RU2019132146A - Композиция для восстановления твердых тканей и набор для восстановления твердых тканей - Google Patents

Композиция для восстановления твердых тканей и набор для восстановления твердых тканей Download PDF

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RU2019132146A
RU2019132146A RU2019132146A RU2019132146A RU2019132146A RU 2019132146 A RU2019132146 A RU 2019132146A RU 2019132146 A RU2019132146 A RU 2019132146A RU 2019132146 A RU2019132146 A RU 2019132146A RU 2019132146 A RU2019132146 A RU 2019132146A
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composition
hard tissue
polymer powder
parts
monomer
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RU2019132146A
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RU2760390C2 (ru
RU2019132146A3 (ru
Inventor
Кенго ГОТО
Синия АОКИ
Такаси МИУРА
Тетсуя ХАМАДА
Аяко БАНДО
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Митсуи Кемикалс, Инк.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/44—Radioisotopes, radionuclides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Materials Engineering (AREA)
  • Molecular Biology (AREA)
  • Materials For Medical Uses (AREA)
  • Gloves (AREA)

Claims (9)

1. Композиция для восстановления твердых тканей, содержащая мономер (A), полимерный порошок (B), содержащий 54 мас.% или более полимерного порошка (b1), имеющего среднеобъемный диаметр частиц от 27 до 80 мкм, и инициатор полимеризации (C).
2. Композиция для восстановления твердых тканей по п.1, в которой имитируемая проницаемость кости, измеренная следующим способом, составляет 1,0 мм или более:
[метод измерения имитируемой проницаемости кости]
имитируемую проницаемость кости измеряют путем пропитки пенополиуретана, имеющего пористость с открытыми ячейками (пористость 95%), физиологическим солевым раствором, путем размещения композиции на полиуретан, пропитанный физиологическим солевым раствором, через 5 минут после того, как композиция становится мягкой массой и больше не имеет вязкости, путем приложения к композиции на полиуретане нагрузки давления 75 кПа в течение 30 секунд, путем измерения глубины проникновения (мм) композиции в пенополиуретан.
3. Композиция для восстановления твердых тканей по п.1, дополнительно содержащая контрастное вещество (Х), имеющее среднеобъемный диаметр частиц менее 3,0 мкм.
4. Композиция для восстановления твердой ткани по п.1, в которой мономер (А) представляет собой мономер на основе (мет) акрилата.
5. Композиция для восстановления твердой ткани по п.1, в которой полимерный порошок (В) представляет собой полимерный порошок на основе (мет) акрилата.
6. Композиция для восстановления твердых тканей по п.1, содержащая от 10 до 45 мас. частей мономера (А), от 54,9 до 80 мас. частей порошка полимера (В) и от 0,1 до 10 мас. частей инициатора полимеризации (C) (сумма компонентов (A)–(C) принимается за 100 частей по массе) и от 0 до 70 мас. частей контрастного вещества (X).
7. Набор для восстановления твердых тканей, включающий в себя по меньшей мере три элемента, в котором каждый из компонентов мономера (A), полимерного порошка (B) и инициатора полимеризации (C) композиции для восстановления твердых тканей по п.1 являются отдельными и содержатся в элементах в сочетании по выбору.
RU2019132146A 2017-03-31 2018-03-29 Композиция для восстановления твердых тканей и набор для восстановления твердых тканей RU2760390C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2017-072727 2017-03-31
JP2017072727 2017-03-31
PCT/JP2018/013471 WO2018181821A1 (ja) 2017-03-31 2018-03-29 硬組織補修用組成物及び硬組織補修用キット

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RU2019132146A true RU2019132146A (ru) 2021-04-30
RU2019132146A3 RU2019132146A3 (ru) 2021-04-30
RU2760390C2 RU2760390C2 (ru) 2021-11-24

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US (1) US11311642B2 (ru)
EP (1) EP3603684B1 (ru)
JP (1) JP7021836B2 (ru)
KR (1) KR102394502B1 (ru)
CN (1) CN110461377B (ru)
AU (1) AU2018242783B2 (ru)
BR (1) BR112019020581B1 (ru)
DK (1) DK3603684T3 (ru)
ES (1) ES2942753T3 (ru)
RU (1) RU2760390C2 (ru)
TW (1) TWI832813B (ru)
WO (1) WO2018181821A1 (ru)

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JP7096324B2 (ja) * 2018-03-20 2022-07-05 三井化学株式会社 硬組織補修用組成物及び硬組織補修用キット
CN113332486B (zh) * 2021-01-09 2022-09-20 嘉兴市京吟生物科技有限公司 一种硬组织修补用粘合剂组成物及其硬组织修补用套装

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Publication number Publication date
CN110461377A (zh) 2019-11-15
RU2760390C2 (ru) 2021-11-24
KR102394502B1 (ko) 2022-05-03
EP3603684B1 (en) 2023-03-22
BR112019020581B1 (pt) 2022-11-29
AU2018242783A1 (en) 2019-10-24
TW201841662A (zh) 2018-12-01
DK3603684T3 (da) 2023-05-15
BR112019020581A2 (pt) 2020-05-19
JPWO2018181821A1 (ja) 2020-02-06
CN110461377B (zh) 2022-05-10
US20200030484A1 (en) 2020-01-30
AU2018242783B2 (en) 2021-01-07
WO2018181821A1 (ja) 2018-10-04
US11311642B2 (en) 2022-04-26
JP7021836B2 (ja) 2022-02-17
ES2942753T3 (es) 2023-06-06
RU2019132146A3 (ru) 2021-04-30
TWI832813B (zh) 2024-02-21
KR20190122869A (ko) 2019-10-30
EP3603684A1 (en) 2020-02-05
EP3603684A4 (en) 2020-12-30

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