RU2020121533A - Антагонисты ildr2 и их комбинации - Google Patents
Антагонисты ildr2 и их комбинации Download PDFInfo
- Publication number
- RU2020121533A RU2020121533A RU2020121533A RU2020121533A RU2020121533A RU 2020121533 A RU2020121533 A RU 2020121533A RU 2020121533 A RU2020121533 A RU 2020121533A RU 2020121533 A RU2020121533 A RU 2020121533A RU 2020121533 A RU2020121533 A RU 2020121533A
- Authority
- RU
- Russia
- Prior art keywords
- ildr2
- antibody
- seq
- fragment
- derivative
- Prior art date
Links
- 101001010614 Homo sapiens Immunoglobulin-like domain-containing receptor 2 Proteins 0.000 title claims 24
- 102100030712 Immunoglobulin-like domain-containing receptor 2 Human genes 0.000 title claims 24
- 239000005557 antagonist Substances 0.000 title claims 16
- 239000012634 fragment Substances 0.000 claims 19
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical group 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 230000002134 immunopathologic effect Effects 0.000 claims 2
- 230000001613 neoplastic effect Effects 0.000 claims 2
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 2
- 229940046168 CpG oligodeoxynucleotide Drugs 0.000 claims 1
- 101100072427 Homo sapiens ILDR2 gene Proteins 0.000 claims 1
- 229940123751 PD-L1 antagonist Drugs 0.000 claims 1
- 229940123237 Taxane Drugs 0.000 claims 1
- 239000000611 antibody drug conjugate Substances 0.000 claims 1
- 229940049595 antibody-drug conjugate Drugs 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762592913P | 2017-11-30 | 2017-11-30 | |
| US62/592,913 | 2017-11-30 | ||
| PCT/EP2018/082779 WO2019105972A1 (en) | 2017-11-30 | 2018-11-28 | Ildr2 antagonists and combinations thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2020121533A true RU2020121533A (ru) | 2021-12-30 |
Family
ID=64559680
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2020121533A RU2020121533A (ru) | 2017-11-30 | 2018-11-28 | Антагонисты ildr2 и их комбинации |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US11655297B2 (enExample) |
| EP (1) | EP3717007B1 (enExample) |
| JP (1) | JP7350740B2 (enExample) |
| KR (1) | KR20200096223A (enExample) |
| CN (1) | CN111655287B (enExample) |
| AR (1) | AR113850A1 (enExample) |
| AU (1) | AU2018376231A1 (enExample) |
| BR (1) | BR112020010767A2 (enExample) |
| CA (1) | CA3083675A1 (enExample) |
| IL (1) | IL274751B2 (enExample) |
| MX (1) | MX2020005483A (enExample) |
| PE (1) | PE20200956A1 (enExample) |
| RU (1) | RU2020121533A (enExample) |
| SG (1) | SG11202003323TA (enExample) |
| TW (1) | TW201934119A (enExample) |
| WO (1) | WO2019105972A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3952910A1 (en) * | 2019-04-11 | 2022-02-16 | Bayer Aktiengesellschaft | Combinations of anti-ildr2 antibodies and pd-1 antagonists |
| CN111574626B (zh) * | 2020-05-27 | 2021-12-31 | 斯爱玲 | 一种ildr2抗体、其药物组合物及其用途 |
| CN111558038B (zh) * | 2020-05-27 | 2022-04-19 | 北京加美康联健康管理集团有限公司 | 一种用于癌症治疗的免疫检查点抑制剂 |
| IL301396A (en) | 2020-09-30 | 2023-05-01 | Nobell Foods Inc | Recombinant milk proteins and food compositions comprising the same |
| US10947552B1 (en) | 2020-09-30 | 2021-03-16 | Alpine Roads, Inc. | Recombinant fusion proteins for producing milk proteins in plants |
| US10894812B1 (en) | 2020-09-30 | 2021-01-19 | Alpine Roads, Inc. | Recombinant milk proteins |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| CA2026147C (en) | 1989-10-25 | 2006-02-07 | Ravi J. Chari | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| US5635483A (en) | 1992-12-03 | 1997-06-03 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Tumor inhibiting tetrapeptide bearing modified phenethyl amides |
| US5780588A (en) | 1993-01-26 | 1998-07-14 | Arizona Board Of Regents | Elucidation and synthesis of selected pentapeptides |
| SG149815A1 (en) | 2003-11-06 | 2009-02-27 | Seattle Genetics Inc | Monomethylvaline compounds capable of conjugation to ligands |
| MY146381A (en) * | 2004-12-22 | 2012-08-15 | Amgen Inc | Compositions and methods relating relating to anti-igf-1 receptor antibodies |
| EP2769729B1 (en) | 2007-09-04 | 2019-01-09 | Compugen Ltd. | Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics |
| US20130209463A1 (en) * | 2010-06-30 | 2013-08-15 | Compugen Ltd. | Polypeptides and uses thereof as a drug for treatment of multiple sclerosis, rheumatoid arthritis and other autoimmune disorders |
| AU2012277376B2 (en) * | 2011-06-30 | 2016-11-24 | Compugen Ltd. | Polypeptides and uses thereof for treatment of autoimmune disorders and infection |
| JP2015512616A (ja) * | 2012-02-01 | 2015-04-30 | コンピュゲン エルティーディー． | Ｃ１ｏｒｆ３２抗体およびがんの治療のためのその使用 |
| US20170233473A1 (en) * | 2014-05-27 | 2017-08-17 | Compugen Ltd. | C10rf32 antibodies, and uses thereof for treatment of cancer |
| US9682123B2 (en) | 2013-12-20 | 2017-06-20 | The Trustees Of Columbia University In The City Of New York | Methods of treating metabolic disease |
| PT3789042T (pt) | 2014-04-10 | 2025-01-14 | Daiichi Sankyo Europe Gmbh | Método para produzir conjugado anticorpo-fármaco anti-her3 |
| AU2016323582B2 (en) | 2015-09-16 | 2022-09-15 | Ablexis, Llc | Anti-CD115 antibodies |
-
2018
- 2018-11-28 EP EP18811506.7A patent/EP3717007B1/en active Active
- 2018-11-28 WO PCT/EP2018/082779 patent/WO2019105972A1/en not_active Ceased
- 2018-11-28 US US16/766,224 patent/US11655297B2/en active Active
- 2018-11-28 JP JP2020529368A patent/JP7350740B2/ja active Active
- 2018-11-28 MX MX2020005483A patent/MX2020005483A/es unknown
- 2018-11-28 CN CN201880077055.9A patent/CN111655287B/zh active Active
- 2018-11-28 KR KR1020207015214A patent/KR20200096223A/ko not_active Ceased
- 2018-11-28 AR ARP180103490A patent/AR113850A1/es not_active Application Discontinuation
- 2018-11-28 RU RU2020121533A patent/RU2020121533A/ru unknown
- 2018-11-28 PE PE2020000620A patent/PE20200956A1/es unknown
- 2018-11-28 IL IL274751A patent/IL274751B2/en unknown
- 2018-11-28 CA CA3083675A patent/CA3083675A1/en active Pending
- 2018-11-28 BR BR112020010767-0A patent/BR112020010767A2/pt not_active IP Right Cessation
- 2018-11-28 AU AU2018376231A patent/AU2018376231A1/en not_active Abandoned
- 2018-11-28 SG SG11202003323TA patent/SG11202003323TA/en unknown
- 2018-11-30 TW TW107142979A patent/TW201934119A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2020005483A (es) | 2020-08-27 |
| EP3717007A1 (en) | 2020-10-07 |
| KR20200096223A (ko) | 2020-08-11 |
| CN111655287A (zh) | 2020-09-11 |
| AR113850A1 (es) | 2020-06-17 |
| AU2018376231A1 (en) | 2020-05-07 |
| CN111655287B (zh) | 2024-12-27 |
| IL274751B1 (en) | 2024-07-01 |
| TW201934119A (zh) | 2019-09-01 |
| WO2019105972A1 (en) | 2019-06-06 |
| EP3717007B1 (en) | 2025-09-17 |
| IL274751A (en) | 2020-07-30 |
| US20200369769A1 (en) | 2020-11-26 |
| EP3717007C0 (en) | 2025-09-17 |
| JP7350740B2 (ja) | 2023-09-26 |
| IL274751B2 (en) | 2024-11-01 |
| BR112020010767A2 (pt) | 2020-11-24 |
| SG11202003323TA (en) | 2020-05-28 |
| US11655297B2 (en) | 2023-05-23 |
| JP2021504404A (ja) | 2021-02-15 |
| CA3083675A1 (en) | 2019-06-06 |
| PE20200956A1 (es) | 2020-09-24 |
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