RU2139061C1 - Method of treating discirculatory encephalopathy - Google Patents

Abstract

FIELD: neurology. SUBSTANCE: when treating nervous system vascular diseases, 200 ml of physiological solution containing 4-6 mg/l ozone is intravenously administered daily for 5 days in addition to conventional therapy. EFFECT: enhanced treatment efficiency. 3 ex

Description

 The invention relates to medicine, in particular to neurology, and can be used in the treatment of vascular diseases of the nervous system.

 Discirculatory encephalopathy (DE) is a gradually progressing organic change in brain tissue due to chronic cerebral vascular insufficiency, accompanied by brain hypoxia, most often caused by atherosclerosis and hypertension.

 Known methods of treating DE, which include: medicines that improve microcirculation, trophic tissue, normalizing the activity of the cardiovascular system; antiatherosclerotic, nootropic, sedatives, vitamins; physiotherapy (baths, magnetic field, massage, etc.), exercise therapy, ИРТ, diet I I I. These methods allow you to influence the main pathogenetic mechanisms and contribute to the development of compensatory reactions, which is expressed in improving the well-being and condition of patients.

 However, therapeutic effects are more effective in the initial stages of the disease, namely, with the initial manifestations of insufficient blood supply to the brain. At later stages, as a rule, there are significant changes in the heart, blood vessels, liver, pancreas, gastrointestinal tract, which limit treatment options (a large number of contraindications, side effects and allergic reactions to medications; inability to apply active physiotherapy and exercise therapy); the need for long-term medication (2-4 months. 2-3 times a year).

 A known method of treating patients with initial manifestations of insufficiency of blood supply to the brain, which can be used to treat discirculatory encephalopathy 1 3 1. This method is selected by the authors as a prototype and is as follows. A patient with DE along with a course of traditional therapy (picamilon 0.02 g 2-3 times a day for 2 weeks, vitamins, massage, electrophoresis of nicotinic acid in the sinocarotid zone, therapeutic exercises) is given a course of hyperbaric oxygenation (HBO), placing the patient in a pressure chamber, the oxygen pressure in which is 1.2-1.25 atm. HBO course is 3 sessions. In the process of HBO, constant monitoring of the patient's condition is necessary. The introduction of oxygen into the patient’s body under pressure through the respiratory system can reduce oxygen deficiency, which is an essential component of many diseases, including vascular diseases of the brain. The use of short courses of HBO at low excess pressures is accompanied by activation of the adaptive capabilities of the body, normalization of parameters of free radical oxidation and rheological properties of blood 1 2 1.

 However, the use of the HBO method has limitations and disadvantages. Contraindications include: 1. Hypertension. 2. Drain bilateral pneumonia. 3. Pneumothorax. 4. Violations of the patency of the auditory tubes. 5. Acute respiratory infections. 6. Claustrophobia. 7. Hypersensitivity to oxygen. The patient is closed in an isolated volume and many control procedures necessary for continuous monitoring of the patient's condition are not feasible. Subjective reactions associated with HBO (tachycardia, tachypnea, arterial hypertension, discomfort) occur in 11% of all cases (5000 cases). The HBO department refers to objects of increased danger, there are: 1. danger of explosion of compressed gas; 2. risk of fire; 3. danger of electric shock to the patient. All this determines the great technical complexity and high cost of HBO installations and departments 1 3 1. In addition, the known method is not effective enough, because it does not allow to achieve a lasting effect, and with an increase in the number of sessions there is no regression of symptoms and there is an increase in products freely radical oxidation 1 2 1.

 The objectives of the proposed method are to increase the effectiveness of the treatment of this disease while expanding the indications for use, ease of implementation and its economy. The tasks are solved by a method of treating discirculatory encephalopathy, including a course of traditional therapy and introducing oxygen into the body in its most active form 1 4 1, according to the invention, oxygen is administered in the form of an ozone-oxygen mixture, by intravenous drip infusion of daily ozonized physiological solution for 5 days .

 The introduction of an ozone-oxygen mixture by intravenous drip of a daily ozonized physiological solution for 5 days, along with traditional therapy, allows to achieve persistent clinical improvement in comparison with the prototype due to the possibility of direct delivery of a more active form of oxygen into the bloodstream, more accurate dosing.

 Analysis of scientific, technical and patent information showed that the proposed method is new and meets the criterion of "inventive step".

 The proposed method is as follows: to a patient with dyscirculatory encephalopathy along with a course of traditional therapy, including: vit. column B, calcium antagonists, methionine, aminalon, potassium preparations; with indications of antihypertensive, cardiotrophic agents; Exercise therapy, magnetic field, aeroionization, diet, drop infusions of 200 ml of physiological solution containing 4-6 mg / l of ozone are administered intravenously daily for 5 days. Patients were monitored by clinical, electrophysiological, and biochemical methods. Good tolerance of this method of treatment, the absence of complications was noted.

 The proposed method was treated with a group of patients with DE of 25 people, of 9 consisted of a control group of patients with DE treated with the known method. A positive clinical effect was revealed in 21 patients (85%); the disappearance or significant reduction of headache, dizziness, ataxia, the severity of reflexes of oral automatism, anisoreflexia, previously disturbed auditory-speech memory, praxis improved. According to the REG data, at the end of treatment, vascular tone regulation was noted. Biochemical analysis showed a decrease in the primary and final lipid peroxidation products, activation of the antioxidant defense system, and normalization of lipid metabolism. In the control group, improvement was noted in 6 patients.

 Examples of specific uses of the proposed method.

 Example 1. B-th Korsukov EP, 62 years old, East. illness N 9429789. Date of admission 2.12.94, extracts 12.22.94, Diagnosis: DE II Art. with cephalgic syndrome, pyramidal insufficiency on the left and emotional-volitional disorders against the background of atherosclerosis of the cerebral, coronary vessels, hypertension II tbsp. Sick since 1982

Along with the traditional treatment, a course of drip intravenous infusions of ozonized physiological saline 200 ml daily No. 5 was carried out. Improvement of well-being, mood, gait was noted, headache decreased (from 7–2 points), anisoreflexion was smoothed. REG in dynamics - regulation of vascular tone, increase in pulse inflow in all basins. Dynamics of lipids and lipid peroxidation:
cholesterol (x) 6.4-6.0 mmol / l
triglycerides (tr) 1.2-1.0 g / l
diene conjugates (DC) of 2.62-1.11 units,
superoxide dismutase (CaD) 174.35-404.01. units

 Example 2. B. Merzlyakova EI, 65 years old, N East. illness 9412343. Date of admission 05/18/94, extracts 06/03/94, Diagnosis: DE I-II Art. with cephalgic syndrome and emotional-mnestic and atactic disorders against the background of atherosclerosis of the cerebral and coronary vessels. Sick since 1987 A history of chronic otitis media.

Conducted a course of traditional treatment and a course of intravenous drip of ozonized saline 200 ml daily N 5. There was a significant improvement in mood, memory, steady gait, headache decreased from 6 to 2 points, inconstant. REG in dynamics - normalization of previously increased tone of small vessels. Dynamics of lipids and lipid peroxidation:
cholesterol 5,4 - 5,6 mmol / l
triglycerides - 1.3 - 1.2 g / l
diene conjugates - 1.88-0.8 units.

 superoxide dismutase 171.39-217.12 units.

 Example 3. B. Akifyeva Z. V., 55 years old. Source of illness N 9425269. Date of admission 10/12/94, discharge from 2/11/94, the Diagnosis: DE I Art. with cephalgic syndrome and emotional-volitional disorders against the background of cerebral arteriosclerosis and hypertension II tbsp. Sick 4 years. A course of intravenous infusions of ozonized physiological solution of 200 ml daily No. 5 and traditional therapy.

 An improvement in well-being was noted, the headache was inconsistent, decreased from 6 to 1 point. REG in dynamics showed the regulation of vascular tone with a satisfactory influx.

the hall. - 6.6 - 5.8 mmol / l
DK. -2.97-0.21 g / l
TG. - 1.9 - 1.7 units

 SOD - 288.23-387.71 units.

 At the control examination after 2 months, positive dynamics remained.

 As can be seen from the obtained results, the proposed method for the treatment of patients with DE allows to achieve improvement in a shorter period with a more lasting effect, to avoid complications and contraindications of the known method, and also has simplicity and economy.

LITERATURE
1. Karlov V.A. Therapy of nervous diseases. M.Meditsina, 1987, p. 167-182.

 2. The prototype. Kazantseva N.V., Gusev E.I., Solovykh N.N., Voskresenskaya 0. N. Influence of various hyperbaric oxygenation regimes on the state of blood aggregation and free radical oxidation processes in patients with initial manifestations of cerebral blood supply insufficiency. Journal of Neuropathology and Psychiatry. O.S. Korsakova. M.Meditsina, 1994, vol. 94, p. 41-43.

 3. Edited by Efuni S. N. Guide to hyperbaric oxygenation. M. Medicine, 1986, p. 65, III.

 4. Rilling 3., Fiban P. The practice of ozone-oxygen therapy. Vienna, Dr. Ewald Fischer Medical Literature Publishing House, 1990, p. 18-20.

Claims (1)

 A method of treating discirculatory encepholopathy, comprising a course of conventional therapy and introducing oxygen into the body, characterized in that the oxygen is administered as an ozone-oxygen mixture by intravenous drip of 200 ml of physiological solution containing 4-6 mg / l of ozone daily for 5 days.