RU2165253C2 - Method of treatment of patients with oncological diseases - Google Patents

Abstract

FIELD: medicine, oncology. SUBSTANCE: invention proposes to use chitosan as a salt form with L-glutamic acid in combination with special phytospecies taken in the definite ratios and in different medicinal forms (ointments, infusions, extracts and dry extracts combined with powder-like chitosan salt form, tabletted, capsulated and pure forms). Treatment is carried out by specific schedule corresponding to stages of treatment of oncological diseases. Invention can be used for treatment of oncological patients at different stages and localization of tumors. EFFECT: enhanced effectiveness of treatment, prevention of adverse reactions, prolonged life of patient. 8 cl, 2 tbl, 11 ex

Description

 The invention relates to medicine, namely to clinical phytology and herbal medicine, and relates to special collections of plants in combination with chitosan in the form of a salt form with L-glutamic acid for the treatment of cancer.

 Known anti-cancer drug, representing a combination of bleomycin and chitosan [1]. Bleomycin is an antitumor antibiotic, a waste product of the fungus Str. verticillus, a water soluble polypeptide. Bleomycin is especially effective for cancer of the skin and mucous membranes. With metastases of malignant tumors, a therapeutic effect was not observed [2], therefore bleomycin does not have a wide spectrum of action.

 The use of bleomycin can cause an increase in body temperature, the appearance of nausea, vomiting, anorexia, stomatitis, conjunctivitis, vulvitis, alopecia, focal hyperkeratosis, brittle nails. A remote side effect may be pneumonia. The combination of bleomycin with chitosan has a prolonged effect and does not cause side effects.

 Known phased treatment of malignant tumors: 1 - radiation and (or) chemotherapy, cryotherapy before surgery to compact and localize the tumor, to prevent metastasis; 2 - maximum removal of tumors and regional lymph nodes during surgery; 3 - combined chemotherapy (CCT) and (or) radiation therapy (RT) after surgery. Ignoring one of the stages dramatically reduces the likelihood of recovery. The use of RT and CCT, as a rule, gives the most serious complications: nausea, vomiting, mental depression, hair loss, the formation of purulent mouth ulcers, lack of appetite, diarrhea, pneumonia, leukopenia, thrombopenia, anemia, bleeding, etc. The use of potent drugs, like α-fetoprotein, they can cause undesirable toxicity of the whole organism. It is especially difficult to cure cancer of the blood and lymphogranulomatosis, when the use of the most aggressive chemotherapeutic agents and rays with high penetrating power requires frequent blood transfusions and bone marrow transplantation [3].

 The aim of the invention is to reduce adverse reactions, increase the effectiveness of treatment, accelerate the removal of severe symptoms, expand the spectrum of action, improve the quality of life and lengthen its duration.

 This goal is achieved by the use of chitosan in the form of a salt form with L-glutamic acid in combination with herbal medicine in parallel with RT and CCT before and after surgery in the treatment of cancer. The priority type of herbal medicine is determined by the prognosis of cancer: with a hopeless prognosis - symptomatic herbal medicine; with a favorable or doubtful prognosis - etiopathogenetic herbal medicine; during LT and CCT - syndromic herbal medicine.

 The safety of chitin preparations is due to their carbohydrate nature and the ability, when acting on plants and animals (humans), to be cleaved by enzymes to oligosaccharides, which can penetrate into cells [4]. Studies have shown that a mixture of chitin oligomers and amino sugars (65-70%) with a polymerization degree of 4-8 when administered orally in rats and mice does not cause lethal effects even at a dose of 25 g / kg. With interperitoneal administration, LD-50 for rats is 4.73 ± 1.33, for mice - 5.68 ± 1.10 g / kg [4].

 The antibacterial activity of chitin derivatives depends on their chemical properties and the type of bacteria. It was shown that only oligomers of chitin and chitosan have a significant inhibitory effect on phytopathogenic bacteria [5]. Tests by the standard method revealed the sensitivity of microorganisms: hemolytic and non-hemolytic (white) streptococci, golden, saprophytic and epidermal staphylococci to salt forms of chitosan based on L-glutamic and hydrochloric acids.

 The unique tendency of chitosan to form associates with various organic compounds containing polar groups and complexes with metal salts - chelates is known [6]. Chelation is enhanced in the presence of anionic groups [7]. Chitosan chelates have high heat resistance, and metal ions can be removed at pH ≤ 2 [6, 7]. The presence of an amino group in the coordination sphere of a metal, as in chitosan chelates, activates its participation in the destruction of hydroperoxide without the formation of active radicals [8]. These properties of chitosan can determine its effect as a detoxifier, antidote, and radioprotector.

 Chitosan also has a positive effect in the treatment of wounds, burns, various inflammatory processes, accompanied by a shift in the redox balance of the body and the intensification of free radical processes, and can be considered as a non-toxic antioxidant with a wide spectrum of action in conditions associated with metabolic disorders of reactive oxygen species [9] .

 It is known that in the human body there are no enzymes that promote the absorption of high molecular weight chitin, chitosan and their derivatives. The assimilation of a certain part of the low molecular weight fractions of partially deacetylated chitin can occur by the mechanism of acid hydrolysis of the glycosidic bond in the folds and depressions of the stomach, primarily in the part of its small curvature, where an increased concentration of acids of gastric juice (hydrochloric, milk, pyruvic and creatine phosphoric) is possible [10, 11 ]. The probability of this process may be due to the following factors: hydrolysis of the glycosidic bond of chitosan molecules was experimentally established for its aqueous acidified solutions at room temperature; many hours of presence in the stomach due to adsorption of chitosan in areas with reduced or completely absent secretion; L-glutamic acid can act as a chemical irritant and a transmitter of nervous excitation of secretory cells of the stomach; taking chitosan-based drugs on an empty stomach for 0.5-1.5 hours before or after a meal without drinking liquids. Hydrolysis can occur before the formation of chitinous polymerhomologists and amino sugars with increased biological activity [4, 12, 13, 14, 15, 16, 17, 18].

 The hydrolysis of chitosan under the action of enzymes [4, 12, 19, 20] in the human gastrointestinal tract is apparently possible when co-administered with chitosanase. In principle, this option of hydrolysis is possible in the case of oral administration of phytochitodes, which is a mixture of powders of the salt form of low molecular weight chitosan with L-glutamic acid and a dry aqueous extract of multicomponent collections of medicinal plants, especially if the collection contains insectivorous plants, for example, family sunflower, capable of secreted enzymes decompose and absorb insects and small invertebrates [21]. It is important to note that in this case, L-glutamic acid is directly involved in the activation mechanism of chitosanase [22]. In addition, L-glutamic acid plays an important role in the life of the body and has a wide range of applications in medical practice [2]. Recently, the central neurotransmitter role of L-glutamic acid has been given particular importance, it is attributed to neurotransmitter amino acids that stimulate the transmission of excitation in the signals of the central nervous system [2].

 Chitooligosaccharides stimulate the immune system, inhibit the development of certain tumors, exhibit anticholesterol, antiurin and antiulcer properties and fungicidal activity, and slow the growth of many bacteria [12]. They do not inhibit serum iron and hemoglobin, do not alter the microflora of the human intestines, but reduce rotting processes and bind the toxic fractions of gliadin, diluting their compaction and preventing the development of celiac disease [23]. The authors of [24] consider chitosan to be an antitumor drug with a direct destructive effect on tumor cells.

 The data presented can determine the increased therapeutic effect of the use of drugs based on chitosan in the phytotherapy of cancer patients. Indeed, this is confirmed by the data in tables 1 and 2. It turned out that the combined use of chitosan preparations in combination with herbal medicine according to the proposed method leads to an increased therapeutic effect compared to herbal medicine. From the results for all the symptoms (table 1) it is seen that 4% of the symptoms of the total number are not removed, which is 5 times less than the average value for herbal medicine [3. S. 136, tab. 2]. The unfavorable outcome as a result of all observations (table 2) is 7%, which is 4.5 times less than the average value for herbal medicine (table 3, compiled according to [3. P. 135] and [28. P. 181]) .

 Freshly prepared infusions were used for treatment: one tablespoon of collection (N 1 - 9) or 5-6 g in the form of a powder, tea or tablet to brew 1/2 liter of boiling water. Insist for 1 hour. Strain, drink 1/4 cup (50 ml) at a time 8 times a day for 2-3 days. Then 1/2 cup (100 ml) 4 times a day 15 minutes before meals and at bedtime. If it is difficult to take by mouth, you can enter in the form of suppositories 2 g of collection 3 times a day into the rectum. The internal intake should be combined with local application in the form of lotions, poultices, microclysters (50 ml) from the second fraction (re-welding of thick grass with one glass of boiling water, strain after exposure for one hour).

 Chitodez take 0.025 g under the tongue 30 minutes after eating, rinse your mouth and swallow after 1 hour. Reception of tablets on the basis of phytochitodes is similar. The dose of 0.025 g is taken 3-4 times a day, and in case of pain and other painful symptoms an additional unlimited number of times. Phytomus with chitosan is applied to the skin at the site of pain, inflammation, tumors, as well as per rectum, per vaginum and nose.

 The phased use of herbal medicine and chitosan-based drugs in the treatment of cancer is as follows. Before surgery, during LT and CCT, apply infusion of collection N 2 with chitodez or phytochitodes-2 and phyto-ointment based on this collection with chitosan. After surgery, LT, XT and CCT courses to restore hematopoietic function and immunity for 7-10 days, take infusion of collection No. 5 with chitodez or phytochitodes-5 and phytomase based on this collection with chitosan. After 7 - 10 days in the intervals between the courses of RT, XT and CCT and after the end of all courses, constantly take the infusion of the main anti-oncological collection No. 1 and chitodez or phytochitodes-1 based on this collection. For complications of cancer with purulent, staphylococcal infection, collection N 9 is used according to the same method, for complications with pneumonia, bronchitis, asthma, for allergic dermatitis - collection of N 3 and phytochitodes-3, for fungal and septic mycoses - collection of N 8, with prolonged enteritis - collection N 7. If necessary, antihemorrhoids are used - ointment based on collection No. 6 and standard collection No. 4 (phytocolin) for the treatment of diseases of the genitourinary system. The following are the compositions of the fees used in the treatment of cancer patients.

 Collection No. 1 - the main anti-oncological collection is applied between courses and after them constantly (an improved version of the collection [3. P. 162-163]): medicinal sweet clover grass, large celandine, color of narrow-leaved fireweed, common tansy, white birch leaf in 9 parts by weight . The roots and grass of the meadowsweet of the cirrhifolia, the marsh cinquefoil in 7 parts by weight. Grass of dried marshmallow, buds of ivy, common wormwood, silver cinquefoil, leaves and branches of common raspberry, the color of medicinal marigolds, the roots of the cinquefoil are 5 parts by weight. Grass of ordinary yarrow, St. John's wort, poultry, mountain plantain, Rhizome, Origanum ordinary, common flax, meadow clover, common lingonberry leaf, burdock roots, 3 parts by weight. Grass of biloba marbella, shepherd’s bag, five-lobed motherwort, potato mountaineer, medicinal smoky, real bedstraw, meadow geranium, common cinnamon, field horsetail, barbed quinoa, prickly tartar, medicinal dandelion roots, high elecampane, buckthorn bark buckthorn, and buckthorn buckthorn bark -red, rose hips of May, color of chamomile officinalis in 2 parts by weight. Veronica herb, medicinal and oak groves, sowing oats, tricolor series, tricolor and field violets, garden sow thistle, bitter wormwood, Canadian goldenrod (golden rod), wild chicory, goose cinquefoil, May lily, creeping thyme, meadow cornflower, common popovnik tarragon, peppermint leaf, dioica nettle, black currant, dill seeds, common pine buds, gray alder cones, wheatgrass creeping roots, angelica officinalis, 1 weight part.

 Collection No. 2 - for the treatment of the primary reaction of radiation sickness [25]: a leaf of peppermint, large plantain, the color of chamomile, 2 parts by weight each. The herb of St. John's wort perforated and yarrow on 1 part by weight.

 Collection No. 3 is anti-allergic and for diseases of the respiratory tract (an improved version of the collection [30]): grass of oak birch, common saplings, a series of three-parted, coltsfoot 9 parts by weight each. Buds of Scots pine, grass of Veronica officinalis, ivy buds, color, leaves and branches of common lilac, scepter mullein in 7 parts by weight. The color of chamomile, medicinal sweet clover, officinalis, creeping thyme, color, leaf and twig of small-leaved linden, black elderberry, white cinnamon, horsetail, tricolor and field violets, purum marsh, wheatgrass root, 5 parts by weight. The grass of the celandine is large, the marsh cinquefoil, the color of tansy is 3 parts by weight. Grass of ordinary yarrow, Hypericum perforatum, silver cinquefoil, goose cinquefoil, common oregano, meadow geranium, common fennel, urban gravilate, common cuff, large plantain leaf, color of calendula officinalis, elecampane root, 2 parts by weight. Leaf of peppermint, white birch, fireweed narrow-leaved, burdock big, grass of the mountaineer bird, dioica nettle, dried cough, thistle, prickly rosemary, wormwood, tarragon (tarragon), medicinal fireweed, fireweed narrow-leaved, meadow clover, meadow clover, dandelion officinalis, burdock, angelica officinalis, 1 part by weight.

 Collection N 4 - for the treatment of the genitourinary system [28. P. 127]: grass of the mountaineer bird - 7 parts by weight, leaf of a large plantain, dandelion, Hypericum perforatum grass, roots of the dandelion 5 parts by weight, grass of the sweet clover, mountaineer stamens, the color of meadow clover, lingonberry leaf, peppermint leaf 2 weight parts.

 Collection No. 5 - to restore hematopoietic function (collection option [26], refined using computer statistical processing of the effectiveness of each component): common yarrow, St. John's wort perforated 23 g each, large burdock leaf 21 g, large plantain leaf, white birch tree 20 g, grass of the mountaineer bird, roots of the cinquefoil 19 g each, roots of the dandelion medicinal, tansy ordinary, chamomile, herb nettle 18 g, grass of the sweet clover medicinal, mountaineer stamens, rosehips mayes 17 g each, the color of calendula officinalis, 16 g buckthorn buckwheat leaf and branches, medicinal lungwort herb, peppermint leaf, elecampane roots 15 g each, common oregano grass 14 g, field horsetail grass, tripartite series, grass and roots meadowsweet on 13 g.

 Collection No. 6 - for the preparation of an anti-hemorrhoid ointment (an improved version of the collection [29]), in parts by weight: interior pork fat - 172; grass clover medicinal and white - 5 parts by weight; grass of goose cinquefoil, Hypericum perforatum, meadow geranium, yarrow, white birch leaf, large plantain, color of tansy ordinary in 3 parts by weight; the color of calendula officinalis, medicinal chamomile, grass of the mountaineer, bird's horsetail, dandelion leaf, dandelion root, upright, 2 parts by weight; grass of dried marshmallow, marjoram ordinary, dioica nettle, gold rod, coltsfoot leaf in 1 part by weight and low molecular weight chitosan - 0.5 parts by weight.

 Collection N 7 - with prolonged enteritis [31] in the weight parts: warty birch leaf - 9, horse sorrel fruit and leaf - 5, common wormwood grass - 4, common yarrow - 3, large plantain leaf - 2, bird highlander grass - 1 , oak bark - 1, the color of chamomile - 1.

 Collection N 8 - antifungal action (option [32]) in weight parts: yarrow grass - 9, white birch leaf - 7, common wormwood grass - 5, medicinal veronica - 4, three-colored violets - 4, chamomile - 2, oregano ordinary - 2, the color of calendula officinalis - 2, the color of tansy ordinary - 1, the color of clover meadow - 1.

 Collection No. 9 - antistaphylococcal (option [33]) in parts by weight: yarrow grass - 6; large burdock leaf - 5; grass of St. John's wort perforated, medicinal sweet clover, common oregano, dioica nettle leaf, large plantain, 3 parts by weight; grass of coltsfoot, mountaineer, bird rosehips of cinnamon, roots of cinquefoil erect, dandelion officinalis, the color of calendula officinalis, tansy ordinary in 2 parts by weight; the color of chamomile officinalis, field horsetail grass in 1 part by weight.

 Phyto-ointments are prepared on the basis of pork interior fat according to the technology described in the book [3. P. 134] and patent [29], contain phytosborne extract and low molecular weight chitosan or its soluble salt form.

 Chitodez is a complex of chitosan with L-glutamic acid, obtained at an equifunctional ratio.

 Phytochitodesis - a mixture of chitodez powders and a dry extract of phyto-collections is obtained in a single technological cycle with the final stage of lyophilization under mild conditions.

Example 1. Patient S., 54 years old, diagnosed with cancer of the left breast, T ₃ Mtx. In the preoperative preparation of radiotherapy, at the same time phytosorption N 1, mastectomy operation. After surgery, six courses of CCT, simultaneously for 10 days, phyto-collection of N 2 and chitodesis under the tongue of 0.025 g three times a day 30 minutes after eating, then do not eat, do not drink 1.5 hours. It was observed for three years. Constantly phyto-collection N 1. Good condition, no complaints, blood test after three years: hemoglobin - 113 g / l, red blood cells - 3.8 · 10 ¹² units / l, color indicator - 0.89, reticulocytes - 1.4%, platelets - 190 · 10 ⁹ units / l, leukocytes - 7.4 · 10 ⁹ units / l, stab - 6%, segmented - 64%, lymphocytes - 20%, lung radiography - no pathology was detected. Assigned for six months, zitozonium and herbal medicine - collection of N 1 constantly.

 Example 2. Patient P., 49 years old, dz. - cancer of the left breast. She underwent a preoperative RT course, at the same time herbal collection No. 2, a mastectomy operation, and after 15 days an ovarian removal operation. During the first course of treatment, CCT (5-fluorouracil, cyclophosphamide, methotrexate) took chitodez for 10 days at 0.025 g three times a day under the tongue 0.5 hours after eating without subsequent ingestion of food and liquid for 1.5 hours. there was no intoxication; appetite was maintained.

Example 3. Patient S., 58 years old, thyroidectomy operation for thyroid cancer. Three years later, he underwent a course of radiotherapy (inside iodine-131) for multiple metastases in the bones of the chest and pleura with the formation of exudative pleurisy. Simultaneously with RT, herbal medicine was carried out - collection of N 3 and treatment with chitodesis according to the accepted methodology. The result of treatment: most metastases and exudative pleurisy disappeared, the remaining metastases stabilized, as verified by the γ-camera. No complications were observed during RT, a blood test after treatment: hemoglobin - 146 g / l, red blood cells - 4.43 · 10 ² units / l, color indicator - 0.9, white blood cells - 3.95 · 10 ⁹ units / l, stab - 1%, segmented - 68%, eosinophils - 5%, lymphocytes 26%, monocytes - 3%, erythrocyte sedimentation rate (ESR) - 3 mm.

 Example 4. Patient F., 47 years old, underwent surgery for the extrusion of the mammary gland, before the operation, LT was performed. After 17 years, right-sided exudative pleurisy began to grow, she began the first XT course, which she did not finish due to vomiting, nausea, convulsions, loss of consciousness. Due to the increase in exudate, pulmonary heart failure, asphyxiation, pleural puncture was performed 14 times with the removal of 1.5 l of fluid each time. Herbal medicine was prescribed: collection of N 1, microclysters from the second fraction and lotion on the right half of the chest, ointment N 6 with chitosan (introduced perrectally into the nose and the chest was lubricated). Two weeks later, shortness of breath disappeared, the cough almost stopped (it was strong), it became possible to walk, the fluid in the pleura did not accumulate anymore, the need for puncture disappeared.

 Example 5. Patient M., 37 years old, radical removal of the tumor (removal of the uterus with appendages). After 20 sessions of RT and one course, CCT complained of frequent urination and pain at the end of urination, malaise, severe weakness, rapid fatigue, dizziness, hair loss, leukopenia, thrombopenia, bleeding, anemia (radiation sickness of the second degree, stage of developed phenomena). Herbal medicine was prescribed: collection No. 5 for 7 days, then collection No. 1 and ointment based on this collection with chitosan into the rectum, into the vagina and the sacral region. The second fraction of this collection is microclysters, rubbing and lotions on the lower abdomen and vestibule of the vagina. After two months, a significant improvement, the symptoms disappeared and did not resume.

 Example 6. Patient B., 71 years old, had cancer of the lower third of the esophagus, the operation was not performed, with RT there were vomiting, weakness, dizziness, poor appetite, depression, sour belching, coughing, pain in the esophagus, and swallowing problems. After a course of RT, gastroscopy determined hyperemia, swelling of the mucous membrane of the esophagus, and a second-degree burn on the skin at the sites of irradiation. Appointed: infusion collection No. 1 according to the accepted method, the second fraction of this collection of microclysters and lotions on the chest and back. Ointments with chitosan based on alternating collection of N 1 and collection of N 2 in the nose and cheeks in the form of tampons. After 7 days, vomiting, nausea and dizziness stopped, pain and swallowing disappeared, weakness decreased, appetite improved, there were no signs of esophageal burn with gastroscopy, the burn on the skin healed. When viewed after four months, there are no complaints, the signs of the disease are not detected.

Example 7. Patient K., 44 years old, - cancer of the uterus and appendages (T ₃ ), radical surgery, 18 sessions of radiotherapy. He developed radiation sickness of the second stage, the period of unfolded phenomena - abdominal pain, diarrhea, white blood cells fall to 2 · 10 ⁹ units / l, during the operation bleeding with the formation of a hematoma. Herbal medicine was prescribed: collection of N 2, the second fraction for douching and rubbing, ointment N 6 with chitosan alternately with ointment N 8 with chitosan according to the accepted method. With a second examination, there is no pathology, except for vaginal hyperemia, which may be due to age-related vagenitis. It has been observed for 5 years.

 Example 8. Patient M., 43 years old, 03/18/94 radical surgery of gynecological organs for ovarian cancer of the appendage and uterus. After the operation, 20 RT sessions were performed, one XT course. Radiation sickness, the primary reaction, and the detailed phenomena of radiation sickness developed. She contacted 06/03/96 after the first course of XT, complained of pain during urination, frequent urination, severe weakness, malaise, dizziness, fatigue, hair loss. Appointed: collection N 5 for seven days, then collection N 1, ointment with chitosan and phytochitodes-1 based on this collection under the tongue; the second fraction - microclysters, douching, lotions and rubbing the lower abdomen and sacrum. Two months later (07.08.96), a significant improvement was noted, weakness disappeared, dizziness, malaise, fatigue disappeared, urinated normally and rarely, pain did not bother, hair renewed. Phytochitodes-1 quickly relieved pain, frequent urination, pain when urinating, dizziness.

 Example 9. Patient M., 50 years old, 01.96 diagnosed with esophageal cancer of the fourth degree with metastases in the pancreas and spleen, underwent radical surgery and six courses of strong KHT. He applied on 01.06.97 with complaints of loss of appetite, loose and frequent stools (up to four times a day), pain in the right hypochondrium, severe weakness, weight loss and hair loss. Appointed: collection No. 1, phyto-ointment with chitosan based on this collection and phytochitodes-4. Pain, nausea disappeared 10 minutes after taking phytochitodes-4 under the tongue. The chair returned to normal after 24 hours. Hair grew within a month, there was an appetite, began to gain weight. At the second examination (07/07/97) complained of minor pain in the left hypochondrium. Ultrasound detects chronic pancreatitis, swallowing is free, not broken.

 Example 10. Patient P., 62 years old. 07/06/94 the diagnosis is established - ovarian cancer. Before the operation, the following were prescribed: collection No. 2, tincture of sea water, phytochitodes-1 and phyto-ointment with chitosan based on the collection of No. 1. 08/06/94 the operation was performed - salpingohysterectomy, which was transferred without complications due to phytotherapy with chitosan. Stool and urination the next day alone and freely. A month after the operation, RT was started, during which phytotherapy was carried out - collection of N 2 and phytochitosan-4 on the basis of collection of N 4. Later, after a course of RT for two years, phytotherapy and phytochitodes-1. There was no recurrence of the disease and metastases, it feels good (10.97).

 Example 11. Patient P., 66 years old, diagnosed with a tumor in the jaw and salivary gland. Before surgery (05/21/96) and after phytotherapy: collection No. 1, phyto-ointment with chitosan and phytochitodes-1 based on this collection. The XT operation and two courses were well tolerated. 06/20/96 the second operation - removal of the tumor and regional lymph nodes. The postoperative period without complications. From 07/20/96 to 09/21/96, two courses of CCT were transferred without complications. During the course of radiotherapy before surgery on September 21, 1996, a second-degree radiation burn occurred, which quickly underwent a reverse development under the influence of phytomaz with chitosan.

 The combination of infusions of medicinal plants with a powdered salt form of chitosan based on L-glutamic acid (chitodez), ointments based on medicinal plant materials with the addition of low molecular weight chitosan and phytochitodes based on a mixture of powders of dry extracts of various phyto-collections and chitodez increases the effectiveness of the treatment of cancer by accelerating and prolonging the effects of both drugs used in radiotherapy, XT and CCT, and herbal medicine. It is significant that there are no complications associated with intoxication, decreased immunity, and general mental depression.

Sources of information
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Claims (8)

 1. A method of treating cancer, characterized in that it includes herbal medicine, chitosan in the form of its salt form with L-glutamic acid (chitodez) and / or a mixture of it with a dry aqueous extract of medicinal plants (phytochitodes) inside through the mouth, into the nose, on the skin, per rectum and per vaginum.  2. A method of treating cancer according to claim 1, characterized in that prior to surgery, during courses of radiation therapy (RT), chemotherapy (CT), the method includes the use of collection in a weight ratio of components: peppermint leaf - 2, large plantain - 2, the color of chamomile officinalis is 2, the herb of St. John's wort perforated is 1, the yarrow is 1; after a course of RT, HT for 7 to 10 days to restore blood formation and immunity, it includes taking a collection in a weight ratio of components: ordinary yarrow grass - 23, St. John's wort perforated - 23, big burdock leaf - 21, large plantain leaf - 20, white birch - 20, the grass of the mountaineer bird - 19, the roots of the uprightweed - 19, the roots of the dandelion - 18, the color of tansy ordinary - 18, the grass of the sweet clover - 17, the mountaineer rachis, the rose hips of May - 17, the color of the calendula officinalis - 16, leaf and branches of sea buckthorn a different species - 16, medicinal lungwort herb - 15, peppermint leaf - 15, elecampane roots - 15, common oregano grass - 14, field horsetail grass - 13, three-part train series - 13, meadowsweet roots and grass - 13; between the radiotherapy and chemotherapy courses, after them and constantly, as well as with a hopeless or dubious prognosis, when the operation is not indicated as symptomatic and etiopathogenetic herbal medicine, it includes taking the main anti-oncological collection in the weight ratio of the components: medicinal sweet clover grass - 9, large celandine - 9, the color of narrow-leaved fireweed - 9, tansy ordinary - 9, white birch leaf - 9, the roots and grass of the meadowsweet - 7, the marsh cinquefoil - 7, the grass of the marshmallow - 5, the buds of the ivy - 5, the wormwood - 5, silver cinquefoil - 5, the leaves and branches of raspberry ordinary - 5, the color of medicinal marigolds - 5, the roots of the upright cinquefoil - 5, the grass of the yarrow - 3, St. John's wort - 3, the plantain large - 3, the mountaineer - 3, the common dreams - 3 , oregano - 3, common flax - 3, meadow clover - 3, lingonberry ordinary - 3, burdock roots - 3, oak grass - 2, shepherd’s bag - 2, motherwort five-bladed - 2, mountaineer - 2, smoky officinalis - 2, bedstraws of the present - 2, ge meadow wounds - 2, common cuffs - 2, field horsetail - 2, chamomile quinoa - 2, prickly thistle - 2, medicinal dandelion roots - 2, high elecampane - 2, buckthorn bark — 2, fruits and color of blood-red hawthorn 2, Mayrose - 2, Chamomile - 2, Veronica officinalis and Dubrava - 1, sowing oats - 1, three-part succession - 1, Three-colored and field violets - 1, Garden thistle - 1, Bitter wormwood - 1, Canadian goldenrod - 1, wild chicory - 1, goose cinquefoil - 1, May lily of the valley - 1, creeping thyme - 1 , meadow cornflower - 1, common cattery - 1, tarragon - 1, peppermint leaf - 1, dioecious nettle - 1, black currant - 1, garden dill seeds - 1, ordinary pine buds - 1, gray alder cones - 1 , the roots of wheatgrass creeping - 1, angelica officinalis - 1.  3. The method according to PP. 1 and 2, characterized in that when complicating a purulent, staphylococcal infection, it includes the use of collection in a weight ratio of components: yarrow grass - 6, burdock leaf - 5, St. John's wort perforated - 3, sweet clover - 3, oregano - 3 , dioecious nettle leaf - 3, large plantain - 3, coltsfoot grass - 2, poultry mountain - 2, cinnamon rose hips - 2, upright cinquefoil roots - 2, medicinal dandelion - 2, color of calendula officinalis - 2, tansy ordinary - 2, the color of chamomile lek natural - 1, grass horsetail - 1.  4. The method according to claims 1 and 2, characterized in that in case of complications with pneumonia, bronchitis, asthma, and allergic dermatitis, it includes the use of collection in a weight ratio of components: grass of oak biloba - 9, common rhizome - 9, three-part series - 9, coltsfoot - 9, ordinary pine buds - 7, veronica officinalis grass - 7, ivy buds - 7, leaves and twigs of common lilacs - 7, scepter mullein - 7, color of chamomile - 5, medicinal sweet clover - 5, initial letters of medicine - 5, creeping thyme - 5, color, fox tons and branches of small-leaved linden - 5, black elderberry - 5, white cinnamon - 5, horsetail - 5, tricolor and field violets - 5, purulent swamp - 5, wheatgrass roots - 5, large celandine grass - 3, marsh cinquefoil - 3 , the color of tansy ordinary - 3, the grass of yarrow - 2, St. John's wort - 2, silver cinquefoil - 2, goose cinquefoil - 2, oregano ordinary - 2, meadow geranium - 2, ordinary fennel - 2, urban gravilate - 2, ordinary cuff - 2, a leaf of a large plantain - 2, the color of calendula officinalis - 2, the roots of elecampane are high o - 2, peppermint leaf - 1, white birch - 1, narrow-leaved fireweed - 1, burdock big grass - 1, bird highlander grass - 1, dicotyledonous nettle - 1, marshmallow dried - 1, prickly thistle - 1, marsh rosemary - 1 , tarragon wormwood - 1, drug haze - 1, narrow-leaved fireweed - 1, meadow clover - 1, prickly hawthorn - 1, dandelion roots - 1, large burdock - 1, angelica officinalis - 1.  5. The method according to claims 1 and 2, characterized in that when complicated by fungal, septic mycoses, it includes the use of collection in a weight ratio of components: yarrow grass - 9, white birch leaf - 7, common wormwood grass - 5, medicinal veronica - 4, tricolor violets - 4, chamomile - 2, oregano - 2, the color of calendula officinalis - 2, tansy - 1, clover meadow - 1.  6. The method according to claims 1 and 2, characterized in that when complicated by prolonged enteritis, it includes the use of collection in the weight ratio of components: warty birch leaf - 9, horse sorrel fruit and leaf - 5, common wormwood - 4, yarrow - 3 , a leaf of a large plantain - 2, grass of a mountaineer of a bird - 1, oak bark - 1, the color of chamomile - 1.  7. The method according to claims 1 and 2, characterized in that when complicated by a hemorrhoid disease, it includes the use of a chitosan-containing phyto-ointment based on the collection in a weight ratio of components: medicinal and white clover grass - 5, goose cinquefoil grass - 3, St. John's wort - 3, meadow geraniums - 3, yarrow - 3, white birch leaf - 3, large plantain - 3, tansy ordinary - 3, color of calendula officinalis - 2, chamomile - 2, grass of highlander - 2, horsetail - 2, leaf dandelion officinalis - 2, root tormentil - 2, grass uliginose - 1, Oregano - 1, nettle - 1, golden rod - 1, leaves a mother-and-stepmother - 1.  8. The method according to claims 1 and 2, characterized in that in case of complication of diseases of the genitourinary system, it includes the use of collection in the weight ratio of components: grass of the mountaineer bird - 7, large plantain leaf - 5, medicinal dandelion - 5, Hypericum perforatum - 5 , dandelion roots - 5, sweet clover grass - 2, mountaineer - 2, clover meadow - 2, lingonberry leaf - 2, peppermint - 2.

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