RU2502513C2 - Method of treating patients with multiple organ pathology using ozone therapy - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely therapy, and concerns treating the patients suffering the multiple organ pathology using ozone therapy. That is ensured by the intravenous introducing of ozonised saline 200 ml at 10-15 ml/min for 15-20 min into the patient with the inactive disease. The adult patients require the ozone therapy to be performed daily in the form of 6 sessions with the saline ozone concentration of 0.15 mg/l, while the ozone therapy in the elderly and senile patients is performed every second day in the form of 10 sessions with the saline ozone concentration of 0.10 mg/l.

EFFECT: method provides the effective and safe treatment of the multiple organ pathology ensured by the low saline ozone concentration, providing the absence of hemolysis, and by choosing the mode and ozone concentration optimal for the various age groups.

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Description

The invention relates to medicine, in particular to non-drug types of treatment, and can be used in therapy and neurology.

The problem of aging of the human body is attracting more and more attention of scientists from different fields of medical science in view of its growing relevance. Many factors lead to acceleration of the natural aging process of the body, including physical and mental injuries sustained by people participating in hostilities.

An increasingly widely introduced method of treating patients with ozone - ozone therapy - is based on the introduction of active oxygen forms into the human body. This treatment method allows to enrich tissues with oxygen, improve blood rheology and tissue microcirculation; intensify the utilization of glucose and fatty acids in the liver, increase the synthesis of adenosine triphosphate. One of the mechanisms of the therapeutic effect of ozone is the optimization of pro- and antioxidant systems of the body, implemented through normalization of the balance of the level of products of lipid peroxidation and the antioxidant enzymatic defense system. Based on the determination of the activity of lipid peroxidation processes and the antioxidant system, ozone concentrations for various pathological conditions were selected and substantiated, in particular in dermatology and cosmetology, obstetrics, neurology, and oncology. The possible dose of introduced ozone is determined by the power of the antioxidant defense system of the body. The chemiluscence method in the works of other scientists was previously used as a safety criterion for ozone therapy (Kontorshchikova K.N. Lipid peroxidation in the correction of hypoxic conditions by physicochemical factors. Abstract of thesis, Doctor of Biology, Sciences, St. Petersburg, 1992, 30 sec. .).

Known treatment with ozone in cosmetology and dermatology (I.V. Koshelev, OL L. Ivanov, V.A. Vissarionov, etc. The use of oxygen-ozone mixtures in dermatology and cosmetology, guidelines 2003/84, J. “Experimental and clinical Dermatocosmetology ”, Moscow, 2004, No. 1, p.29-38). The proposed method consists in the introduction of an oxygen-ozone gas mixture (medical ozone) with different concentrations of ozone obtained at a special medical ozonizer installation approved for use by the Ministry of Health of the Russian Federation (UOTA-60-01 "Medozon"). In this installation, the oxygen-ozone mixture is obtained in a gas-discharge plasma by passing medical oxygen through the discharge chamber.

An oxygen-ozone mixture with a concentration of ozone in the gas of 40-80 mg / L is passed through a sterile physiological solution in an amount of 200-400 ml until the concentration of ozone in the liquid is 1-4 mg / L, after which it is administered intravenously to the patient at a rate of 3- 7 ml per minute. The ozone in the solution decays rather quickly, therefore, the ozonation of the physical solution is carried out immediately before administration to the patient.

This method is not safe enough due to its high concentration and has a limited scope.

There is also a methodology for the effect of ozone therapy in acute and chronic cholecystitis (Journal of Biochemistry, "Indicators of antioxidant protection in acute and chronic cholecystitis, 2008, pp. 41-43). The essence of the technique is as follows: during the first 5 days of the postoperative period, 200 ml of an ozonized 0.9% sodium chloride solution with an ozone content of 2 mg / l is administered intravenously.

This method is also not safe enough, due to its high concentration and has a limited scope.

The closest technical solution is the use of ozone in neurology (Manual for doctors "Basic principles and tactics of ozone therapy", Moscow, 2003, p.12-13). The bottom line is the intravenous administration of 200-400 ml of ozone saline solution at an ozone concentration of 1-4 μg / ml. The course of treatment is from 2-3 to 6-10 procedures prescribed 1-2, at least 3 times a week.

This technique allows you to treat patients who have had an ischemic stroke, as well as patients with dyscirculatory encephalopathy, autonomic dystonia, migraine, multiple sclerosis, but are not safe enough due to the high concentration of ozone.

The objective of the invention is to develop a method for the prevention of accelerated aging.

The technical result is to increase the safety of treatment.

The technical result is achieved by the fact that in the method of treating patients with multiple organ pathology by ozone therapy by intravenous administration of 200 ml of ozonized physiological solution. The introduction of ozonized physiological solution is carried out in the phase of remission at a rate of 10-15 ml / min, for 15-20 minutes. Moreover, mature patients undergo ozone therapy daily with a course of 6 sessions with an ozone concentration in physiological saline of 0.15 mg / L, and elderly and senile patients - every other day, with a course of 10 sessions with an ozone concentration in physiological saline of 0.10 mg / L.

The invention consists in the selection of individual indicators of the regimes and concentration of ozone therapy for different age groups.

Conducting a course of treatment in the phase of remission allows you to increase the effectiveness of treatment, increase the sensitivity of the body to drugs, reduce the biological age of patients, improve their quality of life.

The time of administration of ozonized physiological saline (OGF) of 15-20 minutes at a rate of 10-15 ml / min was selected experimentally and is necessary and sufficient for transfusion in both groups. Due to the reduction in the time of transfusion of FGD, treatment can be carried out with or without bubbling, since ozone does not have time to decompose in solution during this time. This allows you to increase patient throughput.

Parameters of ozone therapy for patients of mature age (a course of 6 sessions daily with an ozone concentration in saline solution of 0.15 mg / l), and elderly patients (a course of 10 sessions every other day with an ozone concentration in saline of 0.10 mg / l) are also selected experimentally.

Considering the patient’s age, we found that patients of mature age (35-59 years old) and elderly patients (60-74 years old) and senile (more than 75 years old) have different responses to ozone therapy in terms of lipid peroxidation (LPO) , antioxidant system (AOS) and erythrocyte membrane resistance and this cannot be ignored when he conducts this type of treatment. Otherwise, ozone therapy can be dangerous in terms of the development of intravascular hemolysis.

A decrease in the concentration of ozone in saline allows avoiding such a complication of intravenous ozone therapy as phlebitis at the injection site.

From the analysis of the scientific and patent information literature of the claimed combination of signs, it was not revealed, namely, it allows differentially treating different age groups of patients, which allows us to conclude that the claimed technical solution meets the criteria of "novelty" and "inventive step".

The method is as follows.

Oxygen-ozone gas mixture is prepared with the help of medical ozonizer installations approved for use: Ministry of Health of the Russian Federation UOTA-60-01 “Medozon”; “Quasar” (certificate of conformity No. ROSS RU.АЯ 74.ВO 4065 “Medozons”). An oxygen-ozone gas mixture with a concentration of ozone in the gas of 1-1.5 mg / l for 10 minutes is passed through a sterile physiological solution in an amount of 200 ml, while the concentration of ozone in the physiological solution was 0.10-0.15 mg / l . After that, without interrupting the bubbling, the solution is poured into the patient intravenously dropwise at a rate of 10-15 ml / min. For mature patients with multiple organ pathologies in the remission phase, an “intensely short” regimen of ozone therapy is applied: 6 intravenous infusions daily (except Saturday and Sunday), with a concentration of ozone in the gas of 1.5 mg / l (in solution not more than 0.15 mg / l). For elderly and senile patients - 10 intravenous infusions every other day (except Saturday and Sunday), with a concentration of ozone in a gas of 1 mg / l (in a solution of not more than 0.1 mg / l) - a "sparing long-term" regimen. The transfusion time for both groups is 15-20 minutes.

Example 1. Patient P., male 49 years old. He enrolled in a planned manner for treatment in a neuropsychiatric hospital with a diagnosis of the consequences of a closed head injury in the form of chronic hypertension syndrome with frequent cerebrospinal fluid crises, grade 2 arterial hypertension, without circulatory failure. Suffers from frequent headaches, meteosensitivity, increased blood pressure up to 180/100 mm Hg. The study revealed an accelerated rate of aging. Undergoing annual treatment in the neurological department, where vascular, nootropic, antihypertensive drugs with a positive effect are prescribed. When connecting to the treatment of ozone therapy, by intravenous infusion of 200 ml of OGF in a course of 6 sessions daily with an ozone concentration in physiological solution of 0.15 mg / l for 15 minutes, an improvement was noted compared with previous treatment courses that did not include ozone therapy. The disappearance of headache, stabilization of blood pressure, increased performance, improved memory, mood, sleep. After treatment, the delay in inhalation and exhalation increased by 32% and 18%, respectively; 23% improved test scores for attention and reaction; by 56% increased the time of static balancing on one leg. Biological age decreased by various tests on average by 7 years. Indicators of lipid peroxidation, AOS, erythrocyte resistance remained normal. When re-referring to ozone therapy a year later, he noted that the effect of the previous treatment lasted longer than usual, about eight months against two or three, a decrease in weather sensitivity and the need for analgesics and antihypertensive drugs. He himself asked to appoint a second course of ozone therapy. Since then, he goes to ozone therapy annually.

Example 2. Patient P., a 82-year-old man, a veteran of the Great Patriotic War, a disabled person of group 2, was admitted as planned for treatment to a neuropsychiatric hospital with a diagnosis of discirculatory encephalopathy of the second stage, chronic cerebrovascular accident of the second degree, cognitive and vestibular disorders; coronary heart disease: angina pectoris of the second functional class, hypertension of the third stage, circulatory failure of the third functional class; benign prostatic hyperplasia; open-angle glaucoma, sensorineural hearing loss. Concerned about frequent dizziness, decreased memory for upcoming events, insecurity when walking, insomnia, oppressive sensations behind the sternum with moderate physical exertion, difficulty urinating, decreased vision, hearing. The pace of aging is slow. For twenty years, annually undergoes treatment in the neurological and therapeutic departments. He always notes the positive effect of treatment in a hospital where vascular, nootropic, metabolic, antihypertensive, anti-sclerotic therapy, physiotherapy exercises, and massage are performed. After a course of ozone therapy in a "gentle long-term" regimen of 10 sessions every other day with a concentration of ozone in physiological solution of 0.10 mg / l for 20 minutes, there is a decrease in dizziness, greater confidence in walking, improved sleep, mood, and a feeling of clarity in the head . After a year, she again goes to ozone therapy at her own request, notes improvement in well-being during the year; He considers ozone therapy necessary and useful for him.

Data on the results of treatment are shown in table 1.

BIOLOGICAL INDICATORS

Table 1 №№ Name of indicator Mature patients Elderly and senile patients before treatment after treatment % change before treatment after treatment % change one. Wexler test - test for attention and reaction speed, score 44.6 50.3 12.8 22.6 27.3 20.8 2. The breath holding time, s 47.5 50.6 6.5 42.6 42.7 0.2 3 Exhalation breath holding time, sec 26.3 27.7 3.8 25.9 26.8 3,5 3. Bio-age, mini test, years 43.1 41.2 1.9 years 65,99 61.7 4.29 years four. Bio-age, maxi test 55.1 52,5 2.6 years 64.5 63.6 0.9 years 5. Cardiopulmonary bio-age, years 52.6 52.3 0.3 years 70.3 62,2 8.1 years

As can be seen from table 1, after treatment, the time delay in inhalation and exhalation increased, the performance of tests for attention and reaction rate improved. Biological age in different tests decreased. Indicators of lipid peroxidation, AOS when using both modes did not significantly change after treatment. The indicators of peroxidation and osmotic resistance of red blood cells when applying the "intensive short" mode for elderly patients with multiple organ pathologies in the remission phase significantly and significantly decreased, which was regarded as an unfavorable result, indicating the insecurity of the selected mode. This led to the conclusion that a more gentle technique should be used for this group of patients. The results of studies of the resistance of erythrocyte membranes fully confirmed the correctness of the assumption: after treatment of elderly and senile patients in the "sparing long" mode, the indicators of peroxide and osmotic resistance did not significantly change. Thus, for patients of mature age with multiple organ pathologies in the phase of remission, it is advisable to use the "intensive short" mode of ozone therapy; for elderly and senile patients it is safer to use the "gentle long-term" mode.

Comparative data of the invention are shown in table 2.

table 2 The proposed method Known method 1. Concentration in OFR 0.1-0.15 mg / L 1-4 mg / l 2. Red blood cell resistance after treatment Significantly not changing Decreases, hemolysis is possible 3. The number of FRA 200 ml 200-400 ml 4. Transfusion time 15-20 min 30 minutes - 2 hours 5. Speed 10-15 ml / min 3-7 ml / min

As can be seen from the table, the proposed treatment method allows for a low concentration of ozone in physiological saline makes the procedure safer and avoids hemolysis, reduces the amount of fluid injected to the patient, thereby expanding the range of application of this method. Through the introduction of OFR in 15-20 minutes increases the throughput of patients.

The proposed treatment method is easily feasible in medical institutions.

Claims (1)

A method of treating patients with multiple organ pathology by ozone therapy by intravenous administration of 200 ml of ozonized physiological saline, characterized in that the introduction of ozonized saline is carried out in the remission phase at a rate of 10-15 ml / min for 15-20 min, and ozone therapy is carried out for mature patients daily with a course of 6 sessions with an ozone concentration in physiological solution of 0.15 mg / l, and for elderly patients - every other day, with a course of 10 sessions with an ozone concentration in physiological m solution of 0.10 mg / l.