RU2016103462A - METHOD FOR PRODUCING 3- (o, m, n-HALOGENFENIL) -3, 4-DIHYDRO-2H-BENZO [f] [1, 5, 3] DITIAZEPINES - Google Patents

METHOD FOR PRODUCING 3- (o, m, n-HALOGENFENIL) -3, 4-DIHYDRO-2H-BENZO [f] [1, 5, 3] DITIAZEPINES Download PDF

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RU2016103462A
RU2016103462A RU2016103462A RU2016103462A RU2016103462A RU 2016103462 A RU2016103462 A RU 2016103462A RU 2016103462 A RU2016103462 A RU 2016103462A RU 2016103462 A RU2016103462 A RU 2016103462A RU 2016103462 A RU2016103462 A RU 2016103462A
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benzo
dihydro
halogenfenil
ditiazepines
producing
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RU2016103462A
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RU2632661C2 (en
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Усеин Меметович Джемилев
Асхат Габдрахманович Ибрагимов
Наталия Наильевна Махмудиярова
Гузелия Магавиевна Хатмуллина
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Федеральное государственное бюджетное учреждение науки Институт нефтехимии и катализа Российской академии наук
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/36—Seven-membered rings

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  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Claims (3)

Способ получения 3-(о,м,n-галогенфенил)-3,4-дигидро-2Н-бензо[f][1,5,3]дитиазепинов общей формулы (1):The method of obtaining 3- (o, m, n-halogenophenyl) -3,4-dihydro-2H-benzo [f] [1,5,3] dithiazepines of the general formula (1):
Figure 00000001
Figure 00000001
 отличающийся тем, что N,N-бис(метоксиметил)-N-(o,м, n -галогенфенил)(о,м,n-хлорфенил, о,м,n-бромфенил, о,м,n-фторфенил)амины подвергают взаимодействию с бензол-1,2-дитиолом в присутствии катализатора кристаллогидрата азотнокислого самария Sm(NO3)3⋅6H2O, взятыми в мольном соотношении N,N-бис(метоксиметил)-N-(o,м,n-галогенфенил)амин : бензол-1,2-дитиол : Sm(NO3)3⋅6H2O = 1:1:(0.03-0.07) в этиловом эфире уксусной кислоты в качестве растворителя при комнатной температуре (~20°С) и атмосферном давлении в течение 6-8 ч.characterized in that N, N-bis (methoxymethyl) -N- (o, m, n-halophenyl) (o, m, n-chlorophenyl, o, m, n-bromophenyl, o, m, n-fluorophenyl) amines subjected to interaction with benzene-1,2-dithiol in the presence of a catalyst of crystalline hydrate of samarium nitrate Sm (NO 3 ) 3 ⋅ 6H 2 O, taken in a molar ratio of N, N-bis (methoxymethyl) -N- (o, m, n-halogenophenyl ) amine: benzene-1,2-dithiol: Sm (NO 3 ) 3 ⋅ 6H 2 O = 1: 1: (0.03-0.07) in ethyl acetate, as a solvent at room temperature (~ 20 ° С) and atmospheric pressure for 6-8 hours
RU2016103462A 2016-02-02 2016-02-02 Method for producing 3-(o,m,n-halogenphenyl)-3,4-dihydro-2h-benzo[f][1,5,3]dithiazepines RU2632661C2 (en)

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