RU2019116981A - Композиции и способы лечения желудочно-кишечных полипов - Google Patents

Композиции и способы лечения желудочно-кишечных полипов Download PDF

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RU2019116981A
RU2019116981A RU2019116981A RU2019116981A RU2019116981A RU 2019116981 A RU2019116981 A RU 2019116981A RU 2019116981 A RU2019116981 A RU 2019116981A RU 2019116981 A RU2019116981 A RU 2019116981A RU 2019116981 A RU2019116981 A RU 2019116981A
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polyps
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Махеш КАНДУЛА
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Целликс Био Прайвет Лимитед
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    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
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    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C229/56—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in ortho-position
    • C07C229/58—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in ortho-position having the nitrogen atom of at least one of the amino groups further bound to a carbon atom of a six-membered aromatic ring, e.g. N-phenyl-anthranilic acids
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    • C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C229/62—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino groups and at least two carboxyl groups bound to carbon atoms of the same six-membered aromatic ring
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    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
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    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

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  • Chemical & Material Sciences (AREA)
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  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Claims (26)

1. Соединение с формулой
Figure 00000001
Формула I,
и его фармацевтически приемлемые соли, гидраты, сольваты, пролекарства, энантиомеры и стереоизомеры;
где каждый из R1, R3, R5 независимо представляет собой OD, OCH3, OCOCH3, NULL,
Figure 00000002
Figure 00000003
каждый из R2, R4, R6 независимо представляет собой
Figure 00000004
Figure 00000005
Figure 00000006
Figure 00000007
Figure 00000008
Figure 00000009
n независимо равен 1, 2, 3, 4 или 5;
a независимо равен 2, 3 или 7;
каждый b независимо равен 3, 5 или 6;
e независимо равен 1, 2 или 6;
каждый из c и d независимо представляет собой H, D, -OH, -OD, C1-C6-алкил, -NH2 или -COCH3.
2. Фармацевтическая композиция, содержащая соединение по п. 1 и фармацевтически приемлемый носитель.
3. Фармацевтическая композиция по п. 2, которая составлена для лечения лежащей в основе этиологии эффективным количеством, вводимым нуждающемуся пациенту путем перорального введения, отсроченного или замедленного высвобождения, трансмукозального введения, в виде сиропа, местного, парентерального введения, инъекции, подкожного, перорального раствора, ректального введения, трансбуккального введения или трансдермального введения.
4. Соединения и композиции по п. 3, которые составлены для лечения желудочно-кишечных полипов, кишечных полипов и воспаления.
5. Способ лечения по меньшей мере одного из желудочно-кишечных полипов, кишечных полипов и воспалительного заболевания, включающий
введение пациенту, страдающему по меньшей мере одним из желудочно-кишечных полипов, кишечных полипов и воспалительного заболевания, соединения с формулой I
Figure 00000010
,
Figure 00000011
.
RU2019116981A 2016-11-11 2017-04-19 Композиции и способы лечения желудочно-кишечных полипов RU2749188C2 (ru)

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AU2017357873B2 (en) * 2016-11-11 2022-02-24 Cellix Bio Private Limited Compositions and methods for the treatment of gastrointestinal polyps
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PL387312A1 (pl) * 2009-02-19 2010-08-30 Farma-Projekt Spółka Z Ograniczoną Odpowiedzialnością Zastosowanie sulindaku i/lub jego metabolitu we wspomagającym leczeniu raka jelita grubego u ludzi
US8207363B2 (en) * 2009-03-19 2012-06-26 Martek Biosciences Corporation Thraustochytrids, fatty acid compositions, and methods of making and uses thereof
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ES2602075T3 (es) * 2011-10-31 2017-02-17 Larsen, Claus Selch Profármacos de agentes antiinflamatorios no esteroideos (AINE)
WO2014068461A2 (en) * 2012-11-02 2014-05-08 Mahesh Kandula Compositions and methods for the treatment of acute inflammation
CA2967908C (en) * 2014-09-29 2020-11-17 Mahesh Kandula Compositions and methods for the treatment of multiple sclerosis
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CA3043445A1 (en) 2018-05-17
EP3538086A4 (en) 2021-01-20
KR20190100178A (ko) 2019-08-28
MX2019005568A (es) 2019-09-27
CN110167548A (zh) 2019-08-23
IL266545B (en) 2021-10-31
WO2018087605A1 (en) 2018-05-17
KR102408871B1 (ko) 2022-06-15
JP7118449B2 (ja) 2022-08-16
CA3043445C (en) 2023-08-22
BR112019009615A2 (pt) 2019-08-13
RU2019116981A3 (ru) 2020-11-30
EP3538086A1 (en) 2019-09-18
NZ753702A (en) 2022-03-25
US20200190040A1 (en) 2020-06-18
AU2017357873A1 (en) 2019-06-06
IL266545A (en) 2019-07-31
JP2019535824A (ja) 2019-12-12
US20220162171A1 (en) 2022-05-26
AU2017357873B2 (en) 2022-02-24
ZA201903222B (en) 2021-08-25
SG10202104160TA (en) 2021-06-29
RU2749188C2 (ru) 2021-06-07

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