RU2018134167A - Комбинированная терапия для лечения острого миелоидного лейкоза - Google Patents
Комбинированная терапия для лечения острого миелоидного лейкоза Download PDFInfo
- Publication number
- RU2018134167A RU2018134167A RU2018134167A RU2018134167A RU2018134167A RU 2018134167 A RU2018134167 A RU 2018134167A RU 2018134167 A RU2018134167 A RU 2018134167A RU 2018134167 A RU2018134167 A RU 2018134167A RU 2018134167 A RU2018134167 A RU 2018134167A
- Authority
- RU
- Russia
- Prior art keywords
- amino
- salt
- myeloid leukemia
- acute myeloid
- methylpiperazin
- Prior art date
Links
- 208000031261 Acute myeloid leukaemia Diseases 0.000 title claims 15
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 title claims 15
- 238000002648 combination therapy Methods 0.000 title 1
- 150000003839 salts Chemical class 0.000 claims 20
- -1 {3-methoxy-4- [4- (4-methylpiperazin-1-yl) piperidin-1- yl] phenyl} amino Chemical group 0.000 claims 14
- 238000000034 method Methods 0.000 claims 13
- NMUSYJAQQFHJEW-KVTDHHQDSA-N 5-azacytidine Chemical compound O=C1N=C(N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 NMUSYJAQQFHJEW-KVTDHHQDSA-N 0.000 claims 8
- 101000932478 Homo sapiens Receptor-type tyrosine-protein kinase FLT3 Proteins 0.000 claims 8
- 102100020718 Receptor-type tyrosine-protein kinase FLT3 Human genes 0.000 claims 8
- 230000035772 mutation Effects 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- KJVKYXIYRLHNFJ-AZAWLQABSA-N 4-amino-1-[(3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-1,2-oxazolidin-2-yl]pyrimidin-2-one 4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one Chemical compound O=C1N=C(N)C=CN1N1[C@H](O)[C@H](O)[C@@H](CO)O1.O=C1N=C(N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 KJVKYXIYRLHNFJ-AZAWLQABSA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 238000010254 subcutaneous injection Methods 0.000 claims 1
- 239000007929 subcutaneous injection Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662314700P | 2016-03-29 | 2016-03-29 | |
| US62/314,700 | 2016-03-29 | ||
| US201662368343P | 2016-07-29 | 2016-07-29 | |
| US62/368,343 | 2016-07-29 | ||
| PCT/JP2017/012293 WO2017170348A1 (en) | 2016-03-29 | 2017-03-27 | Combination therapy for the treatment of acute myeloid leukemia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2018134167A true RU2018134167A (ru) | 2020-04-29 |
| RU2018134167A3 RU2018134167A3 (cg-RX-API-DMAC7.html) | 2020-06-30 |
Family
ID=59965623
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018134167A RU2018134167A (ru) | 2016-03-29 | 2017-03-27 | Комбинированная терапия для лечения острого миелоидного лейкоза |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20190117649A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3436014A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2019512495A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20180124055A (cg-RX-API-DMAC7.html) |
| CN (1) | CN108883109A (cg-RX-API-DMAC7.html) |
| BR (1) | BR112018069111A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3018155A1 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2018011975A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2018134167A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2017170348A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4467565A3 (en) | 2016-12-21 | 2025-03-12 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| KR101954370B1 (ko) | 2018-07-25 | 2019-03-05 | 한미약품 주식회사 | 피리미딘 화합물 및 이를 포함하는 암의 예방 또는 치료용 약학 조성물 |
| CN113490497B (zh) * | 2019-02-22 | 2025-04-04 | 韩美药品株式会社 | 包括flt3抑制剂和低甲基化剂的用于治疗急性髓系白血病的药物组合物 |
| KR20200102948A (ko) | 2019-02-22 | 2020-09-01 | 한미약품 주식회사 | Flt3 저해제 및 iap 길항제를 포함하는 급성 골수성 백혈병의 치료를 위한 약학적 조합물 |
| JP7577672B2 (ja) * | 2019-02-22 | 2024-11-05 | ハンミ ファーマシューティカルズ カンパニー リミテッド | Ｆｌｔ３阻害剤及び低メチル化剤を含む急性骨髄性白血病の治療のための薬学的組成物 |
| MY204603A (en) | 2019-04-03 | 2024-09-05 | Astellas Pharma Inc | Pharmaceutical composition |
| AU2020308814A1 (en) | 2019-06-27 | 2022-02-03 | Hanmi Pharm. Co., Ltd. | Pharmaceutical composition for treating acute myeloid leukemia, containing FLT3 inhibitor and chemotherapeutic agents |
| US20230029336A1 (en) * | 2019-10-14 | 2023-01-26 | Astrazeneca Ab | Combination Therapy for Treating a Hematological Malignancy |
| US20220387362A1 (en) * | 2019-10-21 | 2022-12-08 | Rhizen Pharmaceuticals Ag | Compositions comprising a dhodh inhibitor for the treatment of acute myeloid leukemia |
| WO2023129667A1 (en) | 2021-12-30 | 2023-07-06 | Biomea Fusion, Inc. | Pyrazine compounds as inhibitors of flt3 |
| KR102559124B1 (ko) | 2022-08-25 | 2023-07-26 | 주식회사 엔젠바이오 | Flt3 유전자 증폭용 조성물 및 이의 용도 |
-
2017
- 2017-03-27 WO PCT/JP2017/012293 patent/WO2017170348A1/en not_active Ceased
- 2017-03-27 JP JP2018548236A patent/JP2019512495A/ja active Pending
- 2017-03-27 MX MX2018011975A patent/MX2018011975A/es unknown
- 2017-03-27 BR BR112018069111-9A patent/BR112018069111A2/pt not_active Application Discontinuation
- 2017-03-27 RU RU2018134167A patent/RU2018134167A/ru not_active Application Discontinuation
- 2017-03-27 US US16/089,603 patent/US20190117649A1/en not_active Abandoned
- 2017-03-27 EP EP17774885.2A patent/EP3436014A4/en not_active Withdrawn
- 2017-03-27 CA CA3018155A patent/CA3018155A1/en not_active Abandoned
- 2017-03-27 KR KR1020187028124A patent/KR20180124055A/ko not_active Withdrawn
- 2017-03-27 CN CN201780021735.4A patent/CN108883109A/zh active Pending
-
2020
- 2020-07-30 US US16/943,379 patent/US20200360372A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP3436014A1 (en) | 2019-02-06 |
| WO2017170348A1 (en) | 2017-10-05 |
| EP3436014A4 (en) | 2019-11-27 |
| BR112018069111A2 (pt) | 2019-03-19 |
| JP2019512495A (ja) | 2019-05-16 |
| US20190117649A1 (en) | 2019-04-25 |
| RU2018134167A3 (cg-RX-API-DMAC7.html) | 2020-06-30 |
| US20200360372A1 (en) | 2020-11-19 |
| CA3018155A1 (en) | 2017-10-05 |
| CN108883109A (zh) | 2018-11-23 |
| KR20180124055A (ko) | 2018-11-20 |
| MX2018011975A (es) | 2019-01-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20210802 |