WO2015136509A3 - Diagnostic and therapeutic targets for preeclampsia and closely related complications of pregnancy - Google Patents
Diagnostic and therapeutic targets for preeclampsia and closely related complications of pregnancy Download PDFInfo
- Publication number
- WO2015136509A3 WO2015136509A3 PCT/IB2015/051906 IB2015051906W WO2015136509A3 WO 2015136509 A3 WO2015136509 A3 WO 2015136509A3 IB 2015051906 W IB2015051906 W IB 2015051906W WO 2015136509 A3 WO2015136509 A3 WO 2015136509A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- preeclampsia
- pregnancy
- closely related
- related complications
- therapeutic targets
- Prior art date
Links
- 201000011461 pre-eclampsia Diseases 0.000 title abstract 3
- 230000035935 pregnancy Effects 0.000 title abstract 3
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 239000000090 biomarker Substances 0.000 abstract 2
- 238000009007 Diagnostic Kit Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Disclosed are specific biomarkers and therapeutic targets that allow for early testing and treatment of preeclampsia and closely related complications of pregnancy. Thus methods are provided for predicting, diagnosing, treating, and following-up preeclampsia and closely related complications of pregnancy in a pregnant woman. Also disclosed are diagnostic kits comprising means for assaying a sample from a pregnant woman for specific biomarkers.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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HUP1400141 | 2014-03-14 | ||
HUP1400141 | 2014-03-14 |
Publications (2)
Publication Number | Publication Date |
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WO2015136509A2 WO2015136509A2 (en) | 2015-09-17 |
WO2015136509A3 true WO2015136509A3 (en) | 2015-12-17 |
Family
ID=89708201
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2015/051906 WO2015136509A2 (en) | 2014-03-14 | 2015-03-16 | Diagnostic and therapeutic targets for preeclampsia and closely related complications of pregnancy |
Country Status (1)
Country | Link |
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WO (1) | WO2015136509A2 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102476709B1 (en) | 2016-11-21 | 2022-12-09 | 나노스트링 테크놀로지스, 인크. | Chemical compositions and methods of using same |
JP7525402B2 (en) | 2018-05-14 | 2024-07-30 | ナノストリング テクノロジーズ,インコーポレイティド | Chemical compositions and methods of using same |
WO2020212588A1 (en) * | 2019-04-17 | 2020-10-22 | Igenomix, S.L. | Non-invasive assay for pre-eclampsia and conditions associated with pre-eclampsia |
CN113249458B (en) * | 2020-02-10 | 2023-07-07 | 北京优乐复生科技有限责任公司 | Method and kit for predicting evaluation and prediction of placenta-derived diseases |
CN112831522B (en) * | 2021-02-18 | 2022-09-16 | 中国人民解放军陆军特色医学中心 | Mouse model for conditionally knocking in human Siglec-6 molecules and construction method thereof |
WO2022194856A1 (en) * | 2021-03-15 | 2022-09-22 | Katholieke Universiteit Leuven | Preeclampsia diagnosis |
KR102663383B1 (en) * | 2021-08-20 | 2024-05-03 | 의료법인 성광의료재단 | Analytical method for diagnosing preeclampsia using methylation levels of CpG sites |
CN113791224B (en) * | 2021-09-18 | 2023-12-01 | 浙江大学 | Early warning method for recurrent abortion caused by unknown reasons based on follicular fluid protein expression |
WO2024188292A1 (en) * | 2023-03-15 | 2024-09-19 | Taipei Medical University | Method for predicting success rate of pregnancy in infertility treatment |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2013188686A2 (en) * | 2012-06-15 | 2013-12-19 | Wayne State University | Biomarker test for prediction or early detection of preeclampsia and/or hellp syndrome |
Family Cites Families (9)
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US5506337A (en) | 1985-03-15 | 1996-04-09 | Antivirals Inc. | Morpholino-subunit combinatorial library and method |
US5010175A (en) | 1988-05-02 | 1991-04-23 | The Regents Of The University Of California | General method for producing and selecting peptides with specific properties |
IE66205B1 (en) | 1990-06-14 | 1995-12-13 | Paul A Bartlett | Polypeptide analogs |
US5650489A (en) | 1990-07-02 | 1997-07-22 | The Arizona Board Of Regents | Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof |
US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
US5593853A (en) | 1994-02-09 | 1997-01-14 | Martek Corporation | Generation and screening of synthetic drug libraries |
US5539083A (en) | 1994-02-23 | 1996-07-23 | Isis Pharmaceuticals, Inc. | Peptide nucleic acid combinatorial libraries and improved methods of synthesis |
US5569588A (en) | 1995-08-09 | 1996-10-29 | The Regents Of The University Of California | Methods for drug screening |
JO3421B1 (en) | 2011-06-20 | 2019-10-20 | H Lundbeck As | Method of administration of 4-((1R,3S)-6-chloro-3-phenyl-indan-1-yl)-1,2,2-trimethyl-piperazine and the salts thereof in the treatment of schizophrenia |
-
2015
- 2015-03-16 WO PCT/IB2015/051906 patent/WO2015136509A2/en active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013188686A2 (en) * | 2012-06-15 | 2013-12-19 | Wayne State University | Biomarker test for prediction or early detection of preeclampsia and/or hellp syndrome |
Non-Patent Citations (8)
Title |
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BRIEGER J ET AL: "Demethylation treatment restores hic1 expression and impairs aggressiveness of head and neck squamous cell carcinoma", ORAL ONCOLOGY, ELSEVIER SCIENCE, OXFORD, GB, vol. 46, no. 9, 1 September 2010 (2010-09-01), pages 678 - 683, XP027249200, ISSN: 1368-8375, [retrieved on 20100821] * |
CHUNG M T ET AL: "Promoter methylation of SFRPs gene family in cervical cancer", GYNECOLOGIC ONCOLOGY, ACADEMIC PRESS, LONDON, GB, vol. 112, no. 2, 1 February 2009 (2009-02-01), pages 301 - 306, XP025872448, ISSN: 0090-8258, [retrieved on 20081126], DOI: 10.1016/J.YGYNO.2008.10.004 * |
HARUKI NISHIZAWA ET AL: "Comparative gene expression profiling of placentas from patients with severe pre-eclampsia and unexplained fetal growth restriction", REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, BIOMED CENTRAL LTD, GB, vol. 9, no. 1, 2 August 2011 (2011-08-02), pages 107, XP021105574, ISSN: 1477-7827, DOI: 10.1186/1477-7827-9-107 * |
HOGG KIRSTEN ET AL: "Hypomethylation of theLEPgene in placenta and elevated maternal leptin concentration in early onset pre-eclampsia", MOLECULAR AND CELLULAR ENDOCRINOLOGY, ELSEVIER IRELAND LTD, IE, vol. 367, no. 1, 26 December 2012 (2012-12-26), pages 64 - 73, XP028972386, ISSN: 0303-7207, DOI: 10.1016/J.MCE.2012.12.018 * |
HONG-JUAN DING: "Screening for differential methylation status in human placenta in preeclampsia using a CpG island plus promoter microarray", INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, vol. 30, 1 January 2012 (2012-01-01), pages 133 - 141, XP055197564, ISSN: 1107-3756, DOI: 10.3892/ijmm.2012.983 * |
J. D. BLAIR ET AL: "Widespread DNA hypomethylation at gene enhancer regions in placentas associated with early-onset pre-eclampsia", MOLECULAR HUMAN REPRODUCTION, vol. 19, no. 10, 13 June 2013 (2013-06-13), pages 697 - 708, XP055197386, ISSN: 1360-9947, DOI: 10.1093/molehr/gat044 * |
LI Y ET AL: "Azacitidine enhances sensitivity of platinum-resistant ovarian cancer cells to carboplatin through induction of apoptosis", AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY, MOSBY, ST LOUIS, MO, US, vol. 200, no. 2, 1 February 2009 (2009-02-01), pages 177.e1 - 177.e9, XP025892761, ISSN: 0002-9378, [retrieved on 20090131], DOI: 10.1016/J.AJOG.2008.08.030 * |
RYAN KC YUEN ET AL: "DNA methylation profiling of human placentas reveals promoter hypomethylation of multiple genes in early-onset preeclampsia", EUROPEAN JOURNAL OF HUMAN GENETICS, vol. 18, no. 9, 5 May 2010 (2010-05-05), pages 1006 - 1012, XP055197568, ISSN: 1018-4813, DOI: 10.1038/ejhg.2010.63 * |
Also Published As
Publication number | Publication date |
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WO2015136509A2 (en) | 2015-09-17 |
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