RU2018122958A - Способ лечения состояний печени путем трансплантации стволовых клеток в стенки желчных протоков - Google Patents

Способ лечения состояний печени путем трансплантации стволовых клеток в стенки желчных протоков Download PDF

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RU2018122958A
RU2018122958A RU2018122958A RU2018122958A RU2018122958A RU 2018122958 A RU2018122958 A RU 2018122958A RU 2018122958 A RU2018122958 A RU 2018122958A RU 2018122958 A RU2018122958 A RU 2018122958A RU 2018122958 A RU2018122958 A RU 2018122958A
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cells
liver
suspension
walls
growth factor
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RU2018122958A
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Лола МакАдамс РЕЙД
Юньфан ВАН
Дейвид А. ГЕРБЕР
Джакомо ЛАНЦОНИ
Лука ИНВЕРАРДИ
Хуан ДОМИНГЕС-БЕНДАЛА
Доменико АЛЬВАРО
Винченцо КАРДИНАЛЕ
Эуженио ГАУДИО
Гвидо КАПРИНО
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Юниверсити Оф Норт Каролина Эт Чепел Хилл
Юниверсити Оф Майами
Сапьенца Университа Ди Рома
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Publication of RU2018122958A publication Critical patent/RU2018122958A/ru

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37Digestive system
    • A61K35/407Liver; Hepatocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3834Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3886Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412Tissue-regenerating or healing or proliferative agents
    • A61L2300/414Growth factors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00Materials or treatment for tissue regeneration
    • A61L2430/28Materials or treatment for tissue regeneration for liver reconstruction

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Developmental Biology & Embryology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
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  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Neurology (AREA)
  • Materials For Medical Uses (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)

Claims (16)

1. Способ лечения дисфункции или состояния печени, включающий
(a) получение суспензии печеночных стволовых клеток/клеток-предшественников; и
(b) введение этой суспензии в стенки или на стенки билиарного дерева субъекту с дисфункцией или состоянием печени; где значительная часть клеток приживается в стенке билиарного дерева,
где эти клетки созревают, становясь функциональными клетками печени, и мигрируют в печень, тем самым осуществляя лечение дисфункции или состояния печени.
2. Способ по п.1, в котором клетки являются стволовыми клетками билиарного дерева или стволовыми клетками печени, или коммитированными клетками-предшественниками, происходящими от указанных стволовых клеток.
3. Способ по п.1, в котором суспензию объединяют с одним или несколькими биологическими материалами для образования матриксного комплекса.
4. Способ по п.3, в котором один или несколько биологических материалов включают коллагены, молекулы адгезии, протеогликаны, гиалуронаны, цепи гликозаминогликанов, хитозан, альгинат и синтетические, биодеградируемые и биологически совместимые полимеры, или их комбинации.
5. Способ по п.4, в котором факторы роста могут включать одно или несколько из следующих веществ: факторы роста фибробластов (FGF), R-спондин, фактор роста гепатоцитов (HGF), эпидермальный фактор роста (EGF), фактор роста эндотелия сосудов (VEGF), инсулиноподобный фактор роста I (IGF-1), инсулиноподобный фактор роста II (IGF-2), онкостатин-M, фактор, ингибирующий лейкоз (LIF), трансферрин, инсулин, глюкокортикоиды, гормоны роста, эстрогены, андрогены, гормоны щитовидной железы, гормоны гипофиза и комбинации этих веществ.
6. Способ по п.1, в котором суспензию комбинируют с факторами роста, дополнительными клетками, или их комбинациями.
7. Способ по п.1, в котором клетки получают из здорового или функционального участка билиарного дерева субъекта.
8. Способ по п.1, в котором клетки получают из билиарного дерева не-аутологичного донора.
9. Способ по п.1, в котором суспензию вводят путем лапароскопического хирургического вмешательства или путем эндоскопии.
10. Способ по п.1, в котором суспензию клеток вводят путем инъекции, в качестве пластыря с биодеградируемым покрытием, или в губке.
11. Способ восстановления функций печени у субъекта с заболеванием или дисфункцией печени, включающий
(а) получение суспензии печеночных стволовых клеток/клеток-предшественников; и
(b) введение этой суспензии в стенки или на стенки желчных протоков поблизости от печени субъекта; и где значительная часть введенных клеток приживается по меньшей мере в части или на части печени в виде зрелых печеночных клеток in vivo.
RU2018122958A 2013-03-13 2014-03-13 Способ лечения состояний печени путем трансплантации стволовых клеток в стенки желчных протоков RU2018122958A (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361780644P 2013-03-13 2013-03-13
US61/780,644 2013-03-13
US14/207,191 2014-03-12
US14/207,191 US9533013B2 (en) 2013-03-13 2014-03-12 Method of treating pancreatic and liver conditions by endoscopic-mediated (or laparoscopic-mediated) transplantation of stem cells into/onto bile duct walls of particular regions of the biliary tree

Related Parent Applications (1)

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RU2015143617A Division RU2015143617A (ru) 2013-03-13 2014-03-13 Способ лечения состояний поджелудочной железы и печени путем трансплантации стволовых клеток в стенки желчных протоков

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RU2018122958A true RU2018122958A (ru) 2019-03-06

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RU2018122958A RU2018122958A (ru) 2013-03-13 2014-03-13 Способ лечения состояний печени путем трансплантации стволовых клеток в стенки желчных протоков
RU2015143617A RU2015143617A (ru) 2013-03-13 2014-03-13 Способ лечения состояний поджелудочной железы и печени путем трансплантации стволовых клеток в стенки желчных протоков

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US (2) US9533013B2 (ru)
EP (2) EP3733219B1 (ru)
JP (1) JP2016513466A (ru)
KR (1) KR20150130434A (ru)
CN (1) CN105264065A (ru)
AU (1) AU2014228310A1 (ru)
BR (1) BR112015021453A8 (ru)
CA (1) CA2904140C (ru)
CL (1) CL2015002557A1 (ru)
CR (1) CR20150543A (ru)
ES (2) ES2848075T3 (ru)
HK (1) HK1218430A1 (ru)
IL (1) IL240934A0 (ru)
MX (1) MX2015012120A (ru)
PH (1) PH12015502034A1 (ru)
RU (2) RU2018122958A (ru)
SG (2) SG11201507285WA (ru)
WO (1) WO2014143632A1 (ru)

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CA2904140C (en) 2023-10-17
SG10201707522RA (en) 2017-10-30
CN105264065A (zh) 2016-01-20
KR20150130434A (ko) 2015-11-23
EP2970879B1 (en) 2020-11-04
US20160058798A1 (en) 2016-03-03
US20140301985A1 (en) 2014-10-09
EP3733219B1 (en) 2023-11-01
AU2014228310A1 (en) 2015-10-08
US9533013B2 (en) 2017-01-03
CA2904140A1 (en) 2014-09-18
BR112015021453A2 (pt) 2017-07-18
EP2970879A4 (en) 2016-12-28
EP3733219A1 (en) 2020-11-04
CL2015002557A1 (es) 2016-08-26
JP2016513466A (ja) 2016-05-16
EP2970879A1 (en) 2016-01-20
WO2014143632A1 (en) 2014-09-18
US9750770B2 (en) 2017-09-05
SG11201507285WA (en) 2015-10-29
IL240934A0 (en) 2015-11-30
ES2848075T3 (es) 2021-08-05
PH12015502034A1 (en) 2016-01-18
RU2015143617A (ru) 2017-04-20
CR20150543A (es) 2016-02-24
ES2968686T3 (es) 2024-05-13
RU2015143617A3 (ru) 2018-03-22
BR112015021453A8 (pt) 2021-07-06
MX2015012120A (es) 2016-05-18
HK1218430A1 (zh) 2017-02-17

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