RU2146706C1 - Моноклональное антитело, связывающееся с поверхностным антигеном вируса гепатита b, fab-фрагмент и способ снижения уровня циркулирующего поверхностного антигена вируса гепатита b у пациента - Google Patents

Моноклональное антитело, связывающееся с поверхностным антигеном вируса гепатита b, fab-фрагмент и способ снижения уровня циркулирующего поверхностного антигена вируса гепатита b у пациента Download PDF

Info

Publication number
RU2146706C1
RU2146706C1 RU95117092/13A RU95117092A RU2146706C1 RU 2146706 C1 RU2146706 C1 RU 2146706C1 RU 95117092/13 A RU95117092/13 A RU 95117092/13A RU 95117092 A RU95117092 A RU 95117092A RU 2146706 C1 RU2146706 C1 RU 2146706C1
Authority
RU
Russia
Prior art keywords
hepatitis
antibody
virus
hbsag
patient
Prior art date
Application number
RU95117092/13A
Other languages
English (en)
Russian (ru)
Other versions
RU95117092A (ru
Inventor
Г.Остберг Ларс (SE)
Г.Остберг Ларс
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Новартис Аг filed Critical Новартис Аг
Priority claimed from PCT/US1992/009749 external-priority patent/WO1994011495A1/en
Publication of RU95117092A publication Critical patent/RU95117092A/ru
Application granted granted Critical
Publication of RU2146706C1 publication Critical patent/RU2146706C1/ru

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • C07K16/082—Hepadnaviridae, e.g. hepatitis B virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G01N33/5761—Hepatitis B

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • General Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
RU95117092/13A 1992-11-06 1992-11-06 Моноклональное антитело, связывающееся с поверхностным антигеном вируса гепатита b, fab-фрагмент и способ снижения уровня циркулирующего поверхностного антигена вируса гепатита b у пациента RU2146706C1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1992/009749 WO1994011495A1 (en) 1992-11-06 1992-11-06 Production of human monoclonal antibodies active against hepatitis b surface antigen

Publications (2)

Publication Number Publication Date
RU95117092A RU95117092A (ru) 1997-03-27
RU2146706C1 true RU2146706C1 (ru) 2000-03-20

Family

ID=22231529

Family Applications (1)

Application Number Title Priority Date Filing Date
RU95117092/13A RU2146706C1 (ru) 1992-11-06 1992-11-06 Моноклональное антитело, связывающееся с поверхностным антигеном вируса гепатита b, fab-фрагмент и способ снижения уровня циркулирующего поверхностного антигена вируса гепатита b у пациента

Country Status (5)

Country Link
JP (1) JP2002502222A (de)
KR (1) KR100281163B1 (de)
AT (1) ATE207119T1 (de)
DE (1) DE69232140D1 (de)
RU (1) RU2146706C1 (de)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2766360C2 (ru) * 2017-10-16 2022-03-15 Ф. Хоффманн-Ля Рош Аг МОЛЕКУЛЫ НУКЛЕИНОВЫХ КИСЛОТ ДЛЯ УМЕНЬШЕНИЯ УРОВНЯ мРНК PAPD5 ИЛИ PAPD7 ДЛЯ ЛЕЧЕНИЯ ИНФЕКЦИОННОГО ГЕПАТИТА В
RU2784915C2 (ru) * 2014-07-15 2022-12-01 МЕДИММЬЮН, ЭлЭлСи Нейтрализующие антитела к вирусу гриппа b и пути их применения
US11534452B2 (en) 2016-06-17 2022-12-27 Hoffmann-La Roche Inc. Nucleic acid molecules for reduction of PAPD5 or PAPD7 mRNA for treating hepatitis B infection

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117247944A (zh) 2015-05-22 2023-12-19 华辉安健（北京）生物科技有限公司 抗前-s1 hbv抗体
JP7490574B2 (ja) * 2018-05-31 2024-05-27 ノバルティス アーゲー Ｂ型肝炎抗体

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2784915C2 (ru) * 2014-07-15 2022-12-01 МЕДИММЬЮН, ЭлЭлСи Нейтрализующие антитела к вирусу гриппа b и пути их применения
US11534452B2 (en) 2016-06-17 2022-12-27 Hoffmann-La Roche Inc. Nucleic acid molecules for reduction of PAPD5 or PAPD7 mRNA for treating hepatitis B infection
RU2766360C2 (ru) * 2017-10-16 2022-03-15 Ф. Хоффманн-Ля Рош Аг МОЛЕКУЛЫ НУКЛЕИНОВЫХ КИСЛОТ ДЛЯ УМЕНЬШЕНИЯ УРОВНЯ мРНК PAPD5 ИЛИ PAPD7 ДЛЯ ЛЕЧЕНИЯ ИНФЕКЦИОННОГО ГЕПАТИТА В
US11484546B2 (en) 2017-10-16 2022-11-01 Hoffman-La Roche Inc. Nucleic acid molecule for reduction of PAPD5 and PAPD7 mRNA for treating hepatitis B infection

Also Published As

Publication number Publication date
KR100281163B1 (ko) 2001-04-02
DE69232140D1 (de) 2001-11-22
KR950704478A (ko) 1995-11-20
RU95117092A (ru) 1997-03-27
ATE207119T1 (de) 2001-11-15
JP2002502222A (ja) 2002-01-22

Similar Documents

Publication Publication Date Title
US5648077A (en) Treatment of patients infected with hepatitis B virus with a human monoclonal antibody
AU8506991A (en) Homoconjugated immunoglobulins
JPS5929622A (ja) モノクロ−ナル抗体、その製造法およびその用途
JP2820402B2 (ja) 補体成分Ｃ５ａに対するモノクローナル抗体
US5750106A (en) Human monoclonal antibodies to cytomegalovirus
EP0158420B1 (de) Monoklonale Antikörper gegen alpha-2 Interferon und Hybridomas, die solche Antikörper produzieren
EP0050129A1 (de) Monoklonale antikörper.
RU2146706C1 (ru) Моноклональное антитело, связывающееся с поверхностным антигеном вируса гепатита b, fab-фрагмент и способ снижения уровня циркулирующего поверхностного антигена вируса гепатита b у пациента
WO1988000472A1 (en) Immunogens and improved methods of making immunogens
AU684455B2 (en) Production of human monoclonal antibodies active against hepatitis B surface antigen
JP2565303B2 (ja) 緑膿菌感染症の予防治療剤
EP0672120B1 (de) Die herstellung von menschlichen, monoklonalen antikörpern, die gegen das oberflächenantigen von hepatitis b aktiv sind
JP4880854B2 (ja) 高い免疫反応性を有するタンパク質及びその製造方法
AU662917B2 (en) Antibodies to streptolysin O derivatives and variants
JPH08510635A (ja) Ｂ型肝炎エスケープミュータント特異的結合分子
EP0205352A2 (de) Monoklonale antimenschliche IgG4-Antikörper, ihre Herstellung und Verwendung
WO1990004634A1 (en) Monoclonal antibodies against receptor-induced binding sites
AU639671B2 (en) Monoclonal antibodies against receptor-induced binding sites
JP2949291B2 (ja) グラム陰性菌感染の処置および予防用組成物ならびに方法
WO1994026784A1 (en) Composition of antibodies against hepatitis b surface antigen
Kawasaki et al. Serial study of phagocytic function in rat bovine serum albumin (BSA) nephritis.
RU2012594C1 (ru) Штамм гибридных культивируемых клеток животных mus musculus l - продуцент моноклональных антител к 146s-компоненту вируса ящура азия-1
JPH0441308B2 (de)
JPS63253098A (ja) ヒト抗体に対するモノクロ−ナル抗体、その製法及び用途
JPH01290698A (ja) 抗ストレプトリジンｏ　モノクローナル抗体

Legal Events

Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20031107