RU2015140619A3 - - Google Patents

Download PDF

Info

Publication number
RU2015140619A3
RU2015140619A3 RU2015140619A RU2015140619A RU2015140619A3 RU 2015140619 A3 RU2015140619 A3 RU 2015140619A3 RU 2015140619 A RU2015140619 A RU 2015140619A RU 2015140619 A RU2015140619 A RU 2015140619A RU 2015140619 A3 RU2015140619 A3 RU 2015140619A3
Authority
RU
Russia
Application number
RU2015140619A
Other versions
RU2015140619A (ru
RU2655171C2 (ru
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of RU2015140619A publication Critical patent/RU2015140619A/ru
Publication of RU2015140619A3 publication Critical patent/RU2015140619A3/ru
Application granted granted Critical
Publication of RU2655171C2 publication Critical patent/RU2655171C2/ru

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4738Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01Sulfonic acids
    • C07C309/28Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13Dicarboxylic acids
    • C07C57/145Maleic acid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
RU2015140619A 2013-04-05 2014-04-03 Соль производного пиразолохинолина и ее кристалл RU2655171C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2013-079639 2013-04-05
JP2013079639 2013-04-05
PCT/JP2014/059853 WO2014163147A1 (ja) 2013-04-05 2014-04-03 ピラゾロキノリン誘導体の塩およびその結晶

Publications (3)

Publication Number Publication Date
RU2015140619A RU2015140619A (ru) 2017-05-11
RU2015140619A3 true RU2015140619A3 (ru) 2018-03-26
RU2655171C2 RU2655171C2 (ru) 2018-05-24

Family

ID=51658438

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2015140619A RU2655171C2 (ru) 2013-04-05 2014-04-03 Соль производного пиразолохинолина и ее кристалл

Country Status (13)

Country Link
US (1) US9573947B2 (ru)
EP (1) EP2982675B1 (ru)
JP (1) JP5666755B1 (ru)
KR (1) KR101997955B1 (ru)
CN (1) CN105121440B (ru)
AU (1) AU2014250392B2 (ru)
BR (1) BR112015024393A2 (ru)
CA (1) CA2907971C (ru)
ES (1) ES2645149T3 (ru)
MX (1) MX359843B (ru)
RU (1) RU2655171C2 (ru)
SG (1) SG11201507897SA (ru)
WO (1) WO2014163147A1 (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017090716A1 (ja) * 2015-11-26 2017-06-01 持田製薬株式会社 ピラゾール誘導体の結晶
CN110603039B (zh) * 2017-06-01 2023-02-28 卫材R&D管理有限公司 组合吡唑并喹啉衍生物和美金刚的痴呆治疗剂
RU2019135261A (ru) * 2017-06-01 2021-07-09 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Фармацевтическая композиция, содержащая ингибитор pde9
AU2018278422B2 (en) * 2017-06-01 2022-03-17 Eisai R&D Management Co., Ltd. Lewy body disease therapeutic agent containing pyrazoloquinoline derivative
JP7079777B2 (ja) * 2017-06-01 2022-06-02 エーザイ・アール・アンド・ディー・マネジメント株式会社 ピラゾロキノリン誘導体とドネペジルの併用による認知症治療剤
US11530218B2 (en) 2020-01-20 2022-12-20 Incyte Corporation Spiro compounds as inhibitors of KRAS
WO2021231526A1 (en) 2020-05-13 2021-11-18 Incyte Corporation Fused pyrimidine compounds as kras inhibitors
US11999752B2 (en) 2020-08-28 2024-06-04 Incyte Corporation Vinyl imidazole compounds as inhibitors of KRAS
US11767320B2 (en) 2020-10-02 2023-09-26 Incyte Corporation Bicyclic dione compounds as inhibitors of KRAS
AU2022367432A1 (en) 2021-10-14 2024-05-02 Incyte Corporation Quinoline compounds as inhibitors of kras

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05132484A (ja) 1991-04-26 1993-05-28 Otsuka Pharmaceut Factory Inc ピラゾロキノリン及びピラゾロナフチリジン誘導体
RU2145606C1 (ru) 1994-05-24 2000-02-20 Ф.Хоффманн-Ля Рош Аг Трициклические дикарбонильные производные и лекарственный препарат на их основе
EA200500322A1 (ru) * 2002-08-07 2005-08-25 Мицубиси Фарма Корпорейшн Соединения дигидропиразолопиридина
RU2426734C2 (ru) 2003-10-03 2011-08-20 Зм Инновейтив Пропертиз Компани Пиразолопиридины и их аналоги
WO2005118583A1 (en) 2004-05-28 2005-12-15 Millennium Pharmaceuticals, Inc. 2, 5-dihydro-pyrazolo`4, 3-c!quinolin-4-ones as chk-1 inhibitors
JP2006045118A (ja) 2004-08-04 2006-02-16 Mochida Pharmaceut Co Ltd 新規ピラゾロキノロン誘導体
KR20080046728A (ko) 2005-09-15 2008-05-27 아스카 세이야쿠 가부시키가이샤 복소환 화합물, 그의 제조 방법 및 용도
CN101553491B (zh) * 2006-12-13 2013-05-29 Aska制药株式会社 喹喔啉衍生物
AP2524A (en) 2007-05-11 2012-12-04 Pfizer Amino-heterocyclic compounds
UA105362C2 (en) 2008-04-02 2014-05-12 Бьорингер Ингельхайм Интернациональ Гмбх 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators
RU2011140333A (ru) * 2009-03-05 2013-04-10 Астеллас Фарма Инк. Хиноксалиновое соединение
CA2757231A1 (en) 2009-03-31 2010-10-07 Boehringer Ingelheim International Gmbh 1-heterocyclyl-1,5-dihydro-pyrazolo [3,4-d] pyrimidin-4-one derivatives and their use as pde9a modulators
DK2615089T3 (en) 2010-09-07 2016-06-06 Astellas Pharma Inc Pyrazoloquinolinforbindelser
JP6042060B2 (ja) 2011-09-26 2016-12-14 サノフイ ピラゾロキノリノン誘導体、その調製および治療上の使用
SI2573073T1 (sl) * 2011-09-26 2015-02-27 Sanofi Pirazolokinolinonski derivati, njihova priprava in njihova terapevtska uporaba
IN2014CN02463A (ru) 2011-10-07 2015-06-19 Eisai R&D Man Co Ltd

Also Published As

Publication number Publication date
RU2015140619A (ru) 2017-05-11
EP2982675B1 (en) 2017-08-16
AU2014250392B2 (en) 2018-03-01
KR101997955B1 (ko) 2019-07-08
CN105121440A (zh) 2015-12-02
ES2645149T3 (es) 2017-12-04
US9573947B2 (en) 2017-02-21
AU2014250392A1 (en) 2015-10-15
JPWO2014163147A1 (ja) 2017-02-16
BR112015024393A2 (pt) 2017-10-24
CA2907971A1 (en) 2014-10-09
RU2655171C2 (ru) 2018-05-24
EP2982675A4 (en) 2016-08-10
CN105121440B (zh) 2017-05-24
EP2982675A1 (en) 2016-02-10
KR20150138203A (ko) 2015-12-09
MX2015013620A (es) 2016-02-25
MX359843B (es) 2018-10-12
WO2014163147A1 (ja) 2014-10-09
CA2907971C (en) 2020-12-29
JP5666755B1 (ja) 2015-02-12
SG11201507897SA (en) 2015-11-27
US20160046623A1 (en) 2016-02-18

Similar Documents

Publication Publication Date Title
AP2016009275A0 (ru)
BR112016005829A2 (ru)
BR102016010778A2 (ru)
BR112014017733A2 (ru)
BR112014018502A2 (ru)
BR112014017739A2 (ru)
BR112014019326A2 (ru)
BR112014018516A2 (ru)
BR112014020341A2 (ru)
BR112014017855A2 (ru)
BR112014017765A2 (ru)
BR112014017669A2 (ru)
BR112014021878A2 (ru)
BR112016001243A2 (ru)
BR112016010679A2 (ru)
BR112016013348A2 (ru)
BR112014017901A2 (ru)
BR112014018207A2 (ru)
BR112014019204A2 (ru)
BR112015015948A2 (ru)
BR112014017722A2 (ru)
BR112014018578A2 (ru)
BR112014017794A2 (ru)
BR112014017653A2 (ru)
BR112016011281A2 (ru)