AU2015306779B2 - Imidazo[1,2-a]pyridine derivatives for use as inhibitors of human immunodeficiency virus replication - Google Patents

Imidazo[1,2-a]pyridine derivatives for use as inhibitors of human immunodeficiency virus replication Download PDF

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Publication number
AU2015306779B2
AU2015306779B2 AU2015306779A AU2015306779A AU2015306779B2 AU 2015306779 B2 AU2015306779 B2 AU 2015306779B2 AU 2015306779 A AU2015306779 A AU 2015306779A AU 2015306779 A AU2015306779 A AU 2015306779A AU 2015306779 B2 AU2015306779 B2 AU 2015306779B2
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AU
Australia
Prior art keywords
hiv
inhibitors
alkyl
mmol
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2015306779A
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English (en)
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AU2015306779A1 (en
Inventor
Timothy P. Connolly
Kyle J. Eastman
B. Narasimhulu Naidu
Kevin Peese
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ViiV Healthcare UK No 5 Ltd
Original Assignee
ViiV Healthcare UK No 5 Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by ViiV Healthcare UK No 5 Ltd filed Critical ViiV Healthcare UK No 5 Ltd
Publication of AU2015306779A1 publication Critical patent/AU2015306779A1/en
Application granted granted Critical
Publication of AU2015306779B2 publication Critical patent/AU2015306779B2/en
Ceased legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2015306779A 2014-08-27 2015-08-25 Imidazo[1,2-a]pyridine derivatives for use as inhibitors of human immunodeficiency virus replication Ceased AU2015306779B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462042300P 2014-08-27 2014-08-27
US62/042,300 2014-08-27
PCT/US2015/046648 WO2016033009A1 (en) 2014-08-27 2015-08-25 Imidazo[1,2-a]pyridine derivatives for use as inhibitors of human immunodeficiency virus replication

Publications (2)

Publication Number Publication Date
AU2015306779A1 AU2015306779A1 (en) 2017-03-16
AU2015306779B2 true AU2015306779B2 (en) 2017-11-02

Family

ID=54064588

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2015306779A Ceased AU2015306779B2 (en) 2014-08-27 2015-08-25 Imidazo[1,2-a]pyridine derivatives for use as inhibitors of human immunodeficiency virus replication

Country Status (13)

Country Link
US (1) US10065953B2 (enExample)
EP (1) EP3186254B1 (enExample)
JP (1) JP2017526748A (enExample)
KR (1) KR20170045308A (enExample)
CN (1) CN107001357A (enExample)
AU (1) AU2015306779B2 (enExample)
BR (1) BR112017003663A2 (enExample)
CA (1) CA2958591A1 (enExample)
CL (1) CL2017000428A1 (enExample)
IL (1) IL250561A0 (enExample)
RU (1) RU2017107715A (enExample)
WO (1) WO2016033009A1 (enExample)
ZA (1) ZA201701214B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6579549B2 (ja) 2014-05-16 2019-09-25 塩野義製薬株式会社 Ｈｉｖ複製阻害作用を有する３環性複素環誘導体
CA2987384A1 (en) 2015-05-29 2016-12-08 Shionogi & Co., Ltd. Nitrogen-containing tricyclic derivative having hiv replication inhibitory activity
CN109232562A (zh) * 2018-10-24 2019-01-18 康化（上海）新药研发有限公司 一种7-氮杂吲哚-5-氯-6-羧酸的合成方法
PE20211781A1 (es) * 2018-10-24 2021-09-08 Viiv Healthcare Uk No 5 Ltd Inhibidores de la replicacion del virus de la inmunodeficiencia humana
WO2020197991A1 (en) 2019-03-22 2020-10-01 Gilead Sciences, Inc. Bridged tricyclic carbamoylpyridone compounds and their pharmaceutical use
IL295677A (en) 2020-02-24 2022-10-01 Gilead Sciences Inc Tetracyclic compounds for treating hiv infection
US12421235B2 (en) 2020-09-30 2025-09-23 Gilead Sciences, Inc. Bridged tricyclic carbamoylpyridone compounds and uses thereof
PT4196479T (pt) 2021-01-19 2024-01-03 Gilead Sciences Inc Compostos de piridotriazinas substituídos e suas utilizações
TWI856796B (zh) 2022-04-06 2024-09-21 美商基利科學股份有限公司 橋聯三環胺甲醯基吡啶酮化合物及其用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010130034A1 (en) * 2009-05-15 2010-11-18 Boehringer Ingelheim International Gmbh Inhibitors of human immunodeficiency virus replication

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8633200B2 (en) * 2010-09-08 2014-01-21 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
WO2012145728A1 (en) * 2011-04-21 2012-10-26 Gilead Sciences, Inc. Benzothiazole compounds and their pharmaceutical use
US9034882B2 (en) 2012-03-05 2015-05-19 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
EP3070081B1 (en) * 2012-04-20 2018-02-28 Gilead Sciences, Inc. Benzothiazol-6-yl acetic acid derivatives and their use for treating an hiv infection
ES2623777T3 (es) * 2013-03-13 2017-07-12 VIIV Healthcare UK (No.5) Limited Inhibidores de la replicación del virus de la inmunodeficiencia humana

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010130034A1 (en) * 2009-05-15 2010-11-18 Boehringer Ingelheim International Gmbh Inhibitors of human immunodeficiency virus replication

Also Published As

Publication number Publication date
WO2016033009A1 (en) 2016-03-03
JP2017526748A (ja) 2017-09-14
RU2017107715A3 (enExample) 2019-03-04
US20180222901A1 (en) 2018-08-09
EP3186254A1 (en) 2017-07-05
AU2015306779A1 (en) 2017-03-16
CL2017000428A1 (es) 2017-08-18
IL250561A0 (en) 2017-03-30
CA2958591A1 (en) 2016-03-03
EP3186254B1 (en) 2019-03-06
US10065953B2 (en) 2018-09-04
BR112017003663A2 (pt) 2017-11-28
CN107001357A (zh) 2017-08-01
RU2017107715A (ru) 2018-09-27
KR20170045308A (ko) 2017-04-26
ZA201701214B (en) 2019-07-31

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired