RU2020142739A - Ингибиторы mdm2 и их комбинации - Google Patents
Ингибиторы mdm2 и их комбинации Download PDFInfo
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- RU2020142739A RU2020142739A RU2020142739A RU2020142739A RU2020142739A RU 2020142739 A RU2020142739 A RU 2020142739A RU 2020142739 A RU2020142739 A RU 2020142739A RU 2020142739 A RU2020142739 A RU 2020142739A RU 2020142739 A RU2020142739 A RU 2020142739A
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- pharmaceutical combination
- cancer
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- pharmaceutical
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Classifications
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- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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| TW201613576A (en) | 2014-06-26 | 2016-04-16 | Novartis Ag | Intermittent dosing of MDM2 inhibitor |
| US11672801B2 (en) | 2016-10-19 | 2023-06-13 | United States Government As Represented By The Department Of Veterans Affairs | Compositions and methods for treating cancer |
| ES2928773T3 (es) | 2017-01-17 | 2022-11-22 | Heparegenix Gmbh | Inhibidores de proteína cinasas para fomentar la regeneración hepática o reducir o prevenir la muerte de hepatocitos |
| WO2018183762A1 (en) * | 2017-03-29 | 2018-10-04 | United States Government As Represented By The Department Of Veterans Affairs | Methods and compositions for treating cancer |
| CA3052543A1 (en) * | 2017-03-31 | 2018-10-04 | Novartis Ag | Dose and regimen for an hdm2-p53 interaction inhibitor in hematological tumors |
| WO2019040511A1 (en) * | 2017-08-22 | 2019-02-28 | University Of Maryland Batimore | DOUBLE INHIBITORS OF BCL-2 AND HDM2 FAMILIES BY CO-MIMETTISM OF ALPHA BH3 AND P53 PROPELLERS |
| CN111868039A (zh) * | 2017-09-26 | 2020-10-30 | 加利福尼亚大学董事会 | 用于治疗癌症的组合物和方法 |
| JP7332589B2 (ja) * | 2017-10-12 | 2023-08-23 | ノバルティス アーゲー | 癌を治療するためのｍｄｍ２阻害剤とｅｒｋの阻害剤との組合せ |
| KR20200118422A (ko) * | 2017-12-31 | 2020-10-15 | 에버그린 바이오사이언시즈 | 동결보존용 조성물 및 이의 사용 방법 |
| WO2019174576A1 (zh) * | 2018-03-12 | 2019-09-19 | 罗欣药业(上海)有限公司 | 咪唑并吡咯酮化合物及其应用 |
| TWI791794B (zh) * | 2018-03-20 | 2023-02-11 | 瑞士商諾華公司 | 藥物組合 |
| TWI725488B (zh) | 2018-07-31 | 2021-04-21 | 大陸商蘇州亞盛藥業有限公司 | Bcl-2抑制劑與化療藥的組合產品及其在預防及/或治療疾病中的用途 |
| CN110772521A (zh) | 2018-07-31 | 2020-02-11 | 苏州亚盛药业有限公司 | Bcl-2抑制剂或Bcl-2/Bcl-xL抑制剂与BTK抑制剂的组合产品及其用途 |
| JP2021516262A (ja) | 2018-07-31 | 2021-07-01 | アセンテージ ファーマ（スーチョウ）カンパニー，リミティド | リツキシマブ及び／若しくはベンダムスチンと組み合わされたＢｃｌ−２阻害剤又はＣＨＯＰと組み合わされたＢｃｌ−２阻害剤の相乗的な抗腫瘍効果 |
| CA3094449C (en) * | 2018-07-31 | 2023-02-28 | Ascentage Pharma (Suzhou) Co., Ltd. | Combination product of bcl-2 inhibitor and mdm2 inhibitor and use thereof in the prevention and/or treatment of diseases |
| MX2021007391A (es) * | 2018-12-20 | 2021-09-23 | Novartis Ag | Regimenes de baja dosis extendida para inhibidores de mdm2. |
| US12194024B2 (en) | 2019-07-26 | 2025-01-14 | Ascentage Pharma (Suzhou) Co., Ltd. | Pharmaceutical composition of MDM2 inhibitor and use thereof for preventing and/or treating disease |
| WO2021110097A1 (en) * | 2019-12-03 | 2021-06-10 | Ascentage Pharma (Suzhou) Co., Ltd. | N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors |
| TW202200147A (zh) * | 2020-05-26 | 2022-01-01 | 韓商韓美藥品股份有限公司 | Ｂｅｌｖａｒａｆｅｎｉｂ用於癌症治療 |
| CN115124533A (zh) * | 2021-03-26 | 2022-09-30 | 浙江海正药业股份有限公司 | 四环类衍生物、其制备方法和其医药上的用途 |
| JP2024157057A (ja) * | 2021-06-29 | 2024-11-07 | 国立大学法人 東京大学 | バレット食道の治療用組成物 |
| CN117562907B (zh) * | 2023-11-17 | 2025-08-22 | 广州医科大学 | 一种提升抗癌效果的可口服吉非替尼复合物及其制备方法与应用 |
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| SG2013013339A (en) | 2002-03-13 | 2014-12-30 | Array Biopharma Inc | N3 alkylated benzimidazole derivatives as mek inhibitors |
| AU2005252110B2 (en) | 2004-06-11 | 2008-09-04 | Shionogi & Co., Ltd. | 5-amino-2,4,7-trioxo-3,4,7,8-tetrahydro-2H-pyrido[2,3-D] pyrimidine derivatives and related compounds for the treatment of cancer |
| SG177981A1 (en) | 2005-05-18 | 2012-02-28 | Array Biopharma Inc | 4-(phenylamino)-6-oxo-1, 6-dihydropyridazine-3-carboxamide derivatives as mek inhibitors for the treatment of hyperproliferative diseases |
| GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
| JO2660B1 (en) | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
| UA104147C2 (uk) | 2008-09-10 | 2014-01-10 | Новартис Аг | Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань |
| WO2010063300A1 (en) * | 2008-12-03 | 2010-06-10 | Università Degli Studi Di Torino | Isogenic human cell lines comprising mutated cancer alleles and process using the cell lines |
| CU24130B1 (es) | 2009-12-22 | 2015-09-29 | Novartis Ag | Isoquinolinonas y quinazolinonas sustituidas |
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| US8815926B2 (en) * | 2012-01-26 | 2014-08-26 | Novartis Ag | Substituted pyrrolo[3,4-D]imidazoles for the treatment of MDM2/4 mediated diseases |
| EP2752191A1 (en) * | 2013-01-07 | 2014-07-09 | Sanofi | Compositions and methods using hdm2 antagonist and mek inhibitor |
| HRP20220718T1 (hr) * | 2013-11-11 | 2022-09-30 | Amgen Inc. | Kombinacijska terapija uključujući inhibitor mdm2 i jedan ili više dodatnih farmaceutski aktivnih sredstava za liječenje raka |
| WO2015084804A1 (en) * | 2013-12-03 | 2015-06-11 | Novartis Ag | Combination of mdm2 inhibitor and braf inhibitor and their use |
| WO2015095834A2 (en) * | 2013-12-20 | 2015-06-25 | Biomed Valley Discoveries, Inc. | Cancer treatments using erk1/2 and bcl-2 family inhibitors |
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2023
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| IL257015A (en) | 2018-03-29 |
| JP2018528206A (ja) | 2018-09-27 |
| US20210260059A1 (en) | 2021-08-26 |
| KR20180041677A (ko) | 2018-04-24 |
| RU2740091C2 (ru) | 2021-01-11 |
| RU2018110770A (ru) | 2019-09-30 |
| EP3340989B1 (en) | 2023-08-16 |
| RU2018110770A3 (https=) | 2020-01-15 |
| IL277239B (en) | 2022-04-01 |
| AU2016314082A1 (en) | 2018-02-08 |
| RU2020142739A3 (https=) | 2021-05-20 |
| IL257015B (en) | 2022-02-01 |
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| US20230398115A1 (en) | 2023-12-14 |
| US20190060309A1 (en) | 2019-02-28 |
| CA2992221A1 (en) | 2017-03-09 |
| JP2021042222A (ja) | 2021-03-18 |
| EP4241850A2 (en) | 2023-09-13 |
| EP4241850A3 (en) | 2023-11-08 |
| WO2017037579A1 (en) | 2017-03-09 |
| IL277239A (en) | 2020-10-29 |
| EP3340989A1 (en) | 2018-07-04 |
| AU2016314082B2 (en) | 2019-07-25 |
| AU2019204938A1 (en) | 2019-07-25 |
| AU2019204938B2 (en) | 2020-07-16 |
| ES2962460T3 (es) | 2024-03-19 |
| CN111821306A (zh) | 2020-10-27 |
| CN108348520A (zh) | 2018-07-31 |
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