RU2019105691A - Биомаркеры для прогнозирования преждевременных родов из-за преждевременного разрыва плодной оболочки при недоношенной беременности и идиопатических самопроизвольных родов - Google Patents

Биомаркеры для прогнозирования преждевременных родов из-за преждевременного разрыва плодной оболочки при недоношенной беременности и идиопатических самопроизвольных родов Download PDF

Info

Publication number
RU2019105691A
RU2019105691A RU2019105691A RU2019105691A RU2019105691A RU 2019105691 A RU2019105691 A RU 2019105691A RU 2019105691 A RU2019105691 A RU 2019105691A RU 2019105691 A RU2019105691 A RU 2019105691A RU 2019105691 A RU2019105691 A RU 2019105691A
Authority
RU
Russia
Prior art keywords
premature
biomarkers
pregnant woman
labor
likelihood
Prior art date
Application number
RU2019105691A
Other languages
English (en)
Inventor
Джон Джей БОНИФЕЙС
Джулия БЕРЧАРД
Грег Чарльз КРИЧФИЛД
Трейси Кристин ФЛЯЙШЕР
Дерлин Эдвард ХИКОК
Чиэнь ХСУ
Original Assignee
Сера Прогностикс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сера Прогностикс, Инк. filed Critical Сера Прогностикс, Инк.
Publication of RU2019105691A publication Critical patent/RU2019105691A/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2570/00—Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/36—Gynecology or obstetrics
    • G01N2800/368—Pregnancy complicated by disease or abnormalities of pregnancy, e.g. preeclampsia, preterm labour
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Claims (4)

1. Композиция, содержащая один или более биомаркеров, выбранных из группы, состоящей из биомаркеров, представленных на фигурах 1 и 2 и в Таблицах 1-3, 6-38 и 44-68.
2. Способ определения вероятности преждевременных родов у беременной женщины, включающий оценку в биологическом образце, взятом у указанной беременной женщины, одного или более биомаркеров, выбранных из группы, состоящей из одного или более из биомаркеров, представленных на фигурах 1 и 2 и в Таблицах 1-3, 6-38 и 44-68, для определения вероятности преждевременных родов у указанной беременной женщины.
3. Способ определения вероятности преждевременных родов, ассоциированных с преждевременным разрывом плодной оболочки при недоношенной беременности (PPROM) у беременной женщины, где способ включает оценку в биологическом образце, взятом у указанной беременной женщины, одного или более биомаркеров, выбранных из группы, состоящей из одного или более биомаркеров, представленных на фигуре 1 и в Таблицах 6-22, 44, 45 и 47-68, для определения вероятности преждевременных родов, ассоциированных с PPROM у указанной беременной женщины.
4. Способ определения вероятности преждевременных родов, ассоциированных с идиопатическими самопроизвольными родами (PTL) у беременной женщины, включающий оценку в биологическом образце, взятом у указанной беременной женщины, одного или более биомаркеров, выбранных из группы, состоящей из одного или более из биомаркеров, представленных на фигуре 2 и в Таблицах 6, 23-38, 43 и 46-68, для определения вероятности преждевременных родов, ассоциированных с PTL у указанной беременной женщины.
RU2019105691A 2016-08-05 2017-08-04 Биомаркеры для прогнозирования преждевременных родов из-за преждевременного разрыва плодной оболочки при недоношенной беременности и идиопатических самопроизвольных родов RU2019105691A (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662371666P 2016-08-05 2016-08-05
US62/371,666 2016-08-05
US201762449862P 2017-01-24 2017-01-24
US62/449,862 2017-01-24
PCT/US2017/045576 WO2018027171A1 (en) 2016-08-05 2017-08-04 Biomarkers for predicting preterm birth due to preterm premature rupture of membranes versus idiopathic spontaneous labor

Publications (1)

Publication Number Publication Date
RU2019105691A true RU2019105691A (ru) 2020-09-08

Family

ID=61073085

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2019105691A RU2019105691A (ru) 2016-08-05 2017-08-04 Биомаркеры для прогнозирования преждевременных родов из-за преждевременного разрыва плодной оболочки при недоношенной беременности и идиопатических самопроизвольных родов

Country Status (10)

Country Link
US (2) US20180172698A1 (ru)
EP (1) EP3494233A4 (ru)
JP (2) JP2019532261A (ru)
KR (1) KR20190046825A (ru)
CN (1) CN110191963A (ru)
AU (1) AU2017307584A1 (ru)
CA (1) CA3032754A1 (ru)
IL (1) IL264576A (ru)
RU (1) RU2019105691A (ru)
WO (1) WO2018027171A1 (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180029046A (ko) 2015-06-19 2018-03-19 세라 프로그노스틱스 인코포레이티드 조산 예측용 바이오마커 쌍
US11662351B2 (en) 2017-08-18 2023-05-30 Sera Prognostics, Inc. Pregnancy clock proteins for predicting due date and time to birth
CN111542619A (zh) * 2017-10-30 2020-08-14 卡门提克斯私人有限公司 早产的生物标记
EP4165416A1 (en) * 2020-06-10 2023-04-19 Board of Regents, The University of Texas System Method for determining risk of pre-term birth
US20240013925A1 (en) * 2020-11-05 2024-01-11 Board Of Regents, The University Of Texas System Individual optimal mode of delivery
CA3220282A1 (en) * 2021-05-21 2022-11-24 Sera Prognostics, Inc. Biomarker pairs and triplets for predicting preterm birth
RU2763707C1 (ru) * 2021-06-01 2021-12-30 Наталья Борисовна Кузнецова Способ прогнозирования преждевременного разрыва плодных оболочек в сроке от 22 до 28 недель беременности
WO2023023475A1 (en) * 2021-08-17 2023-02-23 Birth Model, Inc. Predicting time to vaginal delivery
CN118056016A (zh) * 2021-12-08 2024-05-17 深圳华大基因股份有限公司 基因标志物在预测孕妇早产风险中的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050233400A1 (en) * 2004-03-03 2005-10-20 Weiner Carl P Proteomic method for predicting success of rescue cerclage
RU2586412C2 (ru) * 2012-06-09 2016-06-10 Общество с ограниченной ответственностью научно-технический центр "БиоКлиникум" (ООО НТЦ "БиоКлиникум") Способ оценки риска возникновения патологии беременности
US20140186332A1 (en) * 2012-12-28 2014-07-03 NX Pharmagen Biomarkers of preterm birth
US20160003837A1 (en) * 2013-01-08 2016-01-07 Duke University Biomarkers for the prediction of preterm birth
EP3567371A1 (en) * 2013-03-15 2019-11-13 Sera Prognostics, Inc. Biomarkers and methods for predicting preeclampsia
US20140287948A1 (en) * 2013-03-15 2014-09-25 Sera Prognostics, Inc. Biomarkers and methods for predicting preterm birth
EP3800470A1 (en) * 2013-03-15 2021-04-07 Sera Prognostics, Inc. Biomarkers and methods for predicting preterm birth
KR20180029046A (ko) * 2015-06-19 2018-03-19 세라 프로그노스틱스 인코포레이티드 조산 예측용 바이오마커 쌍

Also Published As

Publication number Publication date
EP3494233A4 (en) 2020-03-18
KR20190046825A (ko) 2019-05-07
EP3494233A1 (en) 2019-06-12
CA3032754A1 (en) 2018-02-08
US20210190792A1 (en) 2021-06-24
US20180172698A1 (en) 2018-06-21
IL264576A (en) 2019-02-28
JP2022140511A (ja) 2022-09-26
JP2019532261A (ja) 2019-11-07
WO2018027171A1 (en) 2018-02-08
CN110191963A (zh) 2019-08-30
AU2017307584A1 (en) 2019-03-21

Similar Documents

Publication Publication Date Title
RU2019105691A (ru) Биомаркеры для прогнозирования преждевременных родов из-за преждевременного разрыва плодной оболочки при недоношенной беременности и идиопатических самопроизвольных родов
JP2019532261A5 (ru)
Salomon et al. ISUOG consensus statement on the impact of non-invasive prenatal testing (NIPT) on prenatal ultrasound practice
ANASTOMÓTICA et al. Predictors for anastomotic leak, postoperative complications, and mortality after right colectomy for cancer: results from an international snapshot audit
Lam et al. Cardiac dysfunction and noncardiac dysfunction as precursors of heart failure with reduced and preserved ejection fraction in the community
Herrera et al. Cell-free DNA, inflammation, and the initiation of spontaneous term labor
Cuppari et al. Subjective global assessment for the diagnosis of protein–energy wasting in nondialysis-dependent chronic kidney disease patients
EA201792389A1 (ru) Пцр в реальном времени для мультиплексной оптимизированной амплификации с несоответствиями (moma) и для оценки неклеточной днк
EA201892489A1 (ru) Число мишеней для мультиплексной оптимизированной амплификации с несоответствиями (moma)
EP4321626A3 (en) Biomarker pairs for predicting preterm birth
Thériault et al. Validation of early risk-prediction models for gestational diabetes based on clinical characteristics
EA202090348A1 (ru) Способ неинвазивного пренатального выявления аномалий половых хромосом у плода и определения пола плода в случае одноплодной и двухплодной беременности
EP3907509A3 (en) Diagnosis of early stage pancreatic cancer
EA201892490A1 (ru) Пцр с мультиплексной оптимизированной амплификацией неправильно спаренных оснований (moma) в реальном времени для анализа состояния плода
WO2015136509A3 (en) Diagnostic and therapeutic targets for preeclampsia and closely related complications of pregnancy
Piotrowski et al. Global cardiovascular mortality risk in the adult Polish population: prospective assessment of the cohorts studied in multicentre national WOBASZ and WOBASZ Senior studies
Frank Wolf et al. Correlation between changes in liver stiffness and preeclampsia as shown by transient elastography
Brady et al. Maternal serum alpha-fetoprotein levels peak at 19-21 weeks' gestation and subsequently decline in an NPHS1 sequence variant heterozygote; implications for prenatal diagnosis of congenital nephrosis of the Finnish type
Patterson et al. Delayed-type hypersensitivity and hepatitis B vaccine responses, in vivo markers of cellular and humoral immune function, and the risk of AIDS or death
Mahmoud et al. The correlation between maternal hypomagnesemia and preterm labour
Barr et al. National HIV transmission in 4–12 week olds in Malawi’s PMTCT option B+ program
Carlqvist et al. Shorter reproductive life span is associated with increased cardiovascular risk and total mortality in Swedish women from an observational, population-based study
RU2012157453A (ru) Способ дифференциальной диагностики цервикальных дисплазий и рака шейки матки
RU2016101941A (ru) Способ диагностики угрожающих преждевременных родов
Wang Response to" concerns about the statistical methodology described in the'clinical application of massively parallel sequencing-based prenatal noninvasive fetal trisomy test for trisomies 21 and 18 in 11,105 pregnancies with mixed risk factors'"

Legal Events

Date Code Title Description
FA93 Acknowledgement of application withdrawn (no request for examination)

Effective date: 20200805