RU2020110056A - Обнаружение рекомбиназной полимеразной амплификации с применением зонда с двойным гаптеном - Google Patents

Обнаружение рекомбиназной полимеразной амплификации с применением зонда с двойным гаптеном Download PDF

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RU2020110056A
RU2020110056A RU2020110056A RU2020110056A RU2020110056A RU 2020110056 A RU2020110056 A RU 2020110056A RU 2020110056 A RU2020110056 A RU 2020110056A RU 2020110056 A RU2020110056 A RU 2020110056A RU 2020110056 A RU2020110056 A RU 2020110056A
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kda
nucleic acid
zone
hapten
bulking agent
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RU2020110056A
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Russian (ru)
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Майкл Л. ПАУЭЛЛ
Фрэнк Рэй БОУЛЕР
Кэтрин Джин ГРИНВУД
Олаф ПИПЕНБУРГ
Найл А. АРМС
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Эбботт Диагностикс Скарборо, Инк.
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Publication of RU2020110056A publication Critical patent/RU2020110056A/ru

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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804Nucleic acid analysis using immunogens
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6818Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • G01N33/54386Analytical elements
    • G01N33/54387Immunochromatographic test strips
    • G01N33/54388Immunochromatographic test strips based on lateral flow
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    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/563Immunoassay; Biospecific binding assay; Materials therefor involving antibody fragments
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • C12Q2563/00Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/131Nucleic acid detection characterized by the use of physical, structural and functional properties the label being a member of a cognate binding pair, i.e. extends to antibodies, haptens, avidin
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    • C12Y302/02Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2) hydrolysing N-glycosyl compounds (3.2.2)
    • C12Y302/02023DNA-formamidopyrimidine glycosylase (3.2.2.23)

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  • Chemical & Material Sciences (AREA)
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RU2020110056A 2017-09-14 2018-09-14 Обнаружение рекомбиназной полимеразной амплификации с применением зонда с двойным гаптеном RU2020110056A (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762558705P 2017-09-14 2017-09-14
US62/558,705 2017-09-14
PCT/US2018/051078 WO2019055780A1 (en) 2017-09-14 2018-09-14 POLYMERASE RECOMBINASE AMPLIFICATION DETECTION USING DOUBLE HAPTEN PROBE

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US (1) US20190078147A1 (https=)
EP (2) EP4464412A3 (https=)
JP (2) JP7412332B2 (https=)
KR (2) KR20250058779A (https=)
CN (1) CN111201328B (https=)
AU (1) AU2018334226B2 (https=)
BR (1) BR112020005121A2 (https=)
CA (1) CA3075629A1 (https=)
ES (1) ES2991912T3 (https=)
MX (1) MX2020002826A (https=)
RU (1) RU2020110056A (https=)
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102020103958B4 (de) * 2020-02-14 2021-08-26 Testo bioAnalytics GmbH Oligonukleotidsonde zum spezifischen Nachweis von Mikroorganismen, korrespondierendes Verfahren und Verwendung
EP3950955A1 (en) * 2020-08-06 2022-02-09 Albert-Ludwigs-Universität Freiburg Multianalyte assay for the simultaneous detection of nucleic acid and analytes
CN113552106B (zh) * 2021-07-23 2022-12-30 济南大学 一种检测ATP、谷胱甘肽、Fpg糖基化酶的通用荧光传感器
GR20220100698A (el) * 2022-08-18 2024-03-12 Πανεπιστημιο Πατρων, Μεθοδος βελτιωσης της ανιχνευσιμοτητας των δοκιμων που βασιζονται σε ταινιες ξηρων αντιδραστηριων

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4591552A (en) * 1982-09-29 1986-05-27 New York Blood Center, Inc. Detection of hepatitis B surface antigen (or antibody to same) with labeled synthetic peptide
PT1024191E (pt) * 1991-12-02 2008-12-22 Medical Res Council Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos
US5770563A (en) * 1991-12-06 1998-06-23 The United States Of America As Represented By The Department Of Health And Human Services Heparin- and sulfatide binding peptides from the type I repeats of human thrombospondin and conjugates thereof
AU692152B2 (en) * 1993-03-17 1998-06-04 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Immunogenic chimeras comprising nucleic acid sequences encoding endoplasmic reticulum signal sequence peptides and at least one other peptide, and their uses in vaccines and disease treatments
DE4441626A1 (de) * 1994-11-23 1996-05-30 Boehringer Mannheim Gmbh Verfahren zum besonders sensitiven Nachweis von Nukleinsäuren
US6031098A (en) * 1997-08-11 2000-02-29 California Institute Of Technology Detection and treatment of duplex polynucleotide damage
AU2001279073B2 (en) * 2000-07-28 2006-08-24 Christopher J. Murphy Transplant media
US7399590B2 (en) 2002-02-21 2008-07-15 Asm Scientific, Inc. Recombinase polymerase amplification
US8030000B2 (en) * 2002-02-21 2011-10-04 Alere San Diego, Inc. Recombinase polymerase amplification
US7270981B2 (en) 2002-02-21 2007-09-18 Asm Scientific, Inc. Recombinase polymerase amplification
WO2007096702A2 (en) 2005-07-25 2007-08-30 Asm Scientific, Inc. Methods for multiplexing recombinase polymerase amplification
SG170028A1 (en) * 2006-02-24 2011-04-29 Callida Genomics Inc High throughput genome sequencing on dna arrays
US8071308B2 (en) 2006-05-04 2011-12-06 Alere San Diego, Inc. Recombinase polymerase amplification
US9334531B2 (en) * 2010-12-17 2016-05-10 Life Technologies Corporation Nucleic acid amplification
JP5847076B2 (ja) 2009-05-20 2016-01-20 バイオサイト インコーポレイテッド Dnaグリコシラーゼ/リアーゼおよびapエンドヌクレアーゼ基質
EP2438196B1 (en) 2009-06-05 2016-12-21 Alere San Diego, Inc. Recombinase polymerase amplification reagents and kits
CN107739750A (zh) * 2009-09-25 2018-02-27 艾利尔圣迭戈公司 粗基质中的核酸的检测
ES2764096T3 (es) 2013-08-19 2020-06-02 Abbott Molecular Inc Bibliotecas de secuenciación de próxima generación
US10227634B2 (en) * 2015-04-15 2019-03-12 University Of Washington Isotachophoresis enhanced isothermal nucleic acid amplification
GB201519565D0 (en) 2015-11-05 2015-12-23 Alere San Diego Inc Sample preparation device
ES3063374T3 (en) * 2015-10-30 2026-04-16 Abbott Diagnostics Scarborough Inc Determination of polymorphisms using isothermal nucleic acid amplification
WO2017123647A1 (en) * 2016-01-15 2017-07-20 Quantapore, Inc. Optically-based nanopore analysis with reduced background

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Publication number Publication date
EP4464412A2 (en) 2024-11-20
MX2020002826A (es) 2020-07-22
WO2019055780A1 (en) 2019-03-21
ES2991912T3 (es) 2024-12-05
AU2018334226A1 (en) 2020-04-02
BR112020005121A2 (pt) 2020-09-24
JP7412332B2 (ja) 2024-01-12
JP2024045115A (ja) 2024-04-02
CN111201328A (zh) 2020-05-26
EP3682029A1 (en) 2020-07-22
KR20200054268A (ko) 2020-05-19
EP3682029A4 (en) 2021-06-02
JP2020537499A (ja) 2020-12-24
AU2018334226B2 (en) 2024-07-11
CN111201328B (zh) 2024-07-02
EP3682029B1 (en) 2024-08-14
KR102800957B1 (ko) 2025-04-30
KR20250058779A (ko) 2025-04-30
EP4464412A3 (en) 2025-02-26
US20190078147A1 (en) 2019-03-14
CA3075629A1 (en) 2019-03-21

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