RU2019126318A - Композиции и соответствующие способы контроля заболеваний, передаваемых переносчиками - Google Patents
Композиции и соответствующие способы контроля заболеваний, передаваемых переносчиками Download PDFInfo
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- RU2019126318A RU2019126318A RU2019126318A RU2019126318A RU2019126318A RU 2019126318 A RU2019126318 A RU 2019126318A RU 2019126318 A RU2019126318 A RU 2019126318A RU 2019126318 A RU2019126318 A RU 2019126318A RU 2019126318 A RU2019126318 A RU 2019126318A
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- seq
- antimicrobial peptide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A61K38/1729—Cationic antimicrobial peptides, e.g. defensins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1767—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
- C07K14/43572—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from bees
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
- C07K14/43577—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from flies
- C07K14/43581—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from flies from Drosophila
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
- C07K14/43586—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from silkworms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Insects & Arthropods (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Marine Sciences & Fisheries (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Claims (10)
1. Способ снижения приспособленности переносчика патогена человека, при этом способ включает
доставку противомикробного пептида, характеризующегося по меньшей мере 90% идентичностью последовательности с одним или несколькими из следующих: цекропина (SEQ ID NO: 82), мелиттина, копсина, дрозомицина (SEQ ID NO: 93), дермсидина (SEQ ID NO: 81), андропина (SEQ ID NO: 83), морицина (SEQ ID NO: 84), цератотоксина (SEQ ID NO: 85), абецина (SEQ ID NO: 86), апидецина (SEQ ID NO: 87), профенина (SEQ ID NO: 88), индолицидина (SEQ ID NO: 89), протегрина (SEQ ID NO: 90), тахиплезина (SEQ ID NO: 91) или дефензина (SEQ ID NO: 92), переносчику.
2. Способ по п. 1, где доставка включает доставку противомикробного пептида в по меньшей мере одну среду обитания, в которой переносчик растет, живет, размножается, питается или осуществляет заражение.
3. Способ по любому из пп. 1, 2, где противомикробный пептид доставляют в композиции, съедобной для насекомого, для поглощения переносчиком.
4. Способ по любому из пп. 1-3, где противомикробный пептид составлен в виде жидкой, твердой, аэрозольной, пастообразной, гелеобразной или газообразной композиции.
5. Способ по любому из пп. 1-4, где насекомое является по меньшей мере одним из комара, галлицы, вши, москита, иксодового клеща, триатомового клопа, мухи цеце или блохи.
6. Композиция, содержащая противомикробный пептид, характеризующийся по меньшей мере 90% идентичностью последовательности с одним или несколькими из следующих: цекропина, мелиттина, копсина, дрозомицина, дермсидина, андропина, морицина, цератотоксина, абецина, апидецина, профенина, индолицидина, протегрина, тахиплезина или дефензина, составленная для целенаправленного воздействия на микроорганизм в переносчике патогена человека.
7. Композиция по п. 6, где противомикробный пептид присутствует в концентрации от приблизительно 0,1 нг/г до приблизительно 100 мг/г в композиции.
8. Композиция по любому из пп. 6, 7, где противомикробный пептид дополнительно содержит нацеливающий домен.
9. Композиция по любому из пп. 6-8, где противомикробный пептид дополнительно содержит пептид, проникающий в клетку.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762450057P | 2017-01-24 | 2017-01-24 | |
| US62/450,057 | 2017-01-24 | ||
| US201762583912P | 2017-11-09 | 2017-11-09 | |
| US62/583,912 | 2017-11-09 | ||
| PCT/US2018/015065 WO2018140507A1 (en) | 2017-01-24 | 2018-01-24 | Compositions and related methods for controlling vector-borne diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2019126318A true RU2019126318A (ru) | 2021-02-26 |
| RU2019126318A3 RU2019126318A3 (ru) | 2021-11-16 |
| RU2804136C2 RU2804136C2 (ru) | 2023-09-26 |
Family
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2018140507A8 (en) | 2018-10-18 |
| EP3573638A4 (en) | 2020-12-23 |
| BR112019014958A2 (pt) | 2020-04-14 |
| JP2020509078A (ja) | 2020-03-26 |
| WO2018140507A1 (en) | 2018-08-02 |
| US20190365853A1 (en) | 2019-12-05 |
| CA3047357A1 (en) | 2018-08-02 |
| CN111148523A (zh) | 2020-05-12 |
| UA126575C2 (uk) | 2022-11-02 |
| AU2018212575A1 (en) | 2019-07-04 |
| RU2019126318A3 (ru) | 2021-11-16 |
| JP2023052111A (ja) | 2023-04-11 |
| US20200261536A1 (en) | 2020-08-20 |
| AU2018212575B2 (en) | 2022-07-07 |
| US20210275635A1 (en) | 2021-09-09 |
| EP3573638A1 (en) | 2019-12-04 |
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