MX2015012120A - Método de tratamiento de condiciones pancreáticas y hepáticas mediante trasplante de células madre en paredes de los conductos biliares. - Google Patents

Método de tratamiento de condiciones pancreáticas y hepáticas mediante trasplante de células madre en paredes de los conductos biliares.

Info

Publication number
MX2015012120A
MX2015012120A MX2015012120A MX2015012120A MX2015012120A MX 2015012120 A MX2015012120 A MX 2015012120A MX 2015012120 A MX2015012120 A MX 2015012120A MX 2015012120 A MX2015012120 A MX 2015012120A MX 2015012120 A MX2015012120 A MX 2015012120A
Authority
MX
Mexico
Prior art keywords
cells
stem cells
liver
pancreatic
bile duct
Prior art date
Application number
MX2015012120A
Other languages
English (en)
Inventor
Yunfang Wang
Vincenzo Cardinale
Eugenio Gaudio
Guido Carpino
Domenico Alvaro
Luca Inverardi
Lola Mcadams Reid
David A Gerber
Giacomo Lanzoni
Juan Dominguez-Bendala
Original Assignee
Univ North Carolina
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ North Carolina filed Critical Univ North Carolina
Publication of MX2015012120A publication Critical patent/MX2015012120A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/407—Liver; Hepatocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/28—Materials or treatment for tissue regeneration for liver reconstruction

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Developmental Biology & Embryology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dispersion Chemistry (AREA)

Abstract

Se proporciona un método de reparación de páncreas enfermo o disfuncional o del hígado; el método consiste en preparar una suspensión de células madre y/o células progenitoras tal como células madre del árbol biliar, células madre hepáticas, células madre pancreáticas o sus descendientes, células progenitoras comprometidas, de tejido sano del paciente o del árbol biliar de un donante no autólogo e injerto de las células en la pared de los conductos biliares cerca del órgano a ser tratado; el injerto consiste de células madre o progenitoras que se mezclan con biomateriales y, opcionalmente, con citoquinas y/o células nativas epitelial-mesenquimales apropiadas para la etapa de maduración de linaje de las células a ser injertadas; las células son específicamente introducidas al conducto común hepato-pancreático del sujeto para el tratamiento de las afecciones pancreáticas o a la pared del conducto biliar cerca del hígado para el tratamiento de afecciones hepáticas y permite migrar al páncreas o al hígado y ampliar y luego reconstruir parte o la totalidad de los órganos enfermos o disfuncionales.
MX2015012120A 2013-03-13 2014-03-13 Método de tratamiento de condiciones pancreáticas y hepáticas mediante trasplante de células madre en paredes de los conductos biliares. MX2015012120A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361780644P 2013-03-13 2013-03-13
US14/207,191 US9533013B2 (en) 2013-03-13 2014-03-12 Method of treating pancreatic and liver conditions by endoscopic-mediated (or laparoscopic-mediated) transplantation of stem cells into/onto bile duct walls of particular regions of the biliary tree
PCT/US2014/026461 WO2014143632A1 (en) 2013-03-13 2014-03-13 Method of treating pancreatic and liver conditions by transplantation of stem cells into bile duct walls

Publications (1)

Publication Number Publication Date
MX2015012120A true MX2015012120A (es) 2016-05-18

Family

ID=51537508

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015012120A MX2015012120A (es) 2013-03-13 2014-03-13 Método de tratamiento de condiciones pancreáticas y hepáticas mediante trasplante de células madre en paredes de los conductos biliares.

Country Status (18)

Country Link
US (2) US9533013B2 (es)
EP (2) EP2970879B1 (es)
JP (1) JP2016513466A (es)
KR (1) KR20150130434A (es)
CN (1) CN105264065A (es)
AU (1) AU2014228310A1 (es)
BR (1) BR112015021453A8 (es)
CA (1) CA2904140C (es)
CL (1) CL2015002557A1 (es)
CR (1) CR20150543A (es)
ES (2) ES2968686T3 (es)
HK (1) HK1218430A1 (es)
IL (1) IL240934A0 (es)
MX (1) MX2015012120A (es)
PH (1) PH12015502034A1 (es)
RU (2) RU2018122958A (es)
SG (2) SG11201507285WA (es)
WO (1) WO2014143632A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104491931B (zh) * 2014-12-02 2017-04-12 清华大学深圳研究生院 含有皮脂腺的皮肤组织及其形成方法和用途
CA2981708A1 (en) 2015-04-03 2016-10-06 Chengkang ZHANG Ex vivo proliferation of epithelial cells
JP6869231B2 (ja) * 2015-09-11 2021-05-12 プロパジェニクス インコーポレイテッド ｅｘ ｖｉｖｏでの上皮細胞の増殖
US20200392465A1 (en) * 2016-11-15 2020-12-17 Regrow Biosciences Pvt. Ltd. A process of preparing buccal epithelial cell suspension and its use
JP2020515544A (ja) * 2017-03-25 2020-05-28 ユニバーシティ オブ マイアミ 治療細胞を含む生物学的足場
KR20200028391A (ko) 2017-06-12 2020-03-16 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 세포 생착용 패치 이식편 조성물
WO2019191402A1 (en) * 2018-03-29 2019-10-03 The University Of North Carolina At Chapel Hill Stem/progenitor cells from duodenal brunner's glands and methods of isolating and using them
CA3136471A1 (en) * 2019-04-11 2020-10-15 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Minimally invasive cell transplant procedure to induce the development of in vivo organogenesis
GB202102235D0 (en) * 2021-02-17 2021-03-31 Cambridge Entpr Ltd Cell transplantation

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US5861313A (en) * 1995-06-07 1999-01-19 Ontogeny, Inc. Method of isolating bile duct progenitor cells
US6960576B2 (en) 1999-09-13 2005-11-01 Bristol-Myers Squibb Pharma Company Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production
JP2002171865A (ja) * 2000-12-05 2002-06-18 Kansai Tlo Kk 内臓疾患実験動物モデル、その作製方法及びそれを用いた薬物の評価方法
JP4680483B2 (ja) * 2001-02-23 2011-05-11 ユニバーシティ オブ ピッツバーグ オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション 組織および臓器の治療および修復に用いるための幹細胞マトリックスの迅速な調製方法
US6805860B1 (en) * 2001-09-30 2004-10-19 Eckhard Alt Method of transluminal application of myogenic cells for repair or replacement of heart tissue
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CA2630355A1 (en) 2005-11-16 2007-05-24 University Of North Carolina At Chapel Hill Extracellular matrix components for expansion or differentiation of hepatic progenitors
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HUE040629T2 (hu) 2006-05-26 2019-03-28 Univ North Carolina Chapel Hill Máj stellát sejt prekurzorok
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MX2009009582A (es) 2007-03-06 2009-10-26 Univ North Carolina Complejos de hialuronanos, otros componentes de matriz, hormonas y factores de crecimiento para el mantenimiento, expansion y/o diferenciacion de celulas hepaticas.
CN101868533A (zh) 2007-06-15 2010-10-20 北卡罗来纳大学查珀尔希尔分校 来自间充质饲养细胞的旁分泌信号以及使用该旁分泌信号调节肝祖细胞的扩增和分化
WO2009111778A2 (en) * 2008-03-07 2009-09-11 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Lymph nodes as a site for regeneration
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JP2013539960A (ja) 2010-07-02 2013-10-31 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 工業規模の散布のためのバイオマトリックス足場
WO2014059402A1 (en) * 2012-10-12 2014-04-17 The Johns Hopkins University Human endocrine progenitors from adult pancreatic tissue

Also Published As

Publication number Publication date
BR112015021453A8 (pt) 2021-07-06
EP2970879A4 (en) 2016-12-28
PH12015502034A1 (en) 2016-01-18
SG10201707522RA (en) 2017-10-30
CR20150543A (es) 2016-02-24
AU2014228310A1 (en) 2015-10-08
CN105264065A (zh) 2016-01-20
RU2018122958A (ru) 2019-03-06
BR112015021453A2 (pt) 2017-07-18
CA2904140C (en) 2023-10-17
HK1218430A1 (zh) 2017-02-17
IL240934A0 (en) 2015-11-30
WO2014143632A1 (en) 2014-09-18
RU2015143617A (ru) 2017-04-20
US9750770B2 (en) 2017-09-05
ES2968686T3 (es) 2024-05-13
EP3733219A1 (en) 2020-11-04
EP2970879B1 (en) 2020-11-04
CL2015002557A1 (es) 2016-08-26
US20160058798A1 (en) 2016-03-03
US20140301985A1 (en) 2014-10-09
CA2904140A1 (en) 2014-09-18
EP3733219B1 (en) 2023-11-01
SG11201507285WA (en) 2015-10-29
EP2970879A1 (en) 2016-01-20
US9533013B2 (en) 2017-01-03
RU2015143617A3 (es) 2018-03-22
KR20150130434A (ko) 2015-11-23
JP2016513466A (ja) 2016-05-16
ES2848075T3 (es) 2021-08-05

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