RU2018140557A - Конъюгаты на основе гиалуроновой кислоты и их пути применения - Google Patents
Конъюгаты на основе гиалуроновой кислоты и их пути применения Download PDFInfo
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- RU2018140557A RU2018140557A RU2018140557A RU2018140557A RU2018140557A RU 2018140557 A RU2018140557 A RU 2018140557A RU 2018140557 A RU2018140557 A RU 2018140557A RU 2018140557 A RU2018140557 A RU 2018140557A RU 2018140557 A RU2018140557 A RU 2018140557A
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- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title claims 7
- 229920002674 hyaluronan Polymers 0.000 title claims 7
- 229960003160 hyaluronic acid Drugs 0.000 title claims 7
- 229920000578 graft copolymer Polymers 0.000 claims 24
- 239000000203 mixture Substances 0.000 claims 23
- 229920000642 polymer Polymers 0.000 claims 15
- 238000000034 method Methods 0.000 claims 10
- QNILTEGFHQSKFF-UHFFFAOYSA-N n-propan-2-ylprop-2-enamide Chemical compound CC(C)NC(=O)C=C QNILTEGFHQSKFF-UHFFFAOYSA-N 0.000 claims 8
- 210000001519 tissue Anatomy 0.000 claims 8
- 125000000524 functional group Chemical group 0.000 claims 7
- 125000005647 linker group Chemical group 0.000 claims 7
- 239000000017 hydrogel Substances 0.000 claims 5
- 230000007170 pathology Effects 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 239000002202 Polyethylene glycol Substances 0.000 claims 3
- 238000006243 chemical reaction Methods 0.000 claims 3
- 230000007547 defect Effects 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 239000002105 nanoparticle Substances 0.000 claims 3
- 229920001223 polyethylene glycol Polymers 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 208000012659 Joint disease Diseases 0.000 claims 2
- 208000009443 Vascular Malformations Diseases 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- 230000006378 damage Effects 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000005415 substituted alkoxy group Chemical group 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 210000002229 urogenital system Anatomy 0.000 claims 2
- 150000001345 alkine derivatives Chemical class 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- IVRMZWNICZWHMI-UHFFFAOYSA-N azide group Chemical group [N-]=[N+]=[N-] IVRMZWNICZWHMI-UHFFFAOYSA-N 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000002843 carboxylic acid group Chemical group 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000012377 drug delivery Methods 0.000 claims 1
- 239000004744 fabric Substances 0.000 claims 1
- 239000000945 filler Substances 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000000977 initiatory effect Effects 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 235000015097 nutrients Nutrition 0.000 claims 1
- -1 polyethylene chain Polymers 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 210000004872 soft tissue Anatomy 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
Classifications
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- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F290/00—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
- C08F290/08—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups on to polymers modified by introduction of unsaturated side groups
- C08F290/10—Polymers provided for in subclass C08B
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
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- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
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- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/52—Amides or imides
- C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
- C08F220/60—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide containing nitrogen in addition to the carbonamido nitrogen
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- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
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- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
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- C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
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- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
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- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
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- C08K5/34—Heterocyclic compounds having nitrogen in the ring
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
- A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
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- A61K47/6939—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer the polymer being a polysaccharide, e.g. starch, chitosan, chitin, cellulose or pectin
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/02—Applications for biomedical use
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Public Health (AREA)
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- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Dispersion Chemistry (AREA)
- Materials Engineering (AREA)
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- Nanotechnology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Birds (AREA)
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- Oral & Maxillofacial Surgery (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Materials For Medical Uses (AREA)
- Graft Or Block Polymers (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16166100.4A EP3235514A1 (en) | 2016-04-19 | 2016-04-19 | Hyaluronic acid conjugates and uses thereof |
| EP16166100.4 | 2016-04-19 | ||
| PCT/EP2017/059213 WO2017182483A1 (en) | 2016-04-19 | 2017-04-18 | Hyaluronic acid conjugates and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2018140557A true RU2018140557A (ru) | 2020-05-19 |
| RU2018140557A3 RU2018140557A3 (enExample) | 2020-08-20 |
Family
ID=55913460
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018140557A RU2018140557A (ru) | 2016-04-19 | 2017-04-18 | Конъюгаты на основе гиалуроновой кислоты и их пути применения |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10767037B2 (enExample) |
| EP (2) | EP3235514A1 (enExample) |
| JP (1) | JP2019513868A (enExample) |
| KR (1) | KR20180135013A (enExample) |
| CN (1) | CN109069660A (enExample) |
| AU (1) | AU2017251957B2 (enExample) |
| CA (1) | CA3021222A1 (enExample) |
| IL (1) | IL262036A (enExample) |
| MX (1) | MX2018012682A (enExample) |
| RU (1) | RU2018140557A (enExample) |
| WO (1) | WO2017182483A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020006255A1 (en) * | 2018-06-27 | 2020-01-02 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for in situ-forming tissue constructs |
| MY208431A (en) | 2019-06-03 | 2025-05-08 | Aihol Corp | Hyaluronan conjugates and uses thereof |
| US12426594B2 (en) | 2020-09-24 | 2025-09-30 | Everest Medical Innovation GmbH | Cryoprotective compositions and methods for protection of a surgical site during cryosurgery |
| US12453805B2 (en) | 2020-09-24 | 2025-10-28 | Everest Medical Innovation GmbH | Cryoprotective compositions, surgical kits, and methods for protection of a surgical site during cryosurgery |
| KR20240036037A (ko) * | 2021-07-14 | 2024-03-19 | 나브솔루트 컴퍼니 리미티드 | 히알루론산 그래프팅된 폴리(n-이소프로필아크릴아미드)(HA-g-pNIPAM)를 제조하는 방법 |
| CN113736043B (zh) * | 2021-11-03 | 2022-05-20 | 北京华芢生物技术有限公司 | 一种pH响应型水凝胶生物载体及应用 |
| CN116510066A (zh) * | 2023-04-07 | 2023-08-01 | 华南理工大学 | 温敏转变点可调控药物缓释载体水凝胶及其制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010099818A1 (en) | 2009-03-03 | 2010-09-10 | Ao Technology Ag | Thermoreversible polysaccharide hydrogel |
| US8912322B2 (en) * | 2010-07-29 | 2014-12-16 | University Of Georgia Research Foundation, Inc. | Aza-dibenzocyclooctynes and methods of making and using same |
| CA2848142C (en) * | 2011-09-07 | 2021-05-18 | Prolynx Llc | Hydrogels with biodegradable crosslinking |
| US20130171197A1 (en) * | 2011-12-28 | 2013-07-04 | Kaohsiung Medical University | Hyaluronic acid hydrogel and use thereof |
| WO2015048988A1 (en) * | 2013-10-02 | 2015-04-09 | Ao Technology Ag | Thermosensitive hyaluronic acid conjugates and methods for the preparation thereof |
-
2016
- 2016-04-19 EP EP16166100.4A patent/EP3235514A1/en not_active Withdrawn
-
2017
- 2017-04-18 EP EP17716940.6A patent/EP3445403A1/en active Pending
- 2017-04-18 KR KR1020187033324A patent/KR20180135013A/ko not_active Ceased
- 2017-04-18 RU RU2018140557A patent/RU2018140557A/ru not_active Application Discontinuation
- 2017-04-18 US US16/094,559 patent/US10767037B2/en active Active
- 2017-04-18 AU AU2017251957A patent/AU2017251957B2/en active Active
- 2017-04-18 CA CA3021222A patent/CA3021222A1/en active Pending
- 2017-04-18 JP JP2018553233A patent/JP2019513868A/ja active Pending
- 2017-04-18 MX MX2018012682A patent/MX2018012682A/es unknown
- 2017-04-18 WO PCT/EP2017/059213 patent/WO2017182483A1/en not_active Ceased
- 2017-04-18 CN CN201780024435.1A patent/CN109069660A/zh active Pending
-
2018
- 2018-10-02 IL IL262036A patent/IL262036A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2018140557A3 (enExample) | 2020-08-20 |
| AU2017251957A1 (en) | 2018-11-22 |
| CA3021222A1 (en) | 2017-10-26 |
| JP2019513868A (ja) | 2019-05-30 |
| EP3445403A1 (en) | 2019-02-27 |
| EP3235514A1 (en) | 2017-10-25 |
| US10767037B2 (en) | 2020-09-08 |
| WO2017182483A1 (en) | 2017-10-26 |
| IL262036A (en) | 2018-11-29 |
| BR112018071394A2 (pt) | 2019-02-05 |
| AU2017251957B2 (en) | 2022-07-21 |
| CN109069660A (zh) | 2018-12-21 |
| KR20180135013A (ko) | 2018-12-19 |
| MX2018012682A (es) | 2019-01-31 |
| US20190119486A1 (en) | 2019-04-25 |
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| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20211025 |