RU2063762C1 - Ointment for skin disease and trophic ulcer treatment - Google Patents

Abstract

FIELD: medicine, chemical-pharmaceutical industry. SUBSTANCE: method involves the development of ointment containing propolis and dimexide and taken at definite ratio of components. EFFECT: broadened range of the use. 2 tbl

Description

 The invention relates to medicine, in particular to dermatology.

 Known drugs, in particular ointment "Propocium" containing propolis.

 "Propoceum" contains a 10% extract of thick alcohol propolis, petroleum jelly, glycerin and an emulsifier.

The disadvantages of ointment "Propoceum":
1. The low content of propolis in the ointment reduces its biological activity.

 2. The presence in the ointment of auxiliary substances of the extractant and emulsifier.

 3. Low ability of vaseline and glycerin to penetrate the skin and body tissues.

 4. A quick exit from the composition of the extractant during its use reduces the activity of the ointment.

 5. Only propolis has healing properties in ointments.

 6. The low viscosity of the ointment makes it difficult to store and transport the ointment.

The proposed ointment has the following advantages:
1. High concentration of propolis in the ointment.

 2. The absence of auxiliary substances in the ointment.

 3. The ability to easily penetrate the skin and create a high concentration of propolis in places remote from the surface of the skin, due to the properties of dimexide.

 4. The ointment retains its activity much longer during use, since dimexide evaporates much more slowly from the ointment volume than alcohol.

 5. Each of the components of the ointment enhances and complements the properties of the other.

 6. The high viscosity of the ointment greatly simplifies its storage and transportation conditions.

 The aim of the invention is to reduce the time of epithelization and treatment.

 This goal is achieved in that the ointment contains propolis and dimexide in the following ratio of components, weight.

propolis 80-90
dimexide 10-20
The ointment is a dark viscous mass with a characteristic specific odor.

 The healing properties of the ointment are based on the interaction of the properties of propolis and dimexide.

 The ointment is applied in a thin layer, it is easily rubbed or applied with a bandage, excluding places with violations of the epithelium.

 The use of dimexide in combination with other drugs in the complex treatment of certain diseases is known. Dimexide (l.1, t.1, p.222) is used in a number of cases and in combination with antimicrobial agents.

 The proposed new combination of propolis and dimexide, which is suitable for accelerating epithelization and treatment of abscesses, boils, carbuncles, trophic ulcers, eczema and neurodermatitis.

 In these diseases, a characteristic is a decrease in the body's resistance. For this reason, it is advisable to use propolis, which, in addition to antimicrobial properties, also has antifungal, immunostimulating, antipruritic and anesthetic properties (l.2, p.37, 59, 71, 76, 78, 81.103).

 The goal is achieved by the fact that the ointment contains in weight. propolis 80-90; dimexide 10-20.

 It was experimentally established that the complete dissolution of propolis in dimexide occurs if the content of dimexide is not less than 10% by weight of the ointment. If propolis in the ointment is less than 80% of its weight, then this reduces its biological activity, delays the treatment and reduces the effect of its use.

 A high concentration of propolis is necessary to achieve the necessary therapeutic effect (l.2, p. 59).

 With these parameters of the content of the ingredients, the ointment is most effective.

 To confirm that it is with the given parameters of the content of the ingredients that a technical result is achieved, the applicant gives the following examples, where an ointment with different propolis content was used to treat furunculosis.

 Example 1. Patient F. 42 l. On the right thigh, a boil with a purulent head, hyperemia and swelling of the tissues around it, pain, fever. Appointed: rubbing around the boil and dressing on the boil with ointment in the composition, weight.

propolis 90
dimexide 10.

 Rubbing the ointment was carried out around the boil 2 times a day: morning and evening at night, a bandage was applied to the boil itself with the ointment applied to it. On day 2, hyperemia and edema subsided, the boil cleansed of pus, epithelization began. On day 4, treatment is complete.

 Example 2. Patient S. 38 l. Boil on the right thigh. Fever, pain, hyperemia, swelling. Appointed: rubbing the ointment around the head, on the head a napkin with ointment in the composition, weight.

propolis 80
dimexide 20.

 The ointment was rubbed into the skin around the head, the ointment was applied to the head with a bandage twice a day: morning and evening at night. On day 3, hyperemia and edema subsided, the head cleared of pus, and epithelization began. On day 5, treatment is complete.

 Example 3. Patient C. 28 l. Boil on the right shin. Purulent head, hyperemia, swelling, fever, pain. Appointed: rubbing into the area near the head, a napkin on the head with ointment in the composition, weight.

propolis 40
dimexide 60.

 Rubbing and changing dressings with ointment was carried out 2 times a day: morning and evening before bedtime. On day 4, the head was cleansed of pus, epithelization began, hyperemia and swelling were absent. On day 6, treatment was completed. Pain on palpation was not observed.

Example 4. Patient C. 47 l. Furuncle on the left thigh. Fever, pain, hyperemia and swelling of the tissues, purulent discharge from the head. Appointed: rubbing ointments around the head and a bandage with ointment on the head. Ointment, weight
propolis 20
dimexide 80.

 Rubbing and changing dressings were carried out 2 times a day: morning and evening at night. On day 5, the discharge stopped, hyperemia and swelling subsided, epithelization began. On day 7, treatment was completed.

 Analysis of these examples shows that a decrease in the concentration of propolis in the ointment increases the duration of treatment. The effectiveness of the proposed ointment was confirmed by its use.

 Example 1. Patient S. 36 l. Complaints of itchy skin rashes, suffering from neurodermatitis for a year. It is prescribed rubbing in areas adjacent to the affected, ointments in the composition, weight.

propolis 80
dimexide 20
After 7 days of treatment, his health improved, skin itching stopped, plaques disappeared, instead of them there appeared bluish spots. On day 14, the spots acquired a healthy skin color. It is recommended to appear for inspection after 6 months.

 Example 2. Patient E. 60 liters Appeared about a chronic ulcer on the lower leg of the right leg. Assigned dressings with ointment in the composition, weight.

propolis 90
dimexide 10
Dressings were changed 2 times a day: in the morning and in the evening at night. On day 3, the surface of the ulcer cleared, granulation appeared on day 4, on day 10, the ulcer epithelized, and on day 18 it closed.

 Example 3. Patient B. 35 l. Complaints of pain in the lower back, fever. Observed: purulent discharge from several holes, flushing of the skin, edema, diagnosis of carbuncle. Appointed: bandage with ointment in the composition, weight.

propolis 90
dimexide 10
Dressings were changed 3 times a day, ointment was rubbed into the area near the holes: morning, afternoon and evening at night. On day 3, the temperature returned to normal, swelling and hyperemia were absent. On day 4, purulent discharge ceased and the holes cleared of pus. On day 6, epithelization began. On day 8, pain during palpation was not manifested. On day 10, treatment was completed.

 Example 4. Patient T. 32 L. Appeal for fever, increasing pain after injection in the right buttock. Observed: edema, flushing of the skin, infiltration. The diagnosis of postinjection soft tissue abscess. Appointed: rubbing ointment in the composition, weight.

propolis 85
dimexide 15.

 The ointment was rubbed in places of hyperemia of the skin, excluding places with infiltration, 3 times a day: morning, afternoon and evening at night. On day 2, the infiltration stopped, the temperature returned to normal. On day 4, hyperemia and swelling were absent. On day 6, palpation became painless. On day 7, treatment is complete.

 Example 5. Patient D. 28 l. He complained of burning, itching, rashes and pustules on the knife, suffering from eczema for six months. It is prescribed rubbing in areas adjacent to the affected, ointments in the composition, weight.

propolis 80
dimexide 20.

 The patient rubbed the ointment with a thin layer into the skin adjacent to the affected, 2 times a day: morning and evening at night. In the first two days, the sensation of itching and burning decreased, the number of pustules, especially along the periphery of the affected area, decreased. The lesion area has decreased. On day 4, sensations of itching and burning were practically absent, abscesses were absent. On the 6th day, the infiltration stopped, the area of the affected area decreased and the ointment was rubbed already into the areas that left the affected area. The skin in previously affected areas, especially on the periphery, began to separate in the form of crusts. On day 15, treatment was completed.

In support of the technical result, the results of applying the proposed ointment are given (Table 1) and for comparison, the results of treatment of some diseases with Propocium ointment (Table 2) according to the indications for Propocium ointment when used as an additional tool
A comparison of the data from table 1 and table 2 shows that the effectiveness of the proposed ointment is higher than that of the prototype, because its scope is wider, the number of relapses and negative results in the treatment is less, the healing time is less. TTT1

Claims (1)

 An ointment for the treatment of skin disease and trophic ulcers based on propolis, characterized in that it additionally contains dimexide in the following ratio of components, wt. Propolis 80 90
Dimexide 10 20

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