RU2018130831A - Применение ингибиторов деацетилаз гистонов для улучшения иммунотерапии - Google Patents
Применение ингибиторов деацетилаз гистонов для улучшения иммунотерапии Download PDFInfo
- Publication number
- RU2018130831A RU2018130831A RU2018130831A RU2018130831A RU2018130831A RU 2018130831 A RU2018130831 A RU 2018130831A RU 2018130831 A RU2018130831 A RU 2018130831A RU 2018130831 A RU2018130831 A RU 2018130831A RU 2018130831 A RU2018130831 A RU 2018130831A
- Authority
- RU
- Russia
- Prior art keywords
- composition
- inhibitor
- entinostat
- class
- administered
- Prior art date
Links
- 238000009169 immunotherapy Methods 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 238000000034 method Methods 0.000 claims 22
- INVTYAOGFAGBOE-UHFFFAOYSA-N entinostat Chemical group NC1=CC=CC=C1NC(=O)C(C=C1)=CC=C1CNC(=O)OCC1=CC=CN=C1 INVTYAOGFAGBOE-UHFFFAOYSA-N 0.000 claims 9
- 229940121372 histone deacetylase inhibitor Drugs 0.000 claims 9
- 239000003276 histone deacetylase inhibitor Substances 0.000 claims 9
- 239000012270 PD-1 inhibitor Substances 0.000 claims 8
- 239000012668 PD-1-inhibitor Substances 0.000 claims 8
- 229950005837 entinostat Drugs 0.000 claims 8
- 229940121655 pd-1 inhibitor Drugs 0.000 claims 8
- NIJJYAXOARWZEE-UHFFFAOYSA-N Valproic acid Chemical compound CCCC(C(O)=O)CCC NIJJYAXOARWZEE-UHFFFAOYSA-N 0.000 claims 4
- 229960003301 nivolumab Drugs 0.000 claims 4
- BWDQBBCUWLSASG-MDZDMXLPSA-N (e)-n-hydroxy-3-[4-[[2-hydroxyethyl-[2-(1h-indol-3-yl)ethyl]amino]methyl]phenyl]prop-2-enamide Chemical compound C=1NC2=CC=CC=C2C=1CCN(CCO)CC1=CC=C(\C=C\C(=O)NO)C=C1 BWDQBBCUWLSASG-MDZDMXLPSA-N 0.000 claims 2
- WWMASNYTEATYTC-KPKJPENVSA-N 4-(dimethylamino)-n-[[4-[(e)-3-(hydroxyamino)-3-oxoprop-1-enyl]phenyl]methyl]benzamide Chemical compound C1=CC(N(C)C)=CC=C1C(=O)NCC1=CC=C(\C=C\C(=O)NO)C=C1 WWMASNYTEATYTC-KPKJPENVSA-N 0.000 claims 2
- 102000010565 Apoptosis Regulatory Proteins Human genes 0.000 claims 2
- 108010063104 Apoptosis Regulatory Proteins Proteins 0.000 claims 2
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 2
- NCNRHFGMJRPRSK-MDZDMXLPSA-N belinostat Chemical compound ONC(=O)\C=C\C1=CC=CC(S(=O)(=O)NC=2C=CC=CC=2)=C1 NCNRHFGMJRPRSK-MDZDMXLPSA-N 0.000 claims 2
- DLVJMFOLJOOWFS-INMLLLKOSA-N depudecin Chemical compound C[C@@H](O)[C@@H]1O[C@H]1\C=C\[C@H]1[C@H]([C@H](O)C=C)O1 DLVJMFOLJOOWFS-INMLLLKOSA-N 0.000 claims 2
- 238000001802 infusion Methods 0.000 claims 2
- 229960002621 pembrolizumab Drugs 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 229940121649 protein inhibitor Drugs 0.000 claims 2
- 239000012268 protein inhibitor Substances 0.000 claims 2
- 229960000604 valproic acid Drugs 0.000 claims 2
- 230000003442 weekly effect Effects 0.000 claims 2
- ZYHQGITXIJDDKC-UHFFFAOYSA-N 2-[2-(2-aminophenyl)ethyl]aniline Chemical group NC1=CC=CC=C1CCC1=CC=CC=C1N ZYHQGITXIJDDKC-UHFFFAOYSA-N 0.000 claims 1
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical class C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 claims 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims 1
- FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 claims 1
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims 1
- DLVJMFOLJOOWFS-UHFFFAOYSA-N Depudecin Natural products CC(O)C1OC1C=CC1C(C(O)C=C)O1 DLVJMFOLJOOWFS-UHFFFAOYSA-N 0.000 claims 1
- 102000003964 Histone deacetylase Human genes 0.000 claims 1
- 108090000353 Histone deacetylase Proteins 0.000 claims 1
- PTJGLFIIZFVFJV-UHFFFAOYSA-N N'-hydroxy-N-(3-pyridinyl)octanediamide Chemical compound ONC(=O)CCCCCCC(=O)NC1=CC=CN=C1 PTJGLFIIZFVFJV-UHFFFAOYSA-N 0.000 claims 1
- GXVXXETYXSPSOA-UHFFFAOYSA-N Trapoxin A Natural products C1OC1C(=O)CCCCCC(C(NC(CC=1C=CC=CC=1)C(=O)N1)=O)NC(=O)C2CCCCN2C(=O)C1CC1=CC=CC=C1 GXVXXETYXSPSOA-UHFFFAOYSA-N 0.000 claims 1
- 229960003094 belinostat Drugs 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 229950005259 dacinostat Drugs 0.000 claims 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- JKVNVKOVLBVYHQ-UHFFFAOYSA-N n-[[4-[3-(hydroxyamino)-3-oxoprop-1-enyl]phenyl]methyl]-4-pyrrolidin-1-ylbenzamide Chemical compound C1=CC(C=CC(=O)NO)=CC=C1CNC(=O)C1=CC=C(N2CCCC2)C=C1 JKVNVKOVLBVYHQ-UHFFFAOYSA-N 0.000 claims 1
- 229960005184 panobinostat Drugs 0.000 claims 1
- FWZRWHZDXBDTFK-ZHACJKMWSA-N panobinostat Chemical compound CC1=NC2=CC=C[CH]C2=C1CCNCC1=CC=C(\C=C\C(=O)NO)C=C1 FWZRWHZDXBDTFK-ZHACJKMWSA-N 0.000 claims 1
- 210000003289 regulatory T cell Anatomy 0.000 claims 1
- 108010060597 trapoxin A Proteins 0.000 claims 1
- GXVXXETYXSPSOA-UFEOFEBPSA-N trapoxin A Chemical compound C([C@H]1C(=O)N2CCCC[C@@H]2C(=O)N[C@H](C(N[C@@H](CC=2C=CC=CC=2)C(=O)N1)=O)CCCCCC(=O)[C@H]1OC1)C1=CC=CC=C1 GXVXXETYXSPSOA-UFEOFEBPSA-N 0.000 claims 1
- RTKIYFITIVXBLE-QEQCGCAPSA-N trichostatin A Chemical compound ONC(=O)/C=C/C(/C)=C/[C@@H](C)C(=O)C1=CC=C(N(C)C)C=C1 RTKIYFITIVXBLE-QEQCGCAPSA-N 0.000 claims 1
- WAEXFXRVDQXREF-UHFFFAOYSA-N vorinostat Chemical compound ONC(=O)CCCCCCC(=O)NC1=CC=CC=C1 WAEXFXRVDQXREF-UHFFFAOYSA-N 0.000 claims 1
- 229960000237 vorinostat Drugs 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662288121P | 2016-01-28 | 2016-01-28 | |
| US62/288,121 | 2016-01-28 | ||
| PCT/US2017/015389 WO2017132536A1 (en) | 2016-01-28 | 2017-01-27 | Use of histone deacetylase inhibitors for enhancing immunotherapies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2018130831A true RU2018130831A (ru) | 2020-03-02 |
| RU2018130831A3 RU2018130831A3 (enExample) | 2020-04-23 |
Family
ID=58010402
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018130831A RU2018130831A (ru) | 2016-01-28 | 2017-01-27 | Применение ингибиторов деацетилаз гистонов для улучшения иммунотерапии |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10813919B2 (enExample) |
| EP (1) | EP3407913A1 (enExample) |
| JP (1) | JP2019503386A (enExample) |
| KR (1) | KR20180104122A (enExample) |
| CN (1) | CN108883179A (enExample) |
| AU (1) | AU2017211383A1 (enExample) |
| BR (1) | BR112018015291A2 (enExample) |
| CA (1) | CA3013047A1 (enExample) |
| IL (1) | IL260765A (enExample) |
| MX (1) | MX2018009247A (enExample) |
| RU (1) | RU2018130831A (enExample) |
| WO (1) | WO2017132536A1 (enExample) |
| ZA (1) | ZA201805066B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114605548A (zh) | 2015-09-01 | 2022-06-10 | 艾吉纳斯公司 | 抗-pd-1抗体及其使用方法 |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| KR102603681B1 (ko) | 2016-12-07 | 2023-11-17 | 아게누스 인코포레이티드 | 항체 및 이의 사용방법 |
| JP7348074B2 (ja) * | 2017-06-04 | 2023-09-20 | ラパポート・ファミリー・インスティテュート・フォー・リサーチ・イン・ザ・メディカル・サイエンシーズ | がん治療に対する個別化応答の予測方法およびそのキット |
| US12016900B2 (en) | 2017-06-04 | 2024-06-25 | Rappaport Family Institute For Research In The Medical Sciences | Method of treating cancer with an immune checkpoint inhibitor in combination with another therapeutic agent |
| US12070489B2 (en) | 2018-12-12 | 2024-08-27 | Rappaport Family Institute For Research In The Medical Sciences | Method of treating cancer with a cancer therapy in combination with another therapeutic agent |
| TR201900059A2 (tr) * | 2018-01-05 | 2019-07-22 | Gnt Biotech & Medicals Corp | Bi̇r farmasöti̇k kombi̇nasyon ve tümör mi̇kroortaminin ve i̇mmünoterapi̇ni̇n regülasyonu i̇çi̇n yöntem |
| JP2021511293A (ja) * | 2018-01-12 | 2021-05-06 | ビラクタ セラピューティクス，インク． | 細胞免疫療法で使用されるエピジェネティック修飾因子 |
| KR20210028339A (ko) * | 2019-09-04 | 2021-03-12 | 크리스탈지노믹스(주) | Hdac 저해제와 항 pd-1 항체 또는 항 pd-l1 항체를 포함하는 약학 조성물 |
| CN112569360A (zh) * | 2019-09-30 | 2021-03-30 | 中国医学科学院药物研究所 | 一种基于阻断pd-1/pd-l1的抗肿瘤药物组合物及其应用 |
| EP4385024A4 (en) | 2021-08-11 | 2025-06-25 | Oncohost Ltd | PREDICTING PATIENT RESPONSE |
| WO2024231293A1 (en) * | 2023-05-05 | 2024-11-14 | Euro-Celtique S.A. | Combinations for treating cancer |
| WO2024238811A2 (en) * | 2023-05-18 | 2024-11-21 | Avstera Therapeutics Corp. | Composition comprising hdac inhibitor and immune checkpoint inhibitor and methods for using the same |
| WO2025155922A1 (en) * | 2024-01-19 | 2025-07-24 | The Trustees Of Indiana University | Hdac3 inhibitors to treat arrhythmogenic cardiomyopathy |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ600281A (en) | 2006-12-27 | 2013-03-28 | Harvard College | Compositions and methods for the treatment of infections and tumors |
| US9987258B2 (en) * | 2014-04-06 | 2018-06-05 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Histone deacetylase as a modulator of PDL1 expression and activity |
| CN107614011A (zh) | 2015-03-20 | 2018-01-19 | 欣达克斯制药公司 | Hdac抑制剂和抗pd‑1抗体联合用于癌症的治疗 |
| WO2017035453A1 (en) * | 2015-08-26 | 2017-03-02 | The Johns Hopkins University | Compositions and methods for treating solid tumors |
| KR102631377B1 (ko) | 2015-09-02 | 2024-01-29 | 신닥스 파마슈티컬스, 인크. | 조합 요법을 위한 환자의 선별 |
-
2017
- 2017-01-27 AU AU2017211383A patent/AU2017211383A1/en not_active Abandoned
- 2017-01-27 US US16/072,659 patent/US10813919B2/en active Active
- 2017-01-27 EP EP17704370.0A patent/EP3407913A1/en not_active Withdrawn
- 2017-01-27 WO PCT/US2017/015389 patent/WO2017132536A1/en not_active Ceased
- 2017-01-27 MX MX2018009247A patent/MX2018009247A/es unknown
- 2017-01-27 RU RU2018130831A patent/RU2018130831A/ru not_active Application Discontinuation
- 2017-01-27 CN CN201780020460.2A patent/CN108883179A/zh active Pending
- 2017-01-27 JP JP2018539087A patent/JP2019503386A/ja active Pending
- 2017-01-27 KR KR1020187024674A patent/KR20180104122A/ko not_active Withdrawn
- 2017-01-27 BR BR112018015291A patent/BR112018015291A2/pt not_active IP Right Cessation
- 2017-01-27 CA CA3013047A patent/CA3013047A1/en not_active Abandoned
-
2018
- 2018-07-24 IL IL260765A patent/IL260765A/en unknown
- 2018-07-27 ZA ZA2018/05066A patent/ZA201805066B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA3013047A1 (en) | 2017-08-03 |
| MX2018009247A (es) | 2019-03-11 |
| ZA201805066B (en) | 2019-05-29 |
| EP3407913A1 (en) | 2018-12-05 |
| CN108883179A (zh) | 2018-11-23 |
| US20190030011A1 (en) | 2019-01-31 |
| US10813919B2 (en) | 2020-10-27 |
| JP2019503386A (ja) | 2019-02-07 |
| KR20180104122A (ko) | 2018-09-19 |
| WO2017132536A1 (en) | 2017-08-03 |
| BR112018015291A2 (pt) | 2018-12-18 |
| IL260765A (en) | 2018-10-31 |
| RU2018130831A3 (enExample) | 2020-04-23 |
| AU2017211383A1 (en) | 2018-08-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2018130831A (ru) | Применение ингибиторов деацетилаз гистонов для улучшения иммунотерапии | |
| JP2019503386A5 (enExample) | ||
| US12083119B2 (en) | Methods and compositions for treating viral or virally-induced conditions | |
| RU2012135396A (ru) | Способы лечения рака с применением ингибитора аутофагии на основе тиоксантона | |
| Demonté et al. | Administration of HDAC inhibitors to reactivate HIV-1 expression in latent cellular reservoirs: implications for the development of therapeutic strategies | |
| JP2021038228A5 (enExample) | ||
| ES2342378T3 (es) | Inhibidor de degradacion de matriz extracelular del cartilago artrodial. | |
| JP2007519619A5 (enExample) | ||
| US20090105168A1 (en) | Use Of HDAC And/Or DNMT Inhibitors For Treatment Of Ischemic Injury | |
| CY1109363T1 (el) | Υδροξαμικες ενωσεις ως θεραπευτικοι παραγοντες | |
| AU751701B2 (en) | Ace inhibitor-MMP inhibitor combinations | |
| JP2009539862A5 (enExample) | ||
| EA200801492A1 (ru) | Фармацевтическое применение замещенных амидов | |
| HRP20100577T1 (hr) | Uporaba agomelatina za dobivanje lijeka s ciljem liječenja općeg poremećaja anksioznosti | |
| JP2009521424A (ja) | 抗真菌剤の活性を増強するためのヒストンデアセチラーゼ阻害剤 | |
| HUP0100998A2 (hu) | (2E)-5-amino-5-metil-hex-2-én-sav-N-metil-N-{(1R)-1-[N-metil-N-/(1R)-1-(metil-karbamoil)-2-fenil-etil/-karbamoil]-2-(2-naftil)-etil}-amid-sók, eljárás azok előállítására, azokat tartalmazó gyógyszerkészítmények és alkalmazásuk | |
| PH12021552930A1 (en) | 1,3,4-oxadiazole derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same | |
| RU2011140701A (ru) | Замещенные 3-амино-2-меркаптохинолины в качестве kcnq2/3 модуляторов | |
| RU2008107871A (ru) | Применение ингибиторов hdac для лечения миеломы | |
| WO2007049262A1 (en) | Methods and compositions for the promotion of neuronal growth and the treatment of asociality and affective disorders | |
| RU2011141189A (ru) | Замещенные 2-меркапто-3-аминопиридины в качестве кcnq 2/3 модуляторов | |
| EA202190621A1 (ru) | Фармацевтическая композиция, содержащая антитромбоцитарное средство и ингибитор секреции желудочной кислоты | |
| EA202190077A1 (ru) | Ингибиторы гистондеацетилазы | |
| AU2006311723A1 (en) | Combination of an angiotensin II receptor blocker, a calcium channel blocker and another active agent | |
| EA201101305A1 (ru) | Лечение рака поджелудочной железы |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA94 | Acknowledgement of application withdrawn (non-payment of fees) |
Effective date: 20211015 |