RU2110517C1 - N, n-диметил-2-[5-(2-оксо-1,3-оксазолидин-4-илметил)-1н-индол-3-ил]-этиламин в его (s)- или (r)-форме или в виде их смеси, или его физиологически приемлемая соль, или сольват, способ его получения, лекарственное средство для лечения или профилактики клинических состояний, для которых показан прием агониста "5-нт1-подобного" рецептора, способ профилактики или лечения указанного клинического состояния у млекопитающих и способ получения лекарственного средства - Google Patents
N, n-диметил-2-[5-(2-оксо-1,3-оксазолидин-4-илметил)-1н-индол-3-ил]-этиламин в его (s)- или (r)-форме или в виде их смеси, или его физиологически приемлемая соль, или сольват, способ его получения, лекарственное средство для лечения или профилактики клинических состояний, для которых показан прием агониста "5-нт1-подобного" рецептора, способ профилактики или лечения указанного клинического состояния у млекопитающих и способ получения лекарственного средства Download PDFInfo
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- RU2110517C1 RU2110517C1 SU5011473/04A SU5011473A RU2110517C1 RU 2110517 C1 RU2110517 C1 RU 2110517C1 SU 5011473/04 A SU5011473/04 A SU 5011473/04A SU 5011473 A SU5011473 A SU 5011473A RU 2110517 C1 RU2110517 C1 RU 2110517C1
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- formula
- compound
- mixture
- physiologically acceptable
- acceptable salt
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- 241000124008 Mammalia Species 0.000 title claims abstract description 8
- 229940079593 drug Drugs 0.000 title claims abstract description 7
- 239000003795 chemical substances by application Substances 0.000 title claims abstract description 4
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- 230000015572 biosynthetic process Effects 0.000 title abstract 3
- 238000003786 synthesis reaction Methods 0.000 title abstract 3
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- 206010027599 migraine Diseases 0.000 claims abstract description 14
- ASNHGEVAWNWCRQ-UHFFFAOYSA-N 4-(hydroxymethyl)oxolane-2,3,4-triol Chemical compound OCC1(O)COC(O)C1O ASNHGEVAWNWCRQ-UHFFFAOYSA-N 0.000 claims abstract description 7
- 238000011321 prophylaxis Methods 0.000 claims abstract description 7
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- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims abstract 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 claims description 35
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- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 4
- ULSDMUVEXKOYBU-UHFFFAOYSA-N 2-Oxazolidinone, 4-[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]- Chemical compound C1=C2C(CCN(C)C)=CNC2=CC=C1CC1COC(=O)N1 ULSDMUVEXKOYBU-UHFFFAOYSA-N 0.000 claims description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
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- 239000007858 starting material Substances 0.000 description 11
- 238000003756 stirring Methods 0.000 description 11
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- 238000010438 heat treatment Methods 0.000 description 9
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- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 8
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- 238000010521 absorption reaction Methods 0.000 description 7
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
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Images
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB909012672A GB9012672D0 (en) | 1990-06-07 | 1990-06-07 | Therapeutic heterocyclic compounds |
| GB9012672.3 | 1990-06-07 | ||
| PCT/GB1991/000908 WO1991018897A1 (en) | 1990-06-07 | 1991-06-06 | Therapeutic heterocyclic compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU95112537 Division | 1991-06-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2110517C1 true RU2110517C1 (ru) | 1998-05-10 |
Family
ID=10677193
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU5011473/04A RU2110517C1 (ru) | 1990-06-07 | 1991-06-06 | N, n-диметил-2-[5-(2-оксо-1,3-оксазолидин-4-илметил)-1н-индол-3-ил]-этиламин в его (s)- или (r)-форме или в виде их смеси, или его физиологически приемлемая соль, или сольват, способ его получения, лекарственное средство для лечения или профилактики клинических состояний, для которых показан прием агониста "5-нт1-подобного" рецептора, способ профилактики или лечения указанного клинического состояния у млекопитающих и способ получения лекарственного средства |
Country Status (7)
| Country | Link |
|---|---|
| GB (1) | GB9012672D0 (enExample) |
| GE (1) | GEP19981392B (enExample) |
| RU (1) | RU2110517C1 (enExample) |
| SA (1) | SA91120058B1 (enExample) |
| SG (1) | SG52664A1 (enExample) |
| TW (1) | TW223072B (enExample) |
| ZA (1) | ZA914340B (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2167875C2 (ru) * | 1995-08-07 | 2001-05-27 | Зенека Лимитед | Получение производных 2-оксазолидинона в одном реакторе |
| RU2255736C2 (ru) * | 1999-12-03 | 2005-07-10 | Астразенека Аб | Фармацевтические композиции, содержащие золмитриптан |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2186874B (en) * | 1986-01-08 | 1990-02-07 | Glaxo Group Ltd | Indole derivatives |
-
1990
- 1990-06-07 GB GB909012672A patent/GB9012672D0/en active Pending
-
1991
- 1991-06-05 TW TW80104430A patent/TW223072B/zh not_active IP Right Cessation
- 1991-06-06 SG SG1996007538A patent/SG52664A1/en unknown
- 1991-06-06 ZA ZA914340A patent/ZA914340B/xx unknown
- 1991-06-06 RU SU5011473/04A patent/RU2110517C1/ru active
- 1991-08-05 SA SA91120058A patent/SA91120058B1/ar unknown
-
1993
- 1993-07-22 GE GEAP19931112A patent/GEP19981392B/en unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2186874B (en) * | 1986-01-08 | 1990-02-07 | Glaxo Group Ltd | Indole derivatives |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2167875C2 (ru) * | 1995-08-07 | 2001-05-27 | Зенека Лимитед | Получение производных 2-оксазолидинона в одном реакторе |
| RU2255736C2 (ru) * | 1999-12-03 | 2005-07-10 | Астразенека Аб | Фармацевтические композиции, содержащие золмитриптан |
Also Published As
| Publication number | Publication date |
|---|---|
| SG52664A1 (en) | 1998-09-28 |
| GEP19981392B (en) | 1998-11-10 |
| ZA914340B (en) | 1993-02-24 |
| TW223072B (enExample) | 1994-05-01 |
| SA91120058B1 (ar) | 2005-11-30 |
| GB9012672D0 (en) | 1990-08-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RH4A | Copy of patent granted that was duplicated for the russian federation |
Effective date: 20061120 |
|
| PC4A | Invention patent assignment |
Effective date: 20061226 |