WO2015136509A3 - Diagnostic and therapeutic targets for preeclampsia and closely related complications of pregnancy - Google Patents

Diagnostic and therapeutic targets for preeclampsia and closely related complications of pregnancy Download PDF

Info

Publication number
WO2015136509A3
WO2015136509A3 PCT/IB2015/051906 IB2015051906W WO2015136509A3 WO 2015136509 A3 WO2015136509 A3 WO 2015136509A3 IB 2015051906 W IB2015051906 W IB 2015051906W WO 2015136509 A3 WO2015136509 A3 WO 2015136509A3
Authority
WO
WIPO (PCT)
Prior art keywords
preeclampsia
pregnancy
closely related
related complications
therapeutic targets
Prior art date
Application number
PCT/IB2015/051906
Other languages
French (fr)
Other versions
WO2015136509A2 (en
Inventor
Nándor Gábor THAN
Tzu Hung CHUNG
Gábor JUHÁSZ
Adrienna Katalin KÉKESI
Manuel Krispin
Ron LEAVITT
Zoltán PAPP
Roberto Romero
Adi L. TARCA
Original Assignee
Genesis Theranostix Korlatolt Felelossegu Tarsasag
Semmelweis University
Wayne State University
The United States Of America As Represented By The Secretary, Department Of Health And Human Services Office Of Technology Transfer, National Institutes Of Health
Zymo Research Corporation
Eotvos Lorand University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genesis Theranostix Korlatolt Felelossegu Tarsasag, Semmelweis University, Wayne State University, The United States Of America As Represented By The Secretary, Department Of Health And Human Services Office Of Technology Transfer, National Institutes Of Health, Zymo Research Corporation, Eotvos Lorand University filed Critical Genesis Theranostix Korlatolt Felelossegu Tarsasag
Publication of WO2015136509A2 publication Critical patent/WO2015136509A2/en
Publication of WO2015136509A3 publication Critical patent/WO2015136509A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Disclosed are specific biomarkers and therapeutic targets that allow for early testing and treatment of preeclampsia and closely related complications of pregnancy. Thus methods are provided for predicting, diagnosing, treating, and following-up preeclampsia and closely related complications of pregnancy in a pregnant woman. Also disclosed are diagnostic kits comprising means for assaying a sample from a pregnant woman for specific biomarkers.
PCT/IB2015/051906 2014-03-14 2015-03-16 Diagnostic and therapeutic targets for preeclampsia and closely related complications of pregnancy WO2015136509A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HUP1400141 2014-03-14
HUP1400141 2014-03-14

Publications (2)

Publication Number Publication Date
WO2015136509A2 WO2015136509A2 (en) 2015-09-17
WO2015136509A3 true WO2015136509A3 (en) 2015-12-17

Family

ID=89708201

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2015/051906 WO2015136509A2 (en) 2014-03-14 2015-03-16 Diagnostic and therapeutic targets for preeclampsia and closely related complications of pregnancy

Country Status (1)

Country Link
WO (1) WO2015136509A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102476709B1 (en) 2016-11-21 2022-12-09 나노스트링 테크놀로지스, 인크. Chemical compositions and methods of using same
JP7525402B2 (en) 2018-05-14 2024-07-30 ナノストリング テクノロジーズ，インコーポレイティド Chemical compositions and methods of using same
WO2020212588A1 (en) * 2019-04-17 2020-10-22 Igenomix, S.L. Non-invasive assay for pre-eclampsia and conditions associated with pre-eclampsia
CN113249458B (en) * 2020-02-10 2023-07-07 北京优乐复生科技有限责任公司 Method and kit for predicting evaluation and prediction of placenta-derived diseases
CN112831522B (en) * 2021-02-18 2022-09-16 中国人民解放军陆军特色医学中心 Mouse model for conditionally knocking in human Siglec-6 molecules and construction method thereof
WO2022194856A1 (en) * 2021-03-15 2022-09-22 Katholieke Universiteit Leuven Preeclampsia diagnosis
KR102663383B1 (en) * 2021-08-20 2024-05-03 의료법인 성광의료재단 Analytical method for diagnosing preeclampsia using methylation levels of CpG sites
CN113791224B (en) * 2021-09-18 2023-12-01 浙江大学 Early warning method for recurrent abortion caused by unknown reasons based on follicular fluid protein expression
WO2024188292A1 (en) * 2023-03-15 2024-09-19 Taipei Medical University Method for predicting success rate of pregnancy in infertility treatment

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013188686A2 (en) * 2012-06-15 2013-12-19 Wayne State University Biomarker test for prediction or early detection of preeclampsia and/or hellp syndrome

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5506337A (en) 1985-03-15 1996-04-09 Antivirals Inc. Morpholino-subunit combinatorial library and method
US5010175A (en) 1988-05-02 1991-04-23 The Regents Of The University Of California General method for producing and selecting peptides with specific properties
IE66205B1 (en) 1990-06-14 1995-12-13 Paul A Bartlett Polypeptide analogs
US5650489A (en) 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
US5593853A (en) 1994-02-09 1997-01-14 Martek Corporation Generation and screening of synthetic drug libraries
US5539083A (en) 1994-02-23 1996-07-23 Isis Pharmaceuticals, Inc. Peptide nucleic acid combinatorial libraries and improved methods of synthesis
US5569588A (en) 1995-08-09 1996-10-29 The Regents Of The University Of California Methods for drug screening
JO3421B1 (en) 2011-06-20 2019-10-20 H Lundbeck As Method of administration of 4-((1R,3S)-6-chloro-3-phenyl-indan-1-yl)-1,2,2-trimethyl-piperazine and the salts thereof in the treatment of schizophrenia

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013188686A2 (en) * 2012-06-15 2013-12-19 Wayne State University Biomarker test for prediction or early detection of preeclampsia and/or hellp syndrome

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BRIEGER J ET AL: "Demethylation treatment restores hic1 expression and impairs aggressiveness of head and neck squamous cell carcinoma", ORAL ONCOLOGY, ELSEVIER SCIENCE, OXFORD, GB, vol. 46, no. 9, 1 September 2010 (2010-09-01), pages 678 - 683, XP027249200, ISSN: 1368-8375, [retrieved on 20100821] *
CHUNG M T ET AL: "Promoter methylation of SFRPs gene family in cervical cancer", GYNECOLOGIC ONCOLOGY, ACADEMIC PRESS, LONDON, GB, vol. 112, no. 2, 1 February 2009 (2009-02-01), pages 301 - 306, XP025872448, ISSN: 0090-8258, [retrieved on 20081126], DOI: 10.1016/J.YGYNO.2008.10.004 *
HARUKI NISHIZAWA ET AL: "Comparative gene expression profiling of placentas from patients with severe pre-eclampsia and unexplained fetal growth restriction", REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, BIOMED CENTRAL LTD, GB, vol. 9, no. 1, 2 August 2011 (2011-08-02), pages 107, XP021105574, ISSN: 1477-7827, DOI: 10.1186/1477-7827-9-107 *
HOGG KIRSTEN ET AL: "Hypomethylation of theLEPgene in placenta and elevated maternal leptin concentration in early onset pre-eclampsia", MOLECULAR AND CELLULAR ENDOCRINOLOGY, ELSEVIER IRELAND LTD, IE, vol. 367, no. 1, 26 December 2012 (2012-12-26), pages 64 - 73, XP028972386, ISSN: 0303-7207, DOI: 10.1016/J.MCE.2012.12.018 *
HONG-JUAN DING: "Screening for differential methylation status in human placenta in preeclampsia using a CpG island plus promoter microarray", INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, vol. 30, 1 January 2012 (2012-01-01), pages 133 - 141, XP055197564, ISSN: 1107-3756, DOI: 10.3892/ijmm.2012.983 *
J. D. BLAIR ET AL: "Widespread DNA hypomethylation at gene enhancer regions in placentas associated with early-onset pre-eclampsia", MOLECULAR HUMAN REPRODUCTION, vol. 19, no. 10, 13 June 2013 (2013-06-13), pages 697 - 708, XP055197386, ISSN: 1360-9947, DOI: 10.1093/molehr/gat044 *
LI Y ET AL: "Azacitidine enhances sensitivity of platinum-resistant ovarian cancer cells to carboplatin through induction of apoptosis", AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY, MOSBY, ST LOUIS, MO, US, vol. 200, no. 2, 1 February 2009 (2009-02-01), pages 177.e1 - 177.e9, XP025892761, ISSN: 0002-9378, [retrieved on 20090131], DOI: 10.1016/J.AJOG.2008.08.030 *
RYAN KC YUEN ET AL: "DNA methylation profiling of human placentas reveals promoter hypomethylation of multiple genes in early-onset preeclampsia", EUROPEAN JOURNAL OF HUMAN GENETICS, vol. 18, no. 9, 5 May 2010 (2010-05-05), pages 1006 - 1012, XP055197568, ISSN: 1018-4813, DOI: 10.1038/ejhg.2010.63 *

Also Published As

Publication number Publication date
WO2015136509A2 (en) 2015-09-17

Similar Documents

Publication Publication Date Title
WO2015136509A3 (en) Diagnostic and therapeutic targets for preeclampsia and closely related complications of pregnancy
WO2019213282A8 (en) Biomarkers for evaluating car-t cells to predict clinical outcome
WO2014201516A3 (en) Biomarker identification
MX2018012580A (en) Methods and kits for the diagnosis and risk stratification of patients with ischemia.
WO2014151006A3 (en) Biomarkers and methods of treating pd-1 and pd-l1 related conditions
EP3907509A3 (en) Diagnosis of early stage pancreatic cancer
EP3182126A3 (en) Biomarker test for prediction or early detection of preeclampsia and/or hellp syndrome
EP4060048A3 (en) Non-invasive diagnostic method for diagnosing bladder cancer
EP3159695A3 (en) Methods for diagnosing pancreatic cancer
WO2015094996A3 (en) Pd-l1 gene signature biomarkers of tumor response to pd-1 antagonists
WO2015054700A3 (en) Biomarkers for predicting risk of acute ischemic stroke and methods of use thereof
WO2014078468A3 (en) Biomarkers for predicting clinical response of cancer patients to treatment with immunotherapeutic agent
MY195045A (en) Specific Biomarker Set For Non-Invasive Diagnosis of Liver Cancer
EP3285071A4 (en) Biomarker composition for diagnosing still's disease, diagnostic kit, and diagnostic method
WO2016176446A3 (en) Colorectal cancer screening method and device
NZ729773A (en) Biomarkers for disease progression in melanoma
WO2019074615A3 (en) In vitro methods for skin therapeutic compound discovery using skin age biomarkers
WO2015189591A3 (en) Method and arrays for use in diagnosing early breast cancer
WO2016145308A3 (en) Whole blood based mrna markers for predicting prostate cancer and methods of detecting the same
EP3295174A4 (en) Method for re-using test probe and reagents in an immunoassay
WO2016012864A3 (en) Biomarkers for anderson-fabry disease
WO2016205828A3 (en) Role of citrullination in diagnosing diseases
WO2015166353A3 (en) Early detection of preeclampsia
WO2015125027A3 (en) Kit and method for detecting bladder cancer
WO2015173430A3 (en) Early placenta insulin-like peptide (pro-epil)

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 15718600

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 15718600

Country of ref document: EP

Kind code of ref document: A2