RU2030180C1 - Method for treatment of endometritis at cow - Google Patents

Abstract

FIELD: veterinary. SUBSTANCE: method involves applying mixture of iodinebismuthsulfatisole and furacin simultaneously with hypodermic injection of tissue preparation and intramuscular injection of neostigmine methylsulfate. EFFECT: improves efficiency of the method.

Description

 The invention relates to veterinary medicine, in particular to the treatment of endometritis in cows.

 A known method of treating endometritis in cows (see book. Goncharov V.P., Karpov V.A. Prevention and treatment of gynecological diseases of cows M .: Rosselkhozizdat-1981, p. 115-116), which consists in the introduction of antimicrobial agents into the uterine cavity in combination with proteolytic enzymes to enhance the antimicrobial spectrum of action and better effects on the inflamed endometrium.

 A method of treating endometritis in cows is also known - the author took it as a prototype, which consists in the introduction of intrauterine iodismuthsulfathiazole-IVST.

 A disadvantage of the known method for the treatment of endometritis is that the activity of iodobismuthsulfathiazole (IVST) is low in relation to anaerobic strains of microorganisms, in particular to staphylococci, in addition, IVST is used without general stimulating and uterine drugs. Thus, the treatment of endometritis in cows in a known manner is not effective enough.

 The aim of the invention is to increase the effectiveness of treatment.

 This goal is achieved by the fact that in the method of treating endometritis in cows, including the introduction of intrauterine 100 ml of iodismuthsulfathiazole, 1.0 furatsillin per 100.0 of the drug is added to iodismuthsulfathiazole previously and administered at intervals of 22-24 hours, 3-6 times depending on the form the course of endometritis until the disappearance of clinical signs, with an additional subcutaneous injection of 20-25 ml of a tissue preparation from the spleen, three times with an interval of 3 days and intramuscular injection of a 0.5% solution of proserin in a dose of 1.5-2 ml for three days series.

 The novelty of the proposed technical solution is due to the fact that, compared with the known technical solutions, it has a higher activity for staphylococci, which increases the effectiveness of treatment.

 According to the patent and scientific and technical literature, the proposed combination of features is not found, which allows us to judge the materiality of the proposed features.

 A method of treating endometritis in cows is as follows.

 Before treatment, furatsillin is added to iodismuthsulfathiazole in a ratio of 1: 100, then it is administered intrauterine at a dose of 100.0 with an interval of 22-24 hours from 3 to 6 times depending on the form of the endometritis until the clinical signs disappear, i.e. until the cessation of pathological discharge. Then, after drug administration, 20-25 ml of tissue preparation from the spleen are subcutaneously administered three times with an interval of 3 days. The dose of the drug depends on the weight of the animal. Next, a 0.5% solution of proserin 1.5-2 ml is administered intramuscularly for three consecutive days.

 The addition of furatsillin provides effective treatment, this is due to the fact that furatsillin has a wide antimicrobial spectrum of action, enteropathogenic strains of E. coli, staphylococci, pathogens of salmonellosis, and gas gangrene are most sensitive to it. The antimicrobial effect is based on the bacteriostatic effect, inhibits the enzyme dehydrogenase, which disrupts the absorption of oxygen by microbes, as a result of the disorganization of redox processes. The degree of antimicrobial action of furacilin is due to the activity of the respiratory processes in the microbial cell - the higher they are (which causes iodine, which is why furacilin is added), the faster and stronger the antimicrobial effect of furacilin. Along with the antimicrobial effect, furatsillin activates the processes of erythropoiesis, increases the level of sugar in the blood. An adaptation phenomenon may develop to furacilin, but the formation of resistant bacteria occurs more slowly than with sulfonamides and some antibiotics. With prolonged use in large doses, it can cause allergies, nephronephritis, toxic liver dystrophy, polyneuritis, liver hypertrophy, eosinophilia, and visual impairment.

 The active principle of iodismuthsulfathiazole-furatsillin (IVST-F) is iodine, bismuth, norsulfazole, furatsillin, each of which has a specific antimicrobial spectrum of action.

 Iodine acts antimicrobially, antifungal, topically and resorptively. During the interaction of iodine with water of the protoplasm of microbial cells, active oxygen is formed, which has a strong oxidizing effect, which causes a quick and strong antimicrobial effect of furacilin.

 Bismuth nitrate basic contains up to 80-82% bismuth oxide in an acidic and alkaline environment, it dissolves slowly and, forming albuminates, acts astringently, anti-inflammatory, and hemostatic.

 As for the tissue preparation, it should be noted that it enhances the body's immunobiological reactivity, the body's defenses increase, as a biogenic stimulator improves metabolism, activates enzyme activity, and improves organs.

 The anticholinergic drug proserin is introduced to enhance contractility and speedy expulsion of pathological secretions from the uterine cavity.

 As a result of studies in the farms of the region, it was found that the main causative agents of postpartum endometritis in cows were: E. coli - 20.56% of cases (446 cows), Staphylococcus - 12.14% Vulgar Proteus 9.03%, Septic Dippococcus - 7.47 %, Pseudomonas aeruginosa - 5.29%, hemolytic streptococcus - 4.04%, Hay bacillus - 3.42 and the fact that iodismuthsulfathiazole (IVT - previously used to treat endometritis) is not active for staphylococci.

 In order to test the proposed method of treatment (IVST-furatsillin and IVST-tricillin) in combination with various general stimulating and uterine drugs at N 2 farm "Kuban" KSHI on the basis of analogues 7 groups of sick cows were selected (10 in each), treatment regimens for each group were drawn up.

 The essence of the schemes was that the groups were divided into two subgroups (5 each) to obtain more reliable results, and in order to take into account the effects of general stimulating and uterine drugs when two antimicrobial drugs (IVST-T and IVST-F) are used in the same group.

 The cows of each first experimental subgroup were injected with the intrauterine antimicrobial preparation IVST-T, and the second subgroup (5 cows) IVST-F at a dose of 100 ml every other day until the pathological discharge from the uterus disappeared. Of the general stimulating drugs, according to the treatment regimens, ACS, K-hemogen, tissue preparation from the spleen, tetravit, proserin were introduced.

 The control group (10 cows) was injected intrauterine drug mixture: furatsillina - 1.0; norsulfazole - 5.0; polymyxin - 0.1 emulsified in 100 ml of sterile fish oil, 48 hours later until the clinical signs of endometritis disappear, subcutaneously with ACS and intramuscularly a 0.5% solution of proserin.

 According to the results of the experiments, it can be stated (see table) that the therapeutic efficacy in all first subgroups (IVST-T was introduced) averaged 83.3%, in the second subgroups (IVST-F was introduced) -90%, in the control group 70%

 A wide production experience of the proposed treatment regimen was carried out in three farms of the region on a livestock of 340 cows, which confirms its high therapeutic effectiveness in treating cows with patients with various forms of endometritis.

 Positive effect. Collective and state farms of the region annually lose up to 130 thousand calves, this is largely due to the symptomatic infertility of cows, more than 70 thousand cows are affected by postpartum endometritis in the region, which makes up 10% of the total population.

 The introduction of this method of treating endometritis in cows will make it possible to cure a large number of sick cows, thereby reducing the damage to the national economy by sterility and barrenness of cows.

Claims (1)

 METHOD FOR TREATING ENDOMETRITIS IN COWS, including intrauterine administration of iodismuthsulfatisole, characterized in that, in order to increase the effectiveness of the method, furacilin is additionally administered at a rate of 1: 100 in iodismuthsulfatisole, moreover, the mixture is administered at a dose of 100 g per animal with an interval of 22-24 hours 3–6-fold, with simultaneous additional subcutaneous administration of 20–25 ml of tissue preparation from the spleen three times with an interval of 3 days and intramuscular administration of a 0.5% solution of proserin in a dose of 1.5–2 ml for three days, squad.