RU2015129366A - Способы и композиции, относящиеся к лечению злокачественной опухоли - Google Patents
Способы и композиции, относящиеся к лечению злокачественной опухоли Download PDFInfo
- Publication number
- RU2015129366A RU2015129366A RU2015129366A RU2015129366A RU2015129366A RU 2015129366 A RU2015129366 A RU 2015129366A RU 2015129366 A RU2015129366 A RU 2015129366A RU 2015129366 A RU2015129366 A RU 2015129366A RU 2015129366 A RU2015129366 A RU 2015129366A
- Authority
- RU
- Russia
- Prior art keywords
- isc
- cetuximab
- malignant tumor
- treating
- prodrug
- Prior art date
Links
- 201000011510 cancer Diseases 0.000 title claims 40
- 238000000034 method Methods 0.000 title claims 24
- 239000000203 mixture Substances 0.000 title claims 4
- NMPQIJIERCLTOG-UHFFFAOYSA-N 4-isoselenocyanatobutylbenzene Chemical compound [Se]=C=NCCCCC1=CC=CC=C1 NMPQIJIERCLTOG-UHFFFAOYSA-N 0.000 claims 36
- 229960005395 cetuximab Drugs 0.000 claims 32
- 229940002612 prodrug Drugs 0.000 claims 23
- 239000000651 prodrug Substances 0.000 claims 23
- 206010028980 Neoplasm Diseases 0.000 claims 12
- 101000584612 Homo sapiens GTPase KRas Proteins 0.000 claims 11
- 102100030708 GTPase KRas Human genes 0.000 claims 9
- 210000004027 cell Anatomy 0.000 claims 6
- 238000004806 packaging method and process Methods 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims 4
- 229960002949 fluorouracil Drugs 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 2
- 230000003213 activating effect Effects 0.000 claims 2
- 230000006907 apoptotic process Effects 0.000 claims 2
- 210000001072 colon Anatomy 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 102000049555 human KRAS Human genes 0.000 claims 2
- 206010038038 rectal cancer Diseases 0.000 claims 2
- 201000001275 rectum cancer Diseases 0.000 claims 2
- 230000002195 synergetic effect Effects 0.000 claims 2
- 210000004881 tumor cell Anatomy 0.000 claims 2
- 108020004705 Codon Proteins 0.000 claims 1
- 206010069755 K-ras gene mutation Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000004383 glucosinolate group Chemical group 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 102200006532 rs112445441 Human genes 0.000 claims 1
- 102200006531 rs121913529 Human genes 0.000 claims 1
- 102200006537 rs121913529 Human genes 0.000 claims 1
- 102200006541 rs121913530 Human genes 0.000 claims 1
- 102200007373 rs17851045 Human genes 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261740126P | 2012-12-20 | 2012-12-20 | |
| US61/740,126 | 2012-12-20 | ||
| PCT/US2013/076869 WO2014100565A1 (en) | 2012-12-20 | 2013-12-20 | Methods and compositions relating to treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2015129366A true RU2015129366A (ru) | 2017-01-25 |
Family
ID=49950064
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015129366A RU2015129366A (ru) | 2012-12-20 | 2013-12-20 | Способы и композиции, относящиеся к лечению злокачественной опухоли |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20150328310A1 (enExample) |
| EP (1) | EP2934583A1 (enExample) |
| JP (1) | JP2016503063A (enExample) |
| KR (1) | KR20150099588A (enExample) |
| CN (1) | CN105007940B (enExample) |
| AU (1) | AU2013361164A1 (enExample) |
| CA (1) | CA2894547A1 (enExample) |
| RU (1) | RU2015129366A (enExample) |
| SG (1) | SG11201504779YA (enExample) |
| WO (1) | WO2014100565A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102391693B1 (ko) | 2016-06-29 | 2022-04-29 | 프린시피아 바이오파마, 인코퍼레이티드 | 2-[3-[4-아미노-3-(2-플루오로-4-페녹시-페닐)피라졸로[3,4-d]피리미딘-1-일]피페리딘-1-카르보닐]-4-메틸-4-[4-(옥세탄-3-일)피페라진-1-일]펜트-2-엔니트릴의 변형 방출 제제 |
| EP4045051A1 (en) | 2019-10-14 | 2022-08-24 | Principia Biopharma Inc. | Methods for treating immune thrombocytopenia by administering (r)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile |
| WO2021150723A1 (en) | 2020-01-22 | 2021-07-29 | Principia Biopharma Inc. | Crystalline forms of 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9407386D0 (en) | 1994-04-14 | 1994-06-08 | Smithkline Beecham Plc | Pharmaceutical formulation |
| US5648097A (en) | 1995-10-04 | 1997-07-15 | Biotek, Inc. | Calcium mineral-based microparticles and method for the production thereof |
| US6391336B1 (en) | 1997-09-22 | 2002-05-21 | Royer Biomedical, Inc. | Inorganic-polymer complexes for the controlled release of compounds including medicinals |
| US20080306148A1 (en) * | 2007-04-13 | 2008-12-11 | The Penn State Research Foundation | Anti-cancer compositions and methods |
-
2013
- 2013-12-20 SG SG11201504779YA patent/SG11201504779YA/en unknown
- 2013-12-20 CA CA2894547A patent/CA2894547A1/en not_active Abandoned
- 2013-12-20 KR KR1020157019739A patent/KR20150099588A/ko not_active Withdrawn
- 2013-12-20 EP EP13819149.9A patent/EP2934583A1/en not_active Withdrawn
- 2013-12-20 AU AU2013361164A patent/AU2013361164A1/en not_active Abandoned
- 2013-12-20 US US14/652,363 patent/US20150328310A1/en not_active Abandoned
- 2013-12-20 RU RU2015129366A patent/RU2015129366A/ru not_active Application Discontinuation
- 2013-12-20 JP JP2015549772A patent/JP2016503063A/ja active Pending
- 2013-12-20 CN CN201380073538.9A patent/CN105007940B/zh not_active Expired - Fee Related
- 2013-12-20 WO PCT/US2013/076869 patent/WO2014100565A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014100565A1 (en) | 2014-06-26 |
| US20150328310A1 (en) | 2015-11-19 |
| AU2013361164A1 (en) | 2015-07-02 |
| CN105007940A (zh) | 2015-10-28 |
| KR20150099588A (ko) | 2015-08-31 |
| EP2934583A1 (en) | 2015-10-28 |
| SG11201504779YA (en) | 2015-07-30 |
| JP2016503063A (ja) | 2016-02-01 |
| CN105007940B (zh) | 2017-08-25 |
| CA2894547A1 (en) | 2014-06-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20180710 |