RU2149633C1 - Method for treating immunodeficiency states of organism - Google Patents

Abstract

FIELD: medicine. SUBSTANCE: method involves introducing electrically activated salt solutions into organism in quantities not exceeding daily demand of organism in electrolytes and water. Aqueous salt solutions electrically activated on membrane-type electrolyzer unit with negative redox potential(-500-900)mV and pH 9.0-11.0, or positive redox potential (+900-+1200)mV and pH 1.0-2.0, are used as the electrically activated salt solutions. AgNO₃ salt in concentration of at least 7 g/l or NaCl, KCl, CaCl₂,MgCl₂ salt mixture in the same proportions as it is the case in the human blood plasma with total salt concentration being not greater than 10 g/l is usable as the electrically activated aqueous salt solution. The mentioned solutions are administered as intravenous injections and/or per os as well as in aerosol form depending on disease nature. Intestine cleansing with electrically activated salt solution having negative redox potential is carried out with following eubiotic bacteria introduced into different segments of the intestine. EFFECT: enhanced effectiveness of treatment and prophylaxis. 11 cl

Description

 The invention relates to medicine, namely to immunology and gastroenterology, and can be used for the prevention and treatment of immunodeficiency states of the body.

 Immunodeficiency states are violations of the immune status and ability to normal immune response to different antigens. Immunodeficiency conditions can lead to tumors. This is due to a defect in immunological antitumor surveillance. Immunodeficiency can also occur in the form of allergic and autoimmune diseases. A fairly common cause of the development of immunodeficiency are metabolic defects. Metabolic defects occur in diabetes, obesity, atherosclerosis, uremia, exhaustion, against the background of which secondary defects of immunocompetent cells develop.

 Dysbacteriosis, as a rule, is associated with impaired immune systems. Moreover, dysbiosis, according to our studies, is the root cause of many diseases. Imbalance in the microflora and then the immune status is a kind of impetus that determines the development and course of the disease. In some cases, this happens directly, in others - indirectly, through the development of immunodeficiencies. It is characteristic that many outwardly completely different diseases (HIV infections, secondary immunodeficiency states of various etiologies, chronic renal failure, diseases of the cardiovascular system - bacterial endocarditis, allergies, diathesis, bronchial asthma, autoimmune diseases) are characterized by a single sign - colon dysbiosis, a comparatively general deficit of anaerobic bacteria and an increase in the number of opportunistic and pathogenic bacteria.

 Thus, the development of new methods for the correction of immunodeficiency states of the body is primarily associated with the development of new comprehensive methods for cleaning the body of harmful accumulations - toxins, salts, normalizing metabolism, restoring the human microbiocenosis, in particular intestinal microflora, and thus creating opportunities for the body using its natural potential to cope with the disease yourself.

A known method for the treatment of immunodeficiency conditions, including subcutaneous injections of a 0.01% solution of the drug, which uses a hexapeptide of the structural formula: arginyl-alpha-aspartyl-lysyl-valyl-tyrosyl-arginine (the author's name is Immunofan) in an amount of 1 ml per within 20 days (RF patent N 2062096, IPC ⁶ A 61 K 38/08, publ. 06/20/96). The drug showed positive results in the treatment of immunodeficiency in patients with chronic active and persistent hepatitis B, brucellosis and chronic bronchitis.

There is a method of treating AIDS patients or suffering from AIDS-related syndromes by administering to the patient a pharmaceutical composition containing zidovudine (3 ¹ -azid-3 ¹ -deoxythymidine) and inosiplex or paraacetamidebenzoic acid, possibly in combination with inosine (European Patent No. 0362162, IPC ⁶ A 61 K 31/00, publ. 1991).

 However, in the presented analogues, the achievement of a positive therapeutic effect is associated with the use of drugs whose action adversely affects the functioning of other body systems (kidneys, liver, heart), leading to very serious complications. In addition, the immunodeficiency state of the body, as a rule, is accompanied by a violation of the intestinal microbiocenosis, which is not restored by the above methods and the drugs used in them.

A known method of treating immunodeficiency conditions, including conducting a treatment session in which at least one agent is orally administered to a patient over one day, selected from sodium hydrogen carbonate, 5% alcohol solution of iodine, potassium permanganate, 30% solution of sodium sulfyl, taken in 30-125 g of water in the following amount:
Sodium bicarbonate, mg - 0.6-2.5
5% iodine solution, drops - 2-25
Potassium permanganate, crystals - 5-25
30% solution of sulfyl sodium, drops - 2-12
and / or in which they carry out 1-2-fold rectal or vaginal washing, using one of the mentioned funds, taken in the amount of: potassium permanganate 50-100 crystals, the remaining funds are called 1-2 teaspoons in 1-2 liters of water. The treatment session is repeated at least 10 times. In addition, the patient is additionally subjected to bath procedures at least 1 time per day (RF patent N 2077886, IPC ⁶ A 61 K 33/00, 33/18, 33/32; publ. 04/27/97). The claimed method is based on the directed cleansing of the body of harmful accumulations - toxins, stones, sand, salts, normalization of metabolism and thus creating the ability of the body, using its natural potential, to cope with the disease itself.

 However, immunodeficiency states of the body, as a rule, are accompanied by a violation of the intestinal microbiocenosis, which cannot be restored by the above method and the drugs used in it, which reduces the effectiveness of the treatment of patients with immunodeficiency states.

A known method of treating intestinal dysbiosis, which can be used in the correction of immunodeficiency conditions of the body, including preliminary cleaning of the intestine for several days with enemas using solutions and colonoscopy implantation of intestinal microflora separately in the following sequence: into the ascending intestine through a biopsy channel, the culture of lactobacilli , in the transverse section - a culture of bifidobacteria and in the descending section of the colon - a culture of colibacteria, m in each section of the intestine is administered at least 20 ml of liquid culture of intestinal microflora, being in the logarithmic growth phase the said bacteria (RF Patent N 2092167, IPC ⁶ A 61 K 35/74, publ. 10.10.97).

 The disadvantage of the existing method is that it does not provide (except for cleansing enemas) effective procedures for cleansing the body of toxins and other harmful accumulations, which reduces the effectiveness of the treatment.

The prototype adopted a method of treating generalized viral infections, namely HIV infections, herpes, hepatitis C, accompanied by secondary immunodeficiency conditions, including conducting a medical course of treatment, consisting in the introduction into the body in an amount not exceeding the daily requirement of the body for electrolyte and water, electroactivated an aqueous solution of NaCl (sodium hypochlorite) and simultaneously exposed to dry radon with a radiation frequency of 17 GHz for 1.5-2.0 minutes per session (RF patent N 2089194, IPC ⁶ A 61 K 33/14, publ. 10 .09.97).

 However, this method has insufficient treatment effectiveness, because It does not have sufficient detoxifying, immunostimulating, normalizing general metabolic processes and restoring human microbiocenosis.

 The objective of the invention is the creation of such a method of treatment of immunodeficiency conditions, which would provide more effective prevention and treatment of the body from the aforementioned disease by intensively neutralizing and cleansing the body of toxins and restoring the body's microbiocenosis.

 This problem is solved by the fact that in the method of treating immunodeficiency states of the body, which includes conducting a drug course of treatment, consisting in the fact that the body is administered in an amount not exceeding the daily requirement of the body for electrolyte and water, electroactivated aqueous solutions of salts according to the invention as electroactivated salt solutions use aqueous salt solutions, electroactivated on a membrane electrolyzer with a negative redox potential (-500-900) mV and a pH of 9.0-11.0 or positive red ox potential (+900 - +1200) mV and pH 1.0-2.0.

As an electroactivated aqueous solution of salts, an AgNO ₃ salt in a concentration of not more than 7 g / l or a mixture of NaCl, KCl, CaCl ₂ , MgCl ₂ salts in the same proportions as in human blood plasma with a total salt concentration of not more than 10 g are used / l

The ratio of salts of NaCl, KCl, CaCl ₂ , MgCl ₂ in the electroactivated aqueous solution is 80: 2: 2: 1, respectively.

 Electroactivated aqueous solutions of salts on a membrane electrolyzer with a negative redox potential (-500-700) mV and a pH of 9.0-10.0 are injected into the body by injection no more than 200 ml per day.

 Electroactivated aqueous solutions of salts on a membrane electrolyzer with a negative redox potential (-500-900) mV and a pH of 9.0-11.0 are administered orally to food no more than 300 ml per day for 15-20 days before meals.

 Electroactivated aqueous solutions of salts on a membrane electrolyzer with a negative redox potential (-500-900) mV and a pH of 9.0-11.0 are introduced into the body in the form of cleansing enemas in an amount of 0.5-1.5 liters once a day.

 Electroactivated aqueous solutions of salts on a membrane electrolyzer with a positive redox potential (+900 - +1200) mV and a pH of 1.0-2.0 are injected into the body in aerosol form with a particle size of not more than 3.5 microns in the form of inhalations in the respiratory tract a person alternately through the mouth and nose 1-3 ml per session twice a day in the morning and evening.

 Electroactivated aqueous solutions of salts on a membrane electrolyzer with a positive redox potential (+900 - +1200) mV and a pH of 1.0-2.0 are introduced into the body in the form of vaginal douching, rinsing the mouth and rinsing the nasopharynx in an amount of 100-200 ml per one procedure twice a day in the morning and in the evening.

After preliminary cleansing of the intestine for several days with enemas using electroactivated solutions, colonoscopy implantation of intestinal microflora is carried out separately in the following sequence: lactobacillus culture into the ascending intestine through the biopsy channel, bifidobacteria culture into the transverse section and colibacteria culture into the descending colon moreover, at least 20 ml of the liquid culture of the indicated eubiotics bacteria located in the logarithmic is introduced into each section of the intestine tion growth phase with a titre of each bacterial species of at least 10 ⁸ cfu / ml.

After vaginal douching, a liquid form of lactobacilli with a titer of at least 10 ⁸ CFU / ml in an amount of 5-10 ml is injected into the vaginal cavity, and after rinsing of the oral cavity and rinsing of the nasopharynx, the latter are treated with a liquid form of lactobacilli with a titer of at least 10 ⁸ CFU / ml by application oral cavity (3-5 ml) and instillation into the nose (1-2 ml).

 Experimental studies have established that in a membrane electrolytic cell when passing a constant electric current through an aqueous solution, for example, an aqueous solution of salts, electroactivation of molecules, atoms, ions and redistribution of ions in an electric field occurs in it. As a result, part of the aqueous solution located in the cathode zone (catholyte) acquires reducing properties and stores potential energy. A catholyte with a negative redox potential (redox potential) - redox potential - in the range from -400 to -900 mV and pH 7.5-11.0 has a high biological activity, since it increases the intensity of electrochemical processes that constantly occur in living cells. It accelerates all natural biological processes - the regeneration of cells and tissues, enzymatic, immune processes. The catholyte has immunostimulating, detoxifying, normalizing metabolic processes of the body properties. In addition, catholyte has bacteriostatic properties.

 Water-activated salt solutions with a positive redox potential (+900 - +1200) mV and pH 1.0-2.0 (anolyte) electroactivated on a membrane electrolyzer have antiseptic, anti-inflammatory and antiproliferative properties.

 The following strains of eubiotic bacteria are used to correct human microbiocenosis: Bifidobacterium bifidum 1 or 791, Bifidobacterium longum 397, Bifidobacterium adolescentis MC-42, Lactobacillus acidophilus 317/402 and others.

 Bifidobacteria, for example, the species Bifidobacterium bifidum, and lactobacilli, for example, the species Lactobacillus acidophilus, are the main component of the human intestinal microflora, which determines the therapeutic and prophylactic properties of the drug containing these microorganisms. These eubiotic bacteria have a pronounced antagonistic effect against many pathogens of intestinal and urogenital infections, stimulate the body's own defenses, increasing its resistance to many diseases and adverse factors.

 For example, the proposed strain Lactobacillus acidophilus 317/402 Narine, which is used in the preparation, synthesizes vitamins such as folic acid, thiamine, riboflavin and also induces the production of gamma-interferon (unlike other acidophilus bacteria), which increases the healing properties of the drug.

 The mechanism of action of eubiotics is as follows. With simultaneous oral, intravaginal and / or rectal administration of the drug into the body, eubiotic bacteria (bifidobacteria and / or lactobacilli), having increased antagonistic activity against pathogenic and conditionally pathogenic intestinal microflora and urogenital microflora, compete with it for binding sites on intestinal and genitourinary tract epithelial cells and food chains. In this regard, pathogenic and conditionally pathogenic intestinal and urogenital microflora are supplanted by eubiotics, which are then eliminated, and normoflora of the intestine and urogenital tract take their place.

 The technology of preparation of drugs used to correct immunodeficiency states of the body.

Example 1. To prepare an activated aqueous solution of a silver salt (catholyte and anolyte), a 0.9% solution of AgNO ₃ in an amount of 10 l was taken and poured into a membrane electrolyzer, for example, into an Espero-type apparatus. After treatment of the saline solution for 15-20 minutes, the activated part of the saline solution in the amount of 2 l with a negative redox potential (redox potential) of -700 mV and pH 9.0 is taken from the catholyte container and transferred to a sealed container and stored without air in a dark place.

 The activated part of the saline solution in the amount of 8 l with a positive redox potential (redox potential) of +1000 mV and pH 1.5 is taken from the anolyte container and poured into a sealed container and also stored in a dark place.

Example 2. To prepare an electroactivated aqueous solution of a mixture of salts, a 1.0% solution of a mixture of salts of NaCl, KCl, CaCl ₂ and MgCl ₂ in a ratio of 80: 2: 2: 1 in an amount of 10 l is taken and poured into a membrane electrolyzer, for example, apparatus such as "Espero". After treatment of the saline solution for 30-35 minutes, the activated part of the saline solution in the amount of 2 l with a negative redox potential of 900 mV and pH 11.0 is taken from the catholyte container and transferred to a sealed container and stored without air in the dark.

 The activated part of the saline solution in the amount of 8 l with a positive redox potential (redox potential) +1100 mV and pH 1.0 is taken from the anolyte container and poured into a sealed container and also stored in a dark place.

Example 3. In a nutrient medium based on skim milk with a dry residue of at least 10-12% with the addition of baker's yeast autolysate, a seed dose of a culture of bifidobacteria Bifidobacterium bifidum strain N 791 is introduced in an amount of 3-5 wt. % with a titer of 7 • 10 ⁷ CFU / ml and cultured in an incubator at a temperature of 37.5 ^o C for 18-24 hours until the formation of a dense uniform clot and obtain the biomass of bacteria in the logarithmic growth phase. The acidity of the obtained biomass of the bifidobacteria concentrate is about 100 ^o T, and the biological titer of the cells is (7-9) • 10 ⁹ CFU / ml.

Example 4. In a nutrient medium based on skim milk with a dry residue of at least 10-12% with the addition of milk hydrolyzate, corn extract and ascorbic acid, a seed dose of industrial starter culture of Bifidobacterium adolescentis bacteria strain MC-42 is introduced in an amount of 5.0% by volume culture medium with a titer of 10 ⁸ cells / ml After mixing the suspension, the cells are cultured at a temperature of +38 ± 1.0 ^o C in a fermenter for 12 hours until a bifidobacterium concentrate is obtained in the logarithmic growth phase in the form of a dense uniform clot with a biological titer (1-3) • 10 ¹⁰ CFU / ml and acidity up to 100 ^o T. Next, the drug is cooled to a temperature of 25 ^o C and deoxidized to 50-80 ^o T.

Example 5. In a sterile culture medium based on milk with a dry residue of 12-14 wt.% With the addition of sodium citrate in an amount of 0.1-0.3 • 10 ^-2 wt. % add the starter culture of Lactobacillus acidophilus strain 317/402 in an amount of 2-5 wt.%, incubated in a thermostat at a temperature of 38 ± 1 ^o C for 4-6 hours to obtain bacterial biomass in the logarithmic growth phase. The resulting liquid preparation is kept in a refrigerator + 5-8 ^o C for at least 2 hours. The titer of bacterial cells in the liquid product is (2-4) • 10 ⁹ CFU / ml.

Example 6. A seed dose of Escherichia coli is applied to blood agar with polymyxin and Escherichia coli biomass is grown to obtain a titer of at least 10 ⁸ cells / ml. Biomass is separated from the nutrient medium after bacteria enter the logarithmic growth phase.

 Methodology for the treatment of immunodeficiency states of the body.

 Before conducting medical procedures, the patient undergoes a diagnosis of the underlying disease, as well as the state of microbiocenosis of the intestine, urogenital tract and oral cavity. Depending on the results of the diagnosis, a comprehensive treatment plan for the patient is made.

 Example 7. In the case of, for example, a weakened immune system of the body, frequent colds, herpes, etc. without obvious signs of dysbiosis, a catholyte solution with a negative redox potential prepared according to example 1 or 2 is injected into the body in the form of injections intravenously no more than 200 ml per day for 7-10 days or orally before meals no more than 300 ml per day within 15-20 days.

 Additionally, an electroactivated aqueous solution of salts with a positive redox potential (+900 - +1200) mV and a pH of 1.0-2.0 in aerosol form with a particle size of not more than 3.5 microns in the form of inhalations is alternately introduced into the human respiratory tract through the mouth and nose 1-3 ml per session twice a day in the morning and in the evening.

 Example 8. In the case of, for example, a generalized viral infection (HIV infection, hepatitis A, B or C) with symptoms of secondary immunodeficiency and the presence of various forms of microbiocenosis disturbance, a catholyte solution with negative redox potential prepared according to Example 1 or 2 is introduced into the body , in the form of injections intravenously, not more than 200 ml per day for 7-10 days, but not more than 15-20 days (depending on the patient’s health status).

 At the same time, for several days, the body is cleansed in the form of cleansing enemas with catholyte with a negative redox potential prepared according to Example 1 or 2, in an amount of 0.5-1.5 L once a day. Then, rinsing the mouth and rinsing the nasopharynx in an amount of 100-200 ml are carried out in one procedure twice a day in the morning and evening with an analyte with positive redox potential prepared in accordance with Example 1 or 2. For women, additionally perform vaginal douching in an amount of 200 ml for one procedure twice a day in the morning and in the evening with an analyte with a positive redox potential prepared in accordance with example 1 or 2.

In addition, once or twice during the course of treatment after preliminary bowel cleansing according to the above-described scheme, enemas using electroactivated solutions are carried out using enemas using colonoscopy for several days, the intestinal microflora is implanted separately in the following sequence: a lactobacillus culture is prepared into the ascending intestine through a biopsy channel, prepared according to example 5, in the transverse section - the culture of bifidobacteria, prepared according to example 3 or 4, and in the descending section of the colon - the culture of colibacte R i prepared according to Example 6. Moreover, at least 20 ml of a liquid culture of the indicated eubiotics bacteria, which is in the logarithmic growth phase with a titer of each type of bacteria of at least 10 ⁸ CFU / ml, is introduced into each intestinal section.

After washing the body cavities with electroactivated aqueous saline solutions, the oral cavity is treated daily with the liquid form of lactobacilli with a titer of at least 10 ⁸ CFU / ml daily by application (3-5 ml) and instillation into the nose (1-2 ml), respectively. In addition, women are injected into the vaginal cavity with a liquid form of lactobacilli with a titer of at least 10 ⁸ CFU / ml in an amount of 5-10 ml.

 Data on the treatment of immunodeficiency states of the body.

 Example 9. Research was conducted on the treatment of such an immunodeficiency state of the body as chronic fatigue syndrome (CFS) of a person. 120 patients were examined, and 70% of them were women from 28 to 45 years old, leading an active lifestyle. The diagnosis of CFS was made if they had a complex of symptoms (at least 8) characteristic of this disease, namely: constant fatigue, fatigue, insomnia, pain in the muscles and joints, incomprehensible headaches, poor appetite, lethargy, subfibril temperature, dyspeptic symptoms, diarrhea, or constipation. All patients underwent a general analysis of blood and urine, an immunological blood test and an extended bacteriological analysis of feces.

 Studies have revealed in all patients microecological disturbances of intestinal microflora - dysbacteriosis of the III-IV degree, characterized by a sharp decrease in the number of Escherichia coli and the almost complete disappearance of bifidoflora.

 The immunogram in all patients revealed certain disorders of the immune system, characterized by a sharp decrease in blood levels of serum antibodies IgG, G2-type, glycoproteins and lysozyme.

 In a general blood test, 45% of patients had a low hemoglobin level of 70-100 g / l. The general analysis of urine was practically without deviations from the norm in all patients.

 A course of treatment of patients was carried out, corresponding to example 8. A solution of catholyte with a negative redox potential (-500-700) mV and a pH of 9.0-10.0, prepared according to example 2, is injected into the body by injection no more than 200 ml day.

 At the same time, for several days, the body is cleansed in the form of cleansing enemas with catholyte with a negative redox potential prepared according to Example 1 or 2, in an amount of 0.5-1.5 L once a day. Then, mouth rinses and nasopharynx rinses are carried out in an amount of 100-200 ml per procedure twice a day in the morning and evening with analyte with positive redox potential prepared in accordance with Example 1 or 2. For women, morning and evening vaginal douching is performed in an amount 200 ml per procedure with an analyte with positive redox potential, prepared in accordance with example 1 or 2.

In addition, once per course of treatment after preliminary cleaning of the intestine (according to the above scheme for several days by enemas using electroactivated solutions), colonoscopy implantation of intestinal microflora is carried out separately in the following sequence: in the ascending intestine through a biopsy channel, a culture of lactobacilli prepared according to example 5, in the transverse section - a culture of bifidobacteria, prepared according to example 3 or 4, and in the descending section of the colon - a culture of colibacteria, with prepared according to example 6. Moreover, at least 20 ml of a liquid culture of the indicated eubiotics bacteria in the logarithmic growth phase with a titer of each type of bacteria of at least 10 ⁸ CFU / ml is injected into each intestinal section.

After washing the body cavities with electroactivated aqueous saline solutions, the oral cavity is treated daily with the liquid form of lactobacilli with a titer of at least 10 ⁸ CFU / ml daily by application (3-5 ml) and instillation into the nose (1-2 ml), respectively.

Women additionally injected into the vaginal cavity a liquid form of lactobacilli with a titer of at least 10 ⁸ CFU / ml in an amount of 5-10 ml.

 As a result of the course of treatment, the symptoms of CFS, the level of hemoglobin, serum antibodies in the blood of patients and other immunological parameters were normalized within two weeks.

 Example 10. After examination, patient A., 37 years old, and patient R., 40 years old, was diagnosed with psoriasis (weeping form) in the acute stage and candidiasis against the background of general intestinal dysbiosis and the urogenital tract. Candidiasis was diagnosed by smear candida. Lowered hemoglobin and serum antibodies in the blood.

 The first woman used traditional methods of treatment of the urogenital tract using antibiotic therapy. For the treatment of psoriasis, desensitizing agents were used (calcium chloride - 10%, 1 tablespoon three times a day after meals for 20-25 days or calcium gluconate 0.5 g 3 times a day after meals for 20 days), sedatives ( tincture of valerian root, motherwort herb 30 drops after a meal 3 times a day for 3 weeks or Quater potions), antihistamines (diphenhydramine, suprastin, diazolin 0.05 at night for 3 weeks), vitamin preparations (vitamin B1 alternately with vitamin B6) and other pathogenetically based drugs. In local traditional therapy, anti-inflammatory, hormonal, keratolytic creams and ointments were used.

 The second woman used complex treatment of the body of the proposed method.

 A solution of catholyte with a negative redox potential, prepared according to example 2, is administered orally before meals no more than 300 ml per day for 15 days. At the same time, for several days, the body is cleansed in the form of cleansing enemas with catholyte with a negative redox potential prepared according to Example 1 or 2, in an amount of 0.5-1.5 L, once a day. Next, rinses the mouth and rinses the nasopharynx in an amount of 100-200 ml in one procedure twice a day in the morning and evening with an analyte with positive rare potential prepared in accordance with Example 1 or 2. In the morning and evening, 200 ml of vaginal douching is performed. for one procedure, an analyte with a positive redox potential, prepared in accordance with example 1 or 2.

In addition, once per course of treatment after preliminary cleaning of the intestine (according to the above-described scheme), colonoscopy implantation of intestinal microflora is carried out separately in the following sequence: to the ascending intestine through a biopsy channel, the culture of lactobacilli prepared in accordance with Example 5, and to the transverse section, the culture of bifidobacteria prepared according to example 3 or 4, and in the descending part of the colon - a culture of colibacilli prepared according to example 6. Moreover, at least 20 ml of liquid rations of the indicated bacteria-eubiotics in the logarithmic growth phase with a titer of each bacterial species of at least 10 ⁸ CFU / ml.

After washing the body cavities with electroactivated aqueous salt solutions, a liquid form of lactobacilli with a titer of at least 10 ⁸ CFU / ml in an amount of 5-10 ml is administered daily into the vaginal cavity during the entire course of treatment, the oral cavity is treated with a liquid form of lactobacilli with a titer of at least 10 ⁸ CFU / ml by application (3-5 ml) and instillation into the nose (1-2 ml), respectively. In addition, the surface of the skin before bedtime is wiped alternately with anolyte prepared in accordance with example 1 or 2.

 After treatment, after 2 months, they again diagnosed candidiasis and psoriasis in patients. After a temporary recovery, the first woman is again diagnosed with candidiasis and after a short remission, signs of psoriasis appear. Moreover, this patient continues to suffer from intestinal dysbiosis.

 The second woman has persistent remission and signs of psoriasis did not appear for 6 months.

 Example 11. Patient S. born in 1973, outpatient in the blood detected HIV infection.

During laboratory examination: LII 5-3; creatinine 154; bilirubin total 36 mmol / l; urea 7.6; Alt 51; ACT 172; pH 7.55; pCO ₂ 27.8; pO ₂ 89.9; BE + 2.7; Hb 90 g / l; NT 33; ECA 26.5 g / l.

 Immunogram: absolute lymphocyte count 480 / μl; Phone 48%; T-helpers: T-suppressors 2.0; ATP in the lymphocytes 3.3 meq / l (deficiency of immunocompetent cells).

 Through microbiological analyzes of feces, intestinal dysbiosis of the fourth degree was established.

 A patient’s treatment course has been started corresponding to Example 8. A solution of catholyte with a negative redox potential (-500-700) mV and a pH of 9.0-10.0 prepared according to Example 1 is injected into the body by injection no more than 200 ml day.

 At the same time, for several days, the body is cleansed in the form of cleansing enemas with catholyte with a negative redox potential prepared according to Example 1 or 2, alternately in an amount of 0.5-1.5 L once a day. Next, rinses the mouth and rinse the nasopharynx in an amount of 100-200 ml in one procedure twice a day in the morning and evening with an analyte with positive redox potential prepared in accordance with example 1.

In addition, twice per treatment course after preliminary cleaning of the intestine (according to the above-described scheme), colonoscopy implantation of intestinal microflora is carried out separately in the following sequence: into the ascending intestine through the biopsy channel, the culture of lactobacilli prepared according to Example 5, and into the transverse section is the culture of bifidobacteria prepared according to example 3, and in the descending section of the colon - a culture of colibacilli prepared according to example 6. Moreover, at least 20 ml of liquid cult is introduced into each section of the intestine s-eubiotics said bacteria, located in the logarithmic growth phase with a titre of each bacterial species of at least 10 ⁸ cfu / ml.

After washing the body cavities with electroactivated aqueous saline solutions, the oral cavity is treated daily with the liquid form of lactobacilli with a titer of at least 10 ⁸ CFU / ml daily by application (3-5 ml) and instillation into the nose (1-2 ml), respectively.

A few days after the start of treatment, laboratory changes were observed in a positive direction: LII 1,2; ECA 33 g / l; urea 5.2; creatinine 115; bilirubin total 11 mol / l; Alt 16; ACT 32; pH 7.51; pCO ₂ 35; pO ₂ 95.0; BE +4.5; Hb 93 g / l; NT 34.

 In the immunogram: the absolute number of lymphocytes is 1050 / μl; Phone 43%; T-helpers: T-suppressors 1.4; ATP in lymphocytes 2.5 meq / l (imbalance in the system of regulatory cells against a background of deficiency of T-helpers).

 Against the background of the therapy, positive dynamics were noted. The course of treatment lasted 21 days.

 As a result of the implementation of the above treatment procedures, the patient's well-being stabilized, a blood test showed a negative reaction to HIV infection.

 Thus, the proposed method significantly increases the effectiveness of the treatment of immunodeficiency states of the body.

 Industrial applicability. The invention can be used in medicine, in particular immunology, microbiology and gastroenterology.

Claims (11)

 1. The method of correction of immunodeficiency states of the body, including the conduct of a medication course of treatment, consisting in the fact that the body is administered in an amount not exceeding the daily requirement of the body for electrolyte and water, electroactivated aqueous solutions of salts, characterized in that electroactive solutions of salts are used aqueous solutions of salts electroactivated on a membrane electrolyzer with a negative redox potential (-500-900) mV and a pH of 9.0 - 11.0 or a positive redox potential (+900 - +1200) mV and pH 1.0 - 2.0. 2. The method according to claim 1, characterized in that the salt of AgNO ₃ in a concentration of not more than 7 g / l is used as an electroactivated aqueous solution of salts. 3. The method according to claim 1, characterized in that as the electroactivated aqueous solutions of salts, a mixture of salts of NaCl, KCl, CaCl ₂ , MgCl ₂ in the same proportions as in human blood plasma with a total salt concentration of not more than 10 g / l 4. The method according to claim 3, characterized in that the ratio of salts of NaCl, KCl, CaCl ₂ , MgCl ₂ in the electroactivated aqueous solution is 80: 2: 2: 1, respectively.  5. The method according to PP. 1 - 4, characterized in that the electroactivated aqueous solutions of salts on a membrane electrolyzer with a negative redox potential (-500-700) mV and a pH of 9.0 - 10.0 are injected into the body by injection no more than 200 ml per day.  6. The method according to PP. 1 to 4, characterized in that the electroactivated aqueous solutions of salts on a membrane electrolyzer with a negative redox potential (-500-900) mV and a pH of 9.0 - 11.0 are administered orally before meals no more than 300 ml per day for 15 to 20 days.  7. The method according to PP. 1 - 4, characterized in that the electroactivated aqueous solutions of salts on a membrane electrolyzer with a negative redox potential (-500-900) mV and pH 9.0 - 11.0 are introduced into the body in the form of cleansing enemas in an amount of 0.5 - 1 5 liters once a day.  8. The method according to claims 1 to 4, characterized in that the electroactivated aqueous solutions of salts on a membrane electrolyzer with a positive redox potential (+900 - +1200) mV and pH 1.0 - 2.0 are introduced into the body in aerosol form with a particle size of not more than 3.5 microns in the form of inhalations in the human respiratory tract alternately through the mouth and nose of 1 to 3 ml per session twice a day in the morning and evening.  9. The method according to PP. 1 - 4, characterized in that the electroactivated aqueous solutions of salts on a membrane electrolyzer with a positive redox potential (+900 - +1200) mV and pH 1.0 - 2.0 are introduced into the body in the form of vaginal douching, rinsing the mouth and rinsing nasopharynx in an amount of 100 - 200 ml per procedure twice a day in the morning and evening. 10. The method according to claim 7, characterized in that after preliminary cleaning of the intestine for several days with enemas using electroactivated solutions, colonoscopy implantation of intestinal microflora is carried out separately in the following sequence: into the ascending intestine through a biopsy channel, the culture of lactobacilli, in the transverse section - a culture of bifidobacteria and in the descending section of the colon - a culture of colibacteria, with at least 20 ml of a liquid culture of these bacteria being injected into each section of the intestine - ubiotikov located in the logarithmic growth phase with a titre of each bacterial species of at least 10 ⁸ cfu / ml. 11. The method according to claim 9, characterized in that after vaginal douching, a liquid form of lactobacilli is introduced into the vaginal cavity with a titer of at least 10 ⁸ CFU / ml in an amount of 5-10 ml, and after rinsing the oral cavity and rinsing the nasopharynx, the latter are treated with a liquid form lactobacilli with a titer of at least 10 ⁸ CFU / ml by applications of 3-5 ml and instillation of 1-2 ml, respectively.