RU2013141994A - Тиолсодержащие соединения для удаления элементов из тканей и их композиции - Google Patents
Тиолсодержащие соединения для удаления элементов из тканей и их композиции Download PDFInfo
- Publication number
- RU2013141994A RU2013141994A RU2013141994/04A RU2013141994A RU2013141994A RU 2013141994 A RU2013141994 A RU 2013141994A RU 2013141994/04 A RU2013141994/04 A RU 2013141994/04A RU 2013141994 A RU2013141994 A RU 2013141994A RU 2013141994 A RU2013141994 A RU 2013141994A
- Authority
- RU
- Russia
- Prior art keywords
- group
- groups
- hydrogen
- carboxyl group
- aryls
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract 8
- 238000000034 method Methods 0.000 claims abstract 23
- 125000000217 alkyl group Chemical group 0.000 claims abstract 18
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract 17
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 16
- 239000001257 hydrogen Substances 0.000 claims abstract 16
- UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims abstract 14
- 150000002431 hydrogen Chemical class 0.000 claims abstract 13
- 125000000962 organic group Chemical group 0.000 claims abstract 13
- 125000003118 aryl group Chemical group 0.000 claims abstract 12
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims abstract 12
- 241000124008 Mammalia Species 0.000 claims abstract 10
- -1 esters carboxylates Chemical class 0.000 claims abstract 10
- 108010024636 Glutathione Proteins 0.000 claims abstract 6
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical group C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 claims abstract 6
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims abstract 6
- MWPLVEDNUUSJAV-UHFFFAOYSA-N anthracene Chemical group C1=CC=CC2=CC3=CC=CC=C3C=C21 MWPLVEDNUUSJAV-UHFFFAOYSA-N 0.000 claims abstract 6
- 229960003180 glutathione Drugs 0.000 claims abstract 6
- YNPNZTXNASCQKK-UHFFFAOYSA-N phenanthrene Chemical group C1=CC=C2C3=CC=CC=C3C=CC2=C1 YNPNZTXNASCQKK-UHFFFAOYSA-N 0.000 claims abstract 6
- 239000000758 substrate Substances 0.000 claims abstract 6
- CWERGRDVMFNCDR-UHFFFAOYSA-N thioglycolic acid Chemical compound OC(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-N 0.000 claims abstract 6
- 229920000642 polymer Polymers 0.000 claims abstract 5
- IZFHEQBZOYJLPK-SSDOTTSWSA-N (R)-dihydrolipoic acid Chemical compound OC(=O)CCCC[C@@H](S)CCS IZFHEQBZOYJLPK-SSDOTTSWSA-N 0.000 claims abstract 3
- DKIDEFUBRARXTE-UHFFFAOYSA-N 3-mercaptopropanoic acid Chemical compound OC(=O)CCS DKIDEFUBRARXTE-UHFFFAOYSA-N 0.000 claims abstract 3
- GCNTZFIIOFTKIY-UHFFFAOYSA-N 4-hydroxypyridine Chemical group OC1=CC=NC=C1 GCNTZFIIOFTKIY-UHFFFAOYSA-N 0.000 claims abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims abstract 3
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims abstract 3
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 claims abstract 3
- RITKHVBHSGLULN-WHFBIAKZSA-N L-gamma-glutamyl-L-cysteine Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(O)=O RITKHVBHSGLULN-WHFBIAKZSA-N 0.000 claims abstract 3
- FFFHZYDWPBMWHY-VKHMYHEASA-N L-homocysteine Chemical compound OC(=O)[C@@H](N)CCS FFFHZYDWPBMWHY-VKHMYHEASA-N 0.000 claims abstract 3
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims abstract 3
- 108010076986 Phytochelatins Proteins 0.000 claims abstract 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims abstract 3
- 229960004308 acetylcysteine Drugs 0.000 claims abstract 3
- 229910052792 caesium Inorganic materials 0.000 claims abstract 3
- TVFDJXOCXUVLDH-UHFFFAOYSA-N caesium atom Chemical compound [Cs] TVFDJXOCXUVLDH-UHFFFAOYSA-N 0.000 claims abstract 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims abstract 3
- 150000007942 carboxylates Chemical class 0.000 claims abstract 3
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims abstract 3
- 235000018417 cysteine Nutrition 0.000 claims abstract 3
- 108010068906 gamma-glutamylcysteine Proteins 0.000 claims abstract 3
- 229910052736 halogen Inorganic materials 0.000 claims abstract 3
- 150000002367 halogens Chemical class 0.000 claims abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 3
- 235000019136 lipoic acid Nutrition 0.000 claims abstract 3
- 229910052744 lithium Inorganic materials 0.000 claims abstract 3
- 229910052700 potassium Inorganic materials 0.000 claims abstract 3
- 239000011591 potassium Substances 0.000 claims abstract 3
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Chemical group COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims abstract 3
- 229910052701 rubidium Inorganic materials 0.000 claims abstract 3
- IGLNJRXAVVLDKE-UHFFFAOYSA-N rubidium atom Chemical compound [Rb] IGLNJRXAVVLDKE-UHFFFAOYSA-N 0.000 claims abstract 3
- 229910052708 sodium Inorganic materials 0.000 claims abstract 3
- 239000011734 sodium Substances 0.000 claims abstract 3
- 239000000126 substance Substances 0.000 claims abstract 3
- 229960002663 thioctic acid Drugs 0.000 claims abstract 3
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims abstract 3
- 206010027439 Metal poisoning Diseases 0.000 claims abstract 2
- 208000010501 heavy metal poisoning Diseases 0.000 claims abstract 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 8
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 4
- 230000037396 body weight Effects 0.000 claims 4
- 239000000377 silicon dioxide Substances 0.000 claims 4
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 claims 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 238000001990 intravenous administration Methods 0.000 claims 2
- AGBQKNBQESQNJD-UHFFFAOYSA-N lipoic acid Chemical compound OC(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-N 0.000 claims 2
- 239000000829 suppository Substances 0.000 claims 2
- 230000036542 oxidative stress Effects 0.000 claims 1
- 235000013601 eggs Nutrition 0.000 abstract 1
- AGBQKNBQESQNJD-UHFFFAOYSA-M lipoate Chemical compound [O-]C(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-M 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/695—Silicon compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/795—Polymers containing sulfur
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/04—Chelating agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D53/00—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols
- B01D53/34—Chemical or biological purification of waste gases
- B01D53/46—Removing components of defined structure
- B01D53/64—Heavy metals or compounds thereof, e.g. mercury
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2253/00—Adsorbents used in seperation treatment of gases and vapours
- B01D2253/10—Inorganic adsorbents
- B01D2253/106—Silica or silicates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2253/00—Adsorbents used in seperation treatment of gases and vapours
- B01D2253/25—Coated, impregnated or composite adsorbents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2257/00—Components to be removed
- B01D2257/60—Heavy metals or heavy metal compounds
- B01D2257/602—Mercury or mercury compounds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2258/00—Sources of waste gases
- B01D2258/02—Other waste gases
- B01D2258/0283—Flue gases
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2258/00—Sources of waste gases
- B01D2258/02—Other waste gases
- B01D2258/0283—Flue gases
- B01D2258/0291—Flue gases from waste incineration plants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Analytical Chemistry (AREA)
- Emergency Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Environmental & Geological Engineering (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/041,798 | 2011-03-07 | ||
| US13/041,798 US8575218B2 (en) | 2009-09-28 | 2011-03-07 | Thiol-containing compounds for the removal of elements from tissues and formulations therefor |
| PCT/US2012/020418 WO2012121798A2 (en) | 2011-03-07 | 2012-01-06 | Thiol-containing compounds for the removal of elements from tissues and formulations therefor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2013141994A true RU2013141994A (ru) | 2015-04-20 |
Family
ID=46798686
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2013141994/04A RU2013141994A (ru) | 2011-03-07 | 2012-01-06 | Тиолсодержащие соединения для удаления элементов из тканей и их композиции |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8575218B2 (OSRAM) |
| EP (1) | EP2683370A4 (OSRAM) |
| JP (1) | JP2014507470A (OSRAM) |
| CN (1) | CN103442706A (OSRAM) |
| AU (1) | AU2012226279A1 (OSRAM) |
| RU (1) | RU2013141994A (OSRAM) |
| WO (1) | WO2012121798A2 (OSRAM) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8950583B2 (en) * | 2008-12-06 | 2015-02-10 | Ermes Medical Company Limited | Method to remove heavy metals from a mammal |
| EP2483239A4 (en) * | 2009-09-28 | 2014-09-03 | Univ Kentucky Res Found | THIOL-CONTAINING COMPOUNDS FOR REMOVING ELEMENTS FROM A CONTAMINATED ENVIRONMENT AND USE METHOD THEREFOR |
| US8426368B2 (en) * | 2010-03-25 | 2013-04-23 | The University Of Kentucky Research Foundation | Method of ameliorating oxidative stress and supplementing the diet |
| GB2524831A (en) | 2014-04-04 | 2015-10-07 | Ermes Medical Company Ltd | New pharmaceutical use |
| GB2526623A (en) | 2014-05-30 | 2015-12-02 | Ermes Medical Company Ltd | New pharmaceutical use |
| US9802889B2 (en) | 2014-12-02 | 2017-10-31 | Covalent Research Technologies, LLC | Solid supported trithiol compounds for removing heavy metals from solution, and filtration systems utilizing the compounds |
| US20160367620A1 (en) | 2015-06-19 | 2016-12-22 | Harry B. Demopoulos | Glutathione |
| CN121926911A (zh) | 2016-08-05 | 2026-04-28 | 埃梅拉米德有限公司 | N,n-双-2-巯基乙基间苯二甲酰胺的新用途 |
| CN113164396B (zh) * | 2018-11-26 | 2023-11-03 | 宝洁公司 | 含有硫辛酸的固体药物制剂及其用途 |
| US11174277B2 (en) | 2019-05-29 | 2021-11-16 | Alliance For Sustainable Energy, Llc | Sequestering compositions and materials |
| GB202005057D0 (en) | 2020-04-06 | 2020-05-20 | Emeramed Ltd | New Use |
| CN114642681B (zh) * | 2022-03-18 | 2023-08-29 | 中国科学院长春应用化学研究所 | 一种聚合物在顺铂解毒中的应用 |
| WO2026037909A1 (en) | 2024-08-16 | 2026-02-19 | Emeramed Limited | N,n-bis-2-mercaptoethyl isophthalamide for use in the treatment of pain |
| GB202413573D0 (en) | 2024-09-13 | 2024-10-30 | Emeramed Ltd | New pharmaceutical use |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4039446A (en) | 1972-06-28 | 1977-08-02 | Sumitomo Chemical Company, Limited | Heavy metal-binding agent process |
| US4281086A (en) | 1978-12-11 | 1981-07-28 | The University Of Illinois Foundation | Polymer bound multidentate complexes |
| JPS57102852A (en) | 1980-12-19 | 1982-06-26 | Shionogi & Co Ltd | Dicarboxylic acid diamide |
| EP0057797B1 (en) | 1981-02-03 | 1986-06-25 | Imperial Chemical Industries Plc | Process for the extraction of metal values and novel metal extractants |
| DE3231982A1 (de) | 1982-08-27 | 1984-03-01 | Süd-Chemie AG, 8000 München | Thiolathaltiges mittel und verfahren zur entfernung von schwermetallionen aus verduennten waessrigen loesungen |
| US4673562A (en) | 1983-08-19 | 1987-06-16 | The Children's Medical Center Corporation | Bisamide bisthiol compounds useful for making technetium radiodiagnostic renal agents |
| US4751286A (en) | 1985-11-19 | 1988-06-14 | The Johns Hopkins University | Protein label and drug delivery system |
| US5200473A (en) | 1988-03-25 | 1993-04-06 | Jeanneret Gris Gilbert | Chelating resins and method for their use in the extraction of metal ions |
| US5073575A (en) | 1988-08-26 | 1991-12-17 | The Regents Of The University Of California | Cadmium ion-chelating synthetic polymers and process thereof |
| US4969995A (en) | 1988-08-26 | 1990-11-13 | The United States Of America As Represented By The United States Department Of Energy | Removal of metal ions from aqueous solution |
| US5173470A (en) | 1991-08-09 | 1992-12-22 | Brigham Young University | Compositions and processes for removing, separating and concentrating desired ions from solutions using sulfur and aralkyl nitrogen containing ligands bonded to inorganic supports |
| US5494935A (en) | 1992-01-17 | 1996-02-27 | University Of Utah Research Foundation | Methods for oral decorporation of metals |
| SE508881C2 (sv) | 1994-03-02 | 1998-11-16 | Ctc Medical Ab | Preparat avsett att vid behandling av i tänder befintliga amalgamfyllningar och/eller vid inserering av nya amalgamfyllningar hämma frisättning av Hg från amalgamet och/eller oskadliggöra frisatt Hg |
| US5615862A (en) | 1995-02-02 | 1997-04-01 | Gaudette; Robert M. | Metal precipitation composition for treating spent dry film stripping solution |
| US5766478A (en) | 1995-05-30 | 1998-06-16 | The Regents Of The University Of California, Office Of Technology Transfer | Water-soluble polymers for recovery of metal ions from aqueous streams |
| US6126964A (en) | 1996-01-04 | 2000-10-03 | Mirus Corporation | Process of making a compound by forming a polymer from a template drug |
| US6896899B2 (en) | 1996-12-31 | 2005-05-24 | Antioxidant Pharmaceuticals Corp. | Pharmaceutical preparations of glutathione and methods of administration thereof |
| CA2298067A1 (en) | 1997-07-24 | 1999-02-04 | Ulo Langel | Conjugates of transporter peptides and nucleic acid analogs, and their use |
| US7087770B2 (en) | 1998-05-16 | 2006-08-08 | Mirus Bio Corporation | Compound containing a labile disulfide bond |
| US6936729B2 (en) | 1998-05-16 | 2005-08-30 | Mirus Bio Corporation | Compound containing a labile disulfide bond |
| US6586600B2 (en) | 2000-12-06 | 2003-07-01 | University Of Kentucky Research Foundation | Multidentate sulfur-containing ligands |
| RS51031B (sr) | 2001-04-30 | 2010-10-31 | Trommsdorff Gmbh & Co.Kg.Arzneimittel | Farmaceutski aktivni estri uridina |
| US20040132101A1 (en) | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
| US20060099239A1 (en) | 2002-04-15 | 2006-05-11 | Coleman Henry D | Dietary supplement for promoting removal of heavy metals from the body |
| US6852369B1 (en) | 2002-09-05 | 2005-02-08 | University Of Kentucky Research Foundation | Method for prevention of solid dissolution through covalent ligand bonding |
| US20060115555A1 (en) | 2004-12-01 | 2006-06-01 | Foulger Sidney W | Nutritional supplements containing xanthone extracts |
| US9226885B2 (en) | 2005-05-24 | 2016-01-05 | Allium Vitalis Incorporated | Personal care and medicinal products incorporating bound organosulfur groups |
| US9186376B2 (en) | 2005-09-30 | 2015-11-17 | Patrick James Baggot | Maternal chelation for embryo, fetal, and infant benefit |
| US8950583B2 (en) | 2008-12-06 | 2015-02-10 | Ermes Medical Company Limited | Method to remove heavy metals from a mammal |
| EP2483239A4 (en) * | 2009-09-28 | 2014-09-03 | Univ Kentucky Res Found | THIOL-CONTAINING COMPOUNDS FOR REMOVING ELEMENTS FROM A CONTAMINATED ENVIRONMENT AND USE METHOD THEREFOR |
| US8426368B2 (en) | 2010-03-25 | 2013-04-23 | The University Of Kentucky Research Foundation | Method of ameliorating oxidative stress and supplementing the diet |
-
2011
- 2011-03-07 US US13/041,798 patent/US8575218B2/en active Active
-
2012
- 2012-01-06 EP EP12754449.2A patent/EP2683370A4/en not_active Withdrawn
- 2012-01-06 WO PCT/US2012/020418 patent/WO2012121798A2/en not_active Ceased
- 2012-01-06 CN CN2012800121240A patent/CN103442706A/zh active Pending
- 2012-01-06 AU AU2012226279A patent/AU2012226279A1/en not_active Abandoned
- 2012-01-06 RU RU2013141994/04A patent/RU2013141994A/ru not_active Application Discontinuation
- 2012-01-06 JP JP2013557712A patent/JP2014507470A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| US20110160150A1 (en) | 2011-06-30 |
| AU2012226279A1 (en) | 2013-09-19 |
| WO2012121798A2 (en) | 2012-09-13 |
| US8575218B2 (en) | 2013-11-05 |
| EP2683370A4 (en) | 2014-10-15 |
| CN103442706A (zh) | 2013-12-11 |
| EP2683370A1 (en) | 2014-01-15 |
| JP2014507470A (ja) | 2014-03-27 |
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