GR20220100698A - Μεθοδος βελτιωσης της ανιχνευσιμοτητας των δοκιμων που βασιζονται σε ταινιες ξηρων αντιδραστηριων - Google Patents
Μεθοδος βελτιωσης της ανιχνευσιμοτητας των δοκιμων που βασιζονται σε ταινιες ξηρων αντιδραστηριων Download PDFInfo
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- GR20220100698A GR20220100698A GR20220100698A GR20220100698A GR20220100698A GR 20220100698 A GR20220100698 A GR 20220100698A GR 20220100698 A GR20220100698 A GR 20220100698A GR 20220100698 A GR20220100698 A GR 20220100698A GR 20220100698 A GR20220100698 A GR 20220100698A
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- detectability
- rapid tests
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- 239000003153 chemical reaction reagent Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- 238000004458 analytical method Methods 0.000 abstract 2
- 239000000523 sample Substances 0.000 abstract 2
- 230000003321 amplification Effects 0.000 abstract 1
- 239000012491 analyte Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 238000003199 nucleic acid amplification method Methods 0.000 abstract 1
- 239000011148 porous material Substances 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54386—Analytical elements
- G01N33/54387—Immunochromatographic test strips
- G01N33/54388—Immunochromatographic test strips based on lateral flow
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- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Molecular Biology (AREA)
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- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Στην παρούσα εφεύρεση παρουσιάζεται μέθοδος βελτίωσης της ανιχνευσιμότητας των ταχυδοκιμών που πραγματοποιούνται με τη χρήση ταινιών ξηρών αντιδραστηρίων, αξιοποιώντας παράγοντες που δημιουργούν μακρομοριακό συνωστισμό, oι οποίοι κατά τη διάρκεια της ροής του διαλύματος/δείγματος μέσω των πόρων της ταινίας δημιουργούν ένα μικροπεριβάλλον που διευκολύνει τις αλληλεπιδράσεις και προάγει τις αντιδράσεις που λαμβάνουν χώρα για την αναγνώριση του αναλυτή και την παραγωγή σήματος στην ταχυδοκιμή. Η βελτίωση της ανιχνευσιμότητας επιτυγχάνεται δίχως να περιορίζονται τα ευρέως γνωστά πλεονεκτήματα των ταχυδοκιμών, δηλαδή η απλότητα και η πρακτικότητα στην εκτέλεσή τους από τον χρήστη και η καταλληλότητά τους για επιτόπιες αναλύσεις (π.χ. ταχυδοκιμές πεδίου, αναλύσεις κατ΄ οίκον, παρακλίνιεςαναλύσεις κλπ). Η προσθήκη μακρομοριακών παραγόντων συνωστισμού δεν αντικαθιστά αλλά είναι συμπληρωματική με άλλες στρατηγικές βελτίωσης της ανιχνευσιμότητας, όπως ο σχεδιασμός νέων ιχνηθετών, η εισαγωγή ενίσχυσης σήματος και η εισαγωγή νέων μεταλλακτών. Αναμένουμε ότι η προτεινόμενη διαμόρφωση θα επεκταθεί σε πολυάριθμους αναλυτές με ποικιλία ιχνηθετών και σε ποικίλες διαμορφώσεις των ταχυδοκιμών πλάγιας ροής.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GR20220100698A GR20220100698A (el) | 2022-08-18 | 2022-08-18 | Μεθοδος βελτιωσης της ανιχνευσιμοτητας των δοκιμων που βασιζονται σε ταινιες ξηρων αντιδραστηριων |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GR20220100698A GR20220100698A (el) | 2022-08-18 | 2022-08-18 | Μεθοδος βελτιωσης της ανιχνευσιμοτητας των δοκιμων που βασιζονται σε ταινιες ξηρων αντιδραστηριων |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR20220100698A true GR20220100698A (el) | 2024-03-12 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR20220100698A GR20220100698A (el) | 2022-08-18 | 2022-08-18 | Μεθοδος βελτιωσης της ανιχνευσιμοτητας των δοκιμων που βασιζονται σε ταινιες ξηρων αντιδραστηριων |
Country Status (1)
| Country | Link |
|---|---|
| GR (1) | GR20220100698A (el) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998039657A1 (en) * | 1997-03-06 | 1998-09-11 | Quidel Corporation | Quantitative lateral flow assays and devices |
| US20090131267A1 (en) * | 2006-01-03 | 2009-05-21 | Peter Porschewski | Use of polymers for increasing the signal intensity when carrying out detection reactions |
| WO2013130002A1 (en) * | 2012-02-29 | 2013-09-06 | General Electric Company | Antibody diluent buffer |
| WO2014012077A1 (en) * | 2012-07-13 | 2014-01-16 | Genisphere, Llc | Lateral flow assays using dna dendrimers |
| US20190078147A1 (en) * | 2017-09-14 | 2019-03-14 | Alere San Diego Inc. | Detection of recombinase polymerase amplification using dual-hapten probe |
| WO2019108412A1 (en) * | 2017-11-28 | 2019-06-06 | Bio-Rad Laboratories, Inc. | Lateral flow assay device |
-
2022
- 2022-08-18 GR GR20220100698A patent/GR20220100698A/el unknown
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998039657A1 (en) * | 1997-03-06 | 1998-09-11 | Quidel Corporation | Quantitative lateral flow assays and devices |
| US20090131267A1 (en) * | 2006-01-03 | 2009-05-21 | Peter Porschewski | Use of polymers for increasing the signal intensity when carrying out detection reactions |
| WO2013130002A1 (en) * | 2012-02-29 | 2013-09-06 | General Electric Company | Antibody diluent buffer |
| WO2014012077A1 (en) * | 2012-07-13 | 2014-01-16 | Genisphere, Llc | Lateral flow assays using dna dendrimers |
| US20190078147A1 (en) * | 2017-09-14 | 2019-03-14 | Alere San Diego Inc. | Detection of recombinase polymerase amplification using dual-hapten probe |
| WO2019108412A1 (en) * | 2017-11-28 | 2019-06-06 | Bio-Rad Laboratories, Inc. | Lateral flow assay device |
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