RU2146706C1 - Моноклональное антитело, связывающееся с поверхностным антигеном вируса гепатита b, fab-фрагмент и способ снижения уровня циркулирующего поверхностного антигена вируса гепатита b у пациента - Google Patents

Моноклональное антитело, связывающееся с поверхностным антигеном вируса гепатита b, fab-фрагмент и способ снижения уровня циркулирующего поверхностного антигена вируса гепатита b у пациента Download PDF

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Publication number
RU2146706C1
RU2146706C1 RU95117092/13A RU95117092A RU2146706C1 RU 2146706 C1 RU2146706 C1 RU 2146706C1 RU 95117092/13 A RU95117092/13 A RU 95117092/13A RU 95117092 A RU95117092 A RU 95117092A RU 2146706 C1 RU2146706 C1 RU 2146706C1
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RU
Russia
Prior art keywords
hepatitis
antibody
virus
hbsag
patient
Prior art date
Application number
RU95117092/13A
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English (en)
Russian (ru)
Other versions
RU95117092A (ru
Inventor
Г.Остберг Ларс (SE)
Г.Остберг Ларс
Original Assignee
Новартис Аг
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Publication date
Application filed by Новартис Аг filed Critical Новартис Аг
Priority claimed from PCT/US1992/009749 external-priority patent/WO1994011495A1/en
Publication of RU95117092A publication Critical patent/RU95117092A/ru
Application granted granted Critical
Publication of RU2146706C1 publication Critical patent/RU2146706C1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • C07K16/082—Hepadnaviridae, e.g. hepatitis B virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G01N33/5761—Hepatitis B

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • General Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
RU95117092/13A 1992-11-06 1992-11-06 Моноклональное антитело, связывающееся с поверхностным антигеном вируса гепатита b, fab-фрагмент и способ снижения уровня циркулирующего поверхностного антигена вируса гепатита b у пациента RU2146706C1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1992/009749 WO1994011495A1 (en) 1992-11-06 1992-11-06 Production of human monoclonal antibodies active against hepatitis b surface antigen

Publications (2)

Publication Number Publication Date
RU95117092A RU95117092A (ru) 1997-03-27
RU2146706C1 true RU2146706C1 (ru) 2000-03-20

Family

ID=22231529

Family Applications (1)

Application Number Title Priority Date Filing Date
RU95117092/13A RU2146706C1 (ru) 1992-11-06 1992-11-06 Моноклональное антитело, связывающееся с поверхностным антигеном вируса гепатита b, fab-фрагмент и способ снижения уровня циркулирующего поверхностного антигена вируса гепатита b у пациента

Country Status (5)

Country Link
JP (1) JP2002502222A (ko)
KR (1) KR100281163B1 (ko)
AT (1) ATE207119T1 (ko)
DE (1) DE69232140D1 (ko)
RU (1) RU2146706C1 (ko)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2766360C2 (ru) * 2017-10-16 2022-03-15 Ф. Хоффманн-Ля Рош Аг МОЛЕКУЛЫ НУКЛЕИНОВЫХ КИСЛОТ ДЛЯ УМЕНЬШЕНИЯ УРОВНЯ мРНК PAPD5 ИЛИ PAPD7 ДЛЯ ЛЕЧЕНИЯ ИНФЕКЦИОННОГО ГЕПАТИТА В
RU2784915C2 (ru) * 2014-07-15 2022-12-01 МЕДИММЬЮН, ЭлЭлСи Нейтрализующие антитела к вирусу гриппа b и пути их применения
US11534452B2 (en) 2016-06-17 2022-12-27 Hoffmann-La Roche Inc. Nucleic acid molecules for reduction of PAPD5 or PAPD7 mRNA for treating hepatitis B infection

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6820278B2 (ja) * 2015-05-22 2021-01-27 フアフイ ヘルス リミテッドＨｕａｈｕｉ Ｈｅａｌｔｈ Ｌｔｄ． 抗Ｐｒｅ−Ｓ１ ＨＢＶ抗体
WO2019229699A1 (en) * 2018-05-31 2019-12-05 Novartis Ag Hepatitis b antibodies

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2784915C2 (ru) * 2014-07-15 2022-12-01 МЕДИММЬЮН, ЭлЭлСи Нейтрализующие антитела к вирусу гриппа b и пути их применения
US11534452B2 (en) 2016-06-17 2022-12-27 Hoffmann-La Roche Inc. Nucleic acid molecules for reduction of PAPD5 or PAPD7 mRNA for treating hepatitis B infection
RU2766360C2 (ru) * 2017-10-16 2022-03-15 Ф. Хоффманн-Ля Рош Аг МОЛЕКУЛЫ НУКЛЕИНОВЫХ КИСЛОТ ДЛЯ УМЕНЬШЕНИЯ УРОВНЯ мРНК PAPD5 ИЛИ PAPD7 ДЛЯ ЛЕЧЕНИЯ ИНФЕКЦИОННОГО ГЕПАТИТА В
US11484546B2 (en) 2017-10-16 2022-11-01 Hoffman-La Roche Inc. Nucleic acid molecule for reduction of PAPD5 and PAPD7 mRNA for treating hepatitis B infection

Also Published As

Publication number Publication date
RU95117092A (ru) 1997-03-27
KR950704478A (ko) 1995-11-20
JP2002502222A (ja) 2002-01-22
DE69232140D1 (de) 2001-11-22
ATE207119T1 (de) 2001-11-15
KR100281163B1 (ko) 2001-04-02

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20031107