RU2017107715A - Производные имидазо[1,2-a]пиридина для применения в качестве ингибиторов репликации вируса иммунодефицита человека - Google Patents

Производные имидазо[1,2-a]пиридина для применения в качестве ингибиторов репликации вируса иммунодефицита человека Download PDF

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Publication number
RU2017107715A
RU2017107715A RU2017107715A RU2017107715A RU2017107715A RU 2017107715 A RU2017107715 A RU 2017107715A RU 2017107715 A RU2017107715 A RU 2017107715A RU 2017107715 A RU2017107715 A RU 2017107715A RU 2017107715 A RU2017107715 A RU 2017107715A
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Russia
Prior art keywords
alkyl
inhibitors
substituted
phenyl
haloalkyl
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RU2017107715A
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English (en)
Russian (ru)
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RU2017107715A3 (enExample
Inventor
Б. Нарасимхулу Наиду
Тимоти П. Коннолли
Кайл Дж. ИСТМАН
Кевин ПИЗ
Original Assignee
ВАЙВ ХЕЛТКЕР ЮКей (N5) ЛИМИТЕД
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54064588&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU2017107715(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ВАЙВ ХЕЛТКЕР ЮКей (N5) ЛИМИТЕД filed Critical ВАЙВ ХЕЛТКЕР ЮКей (N5) ЛИМИТЕД
Publication of RU2017107715A publication Critical patent/RU2017107715A/ru
Publication of RU2017107715A3 publication Critical patent/RU2017107715A3/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
RU2017107715A 2014-08-27 2015-08-25 Производные имидазо[1,2-a]пиридина для применения в качестве ингибиторов репликации вируса иммунодефицита человека RU2017107715A (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462042300P 2014-08-27 2014-08-27
US62/042,300 2014-08-27
PCT/US2015/046648 WO2016033009A1 (en) 2014-08-27 2015-08-25 Imidazo[1,2-a]pyridine derivatives for use as inhibitors of human immunodeficiency virus replication

Publications (2)

Publication Number Publication Date
RU2017107715A true RU2017107715A (ru) 2018-09-27
RU2017107715A3 RU2017107715A3 (enExample) 2019-03-04

Family

ID=54064588

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2017107715A RU2017107715A (ru) 2014-08-27 2015-08-25 Производные имидазо[1,2-a]пиридина для применения в качестве ингибиторов репликации вируса иммунодефицита человека

Country Status (13)

Country Link
US (1) US10065953B2 (enExample)
EP (1) EP3186254B1 (enExample)
JP (1) JP2017526748A (enExample)
KR (1) KR20170045308A (enExample)
CN (1) CN107001357A (enExample)
AU (1) AU2015306779B2 (enExample)
BR (1) BR112017003663A2 (enExample)
CA (1) CA2958591A1 (enExample)
CL (1) CL2017000428A1 (enExample)
IL (1) IL250561A0 (enExample)
RU (1) RU2017107715A (enExample)
WO (1) WO2016033009A1 (enExample)
ZA (1) ZA201701214B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015174511A1 (ja) 2014-05-16 2015-11-19 塩野義製薬株式会社 Ｈｉｖ複製阻害作用を有する３環性複素環誘導体
EP3305789A4 (en) 2015-05-29 2018-11-21 Shionogi & Co., Ltd. Nitrogen-containing tricyclic derivative having hiv replication inhibitory activity
CN109232562A (zh) * 2018-10-24 2019-01-18 康化（上海）新药研发有限公司 一种7-氮杂吲哚-5-氯-6-羧酸的合成方法
US11541055B2 (en) * 2018-10-24 2023-01-03 VIIV Healthcare UK (No.5) Limited Inhibitors of human immunodeficiency virus replication
IL286328B1 (en) 2019-03-22 2026-04-01 Gilead Sciences Inc Tricyclic bridging compounds of carbamoylpyridone and their pharmaceutical use
CR20220418A (es) 2020-02-24 2022-10-10 Gilead Sciences Inc Compuestos tetracíclicos para el tratamiento de infecciones por vih
CA3192145A1 (en) 2020-09-30 2022-04-07 Gilead Sciences, Inc. Bridged tricyclic carbamoylpyridone compounds and uses thereof
JP7591155B2 (ja) 2021-01-19 2024-11-27 ギリアード サイエンシーズ， インコーポレイテッド 置換ピリドトリアジン化合物及びその使用
TWI856796B (zh) 2022-04-06 2024-09-21 美商基利科學股份有限公司 橋聯三環胺甲醯基吡啶酮化合物及其用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8338441B2 (en) * 2009-05-15 2012-12-25 Gilead Sciences, Inc. Inhibitors of human immunodeficiency virus replication
US8633200B2 (en) * 2010-09-08 2014-01-21 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
UA111841C2 (uk) * 2011-04-21 2016-06-24 Гіліад Сайєнсіз, Інк. Сполуки бензотіазолу та їх фармацевтичне застосування
US9034882B2 (en) * 2012-03-05 2015-05-19 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
US9096586B2 (en) * 2012-04-20 2015-08-04 Gilead Sciences, Inc. Therapeutic compounds
JP2016512507A (ja) * 2013-03-13 2016-04-28 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ ヒト免疫不全ウイルス複製の阻害剤

Also Published As

Publication number Publication date
EP3186254B1 (en) 2019-03-06
IL250561A0 (en) 2017-03-30
CA2958591A1 (en) 2016-03-03
JP2017526748A (ja) 2017-09-14
US10065953B2 (en) 2018-09-04
CN107001357A (zh) 2017-08-01
WO2016033009A1 (en) 2016-03-03
KR20170045308A (ko) 2017-04-26
RU2017107715A3 (enExample) 2019-03-04
AU2015306779A1 (en) 2017-03-16
AU2015306779B2 (en) 2017-11-02
ZA201701214B (en) 2019-07-31
BR112017003663A2 (pt) 2017-11-28
US20180222901A1 (en) 2018-08-09
EP3186254A1 (en) 2017-07-05
CL2017000428A1 (es) 2017-08-18

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FA92 Acknowledgement of application withdrawn (lack of supplementary materials submitted)

Effective date: 20190619