CN103442706A - 用于从组织中除去元素的包含巯基的化合物及其制剂 - Google Patents

用于从组织中除去元素的包含巯基的化合物及其制剂 Download PDF

Info

Publication number
CN103442706A
CN103442706A CN2012800121240A CN201280012124A CN103442706A CN 103442706 A CN103442706 A CN 103442706A CN 2012800121240 A CN2012800121240 A CN 2012800121240A CN 201280012124 A CN201280012124 A CN 201280012124A CN 103442706 A CN103442706 A CN 103442706A
Authority
CN
China
Prior art keywords
group
alkyl
hydrogen
carboxyl
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2012800121240A
Other languages
English (en)
Chinese (zh)
Inventor
博伊德·E·黑利
大卫·A·阿特伍德
尼拉德里·N·古普塔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Kentucky Research Foundation
Original Assignee
University of Kentucky Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Kentucky Research Foundation filed Critical University of Kentucky Research Foundation
Publication of CN103442706A publication Critical patent/CN103442706A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/695—Silicon compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/795—Polymers containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/04—Chelating agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D53/00—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols
    • B01D53/34—Chemical or biological purification of waste gases
    • B01D53/46—Removing components of defined structure
    • B01D53/64—Heavy metals or compounds thereof, e.g. mercury
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2253/00—Adsorbents used in seperation treatment of gases and vapours
    • B01D2253/10—Inorganic adsorbents
    • B01D2253/106—Silica or silicates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2253/00—Adsorbents used in seperation treatment of gases and vapours
    • B01D2253/25—Coated, impregnated or composite adsorbents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2257/00—Components to be removed
    • B01D2257/60—Heavy metals or heavy metal compounds
    • B01D2257/602—Mercury or mercury compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2258/00—Sources of waste gases
    • B01D2258/02—Other waste gases
    • B01D2258/0283—Flue gases
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2258/00—Sources of waste gases
    • B01D2258/02—Other waste gases
    • B01D2258/0283—Flue gases
    • B01D2258/0291—Flue gases from waste incineration plants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Analytical Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Environmental & Geological Engineering (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
CN2012800121240A 2011-03-07 2012-01-06 用于从组织中除去元素的包含巯基的化合物及其制剂 Pending CN103442706A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/041,798 2011-03-07
US13/041,798 US8575218B2 (en) 2009-09-28 2011-03-07 Thiol-containing compounds for the removal of elements from tissues and formulations therefor
PCT/US2012/020418 WO2012121798A2 (en) 2011-03-07 2012-01-06 Thiol-containing compounds for the removal of elements from tissues and formulations therefor

Publications (1)

Publication Number Publication Date
CN103442706A true CN103442706A (zh) 2013-12-11

Family

ID=46798686

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2012800121240A Pending CN103442706A (zh) 2011-03-07 2012-01-06 用于从组织中除去元素的包含巯基的化合物及其制剂

Country Status (7)

Country Link
US (1) US8575218B2 (OSRAM)
EP (1) EP2683370A4 (OSRAM)
JP (1) JP2014507470A (OSRAM)
CN (1) CN103442706A (OSRAM)
AU (1) AU2012226279A1 (OSRAM)
RU (1) RU2013141994A (OSRAM)
WO (1) WO2012121798A2 (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114642681A (zh) * 2022-03-18 2022-06-21 中国科学院长春应用化学研究所 一种聚合物在顺铂解毒中的应用

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8950583B2 (en) * 2008-12-06 2015-02-10 Ermes Medical Company Limited Method to remove heavy metals from a mammal
EP2483239A4 (en) * 2009-09-28 2014-09-03 Univ Kentucky Res Found THIOL-CONTAINING COMPOUNDS FOR REMOVING ELEMENTS FROM A CONTAMINATED ENVIRONMENT AND USE METHOD THEREFOR
US8426368B2 (en) * 2010-03-25 2013-04-23 The University Of Kentucky Research Foundation Method of ameliorating oxidative stress and supplementing the diet
GB2524831A (en) 2014-04-04 2015-10-07 Ermes Medical Company Ltd New pharmaceutical use
GB2526623A (en) 2014-05-30 2015-12-02 Ermes Medical Company Ltd New pharmaceutical use
US9802889B2 (en) 2014-12-02 2017-10-31 Covalent Research Technologies, LLC Solid supported trithiol compounds for removing heavy metals from solution, and filtration systems utilizing the compounds
US20160367620A1 (en) 2015-06-19 2016-12-22 Harry B. Demopoulos Glutathione
CN121926911A (zh) 2016-08-05 2026-04-28 埃梅拉米德有限公司 N,n-双-2-巯基乙基间苯二甲酰胺的新用途
CN113164396B (zh) * 2018-11-26 2023-11-03 宝洁公司 含有硫辛酸的固体药物制剂及其用途
US11174277B2 (en) 2019-05-29 2021-11-16 Alliance For Sustainable Energy, Llc Sequestering compositions and materials
GB202005057D0 (en) 2020-04-06 2020-05-20 Emeramed Ltd New Use
WO2026037909A1 (en) 2024-08-16 2026-02-19 Emeramed Limited N,n-bis-2-mercaptoethyl isophthalamide for use in the treatment of pain
GB202413573D0 (en) 2024-09-13 2024-10-30 Emeramed Ltd New pharmaceutical use

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6586600B2 (en) * 2000-12-06 2003-07-01 University Of Kentucky Research Foundation Multidentate sulfur-containing ligands
US20100227812A1 (en) * 2008-12-06 2010-09-09 Haley Boyd E Method of supplementing the diet and ameliorating oxidative stress
CN102612511A (zh) * 2009-09-28 2012-07-25 肯塔基大学研究基金会 用于从污染的环境中去除元素的含巯基化合物及其使用方法

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4039446A (en) 1972-06-28 1977-08-02 Sumitomo Chemical Company, Limited Heavy metal-binding agent process
US4281086A (en) 1978-12-11 1981-07-28 The University Of Illinois Foundation Polymer bound multidentate complexes
JPS57102852A (en) 1980-12-19 1982-06-26 Shionogi & Co Ltd Dicarboxylic acid diamide
EP0057797B1 (en) 1981-02-03 1986-06-25 Imperial Chemical Industries Plc Process for the extraction of metal values and novel metal extractants
DE3231982A1 (de) 1982-08-27 1984-03-01 Süd-Chemie AG, 8000 München Thiolathaltiges mittel und verfahren zur entfernung von schwermetallionen aus verduennten waessrigen loesungen
US4673562A (en) 1983-08-19 1987-06-16 The Children's Medical Center Corporation Bisamide bisthiol compounds useful for making technetium radiodiagnostic renal agents
US4751286A (en) 1985-11-19 1988-06-14 The Johns Hopkins University Protein label and drug delivery system
US5200473A (en) 1988-03-25 1993-04-06 Jeanneret Gris Gilbert Chelating resins and method for their use in the extraction of metal ions
US5073575A (en) 1988-08-26 1991-12-17 The Regents Of The University Of California Cadmium ion-chelating synthetic polymers and process thereof
US4969995A (en) 1988-08-26 1990-11-13 The United States Of America As Represented By The United States Department Of Energy Removal of metal ions from aqueous solution
US5173470A (en) 1991-08-09 1992-12-22 Brigham Young University Compositions and processes for removing, separating and concentrating desired ions from solutions using sulfur and aralkyl nitrogen containing ligands bonded to inorganic supports
US5494935A (en) 1992-01-17 1996-02-27 University Of Utah Research Foundation Methods for oral decorporation of metals
SE508881C2 (sv) 1994-03-02 1998-11-16 Ctc Medical Ab Preparat avsett att vid behandling av i tänder befintliga amalgamfyllningar och/eller vid inserering av nya amalgamfyllningar hämma frisättning av Hg från amalgamet och/eller oskadliggöra frisatt Hg
US5615862A (en) 1995-02-02 1997-04-01 Gaudette; Robert M. Metal precipitation composition for treating spent dry film stripping solution
US5766478A (en) 1995-05-30 1998-06-16 The Regents Of The University Of California, Office Of Technology Transfer Water-soluble polymers for recovery of metal ions from aqueous streams
US6126964A (en) 1996-01-04 2000-10-03 Mirus Corporation Process of making a compound by forming a polymer from a template drug
US6896899B2 (en) 1996-12-31 2005-05-24 Antioxidant Pharmaceuticals Corp. Pharmaceutical preparations of glutathione and methods of administration thereof
CA2298067A1 (en) 1997-07-24 1999-02-04 Ulo Langel Conjugates of transporter peptides and nucleic acid analogs, and their use
US7087770B2 (en) 1998-05-16 2006-08-08 Mirus Bio Corporation Compound containing a labile disulfide bond
US6936729B2 (en) 1998-05-16 2005-08-30 Mirus Bio Corporation Compound containing a labile disulfide bond
RS51031B (sr) 2001-04-30 2010-10-31 Trommsdorff Gmbh & Co.Kg.Arzneimittel Farmaceutski aktivni estri uridina
US20040132101A1 (en) 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
US20060099239A1 (en) 2002-04-15 2006-05-11 Coleman Henry D Dietary supplement for promoting removal of heavy metals from the body
US6852369B1 (en) 2002-09-05 2005-02-08 University Of Kentucky Research Foundation Method for prevention of solid dissolution through covalent ligand bonding
US20060115555A1 (en) 2004-12-01 2006-06-01 Foulger Sidney W Nutritional supplements containing xanthone extracts
US9226885B2 (en) 2005-05-24 2016-01-05 Allium Vitalis Incorporated Personal care and medicinal products incorporating bound organosulfur groups
US9186376B2 (en) 2005-09-30 2015-11-17 Patrick James Baggot Maternal chelation for embryo, fetal, and infant benefit
US8426368B2 (en) 2010-03-25 2013-04-23 The University Of Kentucky Research Foundation Method of ameliorating oxidative stress and supplementing the diet

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6586600B2 (en) * 2000-12-06 2003-07-01 University Of Kentucky Research Foundation Multidentate sulfur-containing ligands
US20100227812A1 (en) * 2008-12-06 2010-09-09 Haley Boyd E Method of supplementing the diet and ameliorating oxidative stress
CN102612511A (zh) * 2009-09-28 2012-07-25 肯塔基大学研究基金会 用于从污染的环境中去除元素的含巯基化合物及其使用方法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114642681A (zh) * 2022-03-18 2022-06-21 中国科学院长春应用化学研究所 一种聚合物在顺铂解毒中的应用
CN114642681B (zh) * 2022-03-18 2023-08-29 中国科学院长春应用化学研究所 一种聚合物在顺铂解毒中的应用

Also Published As

Publication number Publication date
US20110160150A1 (en) 2011-06-30
AU2012226279A1 (en) 2013-09-19
WO2012121798A2 (en) 2012-09-13
US8575218B2 (en) 2013-11-05
RU2013141994A (ru) 2015-04-20
EP2683370A4 (en) 2014-10-15
EP2683370A1 (en) 2014-01-15
JP2014507470A (ja) 2014-03-27

Similar Documents

Publication Publication Date Title
US8575218B2 (en) Thiol-containing compounds for the removal of elements from tissues and formulations therefor
US20110076246A1 (en) Thiol-containing compounds for the removal of elements from contaminated milieu and methods of use
CN111683684B (zh) 用于治疗半胱胺敏感性病症的方法
CN102573809B (zh) 结晶方法和生物利用度
CN102188383B (zh) 氨基嘧啶修饰的金纳米颗粒及其制备方法和用途
Biswas et al. Schiff bases: versatile mediators of medicinal and multifunctional advancements
US20100016270A1 (en) Bridged polycyclic compound based compositions for controlling cholesterol levels
US20170172990A1 (en) Method of supplementing the diet and ameliorating oxidative stress
Hong et al. Enhanced oral NO delivery through bioinorganic engineering of acid-sensitive prodrug into a transformer-like DNIC@ MOF microrod
CN110392583A (zh) 改进的杂化的末端树枝状聚合物
CN103316352B (zh) 氧化石墨烯纳米药物载体、抗肿瘤药物及其制备方法
CN110612143A (zh) 抗微生物化合物、组合物及其用途
CN105233298A (zh) 一种紫杉醇类磷脂化合物、其药物组合物及应用
MX2008003067A (es) Composicion que comrpende un dendrimero y el uso del mismo para enlazar fosfato.
CN103347849B (zh) 富勒烯с60的均聚氨基酸和杂多氨基酸衍生物、其制备方法和基于该衍生物的药物组合物
JP2021178855A (ja) ヒストンデアセチラーゼの阻害剤としての大環状分子のチオエステルプロドラッグ
US8124364B2 (en) Biotin derivatives
CN1457260A (zh) 填装有配体－二生物素结合物的可重复使用的体外柱
CN111247149A (zh) 肾脏靶向的环氧二十碳三烯酸(eet)类似物
EP4146171A1 (en) Therapeutic carbon nanomaterial h2s oxidants for biological polysulfide synthesis
CN104981249B (zh) 抗微生物化合物、它们的合成及其应用
CN119894523A (zh) 官能化聚合物的医疗用途
Trbojevich et al. Biological synthesis, pharmacokinetics, and toxicity of different metal nanoparticles
CA2828395A1 (en) Thiol-containing compounds for the removal of elements from tissues and formulations therefor
US20120135959A1 (en) Metalloprotein inhibitors containing nitrogen based ligands

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20131211