RU2016117398A - Композиции полиинозиновой-полицитидиловой кислоты (поли (и:ц)) для лечения инфекций верхних дыхательных путей - Google Patents
Композиции полиинозиновой-полицитидиловой кислоты (поли (и:ц)) для лечения инфекций верхних дыхательных путей Download PDFInfo
- Publication number
- RU2016117398A RU2016117398A RU2016117398A RU2016117398A RU2016117398A RU 2016117398 A RU2016117398 A RU 2016117398A RU 2016117398 A RU2016117398 A RU 2016117398A RU 2016117398 A RU2016117398 A RU 2016117398A RU 2016117398 A RU2016117398 A RU 2016117398A
- Authority
- RU
- Russia
- Prior art keywords
- composition
- microparticle
- microparticles
- polyinosine
- polycytidylic acid
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims 43
- 239000002253 acid Substances 0.000 title claims 16
- 229940115272 polyinosinic:polycytidylic acid Drugs 0.000 title claims 10
- 206010057190 Respiratory tract infections Diseases 0.000 title claims 3
- 208000020029 respiratory tract infectious disease Diseases 0.000 title 1
- 239000011859 microparticle Substances 0.000 claims 39
- 238000000034 method Methods 0.000 claims 15
- 229920000642 polymer Polymers 0.000 claims 11
- 230000009385 viral infection Effects 0.000 claims 10
- 229920002472 Starch Polymers 0.000 claims 9
- 235000019698 starch Nutrition 0.000 claims 9
- 239000008107 starch Substances 0.000 claims 9
- 229940032147 starch Drugs 0.000 claims 9
- WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 claims 8
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 8
- 229940014041 hyaluronate Drugs 0.000 claims 8
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 8
- 239000008108 microcrystalline cellulose Substances 0.000 claims 8
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 8
- 229920001592 potato starch Polymers 0.000 claims 8
- 229940116317 potato starch Drugs 0.000 claims 8
- 208000036142 Viral infection Diseases 0.000 claims 7
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 4
- 241000430519 Human rhinovirus sp. Species 0.000 claims 3
- 206010061494 Rhinovirus infection Diseases 0.000 claims 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 241000712461 unidentified influenza virus Species 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 206010046306 Upper respiratory tract infection Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000003960 organic solvent Substances 0.000 claims 2
- 210000002345 respiratory system Anatomy 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000002953 phosphate buffered saline Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 159000000000 sodium salts Chemical class 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
- A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13191742.9 | 2013-11-06 | ||
| EP13191742 | 2013-11-06 | ||
| PCT/EP2014/073762 WO2015067632A1 (en) | 2013-11-06 | 2014-11-05 | Polylnosinic-polycytidylic acid (poly (i:c)) formulations for the treatment of upper respiratory tract infections |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2016117398A true RU2016117398A (ru) | 2017-12-11 |
| RU2016117398A3 RU2016117398A3 (enExample) | 2018-08-22 |
Family
ID=49517426
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2016117398A RU2016117398A (ru) | 2013-11-06 | 2014-11-05 | Композиции полиинозиновой-полицитидиловой кислоты (поли (и:ц)) для лечения инфекций верхних дыхательных путей |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20160271165A1 (enExample) |
| EP (1) | EP3065714B1 (enExample) |
| JP (1) | JP6629216B2 (enExample) |
| KR (1) | KR20160072140A (enExample) |
| CN (1) | CN105939709A (enExample) |
| AU (1) | AU2014345667A1 (enExample) |
| CA (1) | CA2929142A1 (enExample) |
| IL (1) | IL245412A0 (enExample) |
| MX (1) | MX2016005883A (enExample) |
| RU (1) | RU2016117398A (enExample) |
| WO (1) | WO2015067632A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2866230C (en) | 2012-05-03 | 2020-08-18 | Janssen R&D Ireland | Polyinosinic-polycytidylic acid (poly (i:c)) formulations for the treatment of upper respiratory tract infections |
| CA2983659A1 (en) * | 2015-05-11 | 2016-11-17 | Janssen Sciences Ireland Uc | Polyinosinic-polycytidylic acid (poly(i:c)) pea starch formulation for the prevention and/or treatment of upper respiratory tract infections |
| CA3005492C (en) | 2015-11-17 | 2023-01-10 | Bioncotech Therapeutics Sl | Novel pharmaceutical composition comprising particles comprising a complex of a double-stranded polyribonucleotide and a polyalkyleneimine |
| CN110177545A (zh) | 2016-11-16 | 2019-08-27 | 爱尔兰詹森科学公司 | 用于预防上呼吸道感染的聚肌苷酸和聚胞苷酸的制剂 |
| CN115998757A (zh) | 2017-05-17 | 2023-04-25 | 亮点医疗有限责任公司 | 包含具有双链多核糖核苷酸和聚乙烯亚胺的复合物的粒子的新型药物组合物 |
| KR102123489B1 (ko) | 2020-03-13 | 2020-06-16 | 주식회사 휴먼셀바이오 | 자연살해세포 배양액 조성물 및 이를 이용한 자연살해세포 배양방법 |
| WO2021213946A1 (en) | 2020-04-19 | 2021-10-28 | Englmeier Ludwig | Prophylaxis and treatment of coronavirus infection |
| CN118680868A (zh) * | 2023-03-24 | 2024-09-24 | 清华大学 | 一种核酸药物递送系统及其制备和应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5707644A (en) * | 1989-11-04 | 1998-01-13 | Danbiosyst Uk Limited | Small particle compositions for intranasal drug delivery |
| CN101229378A (zh) * | 2005-05-05 | 2008-07-30 | 国家淀粉及化学投资控股公司 | 用于送递活性剂的组合物 |
| US20070166239A1 (en) * | 2006-01-13 | 2007-07-19 | Haixiang Lin | Mucosal immunogenic substances comprising a polyinosinic acid - polycytidilic acid based adjuvant |
| CN101491503A (zh) * | 2008-12-17 | 2009-07-29 | 天津瑞普生物技术股份有限公司 | 一种用于宠物的聚肌胞滴丸及其制备方法 |
| CN101757018A (zh) * | 2008-12-24 | 2010-06-30 | 天津瑞普生物技术股份有限公司 | 一种用于畜禽的聚肌胞干粉及其制备方法 |
| CN102488703A (zh) * | 2011-12-15 | 2012-06-13 | 天津济命生生物科技有限公司 | 一种聚肌胞制剂的制备方法和抗肿瘤的用途 |
| CA2866230C (en) * | 2012-05-03 | 2020-08-18 | Janssen R&D Ireland | Polyinosinic-polycytidylic acid (poly (i:c)) formulations for the treatment of upper respiratory tract infections |
-
2014
- 2014-11-05 KR KR1020167011935A patent/KR20160072140A/ko not_active Ceased
- 2014-11-05 JP JP2016551030A patent/JP6629216B2/ja not_active Expired - Fee Related
- 2014-11-05 EP EP14793168.7A patent/EP3065714B1/en active Active
- 2014-11-05 CN CN201480063745.0A patent/CN105939709A/zh active Pending
- 2014-11-05 RU RU2016117398A patent/RU2016117398A/ru not_active Application Discontinuation
- 2014-11-05 MX MX2016005883A patent/MX2016005883A/es unknown
- 2014-11-05 US US15/034,347 patent/US20160271165A1/en not_active Abandoned
- 2014-11-05 WO PCT/EP2014/073762 patent/WO2015067632A1/en not_active Ceased
- 2014-11-05 AU AU2014345667A patent/AU2014345667A1/en not_active Abandoned
- 2014-11-05 CA CA2929142A patent/CA2929142A1/en not_active Abandoned
-
2016
- 2016-05-01 IL IL245412A patent/IL245412A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2016117398A3 (enExample) | 2018-08-22 |
| AU2014345667A1 (en) | 2016-05-19 |
| EP3065714A1 (en) | 2016-09-14 |
| CN105939709A (zh) | 2016-09-14 |
| KR20160072140A (ko) | 2016-06-22 |
| IL245412A0 (en) | 2016-06-30 |
| JP2016535094A (ja) | 2016-11-10 |
| MX2016005883A (es) | 2016-08-17 |
| JP6629216B2 (ja) | 2020-01-15 |
| US20160271165A1 (en) | 2016-09-22 |
| CA2929142A1 (en) | 2015-05-14 |
| WO2015067632A1 (en) | 2015-05-14 |
| EP3065714B1 (en) | 2020-02-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HC9A | Changing information about inventors | ||
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20190227 |