RU2017110275A - Сконструированные ткани почки, матрицы на их основе и способы их получения - Google Patents
Сконструированные ткани почки, матрицы на их основе и способы их получения Download PDFInfo
- Publication number
- RU2017110275A RU2017110275A RU2017110275A RU2017110275A RU2017110275A RU 2017110275 A RU2017110275 A RU 2017110275A RU 2017110275 A RU2017110275 A RU 2017110275A RU 2017110275 A RU2017110275 A RU 2017110275A RU 2017110275 A RU2017110275 A RU 2017110275A
- Authority
- RU
- Russia
- Prior art keywords
- kidney
- cells
- ink
- interstitial
- bio
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 51
- 239000011159 matrix material Substances 0.000 title claims 4
- 210000005084 renal tissue Anatomy 0.000 title claims 4
- 210000003734 kidney Anatomy 0.000 claims 108
- 210000005239 tubule Anatomy 0.000 claims 65
- 239000010410 layer Substances 0.000 claims 53
- 210000002919 epithelial cell Anatomy 0.000 claims 34
- 210000001519 tissue Anatomy 0.000 claims 30
- 210000000981 epithelium Anatomy 0.000 claims 24
- 210000002889 endothelial cell Anatomy 0.000 claims 21
- 210000002950 fibroblast Anatomy 0.000 claims 21
- 210000004027 cell Anatomy 0.000 claims 20
- 210000002570 interstitial cell Anatomy 0.000 claims 15
- 210000003292 kidney cell Anatomy 0.000 claims 12
- 238000001125 extrusion Methods 0.000 claims 7
- 210000001985 kidney epithelial cell Anatomy 0.000 claims 7
- 210000000738 kidney tubule Anatomy 0.000 claims 6
- 210000004379 membrane Anatomy 0.000 claims 6
- 239000012528 membrane Substances 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 4
- 239000011148 porous material Substances 0.000 claims 4
- 239000002356 single layer Substances 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 210000005081 epithelial layer Anatomy 0.000 claims 3
- 210000003251 kidney tubule epithelial cell Anatomy 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 2
- 239000006143 cell culture medium Substances 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 210000003904 glomerular cell Anatomy 0.000 claims 2
- 210000002865 immune cell Anatomy 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 230000003907 kidney function Effects 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 231100000417 nephrotoxicity Toxicity 0.000 claims 2
- 208000030761 polycystic kidney disease Diseases 0.000 claims 2
- 210000002955 secretory cell Anatomy 0.000 claims 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
- 230000035899 viability Effects 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 210000005233 tubule cell Anatomy 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0684—Cells of the urinary tract or kidneys
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
- C12N2502/1323—Adult fibroblasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/25—Urinary tract cells, renal cells
- C12N2502/256—Renal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/28—Vascular endothelial cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462060416P | 2014-10-06 | 2014-10-06 | |
| US62/060,416 | 2014-10-06 | ||
| US201562140285P | 2015-03-30 | 2015-03-30 | |
| US62/140,285 | 2015-03-30 | ||
| PCT/US2015/054315 WO2016057571A1 (en) | 2014-10-06 | 2015-10-06 | Engineered renal tissues, arrays thereof, and methods of making the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2017110275A true RU2017110275A (ru) | 2018-11-15 |
Family
ID=55632374
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2017110275A RU2017110275A (ru) | 2014-10-06 | 2015-10-06 | Сконструированные ткани почки, матрицы на их основе и способы их получения |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US9481868B2 (https=) |
| EP (1) | EP3204488B1 (https=) |
| JP (2) | JP2017529877A (https=) |
| KR (1) | KR20170064547A (https=) |
| CN (1) | CN107002033B (https=) |
| AU (1) | AU2015328173B2 (https=) |
| CA (1) | CA2962778C (https=) |
| MA (1) | MA40495A (https=) |
| RU (1) | RU2017110275A (https=) |
| SG (1) | SG11201702795QA (https=) |
| WO (1) | WO2016057571A1 (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9719068B2 (en) | 2010-05-06 | 2017-08-01 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
| HK1200483A1 (en) | 2011-09-12 | 2015-08-07 | 奥加诺沃公司 | Engineered tissues for in vitro research uses, arrays thereof, and methods of making the same |
| SG10201801654RA (en) | 2014-05-28 | 2018-04-27 | Childrens Hospital Med Ct | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
| KR20170064547A (ko) | 2014-10-06 | 2017-06-09 | 오가노보, 인크. | 조작된 신장 조직, 이의 어레이, 및 이를 제조하는 방법 |
| AU2015331848B2 (en) | 2014-10-17 | 2022-03-03 | Children's Hospital Medical Center, D/B/A Cincinnati Children's Hospital Medical Center | In vivo model of human small intestine using pluripotent stem cells and methods of making and using same |
| WO2017083402A1 (en) | 2015-11-09 | 2017-05-18 | Organovo, Inc. | Improved methods for tissue fabrication |
| WO2017123722A1 (en) | 2016-01-12 | 2017-07-20 | Cleveland State University | 3d-printed miniature biological constructs |
| EP3447143A4 (en) * | 2016-04-19 | 2019-11-20 | Toppan Printing Co., Ltd. | METHOD OF EVALUATING ANTICROBIAL AGENT |
| CN109415685B (zh) | 2016-05-05 | 2023-07-04 | 儿童医院医疗中心 | 用于体外制造胃底组织的方法和与其相关的组合物 |
| US11268950B2 (en) | 2016-09-28 | 2022-03-08 | Organovo, Inc. | Use of engineered renal tissues in assays |
| EP4553082A3 (en) | 2016-11-04 | 2025-08-20 | Children's Hospital Medical Center | Liver organoid compositions and methods of making and using same |
| US11655456B2 (en) | 2016-11-10 | 2023-05-23 | Organovo, Inc. | Engineered intestinal tissue and uses thereof |
| EP3541518A4 (en) | 2016-11-17 | 2020-09-30 | Cleveland State University | CHIP PLATFORMS FOR MICRO-NETWORK 3D BIO-PRINTING |
| EP3548507A4 (en) | 2016-12-05 | 2020-07-15 | Children's Hospital Medical Center | COLON ORGANOIDS AND PROCESSES FOR THE PREPARATION AND USE THEREOF |
| JP7248586B2 (ja) | 2017-04-14 | 2023-03-29 | チルドレンズ ホスピタル メディカル センター | 複数ドナー幹細胞組成物およびそれを作製する方法 |
| WO2019039452A1 (ja) * | 2017-08-21 | 2019-02-28 | 凸版印刷株式会社 | 抗がん効果の評価方法、及びがん免疫療法の奏効性予測方法 |
| EP3694603B1 (en) | 2017-10-10 | 2026-04-08 | Children's Hospital Medical Center | Esophageal tissue and/or organoid compositions and methods of making same |
| US11262349B2 (en) | 2017-10-11 | 2022-03-01 | Cleveland State University | Multiplexed immune cell assays on a micropillar/microwell chip platform |
| EP3697340A4 (en) | 2017-10-20 | 2021-08-04 | Indiana University Research & Technology Corporation | 3D BIO-PRINTING OF PORCINE CELLS WITHOUT SCAFFOLDING |
| EP3727394A4 (en) | 2017-12-21 | 2021-09-08 | Children's Hospital Medical Center | DIGITALIZED HUMAN ORGANOIDS AND METHOD OF USING THEREOF |
| CN108130313B (zh) * | 2017-12-28 | 2021-04-30 | 杭州枫霖科技有限公司 | 一种基于生物3d打印构建三维胶质瘤组织的方法 |
| DE102018111751A1 (de) * | 2018-05-16 | 2019-11-21 | Cellbricks Gmbh | Verfahren zur Herstellung eines Zellkultureinsatzes mit mindestens einer Membran |
| EP4678727A3 (en) | 2018-07-26 | 2026-03-11 | Children's Hospital Medical Center | Hepato-biliary-pancreatic tissues and methods of making same |
| CA3112026A1 (en) | 2018-09-12 | 2020-03-19 | Children's Hospital Medical Center | Organoid compositions for the production of hematopoietic stem cells and derivatives thereof |
| US12600943B2 (en) | 2019-02-01 | 2026-04-14 | The University Of Hong Kong | Innervated organoid compositions and methods of making same |
| WO2020170240A1 (en) * | 2019-02-21 | 2020-08-27 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Method for reduction drug-induced nephrotoxicity |
| AU2020283048A1 (en) | 2019-05-31 | 2021-12-23 | Children's Hospital Medical Center | Shaped organoid compositions and methods of making same |
| US12497597B2 (en) | 2019-05-31 | 2025-12-16 | Children's Hospital Medical Center | Methods of generating and expanding hematopoietic stem cells |
| CN114667340A (zh) * | 2019-08-23 | 2022-06-24 | 默多克儿童研究所 | 生物打印肾组织 |
| US12019040B2 (en) | 2019-09-30 | 2024-06-25 | Cornell University | System and devices for monitoring cell-containing materials and methods of their use |
| KR102438496B1 (ko) | 2020-09-07 | 2022-09-02 | 포항공과대학교 산학협력단 | 생체외 인공장기 모델 및 세포 치료제로의 적용이 가능한 관류형 이중 근위세뇨관 관상 세포 구조체 및 그 생성 방법 |
| WO2025153590A1 (en) * | 2024-01-16 | 2025-07-24 | Universite Libre De Bruxelles | An in vitro method and kit for determining, predicting, and/or monitoring fibrotoxicity of an agent and use thereof |
Family Cites Families (118)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4759764A (en) | 1985-05-24 | 1988-07-26 | Clayton Foundation For Research | Peripheral nerve regeneration |
| US4808435A (en) | 1987-04-06 | 1989-02-28 | International Business Machines Corporation | Screen printing method for producing lines of uniform width and height |
| US5099090A (en) | 1988-05-11 | 1992-03-24 | Ariel Electronics, Inc. | Circuit writer |
| EP0929271B1 (en) * | 1996-09-05 | 2004-02-25 | Children's Medical Center Corporation | Prosthetic kidney |
| US6537567B1 (en) | 1997-07-03 | 2003-03-25 | Massachusetts Institute Of Technology | Tissue-engineered tubular construct having circumferentially oriented smooth muscle cells |
| US6401795B1 (en) | 1997-10-28 | 2002-06-11 | Sandia Corporation | Method for freeforming objects with low-binder slurry |
| CA2326322C (en) | 1998-04-21 | 2011-03-01 | University Of Connecticut | Free-form nanofabrication using multi-photon excitation |
| US6697694B2 (en) | 1998-08-26 | 2004-02-24 | Electronic Materials, L.L.C. | Apparatus and method for creating flexible circuits |
| US7338798B2 (en) | 1998-09-15 | 2008-03-04 | The Regents Of The University Of Michigan | System and method for forming a cardiac muscle construct |
| EP1029692B9 (en) | 1999-02-17 | 2003-12-03 | Hewlett-Packard Company, A Delaware Corporation | Printing apparatus |
| US6979670B1 (en) | 1999-03-10 | 2005-12-27 | Biora Bioex Ab | Matrix protein compositions for grafting |
| US6642243B1 (en) | 1999-07-22 | 2003-11-04 | Ashkan Imanzahrai | Migraine medicine and method for treating same |
| JP2001145956A (ja) | 1999-11-19 | 2001-05-29 | Meiko:Kk | 光硬化性樹脂三次元造形物の積層造形装置及びその積層造形方法 |
| US6503273B1 (en) | 1999-11-22 | 2003-01-07 | Cyograft Tissue Engineering, Inc. | Tissue engineered blood vessels and methods and apparatus for their manufacture |
| US6454972B1 (en) | 1999-11-24 | 2002-09-24 | Sandia Corporation | Solid freeform fabrication using chemically reactive suspensions |
| US6520997B1 (en) | 1999-12-08 | 2003-02-18 | Baxter International Inc. | Porous three dimensional structure |
| US6315469B1 (en) | 2000-01-19 | 2001-11-13 | Hewlett-Packard Company | Tool and method for adjustment of printhead to platen spacing in a printer |
| DE10013223C2 (de) | 2000-03-13 | 2002-07-18 | Co Don Ag | Verfahren zur in vitro-Herstellung von dreidimensionalem, vitalem Knorpel- oder Knochengewebe und dessen Verwendung als Transplantationsmaterial |
| US20050091576A1 (en) | 2003-10-24 | 2005-04-28 | Microsoft Corporation | Programming interface for a computer platform |
| DE10018987A1 (de) | 2000-04-17 | 2001-10-31 | Envision Technologies Gmbh | Vorrichtung und Verfahren zum Herstellen von dreidimensionalen Objekten |
| US20020182633A1 (en) | 2000-07-11 | 2002-12-05 | Chen Christopher S. | Methods of patterning protein and cell adhesivity |
| US7998735B2 (en) | 2000-08-21 | 2011-08-16 | Victorian Tissue Engineering Centre Pty. Ltd. | Vascularized tissue graft |
| US6561607B1 (en) | 2000-10-05 | 2003-05-13 | Eastman Kodak Company | Apparatus and method for maintaining a substantially constant closely spaced working distance between an inkjet printhead and a printing receiver |
| US6939489B2 (en) | 2001-03-23 | 2005-09-06 | Ivoclar Vivadent Ag | Desktop process for producing dental products by means of 3-dimensional plotting |
| US6849223B2 (en) | 2001-04-19 | 2005-02-01 | Case Western Reserve University | Fabrication of a polymeric prosthetic implant |
| DE10127225A1 (de) | 2001-05-22 | 2002-11-28 | Zeiss Carl | Ultraviolettlicht-Abschwächungsfilter |
| US20060270032A1 (en) | 2005-05-24 | 2006-11-30 | The Regents Of The University Of California | Microscale micropatterened engineered in vitro tissue |
| US20030049839A1 (en) | 2001-08-01 | 2003-03-13 | The University Of Texas System | Transparent multi-channel cell scaffold that creates a cellular and/or molecular gradient |
| WO2003017745A2 (en) | 2001-08-23 | 2003-03-06 | Sciperio, Inc. | Architecture tool and methods of use |
| JP4023597B2 (ja) * | 2001-09-25 | 2007-12-19 | 独立行政法人科学技術振興機構 | 基底膜標品等を用いた再構築人工組織及びその製造方法 |
| US6934600B2 (en) | 2002-03-14 | 2005-08-23 | Auburn University | Nanotube fiber reinforced composite materials and method of producing fiber reinforced composites |
| US20100254900A1 (en) | 2002-03-18 | 2010-10-07 | Campbell Phil G | Biocompatible polymers and Methods of use |
| WO2003079985A2 (en) | 2002-03-18 | 2003-10-02 | Carnegie Mellon University | Method and apparatus for preparing biomimetic scaffold |
| US6907307B2 (en) | 2002-07-02 | 2005-06-14 | 3D Systems, Inc. | Support volume calculation for a CAD model |
| AU2003251874A1 (en) | 2002-07-12 | 2004-02-02 | Dirk R. Albrecht | Three dimensional cell patterned bioploymer scaffolds and method of making the same |
| US7641898B2 (en) | 2003-03-21 | 2010-01-05 | Materials Evolution And Development Usa, Inc. | Keratinocyte-fibrocyte concomitant grafting for wound healing |
| US20040197375A1 (en) | 2003-04-02 | 2004-10-07 | Alireza Rezania | Composite scaffolds seeded with mammalian cells |
| AU2004229465B2 (en) * | 2003-04-09 | 2010-04-29 | The United States Of America Department Of Veterans Affairs | Compositions and methods related to production of erythropoietin |
| US7051654B2 (en) | 2003-05-30 | 2006-05-30 | Clemson University | Ink-jet printing of viable cells |
| WO2005003300A2 (en) | 2003-06-04 | 2005-01-13 | University Of South Carolina | Tissue scaffold having aligned fibrils, apparatus and method for producing same, and methods of using same |
| JP4474858B2 (ja) | 2003-07-07 | 2010-06-09 | セイコーエプソン株式会社 | ギャップ調整装置、これに使用されるキャリブレーション用治具、およびギャップ調整装置を備えた液滴吐出装置、並びに電気光学装置の製造方法 |
| US20050074877A1 (en) | 2003-07-28 | 2005-04-07 | Mao Jeremy Jian | Biological engineering of articular structures containing both cartilage and bone |
| FR2859128B1 (fr) | 2003-08-29 | 2006-03-10 | Centre Nat Rech Scient | Procede et dispositif de fabrication d'un composant multimateriaux tridimensionnel par impression du type jet d'encre |
| US8043614B2 (en) | 2004-03-09 | 2011-10-25 | Ahlfors Jan-Eric W | Autogenic living scaffolds and living tissue matrices: methods and uses thereof |
| DE10353281A1 (de) | 2003-11-14 | 2005-06-16 | Bayer Cropscience Ag | Wirkstoffkombination mit insektiziden und akariziden Eigenschaften |
| US20050276791A1 (en) | 2004-02-20 | 2005-12-15 | The Ohio State University | Multi-layer polymer scaffolds |
| US8241905B2 (en) * | 2004-02-24 | 2012-08-14 | The Curators Of The University Of Missouri | Self-assembling cell aggregates and methods of making engineered tissue using the same |
| US20090142307A1 (en) | 2004-07-09 | 2009-06-04 | Athanasiou Kyriacos A | Shape-Based Approach for Scaffoldless Tissue Engineering |
| US7939003B2 (en) | 2004-08-11 | 2011-05-10 | Cornell Research Foundation, Inc. | Modular fabrication systems and methods |
| US7651665B2 (en) | 2004-09-07 | 2010-01-26 | Hewlett-Packard Development Company, L.P. | Microtray for handling biosubstances |
| US7767446B2 (en) | 2004-09-16 | 2010-08-03 | Becton, Dickinson And Company | Perfusion bioreactors for culturing cells |
| KR100606457B1 (ko) | 2004-11-11 | 2006-11-23 | 한국기계연구원 | 3차원 프린팅 조형시스템 |
| JP4539316B2 (ja) | 2004-12-08 | 2010-09-08 | セイコーエプソン株式会社 | ヘッド位置補正方法およびヘッド位置補正装置、並びに液滴吐出装置、電気光学装置の製造方法 |
| US7568904B2 (en) | 2005-03-03 | 2009-08-04 | Laser Solutions Co., Ltd. | Stereolithography apparatus |
| JP4729948B2 (ja) | 2005-03-09 | 2011-07-20 | ブラザー工業株式会社 | 液体供給装置、この液体供給装置を備えたインクジェット記録装置 |
| US7780897B2 (en) | 2005-04-22 | 2010-08-24 | Board Of Regents, The University Of Texas System | Hydrogel constructs using stereolithography |
| WO2007126411A2 (en) | 2005-07-28 | 2007-11-08 | Carnegie Mellon University | Biocompatible polymers and methods of use |
| US8690957B2 (en) | 2005-12-21 | 2014-04-08 | Warsaw Orthopedic, Inc. | Bone graft composition, method and implant |
| US20070200276A1 (en) | 2006-02-24 | 2007-08-30 | Micron Technology, Inc. | Method for rapid printing of near-field and imprint lithographic features |
| US7680555B2 (en) | 2006-04-03 | 2010-03-16 | Stratasys, Inc. | Auto tip calibration in an extrusion apparatus |
| US20070231787A1 (en) | 2006-04-04 | 2007-10-04 | Voelker Mark A | Methods and devices for imaging and manipulating biological samples |
| CA2648327A1 (en) | 2006-04-05 | 2007-10-11 | William Marsh Rice University | Tissue engineering with human embryonic stem cells |
| WO2007124023A2 (en) | 2006-04-21 | 2007-11-01 | Wake Forest University Health Sciences | Ink-jet printing of tissues |
| JP4051077B2 (ja) | 2006-04-28 | 2008-02-20 | シャープ株式会社 | 液滴塗布装置、液滴吐出部のギャップ測定方法、および、液滴吐出部のギャップ調整方法 |
| FR2901143B1 (fr) | 2006-05-16 | 2008-10-03 | Centre Nat Rech Scient | "methode de construction de materiaux vivants fonctionnels, materiaux obtenus et applications" |
| US7959942B2 (en) | 2006-10-20 | 2011-06-14 | Orbusneich Medical, Inc. | Bioabsorbable medical device with coating |
| DE102006053121B3 (de) | 2006-11-10 | 2007-12-27 | Eos Gmbh Electro Optical Systems | Vorrichtung und Verfahren zum Herstellen eines dreidimensionalen Objektes mittels eines Beschichters für pulverförmiges Aufbaumaterial |
| WO2009038594A2 (en) * | 2007-01-10 | 2009-03-26 | Brett Blackman | Use of an in vitro hemodynamic endothelial/smooth muscle cell co-culture model to identify new therapeutic targets for vascular disease |
| WO2008097906A2 (en) | 2007-02-02 | 2008-08-14 | The Regents Of The University Of Michigan | System and method for forming bone, ligament and bone-ligament constructs |
| US8343740B2 (en) | 2007-03-29 | 2013-01-01 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Micro-organ device |
| JP5645657B2 (ja) | 2007-06-07 | 2014-12-24 | ウェイク・フォレスト・ユニヴァーシティ・ヘルス・サイエンシズ | インクジェット遺伝子印刷法 |
| WO2009013751A2 (en) | 2007-07-25 | 2009-01-29 | Objet Geometries Ltd. | Solid freeform fabrication using a plurality of modeling materials |
| CA2696386C (en) | 2007-08-29 | 2012-12-18 | Vito Nv | Method for producing a three-dimensional macroporous filament construct based on phase inversion and construct thereby obtained |
| US20090076531A1 (en) | 2007-09-18 | 2009-03-19 | Richardson Charles L | Method and apparatus for bypass graft |
| EP2203129A4 (en) | 2007-10-15 | 2011-11-23 | Univ Wake Forest Health Sciences | METHOD AND COMPOSITIONS FOR PRINTING BIOCOMPATIBLE NANOROUS COMPOSITES FROM AUTOLOGOUS TISSUE |
| US7923846B2 (en) | 2007-11-16 | 2011-04-12 | Stats Chippac Ltd. | Integrated circuit package-in-package system with wire-in-film encapsulant |
| EP2090584A1 (en) | 2008-02-13 | 2009-08-19 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Identification of a novel cysteine-rich cell penetrating peptide |
| KR100922232B1 (ko) | 2008-02-13 | 2009-10-16 | 연세대학교 산학협력단 | 전기수력학 프린팅 기법을 이용한 살아있는 세포의 직접패터닝 방법 및 장치 |
| US8691274B2 (en) | 2008-02-14 | 2014-04-08 | Wake Forest University Health Sciences | Inkjet printing of tissues and cells |
| US20090248145A1 (en) | 2008-03-28 | 2009-10-01 | Nanyang Technological University | Method of forming a three-dimensional structure of unidirectionally aligned cells |
| US8876513B2 (en) | 2008-04-25 | 2014-11-04 | 3D Systems, Inc. | Selective deposition modeling using CW UV LED curing |
| EP2310491B1 (en) | 2008-06-20 | 2018-03-07 | Universiteit Maastricht | Self-assembling tissue modules |
| JP5624981B2 (ja) | 2008-06-24 | 2014-11-12 | ザ・キュレーターズ・オブ・ザ・ユニバーシティ・オブ・ミズーリＴｈｅ Ｃｕｒａｔｏｒｓ Ｏｆｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｍｉｓｓｏｕｒｉ | 自己集合性多細胞体、および前記多細胞体を用いて３次元の生物構造体を作製する方法 |
| US9097702B2 (en) | 2008-07-29 | 2015-08-04 | Cornell University | Pathologically relevant tumor microenvironments for high-throughput drug screening |
| WO2010030964A2 (en) | 2008-09-12 | 2010-03-18 | The Brigham And Women's Hospital, Inc. | 3-dimensional multi-layered hydrogels and methods of making the same |
| US20110250688A1 (en) | 2008-11-24 | 2011-10-13 | Immunotrex Corporation | Three Dimensional Tissue Generation |
| EP2450707B1 (en) | 2010-11-04 | 2016-04-27 | University of Pécs | Lung tissue model |
| US8691974B2 (en) | 2009-09-28 | 2014-04-08 | Virginia Tech Intellectual Properties, Inc. | Three-dimensional bioprinting of biosynthetic cellulose (BC) implants and scaffolds for tissue engineering |
| US8409603B2 (en) | 2009-10-01 | 2013-04-02 | University Of South Carolina | Compositions and methods for tissue engineering, tissue regeneration and wound healing |
| WO2011085225A1 (en) | 2010-01-08 | 2011-07-14 | Wake Forest University Health Sciences | Delivery system |
| EP2523656A4 (en) | 2010-01-15 | 2013-12-11 | Univ Utah Res Found | RETICULATED HYDROGELS AND METHODS OF MAKING AND USING THE SAME |
| BR112012019369A2 (pt) | 2010-02-02 | 2018-05-22 | Univ Missouri | fabricação de enxerto de nervo biológico construído e aplicação do mesmo. |
| US9039998B2 (en) | 2010-03-04 | 2015-05-26 | Institut National De La Sante Et De La Recherche Medical (Inserm) | Bioprinting station, assembly comprising such bioprinting station and bioprinting method |
| GB2489081B (en) | 2010-03-16 | 2013-03-27 | Organovo Inc | Multilayered vascular tubes |
| US9012415B2 (en) | 2010-03-26 | 2015-04-21 | Stemmatters, Biotecnologia E Medicina Regenerativa S.A. | Photo-crosslinked gellan gum-based hydrogels: preparation methods and uses thereof |
| WO2012003465A2 (en) | 2010-07-01 | 2012-01-05 | The Regents Of The University Of Michigan | Scaffold-free three dimensional nerve fibroblast constructs |
| US20120089238A1 (en) | 2010-10-06 | 2012-04-12 | Hyun-Wook Kang | Integrated organ and tissue printing methods, system and apparatus |
| AU2011318437B2 (en) | 2010-10-21 | 2015-02-26 | Organovo, Inc. | Devices, systems, and methods for the fabrication of tissue |
| DE202011003443U1 (de) | 2011-03-02 | 2011-12-23 | Bego Medical Gmbh | Vorrichtung zur generativen Herstellung dreidimensionaler Bauteile |
| AU2012225644B2 (en) | 2011-03-07 | 2017-05-04 | Wake Forest University Health Sciences | Delivery system |
| GB201105226D0 (en) | 2011-03-29 | 2011-05-11 | Univ Leiden | Methods |
| JP5599356B2 (ja) | 2011-03-31 | 2014-10-01 | 富士フイルム株式会社 | シミュレーション方法、プログラムおよびそれを記録した記録媒体、並びに、それらを利用した液滴配置パターンの作成方法、ナノインプリント方法、パターン化基板の製造方法およびインクジェット装置。 |
| HK1200483A1 (en) * | 2011-09-12 | 2015-08-07 | 奥加诺沃公司 | Engineered tissues for in vitro research uses, arrays thereof, and methods of making the same |
| EP2755599B1 (en) * | 2011-09-12 | 2020-04-01 | Organovo, Inc. | Platform for engineered implantable tissues and organs and methods of making the same |
| ES2689265T3 (es) * | 2011-11-04 | 2018-11-12 | Inregen | Cribado de fármacos y ensayos de potencia |
| WO2013116443A1 (en) | 2012-02-01 | 2013-08-08 | Nscrypt, Inc. | Micro-dispensing multi-layered 3d objects with curing steps |
| WO2013130823A1 (en) | 2012-02-29 | 2013-09-06 | Massachusetts Institute Of Technology | Inverse patterning process for three-dimensional multi-compartmental micro-organization of multiple cell types |
| EP2822612A4 (en) | 2012-03-06 | 2015-08-12 | Uab Research Foundation | THREE-DIMENSIONAL PREVASCULARIZED TREATED TISSUE CONSTRUCTS, METHOD OF MANUFACTURING AND METHOD OF USE OF THE TISSUE CONSTRUCTS |
| US9499779B2 (en) | 2012-04-20 | 2016-11-22 | Organovo, Inc. | Devices, systems, and methods for the fabrication of tissue utilizing UV cross-linking |
| US20140099709A1 (en) | 2012-06-19 | 2014-04-10 | Organovo, Inc. | Engineered three-dimensional connective tissue constructs and methods of making the same |
| US9421716B2 (en) | 2012-08-08 | 2016-08-23 | Makerbot Industries, Llc | Photo booth for three-dimensional images |
| WO2014144630A1 (en) | 2013-03-15 | 2014-09-18 | Matterfab Corp. | Cartridge for an additive manufacturing apparatus and method |
| US9442105B2 (en) * | 2013-03-15 | 2016-09-13 | Organovo, Inc. | Engineered liver tissues, arrays thereof, and methods of making the same |
| US9802360B2 (en) | 2013-06-04 | 2017-10-31 | Stratsys, Inc. | Platen planarizing process for additive manufacturing system |
| SG11201600770RA (en) | 2013-07-31 | 2016-02-26 | Organovo Inc | Automated devices, systems, and methods for the fabrication of tissue |
| US11903612B2 (en) | 2013-11-04 | 2024-02-20 | University Of Iowa Research Foundation | Bioprinter and methods of using same |
| KR20170064547A (ko) | 2014-10-06 | 2017-06-09 | 오가노보, 인크. | 조작된 신장 조직, 이의 어레이, 및 이를 제조하는 방법 |
| US11268950B2 (en) | 2016-09-28 | 2022-03-08 | Organovo, Inc. | Use of engineered renal tissues in assays |
-
2015
- 2015-10-06 KR KR1020177011672A patent/KR20170064547A/ko not_active Ceased
- 2015-10-06 US US14/876,659 patent/US9481868B2/en active Active
- 2015-10-06 CN CN201580066469.8A patent/CN107002033B/zh active Active
- 2015-10-06 EP EP15848294.3A patent/EP3204488B1/en active Active
- 2015-10-06 WO PCT/US2015/054315 patent/WO2016057571A1/en not_active Ceased
- 2015-10-06 MA MA040495A patent/MA40495A/fr unknown
- 2015-10-06 AU AU2015328173A patent/AU2015328173B2/en active Active
- 2015-10-06 CA CA2962778A patent/CA2962778C/en active Active
- 2015-10-06 RU RU2017110275A patent/RU2017110275A/ru not_active Application Discontinuation
- 2015-10-06 SG SG11201702795QA patent/SG11201702795QA/en unknown
- 2015-10-06 JP JP2017538187A patent/JP2017529877A/ja active Pending
-
2016
- 2016-09-08 US US15/259,264 patent/US10094821B2/en active Active
-
2018
- 2018-10-08 US US16/154,447 patent/US10962526B2/en active Active
-
2019
- 2019-12-13 JP JP2019224961A patent/JP7021177B2/ja active Active
-
2021
- 2021-03-25 US US17/212,480 patent/US11867689B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US9481868B2 (en) | 2016-11-01 |
| CN107002033A (zh) | 2017-08-01 |
| US11867689B2 (en) | 2024-01-09 |
| EP3204488A1 (en) | 2017-08-16 |
| JP2020054377A (ja) | 2020-04-09 |
| US20170131264A1 (en) | 2017-05-11 |
| AU2015328173A1 (en) | 2017-04-13 |
| CN107002033B (zh) | 2021-08-10 |
| CA2962778A1 (en) | 2016-04-14 |
| US10094821B2 (en) | 2018-10-09 |
| US20210208132A1 (en) | 2021-07-08 |
| CA2962778C (en) | 2023-05-16 |
| EP3204488B1 (en) | 2019-07-17 |
| KR20170064547A (ko) | 2017-06-09 |
| SG11201702795QA (en) | 2017-05-30 |
| US20160097039A1 (en) | 2016-04-07 |
| US10962526B2 (en) | 2021-03-30 |
| WO2016057571A1 (en) | 2016-04-14 |
| JP2017529877A (ja) | 2017-10-12 |
| MA40495A (fr) | 2016-04-14 |
| JP7021177B2 (ja) | 2022-02-16 |
| AU2015328173B2 (en) | 2022-01-27 |
| EP3204488A4 (en) | 2018-03-21 |
| US20190041381A1 (en) | 2019-02-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2017110275A (ru) | Сконструированные ткани почки, матрицы на их основе и способы их получения | |
| JP2017529877A5 (https=) | ||
| Fuest et al. | Prospects and challenges of translational corneal bioprinting | |
| Zamprogno et al. | Mechanical properties of soft biological membranes for organ-on-a-chip assessed by bulge test and AFM | |
| JP2017518070A5 (https=) | ||
| Lee et al. | Construction of 3D multicellular microfluidic chip for an in vitro skin model | |
| Marei et al. | 3D tissue-engineered vascular drug screening platforms: promise and considerations | |
| Sellgren et al. | A biomimetic multicellular model of the airways using primary human cells | |
| Zhang et al. | From cardiac tissue engineering to heart-on-a-chip: beating challenges | |
| Besser et al. | Enzymatically crosslinked gelatin–laminin hydrogels for applications in neuromuscular tissue engineering | |
| Bertassoni et al. | Direct-write bioprinting of cell-laden methacrylated gelatin hydrogels | |
| RU2017111686A (ru) | Искусственная роговица, полученная путем трехмерной биопечати | |
| JP2019004912A5 (https=) | ||
| Ahn et al. | Engineering of uniform epidermal layers via sacrificial gelatin bioink‐assisted 3D extrusion bioprinting of skin | |
| JP2014531204A5 (https=) | ||
| Teichmann et al. | Tissue engineering of the corneal endothelium: a review of carrier materials | |
| RU2015139558A (ru) | Искусственные ткани печени, матриксы искусственных тканей и способы их изготовления | |
| Agarwal et al. | based cell culture: paving the pathway for liver tissue model development on a cellulose paper chip | |
| JP2019507602A5 (https=) | ||
| US20250304896A1 (en) | Native Extracellular Matrix-Derived Membrane Inserts for Organs-On-Chips, Multilayer Microfluidics Microdevices, Bioreactors, Tissue Culture Inserts, and Two-Dimensional and Three-Dimensional Cell Culture Systems | |
| JP2010515231A5 (https=) | ||
| Park et al. | Graphene hybrid inner ear organoid with enhanced maturity | |
| US20170143871A1 (en) | Gold Nanorod Incorporated Gelatin based Hybrid Hydrogels for Cardiac Tissue Engineering and Related Methods | |
| Li et al. | Fabrication of paper-based devices for in vitro tissue modeling | |
| Kim et al. | Current and future cornea chip models for advancing ophthalmic research and therapeutics |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA93 | Acknowledgement of application withdrawn (no request for examination) |
Effective date: 20200330 |