CL2015002557A1 - Método para tratar condiciones pancreativas y de higado mediante trasplante de células madre en las paredes del conducto biliar - Google Patents

Método para tratar condiciones pancreativas y de higado mediante trasplante de células madre en las paredes del conducto biliar

Info

Publication number
CL2015002557A1
CL2015002557A1 CL2015002557A CL2015002557A CL2015002557A1 CL 2015002557 A1 CL2015002557 A1 CL 2015002557A1 CL 2015002557 A CL2015002557 A CL 2015002557A CL 2015002557 A CL2015002557 A CL 2015002557A CL 2015002557 A1 CL2015002557 A1 CL 2015002557A1
Authority
CL
Chile
Prior art keywords
pancreative
treating
walls
stem cells
bile duct
Prior art date
Application number
CL2015002557A
Other languages
English (en)
Inventor
Lola Mcadams Reid
Yunfang Wang
David A Gerber
Giacomo Lanzoni
Luca Inverardi
Juan Dominguez-Bendala
Domenico Alvaro
Vincenzo Cardinale
Eugenio Gaudio
Guido Carpino
Original Assignee
Univ North Carolina
Univ Miami
Sapienza Università Di Roma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ North Carolina, Univ Miami, Sapienza Università Di Roma filed Critical Univ North Carolina
Publication of CL2015002557A1 publication Critical patent/CL2015002557A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/407—Liver; Hepatocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/28—Materials or treatment for tissue regeneration for liver reconstruction

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Developmental Biology & Embryology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Neurology (AREA)
  • Materials For Medical Uses (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
CL2015002557A 2013-03-13 2015-09-09 Método para tratar condiciones pancreativas y de higado mediante trasplante de células madre en las paredes del conducto biliar CL2015002557A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361780644P 2013-03-13 2013-03-13
US14/207,191 US9533013B2 (en) 2013-03-13 2014-03-12 Method of treating pancreatic and liver conditions by endoscopic-mediated (or laparoscopic-mediated) transplantation of stem cells into/onto bile duct walls of particular regions of the biliary tree

Publications (1)

Publication Number Publication Date
CL2015002557A1 true CL2015002557A1 (es) 2016-08-26

Family

ID=51537508

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2015002557A CL2015002557A1 (es) 2013-03-13 2015-09-09 Método para tratar condiciones pancreativas y de higado mediante trasplante de células madre en las paredes del conducto biliar

Country Status (18)

Country Link
US (2) US9533013B2 (es)
EP (2) EP3733219B1 (es)
JP (1) JP2016513466A (es)
KR (1) KR20150130434A (es)
CN (1) CN105264065A (es)
AU (1) AU2014228310A1 (es)
BR (1) BR112015021453A8 (es)
CA (1) CA2904140C (es)
CL (1) CL2015002557A1 (es)
CR (1) CR20150543A (es)
ES (2) ES2848075T3 (es)
HK (1) HK1218430A1 (es)
IL (1) IL240934A0 (es)
MX (1) MX2015012120A (es)
PH (1) PH12015502034A1 (es)
RU (2) RU2018122958A (es)
SG (2) SG11201507285WA (es)
WO (1) WO2014143632A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104491931B (zh) * 2014-12-02 2017-04-12 清华大学深圳研究生院 含有皮脂腺的皮肤组织及其形成方法和用途
CN107636149A (zh) 2015-04-03 2018-01-26 普罗帕格尼克斯公司 上皮细胞的离体增殖
JP6869231B2 (ja) * 2015-09-11 2021-05-12 プロパジェニクス インコーポレイテッド ｅｘ ｖｉｖｏでの上皮細胞の増殖
US20200392465A1 (en) * 2016-11-15 2020-12-17 Regrow Biosciences Pvt. Ltd. A process of preparing buccal epithelial cell suspension and its use
JP2020515544A (ja) * 2017-03-25 2020-05-28 ユニバーシティ オブ マイアミ 治療細胞を含む生物学的足場
AU2018282728A1 (en) 2017-06-12 2020-01-30 The University Of North Carolina At Chapel Hill Patch graft compositions for cell engraftment
TW202002997A (zh) * 2018-03-29 2020-01-16 北卡羅來納大學教堂山 來自十二指腸布隆納氏腺之幹細胞／前驅細胞及其分離和使用方法
MX2021012314A (es) * 2019-04-11 2021-11-12 Univ Pittsburgh Commonwealth Sys Higher Education Procedimiento de trasplante celular minimamente invasivo para inducir el desarrollo de organogenesis in vivo.
GB202102235D0 (en) * 2021-02-17 2021-03-31 Cambridge Entpr Ltd Cell transplantation

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US5861313A (en) * 1995-06-07 1999-01-19 Ontogeny, Inc. Method of isolating bile duct progenitor cells
US6960576B2 (en) 1999-09-13 2005-11-01 Bristol-Myers Squibb Pharma Company Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production
JP2002171865A (ja) * 2000-12-05 2002-06-18 Kansai Tlo Kk 内臓疾患実験動物モデル、その作製方法及びそれを用いた薬物の評価方法
US20020155096A1 (en) 2001-02-23 2002-10-24 Chancellor Michael B. Rapid preparation of stem cell matrices for use in tissue and organ treatment and repair
US6805860B1 (en) * 2001-09-30 2004-10-19 Eckhard Alt Method of transluminal application of myogenic cells for repair or replacement of heart tissue
HUE032238T2 (en) * 2002-03-15 2017-09-28 Univ North Carolina Chapel Hill Primitive and proximal liver stem cells
ES2385248T3 (es) * 2004-01-14 2012-07-20 Novahep Ab Células progenitoras hepáticas humanas y métodos de uso de las mismas
WO2007059501A2 (en) 2005-11-16 2007-05-24 University Of North Carolina At Chapel Hill Extracellular matrix components for expansion or differentiation of hepatic progenitors
WO2007127698A2 (en) * 2006-04-25 2007-11-08 Board Of Supervisors Of Louisiana State Universityand Agricultural And Mechanical College Adipose derived adult stem cells in hepatic regeneration
DK2428561T3 (en) 2006-05-26 2019-01-21 Univ North Carolina Chapel Hill HEPATIC STELLATLE CELLS
WO2008101215A1 (en) * 2007-02-16 2008-08-21 Varian Medical Systems Technologies, Inc. Preparative regimen for engraftment, growth and differentiation of non-hematopoeitic cells in vivo
WO2008109659A2 (en) 2007-03-06 2008-09-12 University Of North Carolina At Chapel Hill Complexes of hyaluronans, other matrix components, hormones and growth factors for maintenance, expansion and/or differentiation of cells
KR20100094970A (ko) 2007-06-15 2010-08-27 유니버시티 오브 노스캐롤라이나 앳 채플 힐 중간엽 공급자 세포로부터의 파라크린 시그널 및 이를 이용한 간 전구세포의 확장 및 분화 조절
WO2009111778A2 (en) * 2008-03-07 2009-09-11 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Lymph nodes as a site for regeneration
US20120189702A1 (en) * 2009-08-06 2012-07-26 Albert Einstein College Of Medicine Of Yeshiva University Cell therapy for treatment of liver failure
EP2471542B1 (en) * 2009-08-28 2016-04-27 Osaka Air Machine Service, Ltd. Therapeutic agent for liver-related diseases
KR20200146043A (ko) 2009-10-30 2020-12-31 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 간외 담도계로부터의 다분화능 줄기 세포 및 이의 분리 방법
WO2011068946A1 (en) * 2009-12-02 2011-06-09 Ramtin Agah Devices, methods and kits for delivery of therapeutic materials to a pancreas
NZ630598A (en) 2010-05-07 2016-02-26 Univ North Carolina Method of engrafting cells from solid tissues
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WO2014059402A1 (en) * 2012-10-12 2014-04-17 The Johns Hopkins University Human endocrine progenitors from adult pancreatic tissue

Also Published As

Publication number Publication date
CA2904140C (en) 2023-10-17
SG10201707522RA (en) 2017-10-30
CN105264065A (zh) 2016-01-20
KR20150130434A (ko) 2015-11-23
EP2970879B1 (en) 2020-11-04
US20160058798A1 (en) 2016-03-03
US20140301985A1 (en) 2014-10-09
RU2018122958A (ru) 2019-03-06
EP3733219B1 (en) 2023-11-01
AU2014228310A1 (en) 2015-10-08
US9533013B2 (en) 2017-01-03
CA2904140A1 (en) 2014-09-18
BR112015021453A2 (pt) 2017-07-18
EP2970879A4 (en) 2016-12-28
EP3733219A1 (en) 2020-11-04
JP2016513466A (ja) 2016-05-16
EP2970879A1 (en) 2016-01-20
WO2014143632A1 (en) 2014-09-18
US9750770B2 (en) 2017-09-05
SG11201507285WA (en) 2015-10-29
IL240934A0 (en) 2015-11-30
ES2848075T3 (es) 2021-08-05
PH12015502034A1 (en) 2016-01-18
RU2015143617A (ru) 2017-04-20
CR20150543A (es) 2016-02-24
ES2968686T3 (es) 2024-05-13
RU2015143617A3 (es) 2018-03-22
BR112015021453A8 (pt) 2021-07-06
MX2015012120A (es) 2016-05-18
HK1218430A1 (zh) 2017-02-17

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