and drinking normal water.
3. Test drugs: the medicine decoction extracted by the formula of the invention is equivalent to 2.96g crude drugs per milliliter of extract. The composition is used at a concentration of 1.48g.ml (crude drug) based on 1% carbaryl cellulose.
4. The administration method comprises the following steps: after 4 hours of animal fasting, 0.4ml/10g body weight (liquid medicine concentration is 1.48g/ml) is added once, and the crude drug content is 0.4 multiplied by 1.48 to 0.592(g/10g body weight), so that the dosage of one time ig is 59.29/kg, which is equivalent to 247 times of the clinically recommended dosage of 0.24 g/kg.
5. Observation indexes are as follows: after administration, the animals were observed daily for changes in hair color, behavioral activity, mental state, stool and urine, nasal, ocular and oral secretions, and body weight (weighed respectively 1-7 days after administration). And (4) detecting the death condition, and if the death condition is found, carrying out autopsy in time, and carrying out pathological histological examination on the lesion organ.
6. As a result:
no epilation and no mental activity, and the stool and urine are obviously changed; the nose, eyes and mouth have no bloody or other secretions, and none of the cases die.
7. And (4) conclusion:
7.1 amphiprotic mice given the formulation of the present invention once had an average body weight gain day by day, none of the deaths.
7.2 mice were given the drug of the invention once, with a maximum tolerance of >39.29/kg (crude drug) which is approximately 189 times the clinically recommended dose.
Second, clinical trial
1. Case selection:
1.1 cough after cold in children: the number of children is 40 for 1-2 years old, 30 for 3-4 years old, 60 for 4-6 years old, 80 for 8-12 years old, and 210 for total.
1.2 adult patients: the number of patients with cold and cough over 40 is 60, the number of patients with cold and cough over 30 is 20, the number of patients with cold and cough under 30 is 30, and the total number of patients with cold and cough under 30 is 110.
2. The treatment method comprises the following steps: the capsule preparation of the pharmaceutical composition of the present invention is administered. The dose is as follows: infant patients of 1-2 years old: 0.04-0.06 g; infant patients from 3 to 4 years old: 0.04-0.06 g; children of 4-6 years old: 0.06-0.08 g; infant patients 8-12 years old: 0.1 to 0.2; adult: 0.6-0.8 g; 10 days is a treatment course, and cough after cold of children is: generally, 0.5 treatment course is adopted, and cough of an adult patient after a cold is generally 1-5 days as a treatment course; the cough caused by the senile asthma is generally 5-6 courses of treatment.
3. The treatment results are as follows:
please count the treatment status of patients in each case:
39 children patients of 1-2 years old are completely cured, 1 has reduced cough, and 0 has no effect. The statistical effective rate is 97.5%;
infant patients from 3 to 4 years old: 30 cases were completely cured, and 0 case was not. The statistical effective rate is 100%;
children of 4-6 years old: 60 cases were completely cured, and 0 case was not. The statistical effective rate is 100%;
infant patients 8-12 years old: 80 cases were completely cured, and 0 case was not. The statistical effective rate is 100%;
cough due to common cold in adults: 100 cases are completely cured, 10 cases are relieved from cough, 0 case is invalid, and the statistical effective rate is 91%;
compared with the prior art, the medicament of the invention has the following advantages:
1. the medicine of the invention has obvious curative effect of treating both principal and secondary aspects of diseases on various coughs, acute and chronic bronchitis, bronchial asthma and emphysema, and can expectorate viscous sputum accumulated in the deep lung for a long time.
2. The medicine has the advantages of quick curative effect (generally, the medicine can take effect after being taken for 10 minutes), small dosage (0.6-0.8 g of the medicine is taken by a patient with light cough twice a day, 0.6-0.8 g of the medicine is taken by a patient with pulmonary heart disease and an asthma patient with stubborn disease twice a day, 0.8-1 g of the medicine is taken by a patient with extra weight twice a day, and 0.6-0.8 g of the medicine is taken by a patient with cough caused by cold twice a day.
3. The medicine has no toxic and side effect, is safe and reliable, and is harmless to human bodies.
Detailed Description
Example 1 preparation of capsules of the invention:
the formula is as follows: the weight ratio of:
5 parts of pummelo peel, 5 parts of alum, 0.45 part of pinellia ternate, 0.7 part of pericarpium zanthoxyli, 3.5 parts of meadow rue, 1.5 parts of rhizoma arisaematis, 1 part of myrobalan, 0.8 part of white arbor, 4 parts of poria cocos blocks and 5 parts of dried ginger.
The process comprises the following steps: the capsule is prepared by adopting the conventional auxiliary materials and the process for preparing the capsule.
Example 2 preparation of granules of the invention:
5 parts of pummelo peel, 5 parts of alum, 0.45 part of pinellia ternate, 0.7 part of pericarpium zanthoxyli, 3.5 parts of meadow rue, 1.5 parts of rhizoma arisaematis, 1 part of myrobalan, 0.8 part of white arbor, 4 parts of poria cocos blocks and 5 parts of dried ginger.
The process comprises the following steps: the granules are prepared by adopting the conventional auxiliary materials and the process for preparing the granules.
Claims (4)
1. A traditional Chinese medicine preparation for treating cough and asthma is characterized by being an oral preparation prepared from the following raw material medicines in parts by weight according to a conventional pharmaceutical process and auxiliary materials:
1-9 parts of pummelo peel, 1-9 parts of alum, 0.1-1 part of pinellia ternate, 0.2-1.5 parts of pericarpium zanthoxyli, 1-7 parts of meadow clover, 0.5-4 parts of rhizoma arisaematis, 0.5-2 parts of myrobalan, 0.4-2 parts of white arbor, 1-9 parts of poria cocos blocks and 1-9 parts of dried ginger.
2. The traditional Chinese medicine preparation for treating cough and asthma according to claim 1, wherein the raw materials are mixed according to the following weight portions:
3-7 parts of pummelo peel, 3-7 parts of alum, 0.3-0.5 part of pinellia ternate, 0.5-0.8 part of pericarpium zanthoxyli, 2-4 parts of meadow clover, 1-2 parts of rhizoma arisaematis, 0.7-1.5 parts of myrobalan, 0.6-1.5 parts of white arbor fruit, 3-5 parts of poria cocos blocks and 3-7 parts of dried ginger.
3. The traditional Chinese medicine preparation for treating cough and asthma according to claim 1, wherein the raw materials are mixed according to the following weight portions:
5 parts of pummelo peel, 5 parts of alum, 0.45 part of pinellia ternate, 0.7 part of pericarpium zanthoxyli, 3.5 parts of meadow rue, 1.5 parts of rhizoma arisaematis, 1 part of myrobalan, 0.8 part of white arbor, 4 parts of poria cocos blocks and 5 parts of dried ginger.
4. The traditional Chinese medicine preparation for treating cough and asthma according to claim 1, wherein the oral preparation is granules, capsules or pills.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN202010296818.8A CN111228455A (en) | 2020-04-15 | 2020-04-15 | A Chinese medicinal preparation for treating cough and asthma |
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CN202010296818.8A CN111228455A (en) | 2020-04-15 | 2020-04-15 | A Chinese medicinal preparation for treating cough and asthma |
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CN111228455A true CN111228455A (en) | 2020-06-05 |
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CN202010296818.8A Pending CN111228455A (en) | 2020-04-15 | 2020-04-15 | A Chinese medicinal preparation for treating cough and asthma |
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Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1276242A (en) * | 1999-06-07 | 2000-12-13 | 陈光胜 | Chinese medicine for curing cough and asthma |
CN104027512A (en) * | 2014-05-09 | 2014-09-10 | 天津太平洋制药有限公司 | Traditional Chinese medicine for treating bronchial asthma |
-
2020
- 2020-04-15 CN CN202010296818.8A patent/CN111228455A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1276242A (en) * | 1999-06-07 | 2000-12-13 | 陈光胜 | Chinese medicine for curing cough and asthma |
CN104027512A (en) * | 2014-05-09 | 2014-09-10 | 天津太平洋制药有限公司 | Traditional Chinese medicine for treating bronchial asthma |
Non-Patent Citations (1)
Title |
---|
房经富等: "痰的证治考略", 《实用中医内科杂志》 * |
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