JP7420388B2 - 遺伝毒性を検出し、評価するための方法および試薬 - Google Patents

遺伝毒性を検出し、評価するための方法および試薬 Download PDF

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JP7420388B2
JP7420388B2 JP2020564824A JP2020564824A JP7420388B2 JP 7420388 B2 JP7420388 B2 JP 7420388B2 JP 2020564824 A JP2020564824 A JP 2020564824A JP 2020564824 A JP2020564824 A JP 2020564824A JP 7420388 B2 JP7420388 B2 JP 7420388B2
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double
genotoxic
stranded
nucleic acid
sequence
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ソーク，ジェシー・ジェイ
バレンタイン，チャールズ・クリントン・ザ・サード
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Twinstrand Biosciences Inc
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6858—Allele-specific amplification
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/50—Mutagenesis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
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    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10—Modifications characterised by
    • C12Q2525/191—Modifications characterised by incorporating an adaptor
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/142—Toxicological screening, e.g. expression profiles which identify toxicity

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  • Chemical & Material Sciences (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
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  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
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  • Bioinformatics & Computational Biology (AREA)
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  • Theoretical Computer Science (AREA)
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  • Medical Informatics (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2020564824A 2018-02-13 2019-02-13 遺伝毒性を検出し、評価するための方法および試薬 Active JP7420388B2 (ja)

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JP2023222575A JP2024038208A (ja) 2018-02-13 2023-12-28 遺伝毒性を検出し、評価するための方法および試薬

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US201862630228P 2018-02-13 2018-02-13
US62/630,228 2018-02-13
US201862737097P 2018-09-26 2018-09-26
US62/737,097 2018-09-26
PCT/US2019/017908 WO2019160998A1 (en) 2018-02-13 2019-02-13 Methods and reagents for detecting and assessing genotoxicity

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US (1) US20210355532A1 (https=)
EP (1) EP3752639A4 (https=)
JP (2) JP7420388B2 (https=)
KR (1) KR20200123159A (https=)
CN (1) CN111836905A (https=)
AU (2) AU2019221549C1 (https=)
BR (1) BR112020016516A2 (https=)
CA (1) CA3091022A1 (https=)
IL (1) IL276637A (https=)
MX (1) MX2020008472A (https=)
RU (1) RU2020130024A (https=)
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US10844428B2 (en) 2015-04-28 2020-11-24 Illumina, Inc. Error suppression in sequenced DNA fragments using redundant reads with unique molecular indices (UMIS)
PL3387152T3 (pl) 2015-12-08 2022-05-09 Twinstrand Biosciences, Inc. Ulepszone adaptory, sposoby i kompozycje do sekwencjonowania dupleksowego
US10844429B2 (en) 2017-01-18 2020-11-24 Illumina, Inc. Methods and systems for generation and error-correction of unique molecular index sets with heterogeneous molecular lengths
US11028435B2 (en) 2017-05-01 2021-06-08 Illumina, Inc. Optimal index sequences for multiplex massively parallel sequencing
ES2989056T3 (es) 2017-05-08 2024-11-25 Illumina Inc Método de secuenciación usando adaptadores cortos universales para la indexación de muestras de polinucleótidos
US11447818B2 (en) 2017-09-15 2022-09-20 Illumina, Inc. Universal short adapters with variable length non-random unique molecular identifiers
SG11202003885UA (en) 2017-11-08 2020-05-28 Twinstrand Biosciences Inc Reagents and adapters for nucleic acid sequencing and methods for making such reagents and adapters
WO2020014693A1 (en) * 2018-07-12 2020-01-16 Twinstrand Biosciences, Inc. Methods and reagents for characterizing genomic editing, clonal expansion, and associated applications
GB201911095D0 (en) * 2019-08-02 2019-09-18 Randox Laboratories Ltd Biological status classification
KR20230104966A (ko) * 2020-12-07 2023-07-11 에프. 호프만-라 로슈 아게 인공 지능을 이용한 종양 치료 라인과 관련된 예측 결과를 생성하기 위한 기법
CN112614544B (zh) * 2020-12-28 2024-05-17 杭州瑞普基因科技有限公司 Kraken2软件输出结果的优化方法及鉴定样本中物种类型的方法
CN112553356A (zh) * 2020-12-31 2021-03-26 江苏意诺飞生物科技有限公司 一种高通量检测和判定幽门螺旋杆菌耐药性的方法
CN113554285B (zh) * 2021-07-05 2024-04-26 中国水产科学研究院黄海水产研究所 暴发水母种群波动对渔业资源风险影响的量化评估方法
NL2029132B1 (en) * 2021-09-06 2023-03-21 Prinses Maxima Centrum Voor Kinderoncologie B V Means and methods for assessing genotoxicity
CN115713968A (zh) * 2022-11-21 2023-02-24 苏州新格元生物科技有限公司 一种评估基因毒性的方法、装置、存储介质和设备
US12514461B2 (en) * 2023-08-23 2026-01-06 Wisconsin Alumni Research Foundation System and method for analyzing gene expression using diffusion weighted magnetic resonance imaging (MRI)
KR102698843B1 (ko) * 2024-01-23 2024-08-26 주식회사 이콜트리 유전독성 시험 자동화 시스템 및 방법
WO2025216210A1 (ja) * 2024-04-08 2025-10-16 株式会社ペルセウスプロテオミクス 識別用分子を用いた核酸分子の特定

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AU2019221549C1 (en) 2025-11-27
JP2021513364A (ja) 2021-05-27
SG11202007648WA (en) 2020-09-29
KR20200123159A (ko) 2020-10-28
WO2019160998A1 (en) 2019-08-22
RU2020130024A (ru) 2022-03-14
AU2019221549A1 (en) 2020-09-24
US20210355532A1 (en) 2021-11-18
JP2024038208A (ja) 2024-03-19
AU2025263841A1 (en) 2025-11-27
BR112020016516A2 (pt) 2020-12-15
AU2019221549B2 (en) 2025-08-07
EP3752639A4 (en) 2021-12-01
CN111836905A (zh) 2020-10-27
CA3091022A1 (en) 2019-08-22
MX2020008472A (es) 2020-11-11
IL276637A (en) 2020-09-30
EP3752639A1 (en) 2020-12-23

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