RU2020130024A - Способы и реагенты для обнаружения и оценки генотоксичности - Google Patents
Способы и реагенты для обнаружения и оценки генотоксичности Download PDFInfo
- Publication number
- RU2020130024A RU2020130024A RU2020130024A RU2020130024A RU2020130024A RU 2020130024 A RU2020130024 A RU 2020130024A RU 2020130024 A RU2020130024 A RU 2020130024A RU 2020130024 A RU2020130024 A RU 2020130024A RU 2020130024 A RU2020130024 A RU 2020130024A
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- Russia
- Prior art keywords
- subject
- mutation
- genotoxin
- sample
- dna
- Prior art date
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- 238000000034 method Methods 0.000 title claims 65
- 230000001738 genotoxic effect Effects 0.000 title claims 9
- 231100000025 genetic toxicology Toxicity 0.000 title claims 5
- 239000003153 chemical reaction reagent Substances 0.000 title claims 3
- 230000035772 mutation Effects 0.000 claims 60
- 108020004414 DNA Proteins 0.000 claims 38
- 231100000446 genotoxin Toxicity 0.000 claims 38
- 238000001228 spectrum Methods 0.000 claims 38
- 238000012163 sequencing technique Methods 0.000 claims 29
- 239000000523 sample Substances 0.000 claims 27
- 238000012360 testing method Methods 0.000 claims 23
- 239000003795 chemical substances by application Substances 0.000 claims 19
- 102000053602 DNA Human genes 0.000 claims 15
- 238000003860 storage Methods 0.000 claims 14
- 241001465754 Metazoa Species 0.000 claims 11
- 230000003505 mutagenic effect Effects 0.000 claims 10
- 206010028980 Neoplasm Diseases 0.000 claims 9
- 201000011510 cancer Diseases 0.000 claims 9
- 239000012634 fragment Substances 0.000 claims 9
- 238000012937 correction Methods 0.000 claims 8
- 231100000219 mutagenic Toxicity 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 230000000869 mutational effect Effects 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 230000001225 therapeutic effect Effects 0.000 claims 6
- 230000009261 transgenic effect Effects 0.000 claims 6
- 210000004369 blood Anatomy 0.000 claims 5
- 239000008280 blood Substances 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 5
- 238000009826 distribution Methods 0.000 claims 4
- 231100000024 genotoxic Toxicity 0.000 claims 4
- 210000001519 tissue Anatomy 0.000 claims 4
- 239000012472 biological sample Substances 0.000 claims 3
- 230000000711 cancerogenic effect Effects 0.000 claims 3
- 231100000357 carcinogen Toxicity 0.000 claims 3
- 239000003183 carcinogenic agent Substances 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- 238000011282 treatment Methods 0.000 claims 3
- 230000005778 DNA damage Effects 0.000 claims 2
- 231100000277 DNA damage Toxicity 0.000 claims 2
- 230000009946 DNA mutation Effects 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 108700019146 Transgenes Proteins 0.000 claims 2
- 239000006227 byproduct Substances 0.000 claims 2
- 230000037437 driver mutation Effects 0.000 claims 2
- 210000005260 human cell Anatomy 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 230000010534 mechanism of action Effects 0.000 claims 2
- 239000003471 mutagenic agent Substances 0.000 claims 2
- 231100000707 mutagenic chemical Toxicity 0.000 claims 2
- 230000003546 nucleic acid damage Effects 0.000 claims 2
- 238000003752 polymerase chain reaction Methods 0.000 claims 2
- 230000000069 prophylactic effect Effects 0.000 claims 2
- WZZBNLYBHUDSHF-DHLKQENFSA-N 1-[(3s,4s)-4-[8-(2-chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-3-fluoropiperidin-1-yl]-2-hydroxyethanone Chemical compound CC1=NC2=CN=C3C=C(F)C(C=4C(=CC(OC=5N=CC=CN=5)=CC=4)Cl)=CC3=C2N1[C@H]1CCN(C(=O)CO)C[C@@H]1F WZZBNLYBHUDSHF-DHLKQENFSA-N 0.000 claims 1
- 108700028369 Alleles Proteins 0.000 claims 1
- 108010076525 DNA Repair Enzymes Proteins 0.000 claims 1
- 102000011724 DNA Repair Enzymes Human genes 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 238000004458 analytical method Methods 0.000 claims 1
- 239000012620 biological material Substances 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 238000012512 characterization method Methods 0.000 claims 1
- 238000004891 communication Methods 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 238000004590 computer program Methods 0.000 claims 1
- 239000013068 control sample Substances 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 claims 1
- 239000003599 detergent Substances 0.000 claims 1
- 238000011161 development Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003344 environmental pollutant Substances 0.000 claims 1
- 238000002474 experimental method Methods 0.000 claims 1
- 238000000605 extraction Methods 0.000 claims 1
- 235000013305 food Nutrition 0.000 claims 1
- 230000008826 genomic mutation Effects 0.000 claims 1
- 231100000734 genotoxic potential Toxicity 0.000 claims 1
- 229910001385 heavy metal Inorganic materials 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000003209 petroleum derivative Substances 0.000 claims 1
- 239000004014 plasticizer Substances 0.000 claims 1
- 231100000719 pollutant Toxicity 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 239000000047 product Substances 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 238000007423 screening assay Methods 0.000 claims 1
- 210000000952 spleen Anatomy 0.000 claims 1
- 231100000606 suspected carcinogen Toxicity 0.000 claims 1
- 235000019505 tobacco product Nutrition 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- -1 vaccine Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6858—Allele-specific amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/50—Mutagenesis
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/191—Modifications characterised by incorporating an adaptor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/142—Toxicological screening, e.g. expression profiles which identify toxicity
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Pathology (AREA)
- Medical Informatics (AREA)
- Theoretical Computer Science (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Evolutionary Biology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862630228P | 2018-02-13 | 2018-02-13 | |
| US62/630,228 | 2018-02-13 | ||
| US201862737097P | 2018-09-26 | 2018-09-26 | |
| US62/737,097 | 2018-09-26 | ||
| PCT/US2019/017908 WO2019160998A1 (en) | 2018-02-13 | 2019-02-13 | Methods and reagents for detecting and assessing genotoxicity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2020130024A true RU2020130024A (ru) | 2022-03-14 |
Family
ID=67619087
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2020130024A RU2020130024A (ru) | 2018-02-13 | 2019-02-13 | Способы и реагенты для обнаружения и оценки генотоксичности |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20210355532A1 (https=) |
| EP (1) | EP3752639A4 (https=) |
| JP (2) | JP7420388B2 (https=) |
| KR (1) | KR20200123159A (https=) |
| CN (1) | CN111836905A (https=) |
| AU (2) | AU2019221549C1 (https=) |
| BR (1) | BR112020016516A2 (https=) |
| CA (1) | CA3091022A1 (https=) |
| IL (1) | IL276637A (https=) |
| MX (1) | MX2020008472A (https=) |
| RU (1) | RU2020130024A (https=) |
| SG (1) | SG11202007648WA (https=) |
| WO (1) | WO2019160998A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2807306C1 (ru) * | 2023-04-06 | 2023-11-14 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр онкологии имени Н.Н. Блохина" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ онкологии им. Н.Н. Блохина" Минздрава России) | Способ выявления химерного транскрипта DNAJB1-PRKACA в клинических образцах ткани пациентов с фиброламеллярной карциномой печени методом полимеразной цепной реакции в реальном времени |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10844428B2 (en) | 2015-04-28 | 2020-11-24 | Illumina, Inc. | Error suppression in sequenced DNA fragments using redundant reads with unique molecular indices (UMIS) |
| CA3006792A1 (en) | 2015-12-08 | 2017-06-15 | Twinstrand Biosciences, Inc. | Improved adapters, methods, and compositions for duplex sequencing |
| SG11201906428SA (en) | 2017-01-18 | 2019-08-27 | Illumina Inc | Methods and systems for generation and error-correction of unique molecular index sets with heterogeneous molecular lengths |
| AU2018261332B2 (en) | 2017-05-01 | 2024-12-05 | Illumina, Inc. | Optimal index sequences for multiplex massively parallel sequencing |
| EP3622089B1 (en) | 2017-05-08 | 2024-07-17 | Illumina, Inc. | Method for sequencing using universal short adapters for indexing of polynucleotide samples |
| US11447818B2 (en) | 2017-09-15 | 2022-09-20 | Illumina, Inc. | Universal short adapters with variable length non-random unique molecular identifiers |
| AU2018366213B2 (en) | 2017-11-08 | 2025-05-15 | Twinstrand Biosciences, Inc. | Reagents and adapters for nucleic acid sequencing and methods for making such reagents and adapters |
| BR112021000409A2 (pt) * | 2018-07-12 | 2021-04-06 | Twinstrand Biosciences, Inc. | Métodos e reagentes para caracterizar edição genômica, expansão clonal e aplicações associadas |
| GB201911095D0 (en) * | 2019-08-02 | 2019-09-18 | Randox Laboratories Ltd | Biological status classification |
| IL303423A (en) * | 2020-12-07 | 2023-08-01 | Hoffmann La Roche | Techniques for generating predictive results related to oncology treatment lines using artificial intelligence |
| CN112614544B (zh) * | 2020-12-28 | 2024-05-17 | 杭州瑞普基因科技有限公司 | Kraken2软件输出结果的优化方法及鉴定样本中物种类型的方法 |
| CN112553356A (zh) * | 2020-12-31 | 2021-03-26 | 江苏意诺飞生物科技有限公司 | 一种高通量检测和判定幽门螺旋杆菌耐药性的方法 |
| CN113554285B (zh) * | 2021-07-05 | 2024-04-26 | 中国水产科学研究院黄海水产研究所 | 暴发水母种群波动对渔业资源风险影响的量化评估方法 |
| NL2029132B1 (en) * | 2021-09-06 | 2023-03-21 | Prinses Maxima Centrum Voor Kinderoncologie B V | Means and methods for assessing genotoxicity |
| CN115713968A (zh) * | 2022-11-21 | 2023-02-24 | 苏州新格元生物科技有限公司 | 一种评估基因毒性的方法、装置、存储介质和设备 |
| US12514461B2 (en) * | 2023-08-23 | 2026-01-06 | Wisconsin Alumni Research Foundation | System and method for analyzing gene expression using diffusion weighted magnetic resonance imaging (MRI) |
| KR102698843B1 (ko) * | 2024-01-23 | 2024-08-26 | 주식회사 이콜트리 | 유전독성 시험 자동화 시스템 및 방법 |
| WO2025216210A1 (ja) * | 2024-04-08 | 2025-10-16 | 株式会社ペルセウスプロテオミクス | 識別用分子を用いた核酸分子の特定 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5510099A (en) * | 1987-05-01 | 1996-04-23 | Stratagene | Mutagenesis testing using transgenic non-human animals carrying test DNA sequences |
| KR100300932B1 (ko) * | 1992-07-06 | 2001-10-22 | 조이스 브린톤 | 리포터유전자에융합된세균의스트레스프로모터를이용하여독성을측정하는방법및진단키트 |
| GB0905410D0 (en) * | 2009-03-28 | 2009-05-13 | Gentronix Ltd | Genotoxicity testing |
| PT2828218T (pt) * | 2012-03-20 | 2020-11-11 | Univ Washington Through Its Center For Commercialization | Métodos para baixar a taxa de erro da sequenciação paralela massiva de adn utilizando sequenciação duplex de consensus |
| AU2013267609C1 (en) * | 2012-05-31 | 2019-01-03 | Board Of Regents, The University Of Texas System | Method for accurate sequencing of DNA |
| EP2706123A1 (en) * | 2012-09-05 | 2014-03-12 | Rijksinstituut Voor Volksgezondheid En Milieu | In vitro method for determining genotoxic and non-genotoxic carcinogenicity of a compound. |
| ES2674928T3 (es) * | 2012-11-05 | 2018-07-05 | Gmdx Co Pty Ltd | Métodos para determinar la causa de la mutagénesis somática |
| JP6262922B1 (ja) * | 2017-02-16 | 2018-01-17 | 花王株式会社 | 物質の遺伝毒性の評価方法 |
| BR112021000409A2 (pt) * | 2018-07-12 | 2021-04-06 | Twinstrand Biosciences, Inc. | Métodos e reagentes para caracterizar edição genômica, expansão clonal e aplicações associadas |
-
2019
- 2019-02-13 BR BR112020016516-6A patent/BR112020016516A2/pt unknown
- 2019-02-13 RU RU2020130024A patent/RU2020130024A/ru unknown
- 2019-02-13 WO PCT/US2019/017908 patent/WO2019160998A1/en not_active Ceased
- 2019-02-13 MX MX2020008472A patent/MX2020008472A/es unknown
- 2019-02-13 US US16/969,531 patent/US20210355532A1/en active Pending
- 2019-02-13 CN CN201980013275.XA patent/CN111836905A/zh active Pending
- 2019-02-13 CA CA3091022A patent/CA3091022A1/en active Pending
- 2019-02-13 JP JP2020564824A patent/JP7420388B2/ja active Active
- 2019-02-13 KR KR1020207026362A patent/KR20200123159A/ko not_active Ceased
- 2019-02-13 EP EP19754491.9A patent/EP3752639A4/en active Pending
- 2019-02-13 SG SG11202007648WA patent/SG11202007648WA/en unknown
- 2019-02-13 AU AU2019221549A patent/AU2019221549C1/en active Active
-
2020
- 2020-08-11 IL IL276637A patent/IL276637A/en unknown
-
2023
- 2023-12-28 JP JP2023222575A patent/JP2024038208A/ja active Pending
-
2025
- 2025-11-07 AU AU2025263841A patent/AU2025263841A1/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2807306C1 (ru) * | 2023-04-06 | 2023-11-14 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр онкологии имени Н.Н. Блохина" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ онкологии им. Н.Н. Блохина" Минздрава России) | Способ выявления химерного транскрипта DNAJB1-PRKACA в клинических образцах ткани пациентов с фиброламеллярной карциномой печени методом полимеразной цепной реакции в реальном времени |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3752639A4 (en) | 2021-12-01 |
| JP2024038208A (ja) | 2024-03-19 |
| JP2021513364A (ja) | 2021-05-27 |
| KR20200123159A (ko) | 2020-10-28 |
| WO2019160998A1 (en) | 2019-08-22 |
| SG11202007648WA (en) | 2020-09-29 |
| IL276637A (en) | 2020-09-30 |
| BR112020016516A2 (pt) | 2020-12-15 |
| US20210355532A1 (en) | 2021-11-18 |
| AU2019221549A1 (en) | 2020-09-24 |
| AU2025263841A1 (en) | 2025-11-27 |
| CA3091022A1 (en) | 2019-08-22 |
| AU2019221549C1 (en) | 2025-11-27 |
| AU2019221549B2 (en) | 2025-08-07 |
| JP7420388B2 (ja) | 2024-01-23 |
| CN111836905A (zh) | 2020-10-27 |
| MX2020008472A (es) | 2020-11-11 |
| EP3752639A1 (en) | 2020-12-23 |
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