RU2709488C1 - Method of treating and preventing age-associated diseases - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention relates to geriatrics, namely to prevention and treatment of age-associated diseases, aimed at preventing, eliminating or slowing down the development of geriatric syndromes. For this purpose, the patient is ozone therapy by ozone administration in concentration of 1–20 mg/l, volume 20–120 ml every other day or 2 times a week with course of 3–6 procedures, then introduced fermented dry probiotic product 2 times a day before or during meals, course of 1–3 months, a week after ozone therapy is followed by placental therapy with Laennek preparation, course of 10–12 procedures twice a week, and simultaneously with placental therapy, Hepatosan is prescribed 1–2 capsules 2 times a day or Enterosan 1 capsule 3 times day for 1–3 months.

EFFECT: invention provides a wide holistic coverage of aspects of prevention and treatment of age-associated diseases, which are aimed at improving metabolic processes, restoration of liver detoxification capacity, normalization of carbohydrate, lipid metabolism, restoration of microbiota and intestinal nasal apparatus, restoration of immunity, maintenance of normal whole body homeostasis.

3 cl, 8 ex

Description

The invention relates to medicine, namely to geriatrics, and relates to a complex method of treatment and prevention of age-associated diseases (geriatric syndromes).

Aging is a global problem of mankind. Almost 20% of the world's population is 60 years old or older. Assessing the degree of aging, as well as the level of vitality of the body and its elements, is one of the key tasks of preventive medicine.

More than half of patients who seek the help of a polyclinic physician are elderly and senile. On average, in one patient older than 60 years, four to five different chronic diseases are detected. The main problems are related to the multifaceted effects of aging, primarily the development of age-associated conditions.

Elderly patients require a different approach to assessing health status, monitoring and treatment in connection with changes in the body that develop during physiological aging. Aging is associated not only with an increase in the number of diseases, polypharmacy, but also with the development of a number of geriatric syndromes that reflect morphological and functional evolution in different organs and systems of an aging organism. Geriatric syndromes are multifactorial conditions that are formed in response to a decrease in the functioning of many organs and systems.

Age-related involution of an organism leaves its mark on the course of diseases. Most of the diseases are sluggish, stretched, often atypical. Often the disease proceeds secretly and manifests itself already in the form of complications. The multiplicity of chronic diseases dramatically worsens the well-being of the patient. The number of diagnosed diseases in the same patient increases with age. As a rule, in patients older than 50 years, on average, 4.2 diseases are detected in men and 4.6 in women. By the age of 80, this indicator, as a rule, doubles.

A decrease in metabolic processes that progresses with age (after 30-35 years) serves as the basis for the gradual development of atrophic processes in the organ parenchyma, degenerative changes in bradytrophic tissues. These processes dominate in the arteries of the body and tissues of the musculoskeletal system. As a result of the shifts that occur in an aging organism, its reactions to environmental factors, to external influences change, and compensatory-adaptive mechanisms are significantly modified. The aging process is accompanied by the emergence of new qualities aimed at preserving compensatory mechanisms, but they only partially support adaptation processes.

Today, there are many theories trying to explain the essence of aging, including thermomeric, ontogenetic, adaptive-regulatory, the theory of autointoxication, free radicals, etc. According to certain ideas and hypotheses of aging, there are many ways, means and systems to combat aging, as well as diseases and syndromes associated with it.

The prior art use of energy metabolism regulators in gerontological practice. For example, a therapeutic and prophylactic agent, which is a combination of energy metabolism regulators, including succinic acid and / or its salt and at least one drug selected from the group: a drug that supports the high activity of the fast metabolic cluster of mitochondria, mitochondrial oxidation activators, agents that help maintain the activity of succinate dehydrogenase, transaminases, agents that support the formation of endogenous succinic acid, agents that maintain the resis tents of the energy production system under load, in pharmacologically effective doses (RU 2229293 C1-27.05.2004).

Also, biostimulants of animal and plant origin are successfully used to treat age-associated diseases: aloe extract, planocentric preparations, PhiBS, peloidin, pyrogenal, prodigiosan, humisol, biomed, peat, etc. ("Means and methods of prolonging life", V.E. Chernilevsky, 2000). These funds have a stimulating effect on metabolic processes, a regulatory effect on the functions of the central nervous system, cardiovascular, endocrine and other systems, activate recovery and regeneration processes, slow the development of atherosclerosis and arthritis.

A source of information is known that reveals a method for treating placenta preparations using reflexology at biologically active points, which helps to reduce the manifestations of pathological conditions, prophylactic aging, improves skin regeneration and biorevitalization, and stimulates hair growth (RU 2488376 C1-27.07.20130).

As the closest analogue may be specified patent RU 2657824 C1, publ. 06/15/2018, revealing a method of biocorrection of premature aging of the body and human skin, which is characterized by the fact that the patient is prescribed a 5-week course of drug combination: Laennec drug 4-6 ml once a week, intramuscularly, Enterosan drug in capsule form - 300 each mg 3 times a day, orally, and Hepatosan in capsule form - 400 mg 2 times a day: before dinner and at night, orally.

The present invention is to develop an effective method for the prevention and treatment of age-associated diseases.

The problem is solved by a new comprehensive technique, which provides effective prevention, elimination or retardation of the development of geriatric syndromes.

This comprehensive methodology includes a new combination of agents of natural origin aimed at the treatment and prevention of age-related diseases.

The technical result consists in the fact that the presented method, based on an integrated methodology, allows to comprehensively cover broadly the aspects of prevention and treatment of age-associated diseases that are aimed at improving metabolic processes, restoring the detoxifying ability of the liver, normalizing carbohydrate, lipid metabolism, restoring microbiota and villi intestines, restoration of immunity, maintaining normal homeostasis of the whole organism.

The proposed method for the prevention and treatment of age-associated conditions is characterized in that the patient undergoes ozone therapy by introducing ozone at a concentration of 1-2 mg / liter, a volume of 20-120 ml every other day or 2 times a week with a course of 3-6 procedures, then sour milk dry probiotic product 2 times a day before or during meals, for a course of 1-3 months, a week after the end of ozone therapy, carry out placental therapy with Laennec - a course of 10-12 procedures twice a week, and hepatosum is prescribed simultaneously with placental therapy n 1-2 capsules 2 times a day or Enterosan 1 capsule 3 times a day for 1-3 months.

The general algorithm for phased management of the patient:

1. Diagnostics on a portable device that determines the oxidative status of lipid peroxidation and AS.

2. Ozone No. 3-6 (every other day or 2 times a week).

3. Preparations: a multidisciplinary probiotic product after the end of ozone therapy, Hepatosan or Enterosan - 1-3 months (in combination with Laennec therapy).

4. Laennec No. 10 (beginning a week after ozone therapy). The course may be repeated.

Ozone therapy is a type of physiotherapeutic treatment involving the use of ozone gas O3, which is generated by special medical devices - ozonizers.

Ozone cleans cells from metabolites accumulated during the course of life, suppresses (reduces) viral activity, has a bactericidal and fungicidal effect, thereby allowing the body to restore its immune status and homeostasis, and stops the development of glycation processes.

Ozone restores the phospholipid membrane of the red blood cell and vascular endothelium, thereby helping to eliminate hypoxia.

Ozone reduces hemosiderosis of the skin, contributing to its lightening.

The course of ozone from 3 to 6 calculation procedures is based on the activity of the red blood cell (85-90 days). The introduction of ozone is carried out at a concentration of 1-20 mg / liter, preferably 1-2 mg / liter, with a volume of 20-120 ml every other day or 2 times a week.

For the introduction of ozone, various known methods can be used. Preferred are the following:

- on trigger zones (i.e., areas where the most intense painful muscle contractions are recorded, or at the bioactive (acupuncture) points), subcutaneous administration of an ozone concentration of 1-2 mg / liter, for example in an amount of 10-15-20 ml ( syringe volume).

- rectally at an ozone concentration of 5-10-15-20 mg / liter with a volume of 100-120 ml

- “ozone boots” (placing the arm or leg in a special sealed plastic bag-cuff) at an ozone concentration of 5-10-15 mg / liter volume until the boots are completely filled (cuff); filling time 10 minutes. The exposure time of 20-30 minutes and removal of ozone from the boots (cuff) is 10 minutes.

A second course of ozone can be prescribed after three months according to the same scheme.

After completing the course of ozone therapy, a drug is prescribed, which is a multidisciplinary probiotic product of 1 capsule or 2 tablets in the morning and evening (2 times a day) before or during meals (course 1-2-3 months). Examples of probiotic preparations include Probiologist, Acipol, Atzilact, Bifiform, Linex, Probifor, Bifidumbacterin forte, Narine, Evita, etc.

The multidisciplinary (multifunctional) probiotic product is a fermented milk dry probiotic product of a prophylactic, corrective and restorative effect.

The introduction of probiotics contributes to a prolonged weakening of the influence or complete correction of risk factors for major non-infectious diseases of the gastrointestinal tract, cardiovascular and osteoarticular systems (prevention of angiopathies, arthritis and osteoporosis). With regular or course use, the drug provides an individual dynamic balance of the microflora of the human intestine, improving the physico-dynamic parameters and conditions of intestinal activity. The preventive and corrective effects of the drug are due to the essential symbiotic bacterial composition, its biotic properties against the macroorganism. The differentiated structure of the epithelium, microbiocinosis and the necessary level of acidity and enteral pressure in the corresponding sections of the gastrointestinal tract are restored and preserved.

Indications:

- violation of the structure of intestinal microbiocinosis (during and after treatment with antibiotics and sulfonamides, chemotherapy and radiation therapy, surgical interventions on the digestive tract);

- malabsorption syndrome; digestive insufficiency syndrome; dyspepsia;

- senile intestine syndrome (chronic atrophic gastroenterocolitis);

- GI disorders associated with intoxication, food poisoning; changes in the functioning of the body associated with a change in climate and diet (fasting; fasting);

- chronic gastroenterocolitis; hypoacid and anacid conditions;

- enterogenic liver diseases, cholecystitis; pancreatitis

- convalescence after treatment of salmonellosis

According to the testimony is also prescribed:

Hepatosan 1-2 capsules 2 times a day / morning evening course 1-2-3 months.

Enterosan 1 capsule 3 times a day, course 1-2-3- months

Hepatosan - is a lyophilized mixture of donor pig hepatocytes, mainly has a regulatory and normalizing effect on liver function. Increases its regenerative and protective potential, ensuring the course of various metabolic reactions, including detoxification (https://www.vidal.ru/drugs/hepatosan_42888).

Indications:

- cirrhosis of the liver of various etiologies,

- chronic hepatopathies (hepatitis, hepatosis),

- acute and chronic liver failure,

- medicinal and alcoholic lesions of the liver,

- poisoning,

- violation of the digestive process (as part of complex therapy).

Enterosan - contains a lyophilisate of a natural mixture of frozen secretions of the stomach of birds. It has a complex effect on the digestive tract and its microflora. Restores normoflora, heals the mucous membrane and protects it from the effects of harmful substances, normalizes the processes of impaired digestion. The drug promotes the formation of the epithelial barrier, serves as a synergist for the enzyme-transport mechanism that ensures the delivery of nutrients from the intestine (https://www.vidal.ru/drugs/enterosan_16815).

A week after the end of ozone therapy, placental therapy with the Laennec drug is given, a course of 10-12 procedures twice a week. It is possible to use both intravenous drip or intramuscular injection, and in combination with a reflexotherapy effect - the introduction of trigger or biologically active points. One of the preferred options for placental therapy is the option where the patient is injected with 2-4 ml of Laennec drug at biologically active points (BAP) and 6.0 ml at 10.0 ml of Laennec drug diluted with 250-350 ml of physiological saline (0.9 % sodium chloride solution) or 5% glucose solution, intravenously drip. An additional introduction on trigger points is possible.

Laennec is a preparation based on human placenta hydrolyzate having a complex natural composition — the presence of active centers of cell growth factors and interleukins, the high bioavailability of its components determine the wide range of therapeutic effects of Laennec and the variety of therapeutic “application points”. In addition to peptides, Laenneck's ingredients are represented by groups of substances: amino acids, vitamins and micro and macro elements. The positive effects of the drug are explained not only by the synergistic effect of peptides, cytokines and amino acids, but also by the chemical activity of macro- and microelements, vitamins, it has a non-specific effect on the receptor apparatus of the cell population of the body. It restores the exchange of information between cells, helps to normalize the main metabolic pathways in the liver, skin, and the neuroendocrine system. It has powerful antioxidant, anti-inflammatory and immunomodulating effects. It is registered in the Russian Federation as a hepatoprotector and immunomodulator (RU No. 013851/01 of 10.24.2008) and is approved for use on the territory of the Russian Federation by the Ministry of Health and Social Development (http://www.rlsnet.ru/prep_index_id_83521.htm).

For many years, Laennec has been actively used by Russian doctors in various fields of clinical medicine - in gastroenterology, hepatology, immunology, gerontology, gynecology, dermatology, cosmetology, anti-age medicine, urology, etc.

• to restore liver function after specific treatment of viral hepatitis;

• for the treatment of atopic dermatitis, herpes virus infection

• in the treatment of chronic fatigue syndrome;

• to prevent aging and stimulate active longevity;

Perhaps an additional purpose of the digestive enzyme, which has a complex effect on the digestive tract and its microflora.

The product acts bacteriostatically on gram-positive microorganisms (reduces the processes of decay and fermentation). Promotes the breakdown and absorption of fats in the intestines. Adsorb microorganisms and their toxins, salts of heavy metals. Increases the protective function of the intestinal mucosa; normalizes intestinal microflora. Possessing enzymatic properties, restores impaired absorption. Contains lipoproteins, glycosaminoglycans, bile and nucleic acids, and sialomucins. (from the instructions)

Also, the effectiveness of prescribing supplements, for example, the nutritional supplement Grace Hai Japan Bio Products Co.

Purpose: Food supplement contributes to general healing, increase immunity, reduce fatigue, has a rejuvenating effect, improves skin condition

Ingredients: placenta of nigella pigs, gamma linoleic acid (borage oil of a pharmacy), vitamin E, royal jelly (amino acids, minerals, trace elements, vitamins, pheromones, etc.), beeswax.

The possibility of carrying out the invention can be demonstrated by the following examples.

Example 1

Anamnesis: hr. fatigue, sleep disturbance, herpes does not aggravate often, the menstrual cycle in time, periodically visits fitness, adheres to a balanced diet 3 times a day.

St.pr .: clean skin, physiological color, no edema, A / D 110/70 mm Hg

Subcutaneous injection of ozone 1-2 mg / liter in an amount of 10 ml 3 procedures twice a week. Probiotic Probifor 1 capsule in the morning and evening for 1 month. Enterosan drug 1 capsule 3 times a day for 1 month.

Placental Therapy Plan:

Laennec (2.0-4.0 ml) + BAP (stagnation in the tank) VB (34) + F (3) + GI (11) (2.0 ml) + iv drip Laennec 10 , 0 ml per 250.0 ml of 0.9% physical solution No. 10 twice a week. Dropper time 60-45 min

Prescribed epicrisis: recovered sleep, increased efficiency, improved general condition.

Example 2

Anamnesis: hr. fatigue, frequent flights, occasionally alcohol, often colds, fitness 2-3 times a week, varied meals, not regular

St. pr .: the skin is clean, physiological in color, no edema, A / D 120/80 mm Hg

Subcutaneous injection of ozone 1-2 mg / liter in the amount of 10 ml 3 procedures every other day. Probiotic Probifor 1 capsule in the morning and evening for 2 months. Hepatosan 1 capsule 2 times a day / morning evening course 2 months.

Placental Therapy Plan:

BAT Laennec (2.0 ml) (fever of the liver) F (3) + TR (6) + iv drip Laennec 10.0 ml per 250 ml 0.9% phys. solution, 2 times a week No. 10.

Prescribed epicrisis: increased efficiency, tolerates physical exertion, the color of the skin has improved.

Example 3

Anamnesis: XP fatigue, sleep disturbance, obesity, herpes, overload, frequent stress, timing of the menstrual cycle, a small node in the thyroid gland without changing hormonal status, does not eat regularly, varied, does not engage in sports.

St.pr .: clean skin, physiological color, no edema, A / D 120/80 mm Hg

Ozone rectally at an ozone concentration of 100 mg / liter with a volume of 100 ml

Narine 1 capsule in the morning and evening for 3 months. Hepatosan 1 capsule 2 times a day / morning evening course 2 months.

Placental Therapy Plan:

BAT Laennec (2.0 ml) (pancreatic weakness) RP (6) + E (36) + R (3) + iv drip triggers Laennec (6.0-10.0 ml) per 250 ml 0.9 % physical solution No. 10, 2 times a week

Prescribed epicrisis: recovered sleep, the last three months (after the course of treatment), there have never been colds, herpes does not worsen, her working capacity has improved, her emotional status has improved, she has begun to do gymnastics.

A repeated course of therapy after 4-6 months is recommended.

Example 4

Anamnesis: an irregular working day, frequent overloads and stresses, increased fatigue, herpes is rare, sleep disturbance, often irritated, sports regularly, eating is not regular, rational

St.pr .: the skin is clean, over the upper lip there are residual effects of herpes viral infection in the form of non-inflamed crust and hyperemic skin, physiological skin color, no edema, A / D 120/80 mm Hg

Ozone in trigger zones where painful muscle contractions are recorded subcutaneously at an ozone concentration of 2 mg / liter, 10 ml every other day after 3 treatments.

Probiotic OM-X® from Dr. OHHIRA 2 tablets in the morning and evening for 1 month. Hepatosan 1 capsule 2 times a day / morning evening course 1 month.

Placental Therapy Plan:

BAT Laennec (2.0 ml) (liver or heart fever) F (3) + TR (9) or PR (10) + GI (11), alternate No. 10 + Laennec triggers (2.0 ml) No. 5 + c / in a drop of Laennec 10.0 ml in 350 ml of 0.9% physical solution, slowly (1.5 hours) No. 2/2 times a week and then in / in a drop of Laennec (10.0 ml) per 250 ml 0.9% of the physical solution

Prescribed epicrisis: it became better to tolerate overloads, recovered sleep, herpes in the last 6 months after the course of treatment did not worsen, improved emotional status, decreased manifestations of chronic fatigue, increased performance.

A repeated course of therapy after 8-12 months is recommended.

Example 5

Anamnesis: arterial hypertension, myoma, osteochondrosis, sleep disturbance, the menstrual cycle is not changed, herpes on the lip occasionally occurs. With increased a / d, antihypertensive drugs

St.pr .: skin with areas of hyperpigmentation in the face, small swelling of the lower extremities, rosacea, gravitational ptosis, metabolic changes.

Ozone subcutaneously at an ozone concentration of 1 mg / liter, 20 ml 2 times a week No. 4.

Probiotic Maksilak 1 capsule in the morning and evening for 1 month. Hepatosan 1 capsule 2 times a day / morning evening course 1 month.

Placental Therapy Plan:

BAT Laennec (2.0 ml) (severe stagnation of “Qi” of liver and blood energy) TR (6) + F (3) + RP (6), alternate with triggers + iv infusion of Laennec 4.0-6.0 ml in 250 ml 0.9% of the physical solution No. 10/2 times a week.

Prescribed epicrisis: osteochondrosis began to bother less, pain almost disappeared, herpes did not worsen, sleep became better (practically does not wake up at night), and the emotional status improved.

A repeated course of therapy after 6 months is recommended.

Example 6

Anamnesis: non alcoholic fatty liver disease, herpes, sleep disturbance, fatigue, headache, arterial hypertension.

St.pr .: clean skin, pasty face, pallor of the skin (or hyperemia), A / D 140/90

Ozone in the form of a cuff “ozone boots” at an ozone concentration of 5 mg / liter, a volume of 120 ml until completely filled. The exposure time of 20-30 minutes and removal of ozone from the boots (cuff) is 10 minutes. 3 treatments 2 times a week.

Probiotic Probifor 1 capsule in the morning and evening for 2 months. Hepatosan 2 capsules 2 times a day / morning evening course -3 months.

Placental Therapy Plan:

Triggers Laennec 2.0 ml + BAT Laennec 2.0 ml (dampness and heat in the gall bladder and stagnation in the liver, void kidneys) VB (34) + RP (6) + R (3) or GI (11) + in / in a drop of Laennec (6.0 ml) per 350.0 ml 0.9% of the physical solution Time of a dropper 1 hour 30 minutes No. 3, 2 times a week and further in / in a drop of Laennec (6.0 ml) per 250.0 ml of 0.9% physical solution. №7 / 2 times a week

Prescribed epicrisis: by ultrasound, the liver structure improved, herpes worsened at the very beginning of treatment, headache attacks, a decrease in the manifestation of chronic fatigue decreased, performance increased, and emotional status improved.

A repeated course of therapy after 3 months is recommended.

Example 7

Anamnesis: pre / menopause, hypertension (1-2 tbsp), diabetes mellitus (type 2 or 1), herpes, fatty liver (metabolic) A / D 130/90 mm Hg Accepts antihypertensive drugs, antidiabetic (or insulin), antiplatelet agents, hormone replacement therapy, nootropics, Omega-3.

St.pr .: skin with foci of hyperpigmentation in the face and papillomas in the neck and chest, pale with rosacea, pasty face, gravitational ptosis, hernias of the lower eyelids.

Ozone in the form of a cuff “ozone boots” at an ozone concentration of 10 mg / liter, a volume of 100 ml until completely filled. 3 treatments 2 times a week.

Probiotic Probifor 1 capsule in the morning and evening for 2 months. Hepatosan 2 capsules 2 times a day / morning evening course - 2 months.

Placental Therapy Plan:

BAT Laennec (2.0 ml) (void of kidneys) GI (4) + F (3) + R (3) + triggers (new scheme), intravenous drip of Laennec (6.0-10.0 ml) is possible 2 times a day No. 10.

Prescribed epicrisis: ultrasound of the liver improved the structure, decreased face pastiness and manifestations of hyperpigmentation, compensation of carbohydrate metabolism, positive changes in the metabolic profile.

It is recommended to repeat the course after 6 months.

Example 8

Anamnesis: stenting (shunting), diabetes mellitus (type 1 or 2), overweight, sleep disturbance, fatigue, headache, hypertension (grade 1-2), metabolic syndrome, hr. prostatitis. Accepts antihypertensive drugs, antidiabetic (or insulin), anticoagulants.

St.pr .: the skin is clean, physiological color, pasty.

A / D 130/90 mm Hg

Ozone subcutaneously at an ozone concentration of 1 mg / liter, 20 ml No. 3 2 times a week. Probiotic Maksilak 1 capsule in the morning and evening for 3 months. Hepatosan 1 capsule 2 times a day / morning evening course 3 months. Supplements Grace Hai Japan Bio Products Co. 2 capsules 1 month.

Placental Therapy Plan:

BAT Laennec 2.0 ml (heart fire and weakness of the pancreas) TR (6) + RP (6), alternate with triggers + iv drip Laennec 6.0 ml - 10.0 ml per 350.0 ml 0.9 % physical solution, slowly. Dropper time 1 hour 30 minutes №10 / 2 times a week.

Prescribed epicrisis: Compensation of carbohydrate metabolism, decreased manifestation of chronic fatigue, increased working capacity, improved emotional status, recovered sleep.

It is recommended to repeat the course after 6 months.

Claims (3)

1. A method for the prevention and treatment of age-associated diseases, aimed at preventing, eliminating or slowing the development of geriatric syndromes, characterized in that the patient undergoes ozone therapy by introducing ozone at a concentration of 1-20 mg / liter, a volume of 20-120 ml every other day or 2 once a week in a course of 3-6 procedures, then a fermented milk dry probiotic product is administered 2 times a day before or during meals, in a course of 1-3 months, a week after the end of ozone therapy, placental therapy with Laennec, a course of 10 12 procedures twice a week, and simultaneously with placental therapy, hepatosan is prescribed 1-2 capsules 2 times a day or Enterosan 1 capsule 3 times a day for 1-3 months. 2. The method according to p. 1, characterized in that the ozone is administered via trigger zones or at bioactive (acupuncture) points, subcutaneously at an ozone concentration of 1-2 mg / liter in an amount of 20 ml or rectally at an ozone concentration of 5-20 mg / liter with a volume of 100-120 ml or by placing a hand or foot in an airtight plastic bag cuff at an ozone concentration of 5 mg / liter with a volume of 120 ml until the bag is completely filled at an exposure time of 20-30 minutes and the ozone is removed from the cuff for 10 minutes. 3. The method according to p. 1 or 2, characterized in that the placental therapy is carried out by introducing 2-4 ml of Laennec drug at biologically active points (BAP) and 6.0-10.0 ml of Laennec drug diluted with 250-350 ml saline (0.9% sodium chloride solution) or 5% glucose solution, intravenously.