CN108938694A - A kind of preparation method and applications of rhizome of chuanxiong ice spray - Google Patents
A kind of preparation method and applications of rhizome of chuanxiong ice spray Download PDFInfo
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Abstract
The invention discloses a kind of preparation methods of rhizome of chuanxiong ice spray, comprising the following steps: takes Rhizoma Chuanxiong to clean, impregnates and spare by way of distillation collection distillate；The dregs of a decoction are extracted twice by decocting method and concentrate are obtained by filtration；Distillate is merged with concentrate, then by after borneol 95% ethyl alcohol dissolution, is poured into upper liquid, adding of germicide stirring, filtering, packing.It is compareed through clinical treatment, rhizome of chuanxiong ice spray total effective rate of the invention is 76.9%, obvious effective rate 66.7%, illustrates that rhizome of chuanxiong ice nasal spray treatment AIS has good curative effect, can be safely used for patient AIS.
Description
Technical field
The present invention relates to technical fields, more particularly to a kind of preparation method and applications of rhizome of chuanxiong ice spray.
Background technique
Apoplexy is to be broadly divided into ischemic and hemorrhagic because cranial vascular disease causes sudden local cerebral functional impairment
Two major classes.Ischemic mainly has thrombotic and two kinds of embolic, is caused by vasopasm or brain tumor vascular compression once in a while.Thrombus
Property for cerebrovascular wall because atherosclerotic sample variation keep lumen of vessels more and more small, it is even completely blocking；Embolic is to occur suddenly in blood vessel
One object (embolus) is stuck in the lesser blood vessel of bore with blood flow, has blocked passing through for blood.As for its sign, due to brain group
It is woven in after lacking blood flow filling, can rapidly lose its function, and generate so-called nervous centralis disease.
Acute stage, is best with combination of Chinese tradiational and Western medicine combined therapy effect, and the then Chinese medicine especially acupuncture in the treatment of convalescence
Treatment occupies highly important position, and acupuncture can significantly improve the functions such as paralyzed limbs and language, improves cure rate, is main
Treatment method.
Acupuncture and moxibustion therapy apoplexy is with a long history, takes effect original.In the classical Chinese medicine Huangdi's Internal Classics before more than 2000 years i.e.
Be expressly recited: " hemiplegia (i.e. hemiplegia), body do not have to and pain partially, and speech is constant, and will not disorderly, dividing between the natural fibre line of meat, and big needle takes by disease
It, it is insufficient for benefit, eliminating to treat the excess syndrome, and being can be again." to acupuncture and moxibustion therapy, this disease respectively has discussion, either acupoint selection to ancient Chinese medicine doctor later
Or acupuncture-moxibustion therapy method has all carried out constantly improving and improving, has had accumulated experience abundant.Modern acupuncture worker is before summary
It on the basis of people's Couple herbs, with the method for modern science, constantly brings forth new ideas, makes the effective percentage and cure rate of this disease of acupuncture and moxibustion therapy
Large increase is all obtained.Traditional acupuncture-moxibustion therapy method takes yang channel cave based on dredging the channel more, is aided with yin channel cave, centering paralysis
Most symptoms of paralysis truly have curative effect.There is needle thorn " consciousness regaining " method to be applied to the clinical treatment of apoplexy again, which is selecting recently
Cave prescription is reformed in terms of gimmick of handling the needle, and to take based on yin channel cave, supplemented by yang channel cave, the mainly improvement house of mental activity is big
The function of brain, inducing resuscitation dredging collateral.It is stung thorn acupuncture point using honeybee tailpin, fruit more more effective than simple acupuncture and moxibustion therapy.Bee needle liquid is for brain
The curative effect of apoplexy sequelae is directly related with its contained considerably complicated chemical component, and the mechanism of action is mainly these chemistry
The extensive biological action of ingredient and biology effect censure and play the result of comprehensive function.Headstroke category difficult and complicated illness, Chinese and Western are cured
Treat the drug that there is no ideal effect.Using honeybee acupuncture and moxibustion treatment, to wish to the rehabilitation of Patients with Stroke.
Acute ischemic stroke (AcuteIschemicStroke, AIS) has very high lethality in mid-aged population
And disability rate, in recent years, morbidity has rejuvenation trend again, and disease incidence gradually increases, and is to seriously affect person in middle and old age's physical and mental health
Principal disease.Currently used treatment method has supporting treatment, restores ischemic region perfusion and neurocyte protection drug therapy.
Thromboembolism treatment
(1) intravenous thrombolytic: venous thrombolysis biggest advantage be it is easy, quickly, Non-Invasive, can be shortened from
It breaks out to the time for the treatment of.The disadvantage is that having the danger of bleeding, and recanalization rate is lower, occludes again after thrombolysis.Study table
It is bright, it is effective to headstroke is improved using intravenous thrombolytic in several hours after neurologic impairment appearance, 3 after apoplectic seizure
The therapy is used in hour and when CT is normal, effect is preferable.It is generally acknowledged that thrombolysis chronotherapy window is 3~6 hours after the onset, side
Good result can be obtained.
(2) Intra-arterial Urokinase: Intra-arterial Urokinase is the result of microtubular interventional technique development, is using angiography as base
Plinth, but its major defect is to need a large amount of man power and material, and patient need to be sent to more professional medical centre immediately.Study table
Bright, Intra-arterial Urokinase interventional therapy of acute cerebral infarction is a kind of safely and effectively method, and is advocated at extreme early (6~8 hours
It is interior) thrombolysis, urokinase dosage be 500,000~700,000 units, maximum be 2,000,000 units, it is all more than 1,000,000 units i.e. have it is secondary
The danger of bleeding.
Antiplatelet drug and anticoagulant therapy
(1) aspirin: when cerebral ischemia causes cell metabolism exception, aspirin, which passes through, inhibits cyclooxygenase-2 activity,
Oxidation effect can be effectively reduced, have the function of removing free radical, may also suppress amino acid metabolism and inhibit the generation of free radical.
Researches show that ischemia apoplexy patient's early application aspirin (160 mg/day) can improve prognosis, reduce recurrence, and not
Increase the incidence intracranialed hemorrhage.
(2) heparin anticoagulant therapy: heparin is divided into unfractionated heparin and low molecular weight heparin.The latter is due to its validity and peace
Full property is widely used in various arteriovenous thrombotic diseases compared with the former height.Low molecular weight heparin is effective in early stage, uses
Smaller dose can reduce the generation intracranialed hemorrhage.
Neuroprotective Therapy in Treating Acute
(1) calcium channel blocker: using Nimodipine as representative.Researches show that start to give in morbidity 12~18 hours
60~120 mg/day person of Nimodipine has significant curative effect, and because flow of calcium ions occurs early stage cerebral ischemia, therefore calcium channel hinders
Stagnant dose of application should also have certain stringent time restriction.
(2) glutamate release inhibitor: can prevent glutamic neuron or block its receptor acting makees with neuroprotection
With.Lubeluzole can fight and reverse neuronal programmed cell caused by nitric oxide dead.
(3) citicoline: energy stabilizing cell membrane reduces the generation of free radical, mitigates cerebral ischemia damage.
(4) free radical scavenger: oxygen radical revascularization ischemic region, Reperfu- sion antioxygen chemoprevention after spontaneous or treatment
Brain cell is damaged when imperial insufficient.Free radical scavenger has superoxide dismutase, catalase, vitamin E.
(5) lidocaine: research shows that lidocaine is to the improvement of ischemic, anoxic brain function and brain cell structure and life
Reason aspect has protective effect, and low dose of lidocaine can improve brain regional blood flow, can block calcium ion, in sodium ion
Stream improves intracellular Potassium Level, saves atriphos, removes the free radical because generating after cerebral ischemia, avoids to brain group
The damage knitted.
(6) low-temperature protection ischemic brain damage: headstroke companion body temperature increases (37.5 degrees Celsius or more) person's poor prognosis,
Maintained in a couple of days after apoplexy body temperature in the normal range (NR) (36.7~37 degrees Celsius) of safety be it is beneficial, intracranial pressure can be reduced, changed
Kind prognosis, and without serious adverse reaction.
(7) Microdialysis Technique cerebral ischemia treatment in application: by microdialysis pop one's head in implantation intracerebral specific region, at
Classification is similar to the solution Continuous Perfusion of brain tissue cell external solution, when the concentration of Cucumber is when the side of dialysis membrane is higher, just
Dialysis tubing can be penetrated into or flow out along concentration gradient, to remove the substances such as the amino acid injection-800 after cerebral ischemia, cerebral infarction to brain group
The damage knitted.
Endovascular treatment technology
The development of endovascular treatment technology provides good means, method to carotid artery stenosis and middle cerebral artery stenosis in Chinese
Mainly there are simple Balloon Angioplasty and stented vessel Transluminal Angioplasty.The purpose of angiopoiesis be in order to it is pre- it is anti-stroke reaccess,
Major complications are interlayer, angiorrhoxis, distal vessels embolism, vasopasm and Delayed onset occlusion etc., and post surgery treatment is quite heavy
It wants；Long-term anticoagulant therapy is required after simple balloon expandable, but bracket merging needs Antiplatelet therapy；Acute cerebral infarction row intra-arterial
Thrombosis, still it is contemplated that using Advance of Intravascular Stent in Treating, is expected to improve after carrying out balloon expandable failure again after local thrombolysis
Nervous function.Vein culture relative noninvasive, wide indications, effect is good, with the continuous development of bracket and Transfer Technology,
This technology can be made to be used widely.
Five, surgical operation therapy
(1) carotid endarterectomy and intracranial embolectomy: carotid endarterectomy treats carotid artery stenosis can
To reduce the incidence of symptom carotid artery stenosis headstroke.Research thinks that early operation has satisfied result, can at least prevent
Infarct expands, and especially to Serious Stenosis patient, early operation row peri-operation period Hemodynamics monitoring simultaneously can be to avoid morning
Phase recurrent apoplexy, to the internal carotid lesion of some proximal end embolisms, if chronic obstruction or Serious Stenosis are with intracavitary thrombus, inner membrance
Resection is only selection for restoring perfusion；It is also most widely used hand that arteria cerebri media embolectomy, which is most common,
Art, it is easy to cut off biggish pillar, and blood flow reconstruction only needs 1-2 hours, but certain entire middle cerebral arterials of filling is big
After the failure of embolus row Intra-arterial Urokinase again row embolectomy when, then need slightly to go for a long time to restore Reperfu- sion.
(2) decompressive craniectomy: the case fatality rate of massive cerebral infarction, severe disability rate are high, and customary medical treatment is past
Toward invalid, timely row decompression operation, then becomes " help " property and perform the operation, can not only save life, and reduce brain infarction area, change
Kind nervous function.At present, decompressive craniectomy for treating widespread pole cerebral infarction obtains certain effect.Take inside and outside decompression
Art gives treatment to large area dome-type cerebral infarction, and effect is preferable, is substantially reduced massive cerebral infarction case fatality rate, reduces function to the maximum extent
Energy obstacle, to improve quality of life of patients.
Summary of the invention
Technical problems based on background technology, the invention proposes a kind of rhizome of chuanxiong ice sprays, and it is anxious to be mainly used for treatment
Property ishemic stroke.According to clinical verification, preferable therapeutic effect is obtained to treatment AIS.
Technical scheme is as follows:
A kind of preparation method of rhizome of chuanxiong ice spray, comprising the following steps:
A, Rhizoma Chuanxiong is taken to clean, warm water impregnates 30-60 minutes, and it is spare to collect distillate by the way of distillation；
B, the dregs of a decoction are extracted twice by decocting method, 25-35 minutes each, merge 2 filtrate filterings, and filtrate concentration is added
95% ethanol precipitation.Refrigeration 20-30 hours, by filtering twice, obtains concentrate；
C, distillate is merged with concentrate, then by after borneol 95% ethyl alcohol dissolution, poured into upper liquid, adding of germicide stirs
It mixes, filter, dispense.
Preferably, in the step A, the collection concentration of distillate is 40-60ml/kg.
Preferably, in the step B, the collection concentration of concentrate is 10-20ml/kg.
Preferably, in the step C, the fungicide is surfactant-based wide-spectrum bactericide.
Preferably, in the step C, the fungicide is bromogeramine (benzalkonium bromide).
Preferably, in the rhizome of chuanxiong ice spray, the mass ratio of Rhizoma Chuanxiong and borneol is (120-180): 1.
Preferably, in the rhizome of chuanxiong ice spray, the mass ratio of Rhizoma Chuanxiong and borneol is 150:1.
According to the research of modern medicine, the mechanism of action of rhizome of chuanxiong ice aerosol therapy cerebral ischemia Super acute reperfusion injury is such as
Under:
(1) anti-oxidant, mitigate damage of the free radical to brain cell
During neonatal hypoxia ischemia, will lead to oxygen radical, the generation of per-compound increases, cytotoxicity directly or
The damage to cell is promoted indirectly, permeability of cell membranes, receptor active and configuration can be changed in lipid peroxide (Lpo),
And then changing the integrality of film, free radical derived from oxygen mainly leads to tissue damage by peroxidatic reaction of lipid, makes cell
Cerebrovascular endothelial cell is damaged because of intracellular membranes dysequilibrium, cellular swelling rupture.MDA is lipid peroxide (LPO)
Dead end product, level of lipid peroxidation and free radical can be reflected to the degree to brain tissue impairment by measuring its content, and SOD can be urged
Superoxides, GSH-PX can make lipid peroxide change Viability lower substance, and the two is intracellular anti-lipid peroxy
The enzyme of change effect protects system.Experimental result shows that rhizome of chuanxiong ice spray can significantly reduce brain homogenate and Content of MDA, rises
High GSH-px level and SOD activity, each dosage group all has very significant meaning (P < 0.01) compared with physiological saline group, mentions
Show that rhizome of chuanxiong ice spray can be by anti-oxidant, damage of the elimination free radical to brain cell, and reach cerebral protection.
(2) inhibit inflammatory factor expression, mitigate cytotoxic effect, improve cerebral anoxia tolerance
Tumor necrosis factor-alpha (tumor necrosis factor- α, TNF-α) is a kind of with extensive biology work
Cell factor participates in the immune response and inflammatory reaction of body.After cerebral ischemia, the expression of intracerebral TNF-α increases sharply, office
The expression of TNF-α mRNA just can be observed in 1 hour cortex after stove cerebral ischemia, reaches peak within 12 hours, is continued for after 5 days.
Lavine et al. discovery can make cortical infarction area after ischemic reduce 71% using anti-TNF-α antibody, and infarct size subtracts under cortex
Few 58%.The expression of TNF-α participates in the pathologic process of tissue damage after cerebral ischemia.It can activate polymorphonuclear leukocyte, increase white
The expression of cell-Adhesion Molecules on Endothelial Cells, promotes leukocyte in capillary, gradually penetrates into brain tissue；Promote
The release of the cell factors such as IL-1 (interleukin 1), IL-6 plays collaboration inflammatory effect；There is direct poison to capillary
Property effect, lead to arteriolar spasm, increase capillary permeability, damage blood-brain barrier；It is living that inducing endothelial cell generates blood coagulation
Property, TXA2 increases, and inhibits endothelial cell anticoagulant protein C by-path factor activity, and promote endothelial cell surface to be formed and promotees solidifying state,
Aggravate thrombosis.Separately some researches show that, Acute Cerebral Infarctions and convalescence TNF-α level and IR (insulin resistance) close phase
It closes, and IR and hypertension, high TG, high apolipoprotein B and low HDL mass formed by blood stasis and plasminogen activator inhibitor (PAI-1) are living
Property to increase equal risk factors of cerebrovascular diseases closely related, therefore it is horizontal to reduce TNF-α, can improve insulin sensitivity, reduce brain blood
Pipe risk factor, this will provide a new approach for the prevention and treatment of cerebral infarction.
Interleukin-1 ' beta ' (Interleukin-1 β, IL-1 β).IL-1 β often has in blood circulation, ischemic 6
Hour cortex, shell core, visible IL-1 β protein expression at corpus callosum, ischemic 24~48 hours, immuning positive cell was a large amount of
Increase, is distributed more extensive, the visible a large amount of microglia infiltrations in infarcted region.Yamaskaki etc. is reported, after rat cerebral ischemia,
The exogenous IL-1 β neutralizing antibody of intracerebral injection and IL-1 beta-blocker protoporphyrin zinc (ZnPP) can block IL-1 β to ischemic region
The damage of cranial nerve cell mitigates brain edema, reduces brain infarction area, reduces infarcted region leukocyte infiltration.IL-1 β makes phosphatide
Enzyme increases, and membrane phospholipid excessive degradation directly causes cell membrane damage, while increasing excitatory amino acid, nitric oxide and freedom
The release and generation of the neurotoxic substances such as base[112].This experiment discovery rhizome of chuanxiong ice spray can significantly reduce Serum TNF-α and IL-1 β contains
Amount illustrates rhizome of chuanxiong ice spray by the expression of inhibition Serum TNF-α and IL-1 β, mitigates inflammatory reaction and cytotoxic effect,
Protect cerebral ischemia re-pouring injured brain tissue and cell.
(3) expression of induction brain Protecting gene and HSP70 synthesis, inhibit Apoptosis, fight cerebral injury
HSP70 (heat shock protein 70) major function is the correct position for promoting to maintain nascent polypeptide, and adjusts cell
Growth, development, differentiation, death, while be immune system identification major antigen, antigen processing, processing and presentation with
And key player is play in the activation of effector T cell.Recent studies suggest that high fever and ischemic can induce brain cell synthesis
The protein of heat shock protein (HSP) or stress protein, while also obtaining an of short duration resistance to then damaging.Li Yuan etc.
Result of study shows that HSP70 expression is the impaired index of reliable cerebral ischemia, though the time of each report HSP70 expression is different,
The intrinsic HSP70 expression of the necrosis region in ischemic artery blood supply region is consistent, and (Dienel reports ischemic 30min, Reperfu- sion 3h skin
Layer has HSP70 synthesis；Kinonchi report ischemic 4h has no that HSP70 is expressed, and the focus of infarct peripheral nerve in continuous ischemic for 24 hours
Visible HSP70 expression in cell).This experiment discovery, rat cerebral ischemia Reperfu- sion 24 hours 1 hour, is perfused, brain is cut through left ventricle
Cerebral cortex HSP70 positive cell can be observed in mottled distribution in piece immunohistochemical method, and the expression of rhizome of chuanxiong ice spray group is outstanding
It is obvious, there is highly significant difference (P < 0.01) compared with physiological saline group, illustrates that rhizome of chuanxiong ice spray can be by induction brain protection
The expression of gene, the synthesis of protected protein HSP70 reduce non-viable non-apoptotic cell to inhibit Apoptosis, mitigate cerebral ischemia re-pouring
Damage.
(4) to the influence of the line brush office property made cerebral ischemic model murine brain and Infarction volume
The mechanism of cranial nerve tissue damage caused by hypoxic-ischemic is not still fully aware of, mainly there is following three kinds at present
View: the toxic effect of excitatory amino acid；Free radical generates damage caused by the attack increased and intracellular calcium overload.
Research in recent years prompt, in hypoxic-ischemic, calcium overload plays key effect to the damage of nerve fiber.Histopathology slice
The results show that rhizome of chuanxiong ice spray group can reduce the pyknosis denaturation of brain edema, meronecrosis and nerve cell, partial nerve is only seen
The pyknosis of cell is denaturalized, the visible obvious encephalomalacia of physiological saline group, and edema necrosis becomes in vacuole sample.Illustrate rhizome of chuanxiong ice
Spray learns meaning for mitigating cerebral injury in a organized way.Ischemia Time to TTC dyeing observation after 2 hours, Reperfu- sion 24 hours is sent out
Existing: high, medium and low dosage group and physiological saline group comparing difference are very significant (P < 0.01), high, middle dose group and Buddhist nun
Logical group compares that there was no significant difference (P > 0.05), reflects that a certain amount imitates relationship.As a result it is prompted from tectology angle,
Rhizome of chuanxiong ice spray can mitigate the damage of cortex nerve fiber, have to the ischemical reperfusion injury of brain tissue bright
Aobvious protective effect.
Chinese medicine treats AIS theoretical foundation to nasal-cavity administration
Middle medical official's key-internal organs are theoretical: the defeated cloth and adjustment effect of nose and internal organs
Motherland's medicine thinks that human body is one centered on the five internal organs, by channel system six internal organs, extraordinary Fu-organ, face
The organic whole that nine orifices, four limbs bones of the body collectively connect.It is indivisible in structure between each component part for constituting human body
, functionally refinforce each other, is interactional on the interpretation of the cause, onset and process of an illness.Nose is one of official's key of human body, is located at head and hits exactly,
It is in close relations with cardiopulmonary.The main department's breathing of nose and smell.For official's key of lung, " the deficient the truth opinion of Plain Questions gold " speech: " west redness of the skin or complexion, enters
Lung is passed through, is had one's ideas straightened out in nose "." Plain Questions the five internal organs another matter " speech: " five gas enter nose, are hidden in cardiopulmonary, above make complexion being bright and lustrous, speech energy
It is evident ", " five gas enter nose, are hidden in cardiopulmonary, and cardiopulmonary are ill, and nose is unfavorable for it ".Illustrate no matter under physiology or pathologic condition nose
It is closely bound up with cardiopulmonary, and the heart being a vital viscus like a king of the body, main gods, controlling blood and vessel: lung is mutually auxiliary official, section is cured mainly towards hundred arteries and veins, main gas,
Main a surname's drop, main regulating fluid apssage: drug enters nose, just reachable complete to the defeated cloth of qi-blood-body fluid, operation and whole and effect by cardiopulmonary
Body and play first aid and treat systemic disease purpose." sore pandect " is said: " nose is the blood fortune of the whole body in face, and nostril
To pass through brain on its gas of the key of lung, downlink is in lung ", further illustrate the feasibility of intranasal treatment cranial vascular disease.
Middle medical official's key-meridian theory: the conduction and corrective action of nose and channels and collaterals
Channels and collaterals are the channels of human body operation qi and blood.It is the unique system linked up above and below inside and outside, belongs to internal organs in it, outside
Network plays very important effect in podomere in terms of the physiology of people, pathology and disease preventing and treating.On the one hand, nose is being located at head just
In, and " all YANG-meridians meeting into the head ", all yang channels of whole body all in head, the yin channel of whole body is together in yang channel in addition, yang channel together in
This warp, so nose is communicated with whole body passages through which vital energy circulates.On the other hand, nose is located at head center, precisely conception vessel and governor vessel handover place, and
Conception vessel always appoints the yin channel of whole body, the yang channel of governor vessel governor's whole body, so nose is also communicated with whole body passages through which vital energy circulates.As described in Miraculous Pivot:
" twelve regular channels, 365 networks, qi and blood all on to walk in its pectoral qi of sky key ... ... in face for nose be smelly ".It is thousands of
Oneself demonstrates " nose leads to the twelve regular channels and the vital organs of the human body " indisputablely for the clinical practice in year, and " passages through which vital energy circulates leads to, and cures mainly in one's power ",
Therefore pass through the conduction and corrective action of channels and collaterals, nasal-cavity administration can treat the various diseases of whole body, provide heavily fortified point for clinical treatment AIS
Real science of channels and collaterals foundation.
The main seven apertures of brain are theoretical:
The main seven apertures of brain, the seven apertures rely brain mind to dominate.Although all keys of the eye of people, ear, nose, tongue respectively have internal organs to be led, but it is total
It unites in brain, as the source Ming Dynasty Wang Hui is said in " medicine is original ": " all over the body, the five internal organs are hidden in body people, only to grow it
Tool；It is the tool of consciousness with face occupy；Knowledge mouth and nose gather in head, most aobvious highest, make in connecing object；The institute of knowledge mouth and nose imports
It is most bordering on brain, it must be with brain first by it as and feeling it, and post it, and depositing." function of the seven apertures how is specifically dominated as brain mind
Can, motherland's medicine, which has had long been known that, to be played a decisive role by nerve, as Zhao Yan sunshine is in " depositing vegetarian medical notes ligusticumic " middle finger
" the gas that brain dissipates kinaesthesia faints used in muscle ..., and muscle is even from the brain person of going out six out；Only one occasionally exceedes under neck to chest, hangs down before appetite, remaining know is deposited
In top, air guide is dynamic in face, or order, or the feel of order." and nose is one of seven apertures, therefore the main nose key of brain, nose key rely brain mind to prop up
Match.Wang Qingren is thought: " nose passes through brain, and what is heard is good and foul smells to be attributed to brain ".Famous doctor Zhang Jiegu also Zeng Yun: " audiovisual is bright and refrigerant, fragrant
Smelly distinguish and it is warm, in this by gas of brain outer sharp nine orifices." illustrating the energy view of mesh, it is all that brain plays a leading role that nose, which can be smelt,
Result.Just due to the main nose key of brain, so disease often influences nose, such as " Plain Questions lose consciousness opinion " is pointed out: " the gallbladder transferring pathogenic heat to the brain, then
Xin Junction-of-nose-and-forehead nasosinusitis ".Illustrate that nose is closely bound up with brain, and the brain being the house of mentality no matter under physiology or pathologic condition, be human body most
Height is dominated, main house mind, all minds of uniting, director's object, main regulation, takes charge of thinking, is taken charge of shrewd [5].Drug is received after nose through nose-muscle-brain
Approach acts on brain mind, and achievees the purpose that treat AIS by the adjustment effect of brain mind.
Beneficial effects of the present invention are as follows:
Nasal-cavity administration is a kind of administration route of Chinese medicine interior disease external therapy, and according to ancients, " nose is lung cavity, is passed through on gas
Brain, downlink is in lung ", " nose passes through brain ", " the main seven apertures of brain ", " logical 12 warp of nose and the vital organs of the human body " and " passages through which vital energy circulates leads to, and cures mainly institute
And " scheduling theory, the uplink head logical using the pungent scattered temperature of Rhizoma Chuanxiong, can invigorate blood circulation but also promoting the circulation of qi has to invigorate blood circulation and go for the gas medicine in blood
The function of gas, wind-expelling pain-stopping.Shennong's Herbal calls its " firmly apoplexy enters brain, headache "；Borneol is pungent, bitter, slightly cold, and fragrance is walked to alter, tool
There is the benefits of analepsia inducing resuscitation of having one's ideas straightened out, priming uplink.Compendium of Material Medica meaning " all keys can be led to " " Bencao Jingshu " carry " property is apt to walk to alter out
Key ".Two medicines share, then bring out the best in each other, and qi and blood plays the effect of promoting blood circulation qi-regulating, disperse blood stasis and dredge collateral, consciousness regaining with controlling altogether.
It is compareed through clinical treatment, treatment group's total effective rate is 76.9%, obvious effective rate 66.7%, and control group total effective rate is
78.9%, obvious effective rate 67.9%, above-mentioned curative effect only carries out clinical evaluation in acute cerebral ischemic stroke two weeks, illustrates rhizome of chuanxiong
Ice nasal spray treatment AIS has good curative effect, can be safely used for patient AIS.
Specific embodiment
Embodiment 1:
A kind of preparation method of rhizome of chuanxiong ice spray, comprising the following steps:
A, 15kg Rhizoma Chuanxiong is taken to clean, warm water impregnates 40 minutes, and it is spare to collect distillate 800ml by the way of distillation；
B, the dregs of a decoction are extracted twice by decocting method, 30 minutes every time, merge 2 filtrate filterings, filtrate is concentrated into 200ml, adds
Enter 3 times of 95% ethanol precipitations of amount.Refrigeration 24 hours, by filtering twice, obtains concentrate 200ml；
C, distillate is merged with concentrate, then by after the 95% ethyl alcohol dissolution of 10g borneol, pours into upper liquid, add new clean
You go out stirring, filtering, packing.
Embodiment 2:
A kind of preparation method of rhizome of chuanxiong ice spray, comprising the following steps:
A, 12kg Rhizoma Chuanxiong is taken to clean, warm water impregnates 30 minutes, and it is spare to collect distillate 800ml by the way of distillation；
B, the dregs of a decoction are extracted twice by decocting method, 30 minutes every time, merge 2 filtrate filterings, filtrate is concentrated into 240ml, adds
Enter 3 times of 95% ethanol precipitations of amount.Refrigeration 30 hours, by filtering twice, obtains concentrate 240ml；
C, distillate is merged with concentrate, then by after the 95% ethyl alcohol dissolution of 10g borneol, pours into upper liquid, add new clean
You go out stirring, filtering, packing.
Embodiment 3:
A kind of preparation method of rhizome of chuanxiong ice spray, comprising the following steps:
A, 18kg Rhizoma Chuanxiong is taken to clean, warm water impregnates 60 minutes, and it is spare to collect distillate 1000ml by the way of distillation；
B, the dregs of a decoction are extracted twice by decocting method, 30 minutes every time, merge 2 filtrate filterings, filtrate is concentrated into 220ml, adds
Enter 3 times of 95% ethanol precipitations of amount.Refrigeration 20 hours, by filtering twice, obtains concentrate 220ml；
C, distillate is merged with concentrate, then by after the 95% ethyl alcohol dissolution of 10g borneol, pours into upper liquid, add new clean
You go out stirring, filtering, packing.
Rhizome of chuanxiong ice spray of the invention is through detecting, pH 2.0-3.5:
Clinical application
1, case source: in July, 2002 to during in March, 2004, one internal medicine of The First Affiliated Hospital of Guangzhou University of Traditional Chinese Med
Ward inpatient.61 AIS patients are collected altogether.All cases are diagnosed as AIS patient through head CT or MRI inspection.Wherein 1
Example exits observation because serious pulmonary infection occurs during observation, and 1 is acutely coughed after spraying nose and is discontinued, and sight is exited
It examines, another 1 midway stops observing due to fever suspects and transfers emergency treatment attention to atypical pneumonia under observation.Therefore practical to see
Examine case 58.
2, diagnostic criteria: using the Ministry of Public Health's in October, 1993 promulgate " new Chinese medicine treatment apoplexy soldier clinical research refer to
Lead principle " in the diagnostic criteria recommended.
3, it is included in standard: (1) meeting the diagnostic criteria of apoplexy in Chinese medicine diagnostic criteria and doctor trained in Western medicine ischemic cerebrovascular disease.
(2) morbidity is in 72 hours.
3, it exclusion criteria: (1) does not meet diagnostic criteria and is included in standard person；(2) transient ischemic attack (TIA) patient；
(3) it confirms on inspection by brain tumor, brain trauma, cerebral parasitic disease, dysbolism, rheumatic heart disease, coronary heart disease and other hearts
Popular name for merges atrial fibrillation, causes cerebral embolism person；(4) 75 years old or more person；(5) gestation or breast feeding women；(6) those who are allergic to this drug.
(7) it is associated with the severe primaries disease patient such as liver, kidney, hemopoietic system and endocrine system；(8) mental patient；(9) serious
Complication (such as serious brain edema deep coma person, severe infections, massive bleeding from upper digestive tract；(10) patient dependence is poor, not by regulation
Medication or treatment is not congruent affects the treatment or safety judgement person；(11) thromboembolism treatment in window has been received when being admitted to hospital, may influence
The patient of effect index.
4. therapeutic scheme:
A group: rhizome of chuanxiong ice spray prepared by embodiment 1, usage: bilateral nasal cavity, Qid are sprayed in every 3 spray of side nostril spray every time.
It Nimotop tablet 1, takes orally, Tid.
B group: rhizome of chuanxiong ice spray prepared by embodiment 1, usage: with No. I.
Nimotop tablet, takes orally, Tid by 1.
Two groups are observed 2 weeks.Two groups of patients of traditional Chinese herbal decoction are with awake side's (malt 30g, the rice sprout 30g, Magnoliaceae 30g) water of brain
Decoction, day are one.
5. treatment group (is shown in Table 1) compared with control group curative effect.
Table 1: treatment group is compared with control group curative effect
| Group | n | It is almost recovered | It is effective | Effectively | In vain | Total effective rate | Obvious effective rate |
| Treatment group | 39 | 8 (20.5%) | 18 (46.2%) | 4 (10.3%) | 9 (23.1%) | 76.9% | 66.7% |
| Control group | 19 | 2 (10.5%) | 9 (47.4%) | 4 (21.1%) | 4 (21.1%) | 78.9% | 67.9% |
Note:
(1) statistical method: two groups of total effective rates and obvious effective rate compare, and are examined with X2, and wherein obvious effective rate includes being almost recovered
With effective two parts.
(2) result and meaning: p > 0.05.Illustrate that the clinical efficacy comparison for the treatment of group and control group is not statistically significant, treats
Effect is suitable.This shows that rhizome of chuanxiong ice spray is equal to Nimotop to the effect of ischemia apoplexy.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto,
Anyone skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its
Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.
Claims (8)
1. a kind of preparation method of rhizome of chuanxiong ice spray, which comprises the following steps:
A, Rhizoma Chuanxiong is taken to clean, warm water impregnates 30-60 minutes, and it is spare to collect distillate by the way of distillation；
B, the dregs of a decoction are extracted twice by decocting method, 25-35 minutes each, merge 2 filtrate filterings, and 95% second is added in filtrate concentration
Alcohol precipitating, refrigerates 20-30 hours, by filtering twice, obtains concentrate；
C, distillate is merged to obtain Rhizoma Chuanxiong extracting solution with concentrate, then by after borneol 95% ethyl alcohol dissolution, poured into upper liquid,
Rhizome of chuanxiong ice spray can be obtained in adding of germicide stirring, filtering, packing.
2. a kind of preparation method of rhizome of chuanxiong ice spray as described in claim 1, which is characterized in that in the step A, distillation
The collection concentration of liquid is 40-60ml/kg.
3. a kind of preparation method of rhizome of chuanxiong ice spray as described in claim 1, which is characterized in that in the step B, concentration
The collection concentration of liquid is 10-20ml/kg.
4. a kind of preparation method of rhizome of chuanxiong ice spray as described in claim 1, which is characterized in that described in the step C
Fungicide be surfactant-based wide-spectrum bactericide.
5. a kind of preparation method of rhizome of chuanxiong ice spray as claimed in claim 4, which is characterized in that described in the step C
Fungicide be bromogeramine.
6. a kind of preparation method of rhizome of chuanxiong ice spray as described in claim 1, which is characterized in that the rhizome of chuanxiong ice spray
In, the mass ratio of Rhizoma Chuanxiong and borneol is (120-180): 1.
7. a kind of preparation method of rhizome of chuanxiong ice spray as claimed in claim 6, which is characterized in that the rhizome of chuanxiong ice spray
In, the mass ratio of Rhizoma Chuanxiong and borneol is 150:1.
8. a kind of preparation method of rhizome of chuanxiong ice spray as described in claim 1, which is characterized in that prepared rhizome of chuanxiong ice spray
Applied to treatment acute ischemic stroke.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111000886A (en) * | 2020-01-06 | 2020-04-14 | 南京中医药大学 | Pharmaceutical composition for treating cerebral arterial thrombosis and application thereof |
| CN115569155A (en) * | 2022-09-22 | 2023-01-06 | 西南医科大学附属中医医院 | Traditional Chinese medicine nasal paste for inducing resuscitation and preparation method thereof |
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| CN111000886A (en) * | 2020-01-06 | 2020-04-14 | 南京中医药大学 | Pharmaceutical composition for treating cerebral arterial thrombosis and application thereof |
| CN115569155A (en) * | 2022-09-22 | 2023-01-06 | 西南医科大学附属中医医院 | Traditional Chinese medicine nasal paste for inducing resuscitation and preparation method thereof |
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Application publication date: 20181207 |