RU2547090C2 - Method for correction of individual's functional state and performance - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention refers to medicine and can be used for the correction of the individual's functional state and performance. That is ensured by administering Semax neuroactive peptide in a dose of two drops in each nasal passage. That is followed by the electric current exposure covering a frontal-mastoid region at pulse length 0.2ms, current intensity 0.8mA and pulse train 800Hz for 40 min. The exposure is combined with at least 10 sessions of hyperbaric oxygenation at pressure 1.6 atm.

EFFECT: method provides the rapid and effective increase of performance in sportsmen, military men and individuals involved in the other professions related to significant physical and mental stress by improving the functions of various regions of brain cortex as a result of the selected complex exposure enabling the substantial vasodilatation and maximum tissue oxygenation.

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Description

The invention relates to the field of physiology of sports and diving labor and can be used to quickly and effectively increase the performance of athletes, military personnel and people of other professions associated with significant physical and mental stress.

There are several main ways to improve human performance, including the use of adaptogens, normobaric and hyperbaric oxygenation, hypobaric and normobaric hypoxic training, pharmacological preparations [8, 9, 13].

The disadvantages of these methods is the need for their long-term use for 10 days with a slight increase in efficiency by an average of 5-5% [13, 12, 3, 4, 5]. In addition, side effects may occur when using pharmacological preparations, and in addition, expensive and cumbersome equipment (hyper- and hypobaric pressure chambers) and others are used [6, 7, 13].

A known method of treatment and recovery of patients with somatic diseases, including exposure to a pulsed current on the central nervous system, characterized in that the effect is carried out by a pulsed electric current of a rectangular shape with a frequency of 1250-2000 Hz, duration 0.25-0.35 ms with a current strength of 1, 0-2.0 mA for 30 min with simultaneous inhalation of oxygen [10]. This method is the closest to the claimed and selected as a prototype.

The disadvantages of this method include insufficient tissue oxygen saturation, insufficient regulation of the central nervous system, which leads to a less pronounced increase in human performance.

The task that the proposed method solves is to increase its effectiveness by reducing the amount of exposure while expanding its functionality by accelerating adaptation processes.

The problem in the known method of correcting the functional state and working capacity of a person by influencing the compensatory-adaptive reactions of his organs and systems, including the impact of a rectangular pulsed electric current on the fronto-mastoid region and oxygen breathing, is solved due to the fact that the effect is carried out by taking a neuropeptide semax two drops in each nasal passage, the subsequent exposure to a frontal mastoid region by a pulse of electric pulse duration 0.2 ms, a current of 0.8 mA and a pulse repetition rate of 800 Hz for 40 minutes in combination with at least 10 sessions of hyperbaric oxygenation at a pressure of 1.6 atm.

The analysis of the prior art by the applicant, including a search by patent and scientific and technical sources of information and identification of sources containing information about analogues of the claimed invention, allowed to establish that the applicant did not find a source characterized by features identical to all the essential features of the claimed invention. The definition from the list of identified analogues of the prototype, as the closest in the totality of the features of the analogue, allowed us to establish a set of essential distinguishing features in relation to the technical result perceived by the applicant in the claimed method set forth in the claims.

Therefore, the claimed invention meets the condition of "novelty."

To verify the compliance of the claimed invention with the condition "inventive step", the applicant conducted an additional search for known solutions in order to identify features that match the distinctive features of the claimed method from the prototype. The search results showed that the claimed invention does not follow explicitly from the prior art for the specialist, since the influence of the transformations provided for by the essential features of the claimed invention is not revealed from the prior art determined by the applicant to achieve a technical result.

Therefore, the claimed invention meets the condition of inventive step.

Improving the health of a person in the proposed method is as follows.

20 minutes before the start of other methods of exposure, the neuropeptide is instilled into the athlete while lying or sitting. Before intranasal use of the drug, it is necessary to carefully prepare the athlete’s nasal cavity (using a handkerchief to clear the nasal cavity of mucous secretions). Then, a semax solution is instilled. Immediately after the introduction, the athlete massages the wings of the nose with light movements for 30-40 seconds, after holding them with the thumb and forefinger.

30 minutes after the drug is administered, the athlete takes a sitting position. The athlete's forehead and skin over the mastoid process in the neck are wiped with a degreasing solution. Paired electrodes with the help of a headband were fixed in the forehead (bifurcated cathode) and over the mastoid process in the neck (bifurcated anode). Under the electrodes, gauze pads moistened with saline are placed. At the same time, attention is drawn to the prevention of direct contact with the skin. Then the athlete goes into a prone position. Electrical stimulation is carried out in a prone position for 40 minutes. The surge current is rectangular.

There are several mechanisms of VIET: a focus of cathodic depression is created in the cerebral cortex; nerve centers assimilate the imposed rhythm (the activity frequency of a healthy neuron is 1-2 kHz according to the works of N.P. Bekhtereva), which were used in studies; production of biologically active substances in the hypothalamus and thalamus (pituitary hormones, opioid peptides, GABA, serotonin, dopamine, and other substances [10, 11].

Hyperbaric exposure is carried out in a pressure chamber under the supervision of medical staff. Athletes are seated. Breathing oxygen is carried out under pressure. The session lasts 40 minutes. All equipment for functional research (an electrocardiograph and other necessary devices, such as a defibrillator, are placed outside the pressure chamber. Only electrodes and sensors remain in the pressure chamber, which are connected to a special shield connected by cable to the specified equipment via a pressure seal. Special requirements are placed on the insulation of electrical inputs to the pressure chamber , since all elements of the pressure chamber are made of metal. It is forbidden to use combustible substances, materials accumulating static elec richestvo can not be used explosive anesthetics - ether, cyclopropane, etc.

Staying in a hyperbaric air environment, a person experiences the influence of certain irritating factors, namely: increased barometric pressure and increased partial pressure of oxygen.

For a long time in medicine and sports, hyperbaric oxygenation (HBO) has been widely used. The main factors of HBO are: increased tissue oxygen saturation with improved microcirculation, elimination of hypoxia of organs and tissues. Along with this, the functional state of various body systems improves, it is suggested that the proposed combination of various agents will enhance the effect of hyperbaric oxygenation. More effective course use of this method.

The main active role in the mechanism of action of HBO is played by the following factors:

a) a change in the physical parameters of the habitat,

b) quantitative and qualitative changes in the chemical composition of the surrounding gas environment,

c) a change in the gas composition of body tissues, including blood.

The key point of exposure to the body is the increased partial pressure of oxygen, due to which the oxygen capacity of the body’s liquid media increases significantly, which leads to a rapid increase in the oxygen tension in the cells. Increased pO ₂ triggers the entire mechanism of hyperbaric oxygenation [6, 14, 13].

The application of this technique allows, leaving blood the main oxygen depot of the body, to significantly increase the role of oxygen dissolved in plasma. The oxygen capacity of plasma and other body fluids increases due to the dissolution of additional oxygen in them, facilitating its transport to the mitochondria of cells. Thus, conditions are created for increasing oxygen consumption, and manifestations of general and local hypoxia are reduced. Hyperoxia promotes oxygen diffusion into the cell, activates oxidative phosphorylation with an increase in the number of synthesized ATP and KrF molecules, increases the level of microsomal oxidation, and activates the process of removing toxic products from the body.

An increase in the rate of electron transfer along the mitochondrial chain and stimulation of microsomal oxidation affect the concentration of activated oxygen forms and active forms of radicals in cells, which play an important role in biosynthetic and detoxification reactions, as well as in membrane modification in response to extreme stimuli. At the same time, the oxidation of glucose is accelerated, the level of lactate is reduced. Moderate activation of the oxidation of neutral fats contributes to the renewal of the lipid composition of membranes, increasing their functionality. Membranes become more permeable to ions of biologically active substances, pharmacological agents. However, the activity of the oxygen transporting system under conditions of breathing with compressed oxygen is balanced by an increase in the antioxidant defense power.

The state of hyperoxia causes the body to switch to a more economical level of functioning: the BH and heart rate decrease, the systolic and more significantly diastolic blood pressure rises, the cardiac output and the minute volume of blood circulation decrease, arterioles are spasmodic. Plasma capillaries function. Blood supply to tissues with the presence of a pathological process (destruction, inflammation, necrosis) and a decreased pH relatively increases. The coordinating action of the cerebral cortex is improved: the processes of excitation and internal inhibition are strengthened, the main nervous processes are balanced, which helps increase mental performance.

The increased partial oxygen pressure causes activation of the sympathoadrenal system, the neuro-reflex influence of which in this case demonstrates typical reaction variants to extreme stimuli. We can conclude that hyperbaric oxygenation is quite effective as a way to saturate the body with oxygen under high pressure and as a method of exposure to a healthy person to correct its performance. The method can also be used for medicinal purposes, since it has a solid scientific basis: physiological justification, indications and contraindications, optimal dosage [6, 14, 13].

Semax has a specific mechanism of influence on the central nervous system. It has nootropic properties and is completely devoid of hormonal activity. With the introduction of the drug, the functions of the cerebral cortex improved, the body's level of adaptation to hypoxia and physical performance increased. The introduction of the drug is practically non-toxic, with a single and long-term administration it does not exhibit allergic, embryotoxic and mutagenic properties. Absorption of the drug occurs from the mucous membrane of the nasal cavity, while up to 60-70% of the active substance is absorbed. Semax is rapidly distributed to all organs and tissues, it is also able to cross the blood-brain barrier. When it enters the bloodstream, this drug undergoes rather rapid cleavage and excretion from the body [1, 2]. The drug is approved for use by order of the Ministry of Health of the Russian Federation No. 294 of December 20, 1994, according to which the drug Semax was registered in the Russian Federation and approved for medical use and industrial production (registration certificate No. 94/294/10).

30 minutes after the drug is administered, the athlete takes a sitting position. The athlete's forehead and skin over the mastoid process in the neck area are wiped with a degreasing solution. Paired electrodes with the help of a headband are fixed in the forehead (bifurcated cathode) and above the mastoid process in the neck (bifurcated anode). Under the electrodes place gauze pads moistened with saline. In this case, pay attention to preventing direct contact with the skin. Then the athlete goes into a prone position. Electrical stimulation is carried out in the supine position for 60 minutes. The pulse current has a rectangular shape.

There are several mechanisms of VIEP: a focus of cathodic depression is created in the cerebral cortex; nerve centers assimilate the imposed rhythm (the activity frequency of a healthy neuron is 1-2 kHz according to the works of N.P. Bekhtereva), which were used in studies; production of biologically active substances in the hypothalamus and thalamus (pituitary hormones, opioid peptides, GABA, serotonin, dopamine, and other substances).

The research involved 20 wrestlers aged 19-20 years with the level of mastery of the CCM, MS. 10 people comprised an experimental group and 10 people a control group. In the experimental group, HBO, VIET, and semax were used for 10 hours.

Psychophysiological indicators of wrestlers using hyperbaric oxygenation and a complex of methods for correcting performance No. p / p PSMR, ms SSMR, ms SSMR,% of errors background counter exp background counter. exp background counter exp one 205 219 236 385 358 379 12 four four 2 213 244 231 409 365 360 8 8 16 3 180 199 229 263 277 329 28 24 twenty four 204 215 215 284 338 291 0 12 8 5 192 192 172 345 345 296 32 32 12 6 213 213 213 335 335 334 28 28 four 7 224 215 188 288 301 286 12 12 16 8 223 221 240 357 413 372 four 8 four 9 206 209 204 289 300 326 twenty 8 0 10. 202 230 214.2 315 357 330.5 12 8 10 X cf ± m 206.2 ± 4.8 215.8 ± 5.7 214.2 ± 7.4 327 ± 16.0 322.1 ± 14.9 330.3 ± 10.2 15.6 ± 3.5 13.4 ± 3.1 10.5 ± 2.2

Table continuation No. p / p RDO,% accurate CFSM, Hz Hydrodynamometry background counter. exp background counter. exp before counter. exp one 47 48 40 38 37 32 one hundred 120 140 2 63 24 76 36 39 41 49 60 62 3 57 92 52 39 thirty thirty 48 52 52 four 70 48 80 37 39 37 59 61 62 5 32 32 56 41 41 43 25.66 33 36 6 68 68 80 39 39 43 24 24 26 7 57 57 72 36 36 35 thirty thirty 32 8 57 68 64 36 35 39 37 34 38 9 70 72 84 43 37 39 46 73 82 10 53 68 67 32 26 38 thirty 46 47 X cf ± m 57.4 ± 4.2 57.8 ± 7.4 67.1 ± 4.8 * 37.7 ± 1.2 35.9 ± 1.6 37.7 ± 1.4 44.96 ± 7.13 53.3 ± 8.9 57.7 ± 10.58 *

Table continuation No. p / p Gencha test Individual minute before counter. exp before counter. exp one 37 32 60 61 60.7 59.0 2 27 32 37 62.7 61.7 61.0 3 39 40 42 59.75 61.3 59.0 four 34 42 52.3 60.15 58.6 61.3 5 49.73 44 68,4 62.00 61.7 61.6 6 39.9 43.1 49.2 61.8 66.3 56.3 7 59 56 68 63.3 64.7 67.7 8 48.7 fifty 63 65.35 65.3 61 9 97 90 103 73.7 61.7 61.0 10 35 35 48 70.3 64.0 63.0 X cf ± m 46.63 ± 6.31 46.41 ± 5.40 59.09 ± 5.92 * 64.005 ± 1.44 62.6 ± 0.75 61.09 ± 0.64 Note: * - differences are significant at P <0.05.

As a result of the studies, a tendency toward an improvement in most psychophysiological indicators was noted.

Reliably in comparison with the background and the control group (just before the start of the research), the accuracy of the reaction to a moving object increased, in accordance with the table.

Static endurance (hydrodynamometry) significantly increased on average by 10-12 s, which indicated an increase in the functional state of the cortical department of the motor analyzer.

Significantly increased the level of functioning of the cortical department of the visual analyzer, as evidenced by an increase in the CSFM.

The subjects significantly increased resistance to hypoxia, the Gench test index increased on average by 13 s and amounted to 59.09 s (normal - 24.28).

Thus, there was a marked improvement in the functional state of the cerebral cortex, its various departments, and the balance of the main nervous processes — excitation and inhibition.

In the control group, the training process also allowed to increase the functional state of the central nervous system, however, the severity was lower than in experimental studies. There was a decrease in heart rate from 76.6 ± 0.25 to 60.3 ± 0.28 (p <0.05).

The physical performance indicator increased from 1010 ± 60 kgm / min to 1212 ± 76 kgm / min (p <0.05).

In general, the increase in efficiency occurred due to the expansion of the functional capabilities of the body. This is due to the fact that VIET in combination with a neuropeptide enhances the integral functioning of the brain. Increases the adaptive capacity of the body, translates regulatory mechanisms to a new, higher level of functioning. Any physical activity

Sources of information taken into account during the examination:

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2. Alekseeva G.V. Semax - a new regulatory neuropeptide [Text] / G.V. Alekseeva, N.A. Botaev // In the world of medicines, 1998, No. 2. 59-61 s.

3. Aulik I.V. Determination of physical performance in the clinic and sports: 2nd ed., Revised. and add. [Text] / I.V. Aulik - M .: Medicine, 1990 .-- 192 p.

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Claims (1)

A method for correcting a person’s functional state and working capacity by influencing the compensatory-adaptive reactions of his organs and systems, including applying a rectangular shape pulsed electric current to the fronto-mastoid region and oxygen breathing, characterized in that the effect is achieved by taking two drops of Semax neuropeptide in each nasal passage, subsequent exposure to pulsed electric current on the fronto-mastoid region with a pulse of 0.2 ms duration, a current of 0.8 mA and a trace frequency anija pulses 800 Hz for 40 minutes, combined with at least 10 sessions hyperbaric oxygen at a pressure of 1.6 atm.