RU2014101173A - Новые липидомиметики и их применение - Google Patents
Новые липидомиметики и их применение Download PDFInfo
- Publication number
- RU2014101173A RU2014101173A RU2014101173/04A RU2014101173A RU2014101173A RU 2014101173 A RU2014101173 A RU 2014101173A RU 2014101173/04 A RU2014101173/04 A RU 2014101173/04A RU 2014101173 A RU2014101173 A RU 2014101173A RU 2014101173 A RU2014101173 A RU 2014101173A
- Authority
- RU
- Russia
- Prior art keywords
- formula
- integer
- compound
- independently
- group
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 claims abstract 16
- 239000000126 substance Substances 0.000 claims abstract 7
- 239000000232 Lipid Bilayer Substances 0.000 claims abstract 6
- 239000003814 drug Substances 0.000 claims abstract 4
- 238000001727 in vivo Methods 0.000 claims abstract 4
- 238000012377 drug delivery Methods 0.000 claims abstract 3
- 238000003384 imaging method Methods 0.000 claims abstract 3
- 239000013543 active substance Substances 0.000 claims abstract 2
- 239000000654 additive Substances 0.000 claims abstract 2
- 230000000996 additive effect Effects 0.000 claims abstract 2
- 239000000969 carrier Substances 0.000 claims abstract 2
- 239000012216 imaging agent Substances 0.000 claims abstract 2
- 229940124597 therapeutic agent Drugs 0.000 claims abstract 2
- 229940079593 drug Drugs 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
- C07C69/22—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety
- C07C69/28—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with dihydroxylic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1806—Suspensions, emulsions, colloids, dispersions
- A61K49/1812—Suspensions, emulsions, colloids, dispersions liposomes, polymersomes, e.g. immunoliposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1273—Polymersomes; Liposomes with polymerisable or polymerised bilayer-forming substances
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
- C07C69/22—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety
- C07C69/33—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with hydroxy compounds having more than three hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/708—Ethers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Radiology & Medical Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Dispersion Chemistry (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11170139.7 | 2011-06-16 | ||
| EP11170139A EP2535326A1 (en) | 2011-06-16 | 2011-06-16 | Novel lipidomimetic compounds and uses thereof |
| PCT/IB2012/052829 WO2012172457A1 (en) | 2011-06-16 | 2012-06-06 | Novel lipidomimetic compounds and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2014101173A true RU2014101173A (ru) | 2015-07-27 |
Family
ID=46321195
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014101173/04A RU2014101173A (ru) | 2011-06-16 | 2012-06-06 | Новые липидомиметики и их применение |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9061062B2 (enExample) |
| EP (2) | EP2535326A1 (enExample) |
| JP (1) | JP6085296B2 (enExample) |
| CN (2) | CN103619802B (enExample) |
| BR (1) | BR112013031871A2 (enExample) |
| RU (1) | RU2014101173A (enExample) |
| WO (1) | WO2012172457A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2535326A1 (en) * | 2011-06-16 | 2012-12-19 | Koninklijke Philips Electronics N.V. | Novel lipidomimetic compounds and uses thereof |
| CN104602715A (zh) * | 2012-09-07 | 2015-05-06 | 伯拉考成像股份公司 | 用于MRI的包含金属两亲配合物的顺磁性固体脂质纳米颗粒(pSLN) |
| EP2939999B1 (en) | 2012-12-28 | 2018-03-07 | Dow Corning Toray Co., Ltd. | High-purity monoalkenyl-containing glycerin derivative, and method for producing same |
| CN103304445B (zh) * | 2013-05-27 | 2014-10-22 | 南京大学 | 阳离子聚甘油酯类脂质及其合成方法和应用 |
| MA47824A (fr) * | 2017-03-07 | 2020-01-15 | Translate Bio Inc | Administration polyanionique d'acides nucléiques |
| BR112022023257A2 (pt) * | 2020-06-15 | 2022-12-27 | Bracco Suisse Sa | Aprimoramentos em terapia mediada por ultrassom |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| JP3017035B2 (ja) * | 1993-12-22 | 2000-03-06 | 花王株式会社 | 蛋白質含有食品の改質剤及び改質剤組成物、並びに改質剤で処理した小麦粉製品 |
| US5534499A (en) | 1994-05-19 | 1996-07-09 | The University Of British Columbia | Lipophilic drug derivatives for use in liposomes |
| IL115849A0 (en) | 1994-11-03 | 1996-01-31 | Merz & Co Gmbh & Co | Tangential filtration preparation of liposomal drugs and liposome product thereof |
| US7112337B2 (en) * | 1999-04-23 | 2006-09-26 | Alza Corporation | Liposome composition for delivery of nucleic acid |
| CN100379404C (zh) * | 2003-02-28 | 2008-04-09 | 阿尔扎公司 | 用于减少脂质体诱导的补体激活的脂质体组合物 |
| RU2528104C2 (ru) * | 2008-09-10 | 2014-09-10 | Конинклейке Филипс Электроникс Н.В. | Носитель лекарственного средства, обеспечивающий контрастное усиление при мрт |
| EP2535326A1 (en) * | 2011-06-16 | 2012-12-19 | Koninklijke Philips Electronics N.V. | Novel lipidomimetic compounds and uses thereof |
-
2011
- 2011-06-16 EP EP11170139A patent/EP2535326A1/en not_active Withdrawn
-
2012
- 2012-06-06 CN CN201280029374.5A patent/CN103619802B/zh not_active Expired - Fee Related
- 2012-06-06 BR BR112013031871A patent/BR112013031871A2/pt not_active IP Right Cessation
- 2012-06-06 US US14/122,253 patent/US9061062B2/en not_active Expired - Fee Related
- 2012-06-06 CN CN201511036371.6A patent/CN108276285A/zh active Pending
- 2012-06-06 RU RU2014101173/04A patent/RU2014101173A/ru not_active Application Discontinuation
- 2012-06-06 JP JP2014515312A patent/JP6085296B2/ja not_active Expired - Fee Related
- 2012-06-06 EP EP12728812.4A patent/EP2720999B1/en not_active Not-in-force
- 2012-06-06 WO PCT/IB2012/052829 patent/WO2012172457A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP2014522417A (ja) | 2014-09-04 |
| US9061062B2 (en) | 2015-06-23 |
| US20140127135A1 (en) | 2014-05-08 |
| EP2720999A1 (en) | 2014-04-23 |
| CN108276285A (zh) | 2018-07-13 |
| BR112013031871A2 (pt) | 2016-12-13 |
| CN103619802A (zh) | 2014-03-05 |
| EP2535326A1 (en) | 2012-12-19 |
| CN103619802B (zh) | 2016-01-20 |
| JP6085296B2 (ja) | 2017-02-22 |
| EP2720999B1 (en) | 2017-08-23 |
| WO2012172457A1 (en) | 2012-12-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20160914 |