CN110339206A - It is a kind of for treating the pharmaceutical composition and its application of refractory acne - Google Patents
It is a kind of for treating the pharmaceutical composition and its application of refractory acne Download PDFInfo
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- CN110339206A CN110339206A CN201910696890.7A CN201910696890A CN110339206A CN 110339206 A CN110339206 A CN 110339206A CN 201910696890 A CN201910696890 A CN 201910696890A CN 110339206 A CN110339206 A CN 110339206A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
- A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4172—Imidazole-alkanecarboxylic acids, e.g. histidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4415—Pyridoxine, i.e. Vitamin B6
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
Abstract
The invention belongs to pharmaceutical fields, disclose a kind of for treating the pharmaceutical composition and its application of refractory acne.The pharmaceutical composition is mainly made of amino acid and vitamin, calcium gluconate, it may also be necessary to add the antibiotic of therapeutically effective amount.Targetedly synergistic treatment is carried out to the Etiological that refractory acne occurs; energy quickly human activin vital metabolic activity; quickly correct endocrine disorder and hormone metabolism disorder; have the effects that anti-inflammatory, exudation reduction, anti-angiogenic nervous edema and antiallergy; promote the metabolism of body enzyme, diuresis, removing toxic substances, protection brain and nervous function; the nutrition condition and immune function of body are improved, promotes refractory acne conditions of patients to improve and fully recover, is suitable for clinical expansion.
Description
Technical field
The invention belongs to pharmaceutical fields, are related to a kind of for treating the pharmaceutical composition and its application of refractory acne.
Background technique
One, refractory acne is a kind of illness for being particularly easy to again and again break out, it is desirable to which eradicating this illness is very
It is difficult: refractory acne this be human body it is easy to appear a kind of skin diseases, and be one kind be particularly easy to it is anti-repeatedly
Recur the illness made, it is desirable to which it is very difficult for eradicating this illness.Acne is also known as acne, whelk, and pimples spills thorn, dark sore
Deng, it is the chronic inflammation of pilosebaceous follicle caused by causing embolism, sebum excretion disorder due to hyperkeratosis, general good hair
In face and chest and back, often there are many forms such as blackhead, papulopustule tubercle and tumour, pathogenesis Shang Bushi
Clearly demarcated, some patients again and again break out more than 9 years, very painful.
Refractory acne is usually a variety of by diet, sleep, constipation, mood, sex hormone dyssecretosis, endocrine disturbance etc.
Caused by reason.The situation of the dyscrinic small pox due to caused by irregular work and rest and operating pressure is also very much.Some
People does not take scientific treatment method after having grown whelk, and being scratched with hand for blindness is squeezed, it is believed that small pox is extruded, acne body is deflated
Whelk will be got well, and processing in this way is very dangerous, it is easy in scar on the face, pothole, especially mouth and nose trigonum
Small pox, scratch squeeze after easily cause septicopyemia, sometimes even can threat to life.
Two, the possible cause of disease of refractory acne: acne is generally found from youth of both sexes often with seborrhagia, and puberty has more later
Spontaneous recovery or mitigation, but some patientss are due to heredity, dysendocrinism, greasiness, polysaccharide and irritable food, high temperature and certain
The factors such as chemical factor is paid no attention to hygiene and squeezed with hand, and stress is big, develop for blackhead, inflamed papules, secondary running sore or
Tubercle, it is gradually refractory, it gradually aggravates, Working Life is influenced greatly, to turn to any doctor one can find when critically ill, abuse of antibiotics, hormone.Its disease of acne
Because classification has: 1. bion: such as adolescence is exactly the beginning of sexual development period maturation, and sex hormone secretion increases suddenly.②
Gene genetic type: the secretion of male sex hormone is higher for a long time, belongs to women person, and the certain features of male occur, and such as enlarged pores, upper lip occurs
Black plumelet, chaeta are more, sound ray is thick, Oily etc..The whelk phase is long, and groups of people are seemed because of female hormone hyposecretion
Male sex hormone is higher.3. living environment factor type: dietary structure factor is such as liked eating spicy food, drink；The factor of mood,
As the oppressive of mood, violent rage cause endocrine variation, it appears male sex hormone is higher.It stays up late, seasonal variations etc..Acne inflammation disappears
Slow outside backspace, severity variation is also especially big, often destroys hair follicle sebum glandular structure, and less serious case can not stay trace, compared with
Severe one can leave pigment sexual imprinting.After acne is formed, patient is often subconscious to go to squeeze with hand, and local skin is caused to have
Damage, reduces the barrier protection function of skin, and bacterium is taken advantage of a weak point, and secondary sebaceous glands inflammation aggravates inflammation constantly, until
Form suppurative sebaceous glands inflammation, the reparation of sebaceous glands intraluminal tissue with destroy and deposit, easily cause to form keloid, scar increases
Raw and atrophic scar, rough and uneven in surface type scar.
Three, acne is clinically divided by I~IV degree according to Pillsbury classification:
Clinically according to the severity of the state of an illness, acne is divided by I~IV degree using Pillsbury classification.
1, I degree (slight): distributing to multiple blackhead, can be with the inflamed papules for being dispersed in distribution.
2, II degree (in isocratic): the inflammatory skin lesion number of I degree increases, and superficial warts occurs, but be confined to face.
3, III degree (severe): II degree is deep in property warts, is distributed in face, neck and chest and back.
4, IV degree (severe~cluster): melon degree tubercle, tumour betide above the waist with cicatrization.
Four, the current treatment of refractory acne
1, general treatment: being 1. exactly that sleep wants conditioned, many problems are all Bu Nengao caused by life there is not rule first
Night, so needing first to pick up from life.Based on 2. diet is light.Should not it is greasy too it is heavy it is pungent it is fried too much can not crapulence it is sudden and violent
Food.3. after living and diet is normal, the ripe post-processing of acne on the face can be waited, exactly come to a head head.Get out the tincture of iodine and cotton swab.Deng
When purulence head goes out.Cotton swab keynote purulence head is first used, then is pressed above with iodine disinfection.The pharmacological property of the tincture of iodine is allowed to permeate.It is hard
The a few days is held, until becoming dry and hard scar.It is all right to remove scar.Clean face is wanted 4. usually washing one's face.5. drink more
Water.Vegetable and fruit as far as possible more to be eaten, and pure mind.It not spend time and energy, feelings will wants gentle.Some more open airs are walked about, but can not too acutely
Movement.6. acne can be aggravated too much by sweating, no matter treat while carrying out based on men and women's conditioning, that is, controlled outside interior tune.
2, traditional Chinese medical herbal treatment: clinically the common card type of acne is divided into: 1. wind and heat in the lung meridian, with PIPA QINGFEI YIN plus
Subtract；2. excessive noxious heat, huanglian jiedu decoction closes with wuwei xiaodu drink in side；3. phlegm-blood stasis blocks, plus-minus is decocted with dispersing blood stasis resolving sputum；4. punching is appointed not
It adjusts, Siwu Tang plus-minus is closed with bupleurum powder for relieving liver-qi.The common first two card type of adolescent patients, diagnosis and treatment, curative effect are preferable.Acne is suffered from
Person should be avoided drink, coffee, pungent stimulation and fried food, diet answers light, mostly drinking water fruit vegetable.Durian, mango, dragon
Eye, lichee etc. belong to hot fruit and eat less, in order to avoid the state of an illness " pouring oil on the fire ".It is clear that patient can eat mung bean, wax gourd, lotus seeds, balsam pear etc. more
Hot dampness removing innerpurer.Acne, acne are fundamentally treated by the equilibrium between yin and yang of conditioning human body using Chinese herbal medicine.Its advantage is that
Table is controlled outside, is inside effected a permanent cure, endocrine is adjustable, sterilization is anti-inflammatory, has no obvious adverse reaction, and treatment comedo and acne has certain effect.
3, antibiotic treatment: according to the literature, serious or refractory acne patient takes josamycin treatment.Patient is daily
Receive 500mg drug, totally 2 weeks.More serious case (69) based on papule, pustular eruption starts the dosage for first giving 2g/d, altogether
15 days, then it is kept to maintenance dose 500mg 8d.The severity of disease is according to Plewig-Kligman categorical rating.It is husky with handing over
Mycin is treated in the local topical medicine of use in conjunction, and it to be secondly vitamin A acid (76 that the most commonly used is benzoyl peroxide (445)
Example), 146 use commercially available various cosmetic products.The quantity of the primary skin lesion of 89% patient, severity and other symptoms are equal
It take a favorable turn, applied other antibiotic treatments including former Zeng Quanshen.
4, complex treatment
Under normal circumstances, serious or refractory acne patient requires complex treatment, but currently used complex treatment
Effect or unsatisfactory.
It there is no the safe and effective and low-cost drug of a kind of pair of refractory acne both at home and abroad at present in summary.
Summary of the invention
The object of the present invention is to provide a kind of for treating the pharmaceutical composition of refractory acne.
It is a further object to provide the applications of aforementioned pharmaceutical compositions.
A further object of the present invention is to provide the treatment method using aforementioned pharmaceutical compositions treatment refractory acne.
The purpose of the present invention is what is realized by following technical proposal:
It is a kind of for treating the pharmaceutical composition of refractory acne, the pharmaceutical composition is mainly by amino acid and Wei Sheng
Element, calcium gluconate composition, wherein contain the substance of following mass parts in per unit the composition:
Amino acid: 1.10~8.80 parts of isoleucine, 1.7~13.60 parts of leucine, lysine acetate 1.325
~10.60 parts, 0.15~1.20 part of methionine, 0.20~1.60 part of phenylalanine, 0.575~4.60 part of threonine, color ammonia
0.187~1.50 part of acid, 1.325~10.60 parts of valine, 1.10~8.80 parts of arginine, 0.587~4.70 part of histidine,
0.787~6.30 part of glycine, 1.03~8.30 parts of alanine, 0.887~7.10 part of proline, L-aminobutanedioic acid 0.312~
2.50 parts, 0.067~0.55 part of asparamide, 0.10~0.80 part of N-acetyl-L-cysteine, glutamic acid 0.587~5.70
Part, 0.207~1.66 part of ornithine hcl 99,0.462~3.70 part of serine, 0.107~0.86 part of N- acetyl-L-tyrosine；
Vitamin: vitamin B63~10 parts, 1~5 part of vitamin C；
Calcium gluconate: 0.5~2.0 part of calcium gluconate.
The pharmaceutical composition, also containing the antibiotic of therapeutically effective amount, the antibiotic in per unit the composition
For broad-spectrum antibiotic or the antibiotic determined according to drug sensitive test, preferably Ceftriaxone (ceftriaxone sodium for injection).
The pharmaceutical composition contains following substance in per unit the composition:
Scheme 1:
Amino acid: contain isoleucine 2.20g, leucine 3.40g, lysine acetate 2.65g, methionine
0.30g, phenylalanine 0.40g, threonine 1.15g, tryptophan 0.38g, valine 2.65g, arginase 12 .20g, histidine
1.18g, glycine 1.57g, alanine 2.08g, proline 1.78g, L-aminobutanedioic acid 0.63g, asparamide 0.14g, N- acetyl-
L-cysteine 0.20g, glutamic acid 1.43g, ornithine hcl 99 0.42g, serine 0.93g, N- acetyl-L-tyrosine 0.22g,
It is made into 250ml liquid；
Vitamin: vitamin B63g and vitamin C 2g is added in 0.9% sodium chloride injection of 250ml；
Calcium gluconate: 10% calcium gluconate 10ml is added in 0.9% sodium chloride injection of 50ml；
Or
Scheme 2:
Amino acid: contain isoleucine 2.20g, leucine 3.40g, lysine acetate 2.65g, methionine
0.30g, phenylalanine 0.40g, threonine 1.15g, tryptophan 0.38g, valine 2.65g, arginase 12 .20g, histidine
1.18g, glycine 1.57g, alanine 2.08g, proline 1.78g, L-aminobutanedioic acid 0.63g, asparamide 0.14g, N- acetyl-
L-cysteine 0.20g, glutamic acid 1.43g, ornithine hcl 99 0.42g, serine 0.93g, N- acetyl-L-tyrosine 0.22g,
It is made into 250ml liquid；
Vitamin: vitamin B63~5g and vitamin C 2g is added to 0.9% sodium chloride injection of 250ml；
Calcium gluconate: 10% calcium gluconate 10ml is added in 0.9% sodium chloride injection of 50ml；
Ceftriaxone (ceftriaxone sodium for injection): Ceftriaxone 1g is added in 0.9% sodium chloride injection of 100ml；
Or
Scheme 3:
Amino acid: contain isoleucine 4.40g, leucine 6.80g, lysine acetate 5.30g, methionine
0.60g, phenylalanine 0.80g, threonine 2.30g, tryptophan 0.75g, valine 5.30g, arginine 4.40g, histidine
2.35g, glycine 3.15g, alanine 4.15g, proline 3 .55g, L-aminobutanedioic acid 1.25g, asparamide 0.27g, N- acetyl-
L-cysteine 0.40g, glutamic acid 2.85g, ornithine hcl 99 0.83g, serine 1.85g, N- acetyl-L-tyrosine 0.43g,
It is made into 500ml liquid；
Vitamin: vitamin B63~5g and vitamin C 2g is added in 0.9% sodium chloride injection of 250ml；
Calcium gluconate: 10% calcium gluconate 10ml is added in 0.9% sodium chloride injection of 50ml；
Ceftriaxone (ceftriaxone sodium for injection): Ceftriaxone 2g is added in 0.9% sodium chloride injection of 100ml；
Or
Scheme 4:
Amino acid: contain isoleucine 4.40g, leucine 6.80g, lysine acetate 5.30g, methionine
0.60g, phenylalanine 0.80g, threonine 2.30g, tryptophan 0.75g, valine 5.30g, arginine 4.40g, histidine
2.35g, glycine 3.15g, alanine 4.15g, proline 3 .55g, L-aminobutanedioic acid 1.25g, asparamide 0.27g, N- acetyl-
L-cysteine 0.40g, glutamic acid 2.85g, ornithine hcl 99 0.83g, serine 1.85g, N- acetyl-L-tyrosine 0.43g,
It is made into 500ml liquid；
Vitamin: vitamin B65g and vitamin C 2g is added in 0.9% sodium chloride injection of 250ml；
Calcium gluconate: 10% calcium gluconate 20ml is added in 0.9% sodium chloride injection of 50ml；
Ceftriaxone (ceftriaxone sodium for injection): Ceftriaxone 2g is added in 0.9% sodium chloride injection of 100ml.
The dosage form of the pharmaceutical composition is injection, oral solution, tablet, granule, capsule, electuary.
Application of the pharmaceutical composition in preparation treatment refractory acne drug.
Using the treatment method of the medicine composite for curing refractory acne, this method are as follows:
Amino acid and vitamin in above-mentioned pharmaceutical composition are divided into two groups of successively venoclysises, or will be described
Amino acid and vitamin preparation carry out venoclysis in 1 infusion bag in pharmaceutical composition；By 10% calcium gluconate
10~20ml is added to laggard row vein infusion in appropriate 0.9% sodium chloride injection；When necessary, 1~2g of Ceftriaxone is added
The laggard row vein infusion into appropriate 0.9% sodium chloride injection；Above-mentioned several groups of liquid can be sequentially input, can also it is any before
After input, 1 time a day, it is 10~20 days that vein, which inputs course for the treatment of, and a preferably course for the treatment of is 14 days (antibiotic usage is according to resisting
The therapeutic effect of raw element can deactivate in advance, avoid adverse reaction).
The treatment method, treatment method difference different degrees of for the Pillsbury classification of refractory acne
Are as follows:
I degree (slight): amino acid 250ml, component contain: containing isoleucine 2.20g, leucine 3.40g, relying
Propylhomoserin acetate 2.65g, methionine 0.30g, phenylalanine 0.40g, threonine 1.15g, tryptophan 0.38g, valine
2.65g, arginase 12 .20g, histidine 1.18g, glycine 1.57g, alanine 2.08g, proline 1.78g, L-aminobutanedioic acid
0.63g, asparamide 0.14g, N-acetyl-L-cysteine 0.20g, glutamic acid 1.43g, ornithine hcl 99 0.42g, serine
0.93g, N- acetyl-L-tyrosine 0.22g；Vitamin B63g and vitamin C 2g is added to 0.9% chloride injection of 250ml
In liquid；Amino acid and vitamin be divided into two groups successively venoclysis or by aforementioned pharmaceutical compositions prepare 1 be infused
Venoclysis is carried out in bag, and 10% calcium gluconate 10ml is added to the input of 0.9% sodium chloride injection medium sized vein of 50ml；
1 time a day, 14 days as a treatment course, until refractory acne is clearly better or is cured；
II degree (in isocratic): amino acid 250ml, component contain: containing isoleucine 2.20g, leucine
3.40g, lysine acetate 2.65g, methionine 0.30g, phenylalanine 0.40g, threonine 1.15g, tryptophan 0.38g,
Valine 2.65g, arginase 12 .20g, histidine 1.18g, glycine 1.57g, alanine 2.08g, proline 1.78g, Men Dong
Propylhomoserin 0.63g, asparamide 0.14g, N-acetyl-L-cysteine 0.20g, glutamic acid 1.43g, ornithine hcl 99 0.42g, silk
Propylhomoserin 0.93g, N- acetyl-L-tyrosine 0.22g；Vitamin B63~5g and vitamin C 2g is added to 0.9% chlorine of 250ml
Change in sodium injection；Amino acid and vitamin be divided into two groups successively venoclysis or by aforementioned pharmaceutical compositions prepare exist
Venoclysis is carried out in 1 infusion bag, 10% calcium gluconate 10ml is added to quiet in 0.9% sodium chloride injection of 50ml
Ceftriaxone 1g is added to the input of 100ml0.9% sodium chloride injection medium sized vein by arteries and veins input；1 time a day, 14 days are a treatment
Journey, until refractory acne is clearly better or is cured, wherein antibiotic usage can deactivate in advance according to therapeutic effect；
III degree (severe): amino acid 500ml, component contain: isoleucine 4.40g, leucine 6.80g, rely ammonia
Vinegar hydrochlorate 5.30g, methionine 0.60g, phenylalanine 0.80g, threonine 2.30g, tryptophan 0.75g, valine
5.30g, arginine 4.40g, histidine 2.35g, glycine 3.15g, alanine 4.15g, proline 3 .55g, L-aminobutanedioic acid
1.25g, asparamide 0.27g, N-acetyl-L-cysteine 0.40g, glutamic acid 2.85g, ornithine hcl 99 0.83g, serine
1.85g, N- acetyl-L-tyrosine 0.43g；Vitamin B63~5g and vitamin C 2g is added to 0.9% sodium chloride of 250ml
In injection；Amino acid and vitamin be divided into two groups successively venoclysis or by aforementioned pharmaceutical compositions prepare at 1
Venoclysis is carried out in infusion bag；It is defeated that 10% calcium gluconate 10ml is added to 0.9% sodium chloride injection medium sized vein of 50ml
Enter；Ceftriaxone 2g is added to the input of 0.9% sodium chloride injection medium sized vein of 100ml；1 time a day, vein inputs, until stupid
Solidity acne is clearly better or is cured, wherein antibiotic usage can deactivate in advance according to therapeutic effect；
IV degree (severe~cluster): amino acid 500ml, component contain: isoleucine 4.40g, leucine
6.80g, lysine acetate 5.30g, methionine 0.60g, phenylalanine 0.80g, threonine 2.30g, tryptophan 0.75g,
Valine 5.30g, arginine 4.40g, histidine 2.35g, glycine 3.15g, alanine 4.15g, proline 3 .55g, Men Dong
Propylhomoserin 1.25g, asparamide 0.27g, N-acetyl-L-cysteine 0.40g, glutamic acid 2.85g, ornithine hcl 99 0.83g, silk
Propylhomoserin 1.85g, N- acetyl-L-tyrosine 0.43g；Vitamin B65g and vitamin C 2g is added to 0.9% sodium chloride of 250ml
In injection；Amino acid and vitamin be divided into two groups successively venoclysis or by aforementioned pharmaceutical compositions prepare at 1
Venoclysis is carried out in infusion bag, and it is defeated that 10% calcium gluconate 20ml is added to 0.9% sodium chloride injection medium sized vein of 50ml
Enter, Ceftriaxone 2g is added to the input of 0.9% sodium chloride injection medium sized vein of 100ml；1 time a day, vein inputs, until stupid
Solidity acne is clearly better or is cured, wherein antibiotic usage can deactivate in advance according to therapeutic effect.
The theoretical basis of technical solution of the present invention:
Refractory acne is usually by endocrine disturbance, hormone metabolism disorder, diet, sleep, constipation, mood, heredity, sense
Caused by the reasons such as dye.So good therapeutic effect is often not achieved using single therapy measure to this, cause to cure this
Illness is extremely difficult, and there is presently no a kind of curative for effect, safe and reliable, cheap therapeutic agents.
1, the most important reason of refractory acne is usually as caused by hormone metabolism disorder and endocrine disorder.This drug
Vitamin B in composition6It is the coenzyme of about more than 140 kinds enzymes in human body, more than 80 kinds of biochemical reactions of catalysis is participated in, in human hormone's generation
It thanks, protein metabolism, decomposition of glycogen, there is irreplaceable role in lipid metabolism.It is promoting body hormone metabolism, is correcting
Play the role of in endocrine disorder highly important.
Either hormone control or nerve modulation in human body, are worked by enzymatic reaction.Medicine of the present invention
The vitamin B added in compositions6For the intracorporal hormone metabolism of people, amino acid metabolism, neurotransmitter γ-aminobutyric acid (γ-
Aminobutyric acid, GABA)/glutamic acid (Glutamic, Glu) conversion provides sufficient coenzyme.Vitamin B6It participates in
All amino acid metabolisms, protein synthesis, hormone metabolism, nucleic acid and DNA synthesis, this process maintain refractory acne patient
Suitable hormone metabolism level is very important.In addition vitamin B6There are also promote harmful toxic matter discharge, can reach removing toxic substances,
Detumescence reduces tissue exudation, protects the function of vitals, has to erosion, the exudation for the treatment of refractory acne patient facial region
Place.The state of an illness of patient's hormone metabolism Level tune and correction endocrine disorder is reversed highly beneficial.Due to vitamin B6In people
Intracorporal half-life period is shorter, can comparatively fast be excreted.Therefore, drug safety will not generally generate the secondary work of poison to patient
With.
2, human body maintains normal physiological function, must just there is full nutrition enough, appropriate, otherwise, endocrine etc.
Problem will occur one by one, and endocrine disturbance easilys lead to refractory acne, and amino acid can provide safe height
Effect, the most abundant most general equilibrium of type nutritional support, can correct amino acid metabolic disorder, reduce inhibitory neurotransmitter
It generates, enhances the immune function of human body.The endocrine disorder and hormone metabolism disorder of refractory acne patient can be quickly corrected,
Promote the rehabilitation of patient.
Amino acid in this pharmaceutical composition is that the basic unit for constituting human body protein and body synthesis resist
Body, hormone, enzyme and its hetero-organization raw material, its distinctive feature is its branched-amino in the formula of balanced type amino acid
Acid concentration is up to 33%, provides the nutritional support of the most abundant most general equilibrium of safe and efficient, type, prevention or reduction group for body
Knit the decomposition with visceral proteins such as livers, accelerate the synthesis of skeletal muscle albumen, can correct amino acid metabolic disorder, inhibit pathology
Property raised aromatic amino acid concentration, reduce the generation of inhibitory neurotransmitter, can comprehensively participate in ornithine circulation and
Tricarboxylic acid cycle promotes the generation of liver cell energy, accelerates the self-regeneration and regenerative process of liver cell, safeguard liver just
Chang Gongneng.Enhance the immune function of human body.Endocrine disorder and the hormone metabolism that refractory acne patient can quickly be corrected are disorderly
Disorderly, promote the rehabilitation of patient.
Vitamin B6Machine is improved with both amino acid use in conjunction, energy quickly human activin vital metabolic activity
The efficiency and rate of body metabolism promote the metabolism of body enzyme, diuresis, removing toxic substances, protection brain and nervous function, improve
The vitals such as liver function, the nutrition condition and immune function for improving body, promote the reparation of damaging cells, can accelerate stupid
Sb.'s illness took a favorable turn and recovery from illness for solidity patients with acne.
3, calcium gluconate can reduce the permeability of capillary, increase the compactness of capillary, reduce exudation,
Have the effects that anti-inflammatory, anti-angiogenic nervous edema and antiallergy.In addition secretion and the tune with neurotransmitter and hormone are also participated in
Section, participates in the intake and combination of amino acid, this is highly beneficial to the etiological treatment of refractory acne.
The actually many patients of refractory acne have been substantially all constitution allergy, easy infection, pruritic dermatitis etc., and 10%
Calcium gluconate injection have antiallergy, it is impervious go out, antioedematous and antiinflammation.In addition neurotransmitter and hormone are also participated in
Secretion and adjusting, participate in the activator of intake and the combination and a variety of enzymatic reactions of amino acid.This disease to refractory acne
It is highly beneficial because treating.Calcium gluconate is also able to maintain the normal excitability of nerve with muscle, reinforces cerebral cortex process of inhibition,
This improves the sleep, constipation, mood of patient helpful.When high concentration, calcium ion to the competitive antagonism of magnesium ion,
Also there is the effects of alleviating smooth muscle spasm.
4, the possible cause of disease of refractory acne also resides in inflamed papules, secondary running sore or tubercle, and secondary sebaceous glands inflammation is changed
Purulence sebaceous glands inflammation, it is gradually refractory, caused by gradually aggravating.So the use of some antibiotic being suitably necessary to such patient
's.It generally requires and does Bacteria Culture and drug sensitivity test, determine specific antibiotic according to drug sensitivity tests.And Ceftriaxone (note
Penetrate with Ceftriaxone Sodium) bactericidal effect is played to many gram-negative bacterias and gram positive bacteria in vitro, and to gram positive bacteria
And most of b- lactamases (penicillase and cephalosporinase) of gram-negative bacteria have very high stability, so such
It is suitable that patient, which selects Ceftriaxone to carry out antibacterial therapy,.In addition treating physician can also determine specifically used according to drug sensitivity tests
Suitable antibiotic.
Ceftriaxone (ceftriaxone sodium for injection) is Third generation Cephalosporins antibiotic.Usually to following pathogenic bacteria (intestines
Bacteriaceae bacterium, escherichia coli, Klebsiella Pneumoniae, clostridium perfringen, fluorine labor ground citrobacter, indole-positive deformed rod
Bacterium, haemophilus influenzae, NEISSERIA GONORRHOEAE, Neisseria meningitidis, hemolytic streptococcus, pneumococcus, Pseudomonas aeruginosa, meningitis
Neisseria, haemophilus influenzae, streptococcus pneumonia etc.) play antibacterial action.Infection caused by sensitive pathogenic bacteria, such as: purulence
Toxaemia, soft tissue, skin and wound infection, the infection of immunologic mechanism immunocompromised patients, ear nose larynx infection, genital system infection etc.
Deng.Antibacterial action can be played to the pathogenic bacteria that refractory acne patient infects.Standard dose: adult and 12 years old or more children:
The usual dosage of Ceftriaxone is 1~2 gram, once a day (every 24 hours).It absorbs with after 1 gram of single dose Ceftriaxone intramuscular injection 2
~3 hours reach highest blood concentration, about 81 ml ls.Lower area of blood concentration-time curve after intramuscular injection and same
It is equal after the intravenous injection of dosage, prompt the bioavilability of intramuscular injection ceftriaxone up to 100%.The distribution of Ceftriaxone is held
Product is 7~12 liters.The penetrability of tissue and body fluid well is shown after 1~2 gram of first use Ceftriaxone.Lungs, heart,
60 Various Tissues such as biliary tract, liver, tonsillotome, middle ear and schneiderian membrane, bone, cerebrospinal fluid, liquor pleurae, prostatic fluid and synovial fluid
The minimum inhibitory concentration of infection pathogen is kept above up to 24 hours or more with body fluid drug concentration.After vein uses Ceftriaxone
The rapid disperse of energy keeps the bacteriocidal concentration to sensitive bacterial up to 24 hours into interstitial fluid.In addition treating physician can also root
Specifically used suitable antibiotic is determined according to drug sensitivity tests.But need vigilant: as other class antibiotic, although having been suffered from
Whole medical histories of person, but it has also been not excluded for the possibility that anaphylactic shock occurs for few patients, and anaphylactic shock needs promptly
Processing.It need to prepare the drug that antianaphylaxis shock needs simultaneously when being treated.
Beneficial effects of the present invention
Pharmaceutical composition of the invention carries out targetedly synergistic treatment to the Etiological that refractory acne occurs, can be fast
Fast human activin vital metabolic activity, improves the efficiency and rate of body metabolism, quickly corrects endocrine disorder and swashs
Plain metabolic disorder has the effects that anti-inflammatory, anti-infective, exudation reduction, anti-angiogenic nervous edema and antiallergy.Promote body
Enzyme metabolism, diuresis, removing toxic substances, protection brain and nervous function, improve the nutrition condition and immune function of body, promote obstinate
Property patients with acne sb.'s illness took a favorable turn with recovery from illness.Long-time service safety is without side-effects, and medical expense is low, and effect is good, is suitable for clinical expansion.
Specific embodiment
It is further elaborated with the present invention below according to embodiment, but the present invention is not limited to following embodiments.
Embodiment 1: pharmaceutical composition preparation example
A kind of pharmaceutical composition, component are as follows:
Amino acid: contain isoleucine 2.20g, leucine 3.40g, lysine acetate 2.65g, methionine
0.30g, phenylalanine 0.40g, threonine 1.15g, tryptophan 0.38g, valine 2.65g, arginase 12 .20g, histidine
1.18g, glycine 1.57g, alanine 2.08g, proline 1.78g, L-aminobutanedioic acid 0.63g, asparamide 0.14g, N- acetyl-
L-cysteine 0.20g, glutamic acid 1.43g, ornithine hcl 99 0.42g, serine 0.93g, N- acetyl-L-tyrosine 0.22g,
It is made into 250ml liquid；
Vitamin: vitamin B63g and vitamin C 2g is added in 0.9% sodium chloride injection of 250ml；
Calcium gluconate: 10% calcium gluconate 10ml is added in 0.9% sodium chloride injection of 50ml；
Amino acid, vitamin, calcium gluconate can be divided into three groups and prepare successively venoclysis respectively；It can also will answer
Square amino acid, vitamin-medicine composition require to prepare in 1 infusion bag, by 10% calcium gluconate according to normal operations
10ml is added in 0.9% sodium chloride injection of 50ml, point two groups of carry out venoclysises.
Embodiment 2: pharmaceutical composition preparation example
A kind of pharmaceutical composition, component are as follows:
Amino acid: contain isoleucine 2.20g, leucine 3.40g, lysine acetate 2.65g, methionine
0.30g, phenylalanine 0.40g, threonine 1.15g, tryptophan 0.38g, valine 2.65g, arginase 12 .20g, histidine
1.18g, glycine 1.57g, alanine 2.08g, proline 1.78g, L-aminobutanedioic acid 0.63g, asparamide 0.14g, N- acetyl-
L-cysteine 0.20g, glutamic acid 1.43g, ornithine hcl 99 0.42g, serine 0.93g, N- acetyl-L-tyrosine 0.22g,
It is made into 250ml liquid；
Vitamin: vitamin B63~5g and vitamin C 2g is added to 0.9% sodium chloride injection of 250ml；
Calcium gluconate: 10% calcium gluconate 10ml is added in 0.9% sodium chloride injection of 50ml；
Amino acid, vitamin, calcium gluconate, Ceftriaxone can be divided into four groups and prepare successively venoclysis respectively；?
Amino acid, vitamin-medicine composition can be required to prepare in 1 infusion bag according to normal operations；By 10% grape
Calciofon 10ml is added in 0.9% sodium chloride injection of 50ml；By Ceftriaxone (ceftriaxone sodium for injection): Ceftriaxone 1g
It is added in 0.9% sodium chloride injection of 100ml；Divide three groups of carry out venoclysises.
Embodiment 3: pharmaceutical composition preparation example
A kind of pharmaceutical composition, component are as follows:
Amino acid: contain isoleucine 4.40g, leucine 6.80g, lysine acetate 5.30g, methionine
0.60g, phenylalanine 0.80g, threonine 2.30g, tryptophan 0.75g, valine 5.30g, arginine 4.40g, histidine
2.35g, glycine 3.15g, alanine 4.15g, proline 3 .55g, L-aminobutanedioic acid 1.25g, asparamide 0.27g, N- acetyl-
L-cysteine 0.40g, glutamic acid 2.85g, ornithine hcl 99 0.83g, serine 1.85g, N- acetyl-L-tyrosine 0.43g,
It is made into 500ml liquid；
Vitamin: vitamin B63~5g and vitamin C 2g is added in 0.9% sodium chloride injection of 250ml；
Calcium gluconate: 10% calcium gluconate 10ml is added in 0.9% sodium chloride injection of 50ml；
Ceftriaxone (ceftriaxone sodium for injection): Ceftriaxone 2g is added in 0.9% sodium chloride injection of 100ml；
Amino acid, vitamin, calcium gluconate, Ceftriaxone can be divided into four groups and prepare successively venoclysis respectively；?
Amino acid, vitamin-medicine composition can be required to prepare in 1 infusion bag according to normal operations；By 10% grape
Calciofon 10ml is added in 0.9% sodium chloride injection of 50ml；By Ceftriaxone (ceftriaxone sodium for injection): Ceftriaxone 2g
It is added in 0.9% sodium chloride injection of 100ml；Divide three groups of carry out venoclysises.
Embodiment 4: pharmaceutical composition preparation example
A kind of pharmaceutical composition, component are as follows:
Amino acid: contain isoleucine 4.40g, leucine 6.80g, lysine acetate 5.30g, methionine
0.60g, phenylalanine 0.80g, threonine 2.30g, tryptophan 0.75g, valine 5.30g, arginine 4.40g, histidine
2.35g, glycine 3.15g, alanine 4.15g, proline 3 .55g, L-aminobutanedioic acid 1.25g, asparamide 0.27g, N- acetyl-
L-cysteine 0.40g, glutamic acid 2.85g, ornithine hcl 99 0.83g, serine 1.85g, N- acetyl-L-tyrosine 0.43g,
It is made into 500ml liquid；
Vitamin: vitamin B65g and vitamin C 2g is added in 0.9% sodium chloride injection of 250ml；
Calcium gluconate: 10% calcium gluconate 20ml is added in 0.9% sodium chloride injection of 50ml；
Ceftriaxone (ceftriaxone sodium for injection): Ceftriaxone 2g is added in 0.9% sodium chloride injection of 100ml.
Amino acid, vitamin, calcium gluconate, Ceftriaxone can be divided into four groups and prepare successively venoclysis respectively；?
Amino acid, vitamin-medicine composition can be required to prepare in 1 infusion bag according to normal operations；By 10% grape
Calciofon 20ml is added in 0.9% sodium chloride injection of 50ml；By Ceftriaxone (ceftriaxone sodium for injection): Ceftriaxone 2g
It is added in 0.9% sodium chloride injection of 100ml；Divide three groups of carry out venoclysises.
Embodiment 5: clinical treatment embodiment
Acne is clinically divided by I~IV degree according to Pillsbury classification: using pharmaceutical composition (root of the invention
According to treatment method above-mentioned, for the different degrees of of refractory acne, I degree (slight)；II degree (in isocratic)；III degree (severe)；
IV degree (severe~cluster)；Take corresponding treatment method) 98 refractory acne patients have been treated, due to the present invention
Pharmaceutical composition Etiological that refractory acne is occurred carry out immunotherapy targeted autoantibody, achieve unexpected technology really
Effect.
General information
With in March, 2013 in June, 2018,98 refractory acne patients of the attached Wujin hospitalize of Jiangsu University are
Research object, wherein male 35, women 63；Age 20~53 years old, average age (24.93 ± 5.62) year.According to
Acne is divided into I~IV degree: I degree (slight) 9 by Pillsbury classification, and II degree (in isocratic) 11, III degree (severe) 46
Example, IV degree (severe~cluster) 32.
Inclusion criteria: (1) acne conditions again and again break out, and the course of disease was diagnosed as in tertiary hospitals stupid at 1 year or more
Solidity patients with acne.(2) patient is by treatment without the refractory acne patient of improvement.
Exclusion criteria: (1) malignant tumour.(2) there is mental disease medical history person.
Therapeutic effect judgment criteria:
Cure: (1) face's redness, rotten to the corn, oedema, infection, inflamed papules, inflammatory skin lesion, warts all disappear, itch
Property dermatitis disappear, follow-up -1 year 6 months without recurrence.
Improve: (1) face's redness, rotten to the corn, oedema, infection, inflamed papules, inflammatory skin lesion disappear substantially, and symptom is obvious
It improves, pruritic dermatitis control.3-6 month symptoms of follow-up are without obvious recurrence.
Invalid: face is red and swollen, rotten to the corn, oedema, and infection, inflamed papules, inflammatory skin lesion etc. are without improvement, and clinical symptoms are without changing
Become, pruritic dermatitis does not control.
Specific treatment method is respectively as follows:
I degree (slight): amino acid 250ml, component contain: containing isoleucine 2.20g, leucine 3.40g, relying
Propylhomoserin acetate 2.65g, methionine 0.30g, phenylalanine 0.40g, threonine 1.15g, tryptophan 0.38g, valine
2.65g, arginase 12 .20g, histidine 1.18g, glycine 1.57g, alanine 2.08g, proline 1.78g, L-aminobutanedioic acid
0.63g, asparamide 0.14g, N-acetyl-L-cysteine 0.20g, glutamic acid 1.43g, ornithine hcl 99 0.42g, serine
0.93g, N- acetyl-L-tyrosine 0.22g；Vitamin B63g and Catergen g is added to 0.9% chloride injection of 250ml
In liquid；Amino acid and vitamin be divided into two groups successively venoclysis or by aforementioned pharmaceutical compositions prepare 1 be infused
Venoclysis is carried out in bag, and 10% calcium gluconate 10ml is added to the input of 0.9% sodium chloride injection medium sized vein of 50ml；
1 time a day, 14 days as a treatment course, until refractory acne is clearly better or is cured；
II degree (in isocratic): amino acid 250ml, component contain: containing isoleucine 2.20g, leucine
3.40g, lysine acetate 2.65g, methionine 0.30g, phenylalanine 0.40g, threonine 1.15g, tryptophan 0.38g,
Valine 2.65g, arginase 12 .20g, histidine 1.18g, glycine 1.57g, alanine 2.08g, proline 1.78g, Men Dong
Propylhomoserin 0.63g, asparamide 0.14g, N-acetyl-L-cysteine 0.20g, glutamic acid 1.43g, ornithine hcl 99 0.42g, silk
Propylhomoserin 0.93g, N- acetyl-L-tyrosine 0.22g；Vitamin B63~5g and vitamin C 2g is added to 0.9% chlorine of 250ml
Change in sodium injection；Amino acid and vitamin be divided into two groups successively venoclysis or by aforementioned pharmaceutical compositions prepare exist
Venoclysis is carried out in 1 infusion bag, 10% calcium gluconate 10ml is added to quiet in 0.9% sodium chloride injection of 50ml
Ceftriaxone 1g is added to the input of 100ml0.9% sodium chloride injection medium sized vein by arteries and veins input；1 time a day, 14 days are a treatment
Journey, until refractory acne is clearly better or is cured, wherein antibiotic usage can deactivate in advance according to therapeutic effect；
III degree (severe): amino acid 500ml, component contain: isoleucine 4.40g, leucine 6.80g, rely ammonia
Vinegar hydrochlorate 5.30g, methionine 0.60g, phenylalanine 0.80g, threonine 2.30g, tryptophan 0.75g, valine
5.30g, arginine 4.40g, histidine 2.35g, glycine 3.15g, alanine 4.15g, proline 3 .55g, L-aminobutanedioic acid
1.25g, asparamide 0.27g, N-acetyl-L-cysteine 0.40g, glutamic acid 2.85g, ornithine hcl 99 0.83g, serine
1.85g, N- acetyl-L-tyrosine 0.43g；Vitamin B63~5g and vitamin C 2g is added to 0.9% sodium chloride of 250ml
In injection；Amino acid and vitamin be divided into two groups successively venoclysis or by aforementioned pharmaceutical compositions prepare at 1
Venoclysis is carried out in infusion bag；It is defeated that 10% calcium gluconate 10ml is added to 0.9% sodium chloride injection medium sized vein of 50ml
Enter；Ceftriaxone 2g is added to the input of 0.9% sodium chloride injection medium sized vein of 100ml；1 time a day, vein inputs, until stupid
Solidity acne is clearly better or is cured, wherein antibiotic usage can deactivate in advance according to therapeutic effect；
IV degree (severe~cluster): amino acid 500ml, component contain: isoleucine 4.40g, leucine
6.80g, lysine acetate 5.30g, methionine 0.60g, phenylalanine 0.80g, threonine 2.30g, tryptophan 0.75g,
Valine 5.30g, arginine 4.40g, histidine 2.35g, glycine 3.15g, alanine 4.15g, proline 3 .55g, Men Dong
Propylhomoserin 1.25g, asparamide 0.27g, N-acetyl-L-cysteine 0.40g, glutamic acid 2.85g, ornithine hcl 99 0.83g, silk
Propylhomoserin 1.85g, N- acetyl-L-tyrosine 0.43g；Vitamin B65g and vitamin C 2g is added to 0.9% sodium chloride of 250ml
In injection；Amino acid and vitamin be divided into two groups successively venoclysis or by aforementioned pharmaceutical compositions prepare at 1
Venoclysis is carried out in infusion bag, and it is defeated that 10% calcium gluconate 20ml is added to 0.9% sodium chloride injection medium sized vein of 50ml
Enter, Ceftriaxone 2g is added to the input of 0.9% sodium chloride injection medium sized vein of 100ml；1 time a day, vein inputs, until stupid
Solidity acne is clearly better or is cured, wherein antibiotic usage can deactivate in advance according to therapeutic effect.
Therapeutic effect (is shown in Table 1): being enabled to really using medicine composite for curing refractory acne patient of the invention
Most of patient is fully recovered, and it is to control that follow-up is without recurrence, and this pharmaceutical composition does not have any toxic side effect, medical expense low
Treat the preferred therapy of refractory acne patient.
Table 1 is a kind of for treating the medicine composite for curing effect observation of refractory acne
Note: acne is divided by I~IV degree: I degree (slight) according to Pillsbury classification: being distributed to multiple blackhead powder
Thorn, can be with the inflamed papules for being dispersed in distribution.II degree (in isocratic): the inflammatory skin lesion number of I degree increases, and superficial warts occurs,
But it is confined to face.III degree (severe): II degree is deep in property warts, is distributed in face, neck and chest and back.IV degree (severe~collection
Cluster): melon degree tubercle, tumour betide above the waist with cicatrization.
Conclusion: pharmaceutical composition of the invention, which carries out immunotherapy targeted autoantibody to the Etiological that refractory acne occurs, to be taken
Obtain unexpected technical effect.It is worthy of popularization.
Embodiment 6: clinical treatment embodiment
Patient, female, 51 years old.Head is examined the date: on June 8th, 2014, because refractory acne again and again occurs in face, depth exists
Property warts, pilosebaceous follicle chronic inflammation, often have papulopustule tubercle, again and again break out in 3 years, very painful, cannot
Normal working, is unable to the collective activity of participant.Since face is red and swollen, rotten to the corn, oedema, infection, pruritic dermatitis etc., successively
Clinics and Practices are carried out to 13 large hospitals, diagnosis: refractory acne (is confirmed as IV degree according to Pillsbury classification clinic
(severe~cluster)), but therapeutic effect is unobvious, still again and again breaks out, and pain is unbearably.Drug of the invention is used afterwards
(amino acid 500ml, component contain: isoleucine 4.40g, leucine 6.80g, lysine acetate for composition treatment
5.30g, methionine 0.60g, phenylalanine 0.80g, threonine 2.30g, tryptophan 0.75g, valine 5.30g, arginine
4.40g, histidine 2.35g, glycine 3.15g, alanine 4.15g, proline 3 .55g, L-aminobutanedioic acid 1.25g, asparamide
0.27g, N-acetyl-L-cysteine 0.40g, glutamic acid 2.85g, ornithine hcl 99 0.83g, serine 1.85g, N- acetyl-
L-tyrosine 0.43g；Vitamin B65g and vitamin C 2g is added in 0.9% sodium chloride injection of 250ml；Compound amino
Acid and vitamin be divided into two groups successively venoclysis or by aforementioned pharmaceutical compositions prepare in 1 infusion bag carry out vein it is defeated
10% calcium gluconate 20ml is added to the input of 0.9% sodium chloride injection medium sized vein of 50ml, Ceftriaxone 2g is added by note
It is inputted to 0.9% sodium chloride injection medium sized vein of 100ml；1 time a day, vein input, until refractory acne be clearly better or
It is cured, wherein antibiotic usage can deactivate in advance according to therapeutic effect) it works well.Face is red after treatment in 5 days
Swollen, rotten to the corn, oedema, infection, pruritic dermatitis just gradually subside, wherein Ceftriaxone just deactivates after using 5 days.Patient adopts
After adhering to continuous 15 days with amino acid and vitamin, gluconic acid calcium medicine compound, facial warts, sebaceous glands chronic inflammation
Disease, papulopustule tubercle gradually disappear, my state of mind is clearly better, and face starts bright and clean.Complexion also starts red
Profit is got up.Refractory acne is cured, and follow-up 5 years so far without recurrence.
Embodiment 7: clinical treatment embodiment
Patient, female, 32 years old.Because face again and again acne, with papulopustule tubercle, face's redness, skin erosion,
Oedema simultaneously infects, and pruritic dermatitis etc. occurs, again and again breaks out in 2 years.It successively sees a doctor, diagnoses to various regions hospital: is obstinate
Property acne.Using multiple therapy methods, effect is simultaneously bad, always again and again breaks out, and pain is unbearably.May in 2017 8 Nikkei friend
Friend introduces to come to go to a doctor, and according to inspection and Signs, is diagnosed as refractory acne and (is confirmed as according to Pillsbury classification clinic
III degree (severe)).Using medicine composite for curing of the invention, (amino acid 500ml, component contain: different bright ammonia immediately
Sour 4.40g, leucine 6.80g, lysine acetate 5.30g, methionine 0.60g, phenylalanine 0.80g, threonine
2.30g, tryptophan 0.75g, valine 5.30g, arginine 4.40g, histidine 2.35g, glycine 3.15g, alanine
4.15g, proline 3 .55g, L-aminobutanedioic acid 1.25g, asparamide 0.27g, N-acetyl-L-cysteine 0.40g, glutamic acid
2.85g, ornithine hcl 99 0.83g, serine 1.85g, N- acetyl-L-tyrosine 0.43g；Vitamin B63~5g and vitamin
C 2g is added in 0.9% sodium chloride injection of 250ml；Amino acid and vitamin be divided into two groups successively venoclysis or
Aforementioned pharmaceutical compositions are prepared and carry out venoclysis in 1 infusion bag by person；10% calcium gluconate 10ml is added to
The input of 0.9% sodium chloride injection medium sized vein of 50ml；Ceftriaxone 2g is added to quiet in 0.9% sodium chloride injection of 100ml
Arteries and veins input；1 time a day, vein inputs, until refractory acne is clearly better or is cured, wherein antibiotic usage is according to controlling
Therapeutic effect can deactivate in advance), clinical therapeutic efficacy is good.Wherein, Ceftriaxone uses just deactivated after 3 days.Patient is using multiple
Square amino acid and vitamin, gluconic acid calcium medicine compound adhere to face's redness, skin gruel after the treatment continuously across 8 days
Rotten, oedema simultaneously infects, and concurrent pruritic dermatitis etc. just subsides at leisure, after patient adheres to continuous 13 days, my face
Inflamed papules, inflammatory skin lesion, warts all disappear, and patient mental is in good condition, it appears glowing with health.The stubbornness of patient
Property acne is cured, and follow-up is so far more than 2 years without recurrence.
Embodiment 8: clinical treatment embodiment
Patient, male, 28 years old.Because of face, the frequent acne of chest and back, with papulopustule tubercle, blackhead, inflammatory mound
Rash, skin erosion, oedema simultaneously infect, and pruritic dermatitis etc. occur, again and again break out in 3 years.Successively asked to various regions hospital
It examines, diagnoses: refractory acne.It is treated using a variety of external drugs and endo-medicine, it is ineffective, always again and again break out,
Pain is unbearably.On March 7th, 2016 comes to go to a doctor, and according to inspection and Signs, is diagnosed as refractory acne (according to Pillsbury points
Class method clinic is confirmed as II degree (in isocratic)).Immediately using medicine composite for curing of the invention (amino acid 250ml,
Component contains: containing isoleucine 2.20g, leucine 3.40g, lysine acetate 2.65g, methionine 0.30g, phenylpropyl alcohol ammonia
Sour 0.40g, threonine 1.15g, tryptophan 0.38g, valine 2.65g, arginase 12 .20g, histidine 1.18g, glycine
1.57g, alanine 2.08g, proline 1.78g, L-aminobutanedioic acid 0.63g, asparamide 0.14g, N-acetyl-L-cysteine
0.20g, glutamic acid 1.43g, ornithine hcl 99 0.42g, serine 0.93g, N- acetyl-L-tyrosine 0.22g；Vitamin B6 3
~5g and vitamin C 2g is added in 0.9% sodium chloride injection of 250ml；Amino acid and vitamin be divided into two groups according to
Aforementioned pharmaceutical compositions preparation is carried out venoclysis in 1 infusion bag by secondary venoclysis, by 10% calcium gluconate
10ml is added to the input of 0.9% sodium chloride injection medium sized vein of 50ml, and Ceftriaxone 1g is added to 0.9% sodium chloride of 100ml
The input of injection medium sized vein；1 time a day, 14 days as a treatment course, until refractory acne is clearly better or is cured, wherein
Antibiotic usage can deactivate in advance according to therapeutic effect), patient is good by therapeutic effect.Wherein, Ceftriaxone used after 4 days
Just deactivate.Patient adheres to the treatment continuously across 7 days using amino acid and vitamin, gluconic acid calcium medicine compound
It face, chest and back acne, blackhead, inflamed papules, skin erosion, oedema and infects afterwards, concurrent pruritic dermatitis etc. is just
Start to subside at leisure, after patient adheres to continuous 15 days, my face, chest and back acne, blackhead, inflamed papules, skin
Skin erosion, oedema simultaneously infect, and the symptoms such as concurrent pruritic dermatitis disappear, and patient mental is in good condition, and face is bright and clean.Patient is stupid
Solidity acne is cured, and follow-up is so far more than 3 years without recurrence.
Embodiment 9: clinical treatment embodiment
Patient, female, 36 years old.Because of the frequent acne of face, blackhead, with the inflamed papules for being dispersed in distribution.Skin is rotten
It is rotten etc., it again and again breaks out in 1 year.It successively sees a doctor, diagnoses: refractory acne to 3 hospitals.It is treated using a variety of methods,
The effect is unsatisfactory, always recurrent exerbation, more painful.Come to go to a doctor on September 6th, 2017, according to inspection and Signs, be diagnosed as
Refractory acne (is confirmed as I degree (slight) according to Pillsbury classification clinic).Pharmaceutical composition of the invention is used immediately
(amino acid 250ml, component contain: containing isoleucine 2.20g, leucine 3.40g, lysine acetate for treatment
2.65g, methionine 0.30g, phenylalanine 0.40g, threonine 1.15g, tryptophan 0.38g, valine 2.65g, arginine
2.20g, histidine 1.18g, glycine 1.57g, alanine 2.08g, proline 1.78g, L-aminobutanedioic acid 0.63g, asparamide
0.14g, N-acetyl-L-cysteine 0.20g, glutamic acid 1.43g, ornithine hcl 99 0.42g, serine 0.93g, N- acetyl-
L-tyrosine 0.22g；Vitamin B63g and vitamin C 2g is added in 0.9% sodium chloride injection of 250ml；Compound amino
Acid and vitamin be divided into two groups successively venoclysis or by aforementioned pharmaceutical compositions prepare in 1 infusion bag carry out vein it is defeated
10% calcium gluconate 10ml is added to the input of 0.9% sodium chloride injection medium sized vein of 50ml by note；1 time a day, it is within 14 days
One course for the treatment of, until refractory acne is clearly better or is cured), after patient adheres to continuous 14 days, my face often goes out
Existing acne, blackhead, with the inflamed papules for being dispersed in distribution.The symptoms such as skin erosion all disappear, and face becomes bright and clean.Suffer from
Person's refractory acne is cured, and follow-up nearly 2 years so far without recurrence.
(note: for protection patients' privacy therefore concealing patient's name and admission number in clinical treatment example, such as examines and needs can provide
Original medical record).
Claims (7)
1. it is a kind of for treating the pharmaceutical composition of refractory acne, it is characterized in that the pharmaceutical composition is mainly by amino acid
It is formed with vitamin, calcium gluconate, wherein contain the substance of following mass parts in per unit the composition:
Amino acid: 1.10~8.80 parts of isoleucine, 1.7~13.60 parts of leucine, lysine acetate 1.325~
10.60 parts, 0.15~1.20 part of methionine, 0.20~1.60 part of phenylalanine, 0.575~4.60 part of threonine, tryptophan
It is 0.187~1.50 part, 1.325~10.60 parts of valine, 1.10~8.80 parts of arginine, 0.587~4.70 part of histidine, sweet
0.787~6.30 part of propylhomoserin, 1.03~8.30 parts of alanine, 0.887~7.10 part of proline, L-aminobutanedioic acid 0.312~2.50
Part, 0.067~0.55 part of asparamide, 0.10~0.80 part of N-acetyl-L-cysteine, 0.587~5.70 part of glutamic acid, salt
0.207~1.66 part of sour ornithine, 0.462~3.70 part of serine, 0.107~0.86 part of N- acetyl-L-tyrosine；
Vitamin: vitamin B63~10 parts, 1~5 part of vitamin C；
Calcium gluconate: 0.5~2.0 part of calcium gluconate.
2. pharmaceutical composition according to claim 1, it is characterized in that also containing therapeutically effective amount in per unit the composition
Antibiotic, the antibiotic be broad-spectrum antibiotic or according to drug sensitive test determine antibiotic.
3. pharmaceutical composition according to claim 1 or 2, it is characterized in that containing following substance in per unit the composition:
Scheme 1:
Amino acid: containing isoleucine 2.20g, leucine 3.40g, lysine acetate 2.65g, methionine 0.30g,
Phenylalanine 0.40g, threonine 1.15g, tryptophan 0.38g, valine 2.65g, arginase 12 .20g, histidine 1.18g are sweet
Propylhomoserin 1.57g, alanine 2.08g, proline 1.78g, L-aminobutanedioic acid 0.63g, half Guang ammonia of asparamide 0.14g, N- acetyl-L-
Sour 0.20g, glutamic acid 1.43g, ornithine hcl 99 0.42g, serine 0.93g, N- acetyl-L-tyrosine 0.22g are made into
250ml liquid；
Vitamin: vitamin B63g and vitamin C 2g is added in 0.9% sodium chloride injection of 250ml；
Calcium gluconate: 10% calcium gluconate 10ml is added in 0.9% sodium chloride injection of 50ml；
Or
Scheme 2:
Amino acid: containing isoleucine 2.20g, leucine 3.40g, lysine acetate 2.65g, methionine 0.30g,
Phenylalanine 0.40g, threonine 1.15g, tryptophan 0.38g, valine 2.65g, arginase 12 .20g, histidine 1.18g are sweet
Propylhomoserin 1.57g, alanine 2.08g, proline 1.78g, L-aminobutanedioic acid 0.63g, half Guang ammonia of asparamide 0.14g, N- acetyl-L-
Sour 0.20g, glutamic acid 1.43g, ornithine hcl 99 0.42g, serine 0.93g, N- acetyl-L-tyrosine 0.22g are made into
250ml liquid；
Vitamin: vitamin B63~5g and vitamin C 2g is added to 0.9% sodium chloride injection of 250ml；
Calcium gluconate: 10% calcium gluconate 10ml is added in 0.9% sodium chloride injection of 50ml；
Ceftriaxone (ceftriaxone sodium for injection): Ceftriaxone 1g is added in 0.9% sodium chloride injection of 100ml；
Or
Scheme 3:
Amino acid: containing isoleucine 4.40g, leucine 6.80g, lysine acetate 5.30g, methionine 0.60g,
Phenylalanine 0.80g, threonine 2.30g, tryptophan 0.75g, valine 5.30g, arginine 4.40g, histidine 2.35g are sweet
Propylhomoserin 3.15g, alanine 4.15g, proline 3 .55g, L-aminobutanedioic acid 1.25g, half Guang ammonia of asparamide 0.27g, N- acetyl-L-
Sour 0.40g, glutamic acid 2.85g, ornithine hcl 99 0.83g, serine 1.85g, N- acetyl-L-tyrosine 0.43g are made into
500ml liquid；
Vitamin: vitamin B63~5g and vitamin C 2g is added in 0.9% sodium chloride injection of 250ml；
Calcium gluconate: 10% calcium gluconate 10ml is added in 0.9% sodium chloride injection of 50ml；
Ceftriaxone (ceftriaxone sodium for injection): Ceftriaxone 2g is added in 0.9% sodium chloride injection of 100ml；
Or
Scheme 4:
Amino acid: containing isoleucine 4.40g, leucine 6.80g, lysine acetate 5.30g, methionine 0.60g,
Phenylalanine 0.80g, threonine 2.30g, tryptophan 0.75g, valine 5.30g, arginine 4.40g, histidine 2.35g are sweet
Propylhomoserin 3.15g, alanine 4.15g, proline 3 .55g, L-aminobutanedioic acid 1.25g, half Guang ammonia of asparamide 0.27g, N- acetyl-L-
Sour 0.40g, glutamic acid 2.85g, ornithine hcl 99 0.83g, serine 1.85g, N- acetyl-L-tyrosine 0.43g are made into
500ml liquid；
Vitamin: vitamin B65g and vitamin C 2g is added in 0.9% sodium chloride injection of 250ml；
Calcium gluconate: 10% calcium gluconate 20ml is added in 0.9% sodium chloride injection of 50ml；
Ceftriaxone (ceftriaxone sodium for injection): Ceftriaxone 2g is added in 0.9% sodium chloride injection of 100ml.
4. pharmaceutical composition according to claim 1 or 2, it is characterised in that the dosage form of the pharmaceutical composition be injection,
Oral solution, tablet, granule, capsule, electuary.
5. application of the pharmaceutical composition described in claim 1,2 or 3 in preparation treatment refractory acne drug.
6. using the treatment method of medicine composite for curing refractory acne described in claim 1,2 or 3, it is characterised in that should
Method are as follows:
Amino acid and vitamin in the pharmaceutical composition are divided into two groups of successively venoclysises, or by the drug
Amino acid and vitamin preparation carry out venoclysis in 1 infusion bag in composition；By 10% calcium gluconate 10~
20ml is added to laggard row vein infusion in appropriate 0.9% sodium chloride injection；When necessary, 1~2g of Ceftriaxone is added to suitable
Measure laggard row vein infusion in 0.9% sodium chloride injection；Above-mentioned several groups of liquid can be sequentially input, can also any front and back it is defeated
Enter, 1 time a day, it is 10~20 days that vein, which inputs a course for the treatment of, and preferably a course for the treatment of is 14 days.
7. treatment method according to claim 6, it is characterised in that for refractory acne Pillsbury classification not
Same degree, the treatment method are respectively as follows:
I degree (slight): amino acid 250ml, component contain: containing isoleucine 2.20g, leucine 3.40g, lysine
Acetate 2.65g, methionine 0.30g, phenylalanine 0.40g, threonine 1.15g, tryptophan 0.38g, valine 2.65g,
Arginase 12 .20g, histidine 1.18g, glycine 1.57g, alanine 2.08g, proline 1.78g, L-aminobutanedioic acid 0.63g, door
Winter acyl ammonia 0.14g, N-acetyl-L-cysteine 0.20g, glutamic acid 1.43g, ornithine hcl 99 0.42g, serine 0.93g, N-
Acetyl-L-tyrosine 0.22g；Vitamin B63g and vitamin C 2g is added in 0.9% sodium chloride injection of 250ml；It is multiple
Square amino acid and vitamin be divided into two groups successively venoclysis or prepare aforementioned pharmaceutical compositions carry out in 1 infusion bag
10% calcium gluconate 10ml is added to the input of 0.9% sodium chloride injection medium sized vein of 50ml by venoclysis；1 time a day,
14 days as a treatment course, until refractory acne is clearly better or is cured；
II degree (in isocratic): amino acid 250ml, component contain: containing isoleucine 2.20g, leucine 3.40g, relying
Propylhomoserin acetate 2.65g, methionine 0.30g, phenylalanine 0.40g, threonine 1.15g, tryptophan 0.38g, valine
2.65g, arginase 12 .20g, histidine 1.18g, glycine 1.57g, alanine 2.08g, proline 1.78g, L-aminobutanedioic acid
0.63g, asparamide 0.14g, N-acetyl-L-cysteine 0.20g, glutamic acid 1.43g, ornithine hcl 99 0.42g, serine
0.93g, N- acetyl-L-tyrosine 0.22g；Vitamin B63~5g and vitamin C 2g is added to 0.9% sodium chloride of 250ml
In injection；Amino acid and vitamin be divided into two groups successively venoclysis or by aforementioned pharmaceutical compositions prepare at 1
Venoclysis is carried out in infusion bag, and it is defeated that 10% calcium gluconate 10ml is added to 0.9% sodium chloride injection medium sized vein of 50ml
Enter, Ceftriaxone 1g is added to the input of 0.9% sodium chloride injection medium sized vein of 100ml；1 time a day, 14 days as a treatment course,
Until refractory acne is clearly better or is cured, wherein antibiotic usage can deactivate in advance according to therapeutic effect；
III degree (severe): amino acid 500ml, component contain: isoleucine 4.40g, leucine 6.80g, lysine vinegar
Hydrochlorate 5.30g, methionine 0.60g, phenylalanine 0.80g, threonine 2.30g, tryptophan 0.75g, valine 5.30g, essence
Propylhomoserin 4.40g, histidine 2.35g, glycine 3.15g, alanine 4.15g, proline 3 .55g, L-aminobutanedioic acid 1.25g, Men Dong
Acyl ammonia 0.27g, N-acetyl-L-cysteine 0.40g, glutamic acid 2.85g, ornithine hcl 99 0.83g, serine 1.85g, N- second
Acyl-l-tyrosine 0.43g；Vitamin B63~5g and vitamin C 2g is added in 0.9% sodium chloride injection of 250ml；It is multiple
Square amino acid and vitamin be divided into two groups successively venoclysis or prepare aforementioned pharmaceutical compositions carry out in 1 infusion bag
Venoclysis；10% calcium gluconate 10ml is added to the input of 0.9% sodium chloride injection medium sized vein of 50ml；By Ceftriaxone
2g is added to the input of 0.9% sodium chloride injection medium sized vein of 100ml；1 time a day, vein inputs, until refractory acne is obvious
It improves or is cured, wherein antibiotic usage can deactivate in advance according to therapeutic effect；
IV degree (severe~cluster): amino acid 500ml, component contain: isoleucine 4.40g, leucine 6.80g,
Lysine acetate 5.30g, methionine 0.60g, phenylalanine 0.80g, threonine 2.30g, tryptophan 0.75g, valine
5.30g, arginine 4.40g, histidine 2.35g, glycine 3.15g, alanine 4.15g, proline 3 .55g, L-aminobutanedioic acid
1.25g, asparamide 0.27g, N-acetyl-L-cysteine 0.40g, glutamic acid 2.85g, ornithine hcl 99 0.83g, serine
1.85g, N- acetyl-L-tyrosine 0.43g；Vitamin B65g and vitamin C 2g is added to 0.9% chloride injection of 250ml
In liquid；Amino acid and vitamin be divided into two groups successively venoclysis or by aforementioned pharmaceutical compositions prepare 1 be infused
Venoclysis is carried out in bag, and 10% calcium gluconate 20ml is added to the input of 0.9% sodium chloride injection medium sized vein of 50ml,
Ceftriaxone 2g is added to the input of 0.9% sodium chloride injection medium sized vein of 100ml；1 time a day, vein inputs, until intractable
Acne is clearly better or is cured, wherein antibiotic usage can deactivate in advance according to therapeutic effect.
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| FR3122084A1 (en) * | 2021-04-21 | 2022-10-28 | Mirei International Ltd | Cosmetic or pharmaceutical composition characterized by a combination of bioactives selected from Glycine max seeds for its use in the modulation of the intestinal and cutaneous microbiota and the balance of the intestine-skin-brain axis. |
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| FR3122084A1 (en) * | 2021-04-21 | 2022-10-28 | Mirei International Ltd | Cosmetic or pharmaceutical composition characterized by a combination of bioactives selected from Glycine max seeds for its use in the modulation of the intestinal and cutaneous microbiota and the balance of the intestine-skin-brain axis. |
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